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中国医学创新

2015 Vol.12,No.02

Published 2015-01-15

YANG Fang,GUO Chun-xia.

Objective:To investigate the clinical value of combined detection of erythrocyte sedimentation rate (ESR),rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(anti CCP) and anti keratin antibody (AKA) in diagnosis of rheumatoid arthritis(RA).Method: ESR, RF, anti CCP and AKA in 100 patients with RA and 70 patients with other autoimmune diseases were detected.Result: In RA group, positive rate of four indexs was obviously higher than those of other autoimmune disease group, individual testing RA diagnostic sensitivity for ESR>RF>CCP>AKA,the specificity of CCP>AKA>RF>ESR,combined detection of RA diagnostic sensitivity,specificity was elevated even  higher amounts to 100%.Conclusion:Combined detection of ESR,RF,anti CCP and AKA can improve RA diagnostic  specificity,has high value on early diagnosis of RA.

2015 Vol. 12 (02): 1-3 [Abstract]( 751 HTML (1 KB)  PDF  (759 KB)  ( 253 )

MOU De-tang,QIU Ren-feng.

Objective:To investigate the effects of phytoestrogen isoflavone on balloon catheter-induced  hyperplasia of carotid artery.Method:Forty-eight female New Zealand rabbits were randomly divided into four groups:control( balloon-induced carotid artery injury only); ovariectomy control( ovariectomy and carotid artery injury),oestrogen( ovariectomy, carotid artery injury and nilestriol, 5 mg/kg daily for 28 days), and isoflavone( ovariectomy,carotid artery injury and isoflavone 120 mg/kg daily for 28 days). The arterial wall thickness was assessed by coloured  ultrasonography.Rusult:The medial layer thickness in the isoflavone group was less than in the ovariectomy control group(0.28±0.03 vs.0.35±0.04 mm,P<0.01), and the intimal/medial layer( I/M) ratio was the isoflavone group was also  less than in the ovariectomy control group( 16.85±3.79 vs.48.94±8.92,P<0.01).There was no statistically significant difference in the medial layer thickness or I/M ratio between the isoflavone and the oestrogen groups. Conclusion:Soybean
isoflavones can play a role of protecting blood vessels to inhibit neointimal hyperplasia and the proliferation of vascular  smooth muscle cell in Vascular injury .
 

2015 Vol. 12 (02): 4-7 [Abstract]( 635 HTML (1 KB)  PDF  (931 KB)  ( 144 )

SU Ying-ying,DU Qi-tao,ZHANG Qian,et al.

Objective:To investigate the expression of matrix metalloproteinase 2,9 in oral mucosa, hyperplasia  and dysplasia and to discuss the correlation of MMP-2,9 with oral leukoplakia. Method:The statistical evaluation was used to analyze immunohistochemical results.The study was carried out on clinically and histologically proven 15 cases of normal mucosa and 31 cases of hyperplasia and 35 cases of dysplasia using anti-MMP-2 and anti-MMP-9 antibodies. Result:MMP-2,9 are both present in cytoplasm. In epithelium, the positive rates of MMP-2 and MMP-9 in normal
oral mucosa,hyperplasia and dysplasia was 20.0%,22.6%,34.3% and 6.7%,9.7%,34.3%,respectively.Under epithelium,in fibroblasts,the positive rates of MMP-2 and MMP-9 in above three groups was 0,12.9%,14.3% and  6.7%,25.8%,80.0%,respectively.There was no significant difference in the expression of MMP-2 between three groups(P>0.05),but the expression of MMP-9 was higher in dysplasia than in normal oral mucosa and hyperplasia (P<0.05).Conclusion:MMP-9 maybe plays a role in the occurrence and development of leukoplakia.
(P<0.05).Conclusion:MMP-9 maybe plays a role in the occurrence and development of leukoplakia.

2015 Vol. 12 (02): 7-9 [Abstract]( 540 HTML (1 KB)  PDF  (761 KB)  ( 201 )

GOU Jian-qiang,LI Qiang.

Objective:To compare the effect and safety of budesonide inhalation aerosol with intravenous glucocorticoids in the treatment of the acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Method: Totally 84 subjects with AECOPD were randomly divided into three groups. All patients were treated with budesonide inhalation aerosol, the intravenous methyl-prednisolone(IVM), and the intravenous dexamethasone. Three
groups used 7 days therapy. The mMRC, blood gas analysis, pulmonary function and adverse reactions of three groups were observed.Result:The mMRC,blood gas analysis, and pulmonary function of three groups were significantly  improved after treatment(P<0.05).The group of budesonide inhalation aerosol was no significantly improved compared to intravenous methyl-prednisolone(IVM)(P>0.05).The adverse reactions of budesonide inhalation aerosol group were significantly improved compared to intravenous methyl-prednisolone(IVM) group, and the intravenous dexamethasone
group(P<0.05).Conclusion: The effect of Intravenous glucocorticoids treatment of the acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is significant, there is no significant difference between budesonide inhalation aerosol group and intravenous methyl- prednisolone(IVM) group, but significantly improved than intravenous dexamethasone.At the same time,the adverse reactions of budesonide inhalation aerosol were less than intravenous glucocorticoids.So budesonide inhalation aerosol can be as another method to treat AECOPD,worthy of clinical application.

2015 Vol. 12 (02): 10-12 [Abstract]( 573 HTML (1 KB)  PDF  (760 KB)  ( 322 )

ZHANG Gui-you,LIN Yu-yu, YANG Ge,et al.

Objective:To analyze the efficacy of olecranon shaped plate and tension band in the treatment of  olecranon fractures.Method:60 patients were randomly selected from August 2012 to August 2013 in our hospital for the study, patients were postoperative followed-up completely in August 2013 to August 2014.The 60 cases studied were randomly divided into an experimental group and a control group of 30 patients, the control group were treated with tension band wire fixation method, the experimental group were treated with olecranon anatomical shaped plate fixation.To track the rehabilitation of patient’s condition, including the elbow function assessment, fracture healing and complication rates by postoperative following-up completely.The olecranon fracture treatment of the two groups was compared. Result: 60 patients were followed up in this study ,they all get healed fractures.In the experimental group,25 cases of excellent, 3 cases of good,2 cases of can ,good rate of 93.3%;in the control group,23 cases of excellent,4
cases of good,2 cases of can and 1 case of poor,good rate of 90.0%.There were no statistically significant difference (P>0.05).Conclusion:There are no significant difference between the olecranon anatomical shaped plate fixed and tension band in the efficacy of the treatment of olecranon fractures ,they are all the more effective treatment. The chosen of different surgical methods needs according to the different fracture types and people for clinical treatment of olecranon fractures.
  

2015 Vol. 12 (02): 13-15 [Abstract]( 458 HTML (1 KB)  PDF  (789 KB)  ( 136 )

GUO Hai-rong,LIU Su-su,LIU Ping

Objective:To explore the curative effect of vaginal anterior and posterior prolapse after vaginal bridge repair. Method:Based a retrospective analysis,the clinical data of cases from January 2009 to March 2012 with vaginal anterior and posterior prolapse had been repaired in our hospital were collected,34 cases were treated by vaginal bridge repair and 29 cases by classical repair from January 2006 to March 2009.Then the curative effect of the two operative methods in the near future were compared.Result:The operation time of the vaginal anterior and posterior bridge repair were( 1.20±0.64)hours, the loss blood were( 10.5±3.96)mL,the recurrence rate was 0.Compared with traditional repair, the operation time were( 1.70±0.74)hours,the loss blood were( 36.90±2.46)mL,the recurrence rate was 10.34%, the differences were statistically significant(P<0.05).Conclusion:Comapred with classical repair, vaginal bridge repair can make shorter operation time,less intraoperative bleeding and postoperative recurrence rate is lower, and there is no urethra, bladder injury,and we don’t find the rectum injury and vaginal wall hematoma and so on.The recent curative effect is satisfied.

2015 Vol. 12 (02): 16-18 [Abstract]( 438 HTML (1 KB)  PDF  (773 KB)  ( 243 )

LI Lin-xia,ZHAO Lin,LI Yan-hong,et al.

Objective:To explore the therapeutic effect of valsartan combination treatment with mycophenolate mofetil and prednison in refractory nephropathy syndrome. Method:54 patients with primary refractory nephropathy syndrome were randomly divided into treatment group and control group. 36 cases of treatment group were treated by valsartan combined with MMF and prednisone, and 18 cases of the control groups were only threated with MMF and prednisone.The blood test, 24 h quantitation of proteinuria, liver function and renal function periodically were observed. Result:3 months later,the total effective rate were 94.5% and 83.3% respectively. Conclusion: Valsartan combined with MMF and prednisone is effective on child primary refractory nephropathy syndrome.It is a kind of promising clinical treatment of this disease at present

2015 Vol. 12 (02): 19-21 [Abstract]( 487 HTML (1 KB)  PDF  (760 KB)  ( 213 )

WU Zhe,WANG Tao.

Objective:To observe clinical of dental restorations membrane materials in the application of dental implants in guided bone regeneration. Method:Teeth plant regeneration of 106 patients were selected and divided into two groups according to random number table method, control group( 53 cases) used titanium membrane guided bone regeneration, reserach group( 53 cases) used the oral repair membrane guided bone regeneration,Repair success rate
and 1 week bone thickness, thickness of bone graft, and evaluation of safety of two groups was observed.Result: The repair success rate of reserach group was 94.3%, significantly higher than 83.0% of the control group,( P<0.05). The 1 week bone thickness and thickness of the bone graft of reserach group were significantly higher than that of control group (P<0.05).The incidence of adverse reactions of reserach group was 3.8%, significantly lower than 13.2% of the control group,there was statistically significant difference(P<0.05).Conclusion:The haiao dental restorations membrane guided bone regeneration in the dental implants is good effect, and has high success rate of repair, effectively promote the growth of bone and bone graft, worthy of clinical promotion and popularization.

 

2015 Vol. 12 (02): 22-24 [Abstract]( 864 HTML (1 KB)  PDF  (761 KB)  ( 615 )

LI He-yun,GUO Zheng-hong,DING Lian-he,et al

Objective: To study the clinical effect sodium bicarbonate with nystatin on the treatment of pediatricthrush, for the proof of this kind of disease. Method: A total of 242 cases of 0 to 6 months thrush pediatric patients fromDecember 2010 to September 2013in our hospital were randomly divided into two groups,121 cases in each group. Thecontrol group was coated nystatin powder, the treatment groups was treated by 20% of sodium bicarbonate for 3-4 timesa day on the base of the nystatin powder, the clinical symptoms disappear time, the recurrence rate, the total clinicaleffect and the adverse effect were observed and compared. Result: The time of vitiligo disappear of 1-2 days in treatmentgroup significant higher than the control group,the difference was statistically significant(P<0.05); the treatmentgroup of recurrence rate in 3 months and 6 months were 2.2% and 4.7%, they were significant lower than the control groupof 10.9% and 24.4%,the difference was statistically significant(P<0.05); treatment group of total effective rate was96.7% and the control group of total effective rate was 81.1%, the difference was statistically significant(P<0.05); therash and vomiting were significant lower than the control group, the difference was statistically significant(P<0.05).Conclusion: The effect of sodium bicarbonate with nystatin on pediatric thrush is remarkable, the symptom in clinical isimproved, the recurrence is high, the clinical effect is better, the tolerance is well. It is worth for clinical use.

2015 Vol. 12 (02): 24-26 [Abstract]( 434 HTML (1 KB)  PDF  (760 KB)  ( 200 )

ZHENG Ming-yang,WANG Li.

Objective:To investigate the clinical value of Resistance index( RI) of Ultrasound with serum tumormarkers CA125,CA199 and CA72-4 in diagnosis of ovarian cancer.Method:92 patients were selected in our hospitalfrom May 2011 to May 2014,42 patients with ovarian cancer as the malignant group and 50 patients with benign ovarytumor as the contrast group.They were tested with tumor markers CA125,CA199,CA72-4 prior to the operation andresistance index( RI) of ultrasound and then the diagnostic value were observed.Result: The CA125,CA199,CA72-4in ovarian cancer group were obviously higher and the RI was obviously lower, the differences were statistically significantof the two groups(P<0.05).The sensitivity of tumor maker CA125,CA199,CA72-4 were 71%,35% and 31%;thesensitivity and specificity of resistance index were 66.7% and 92%;Combined Resistance index( RI) of Ultrasound and
tumor markers results,the sensitivity and specificity were 95.7% and 96.2%,the differences were statistically significantof the two groups(P<0.05).Conclusion: The combination of Resistance index( RI) of Ultrasound and tumor marketsCA125,CA199,CA72-4 can improve the sensitivity and the specificity in diagnosis of ovarian cancer ,and can be aneffective diagnosis method.

2015 Vol. 12 (02): 27-29 [Abstract]( 468 HTML (1 KB)  PDF  (759 KB)  ( 234 )

WEN Bao-quan,PENG Yuan-qiang,LIN Xiang-yan.

Objective:To analyze the value of the application of dynamic monitoring of serum H-FABP in the   determination of acute brain injury patient's condition. Method:Patients with acute brain injury in our hospital from   May 2013 to May 2014 were divided into the mild,moderate group and severe group according to the severity,included   26 cases,23 cases and 25 cases. Other 30 cases of healthy were chosen as the control group. The changes of serum  
H-FABP level of different groups were compared,and they were taken for following up. The differences of 24 hours after   hospital admission between serum H-FABP level for different prognosis (severe disability,moderate disability,good   recovery)were compared. Result:The Serum H-FABP levels of various time periods of the acute brain injury group were significantly higher than the control group(P<0.05).The changes of serum H-FABP level among the three groups lasted mild group,moderate group and severe group were with significant differences(P<0.05).The serum H-FABP   levels increased with the disease worsen. The highest point of serum levels of H-FABP occurred 1 day after admission.The   serum H-FABP levels 24 h after hospitalization for acute brain injury patients with different prognosis were with significant differences,the lower of the serum H-FABP level,the worse of the prognosis(P<0.05).Conclusion:Serum H-FABP   level in patients is positively correlated with the situation of acute brain injury,and it has instructive significance for   prognosis.  

2015 Vol. 12 (02): 30-32 [Abstract]( 460 HTML (1 KB)  PDF  (762 KB)  ( 185 )

YAN Zhen-ya,GUO Guo-jian,TIAN Ji-tao.

Objective:To investigate influence of pre-injection Butorphanol on myoclonus caused by Etomidateduring induction of general anesthesia.Method:To be under general anesthesia for elective surgery were 180 cases,ASA Ⅰ or Ⅱ, male 85 cases, female 95 cases, aged 20 to 65 years old, weighing 42-59 kg, were randomly divided intobutorphanol group( group B), Sufentanil group( S group) and control group( N group), 60 cases in each group. GroupB received butorphanol 20 μg/kg( total not more than 2 mg); S group received sufentanil 0.2 μg/kg, N group given thesame volume of saline, 1 min threegroups of patients after intravenous injection of etomidate acetate 0.3 mg/kg, injectiontime 30 s and continued to observe for 2 min, spasm conditions was observed and the severity was assessed.Result:Ofthe three groups of patients during induction BP, HR difference was not statistically significant, all patients SpO2> 97%;compared with the N group, group B, S myoclonic patients significantly reduced the number of cases 1,2,3,muscleArray twin significantly lower incidence(P<0.05).Conclusion:Preinjection 20 μg/kg butorphanol can effectivelyreduce lead time etomidate induced myoclonus occur.

2015 Vol. 12 (02): 32-35 [Abstract]( 459 HTML (1 KB)  PDF  (783 KB)  ( 209 )

HE De-lu.

Objective:To investigate the effect of intrathecal injection of magnesium sulfate on abdominalpanhysterectomy.Method:64 women undergoing abdominal panhysterectomy were randomly divided into observationgroup and control group with 32 cases each.2.5 mL(12.5 mg) of bupivacaine+0.5 mL(25 mg) fentanyl+0.5 mLphysiological saline were injected into subarachnoid administration in control group.2.5 mL( 12.5 mg) of bupivacaine+0.5 mL(25 mg) fentanyl +0.5 mL(100 mg)magnesium sulfate were injected into intrathecal in treatment group.Somaticsensory block, motor block begins occurrence time and duration, duration of analgesia and adverse reaction were observedin two groups.Result:Sensory and motor block start time and duration of analgesia in the treatment group was significantlylonger than that of the control group,there was statistically significant difference compared with the control group(P<0.05).But the duration of motor block and the incidence of side effects was no statistically significant differencein thetwo groups(P>0.05).Conclusion:Intrathecal injection of 100 mg Magnesium sulfate can not increase in the incidence of side effects case duration prolonged analgesia.At the same time,can prolong the starting time of sensory and motor block

2015 Vol. 12 (02): 35-37 [Abstract]( 391 HTML (1 KB)  PDF  (760 KB)  ( 217 )

WAGN Chang-liang,WANG Li-quan,LIN Ming-zhen,et al.

Objective:To explore the expression of long chain of non-encoded RNA-HOTAIR in sentinel lymphnode and axillary lymph node in breast cancer, to analyze the correlation with other indicators of breast cancer, and tohelp guide treatment and predict outcome. Method: Data from 10 surgical patients of breast cancer hospitalized from June2013 to December 2013 was collected. Sentinel lymph node biopsy was performed, and breast tumor tissue, paracanceroustissue,Sentinel lymph node(SLN),and axillary lymph nodes( ALN) were collected.Invasive ductal carcinoma wasconfirmed by pathological examination.Expression of HOTAIR in 4 sets of specimen tissue was measured by real-timefluorescence quantitative RT-PCR.Combined with clinical pathology, the correlation with other indicators was evaluatedusing t test and rank correlation.Result:(1)HOTAIR gene expression in each group was measured.(9.33±1.23) forSLN group and( 6.90±2.00) for ALN Group( t=3.401,P=0.004).(8.81±1.27) for Cancer Group, and( 7.00±1.11)for paracancerous tissue group( t=3.389,P=0.003).The difference of the expression of HOTAIR between SLN group andthe adjacent tissue Group was statistically significant(t=4.441,P<0.001).(2)HOTAIR expression was correlatedwith Clinical pathological indicators. It was positively correlated with Ki-67 protein expression and lymph node metastasis
rate, and the correlation coefficient of 0.67 and 0.82, respectively(P<0.05).Conclusion:Abnormal high expressionof HOTAIR was observed in the Sentinel Lymph nodes of breast cancer as well as the tumor tissue.It can promote cellproliferation, invasion and metastasis,which may provide new therapeutic target for breast cancer

2015 Vol. 12 (02): 38-41 [Abstract]( 496 HTML (1 KB)  PDF  (783 KB)  ( 193 )

DAI Ming-fu

Objective: To explore the improved non prolapse uterus operation safety and superiority.Method: From 2012 January to 2014 January in Shifang City Maternal and Child Health Hospital, 66 patients of uterinebenign lesion and non prolapse uterus resection were treated by improved transvaginal hysterectomy, and their weight,operative time, hospitalization time, postoperative complications of bleeding were observed during and after operation,which were compared with 70 patients who underwent transabdominal and transvaginal hysterectomy traditional surgery, inorder to understand the safety and operation innovation. Result: The amount of bleeding, operation time, hospitalizationtime and postoperative fever, postoperative bleeding, abnormal vaginal secretions of the study group was significantlybetter than that of the control group, with statistically significant differences( P<0.05). Conclusion: The modifiedsurgical method not only bleeding significantly reduces, operation time and hospitalization time is shortened obviously,and the incidence of postoperative complications is significantly lower. To retain the traditional vaginal hysterectomy is notopen, no incision, less trauma, on intestinal interference is small, the advantages of rapid recovery after operation. At thesame time to improve its exposure is difficult, technical requirements are relatively high, organ injury risk shortcomings. Itis worth of promotion in hospitals.

2015 Vol. 12 (02): 41-43 [Abstract]( 440 HTML (1 KB)  PDF  (775 KB)  ( 158 )

LI Bin.

Objective: To compare the total intravenous anesthesia and inhalation anesthesia on postoperativecognitive function in elderly patients. Method: 100 cases with stomach and intestine abdominal operation in elderlypatients were selected from August 2012 to August 2014 in our hospital,the patients were randomly divided into
intravenous group and inhalation group ,50 cases in each group. Intravenous anesthesia was used in the intravenousgroup and inhalation anesthesia was used in the inhalation group. Two groups of patients with postoperative recoverytime, extubation time and MMSE score were compared. Result: Compared withinhalation group, the recovery time andextubation time were shorter, the differences were statistically significant( P<0.05). Compared with the preoperative,postoperative intravenous group by 60 min with lower MMSE scores, inhalation group patients after 60,180,360 minMMSE score was lower , the differences were statistically significant( P<0.05); compared with inhalation group, byintravenous group patients after 60,180,and 360 min MMSE scores were higher, the differences were statisticallysignificant( P<0.05).Conclusion:The intravenous anesthesia group can reduce the incidence of POCD in elderly
patients, cognitive function, better protection of the patients, improve the quality of life of patients, improve the prognosisof patients, and can be widelyused in clinical.
  

2015 Vol. 12 (02): 44-46 [Abstract]( 485 HTML (1 KB)  PDF  (773 KB)  ( 283 )

ZHOU Rong-cu

Objective:To investigate the gastroscopic and pathological characteristics of huge stomach ulcer,and make a guideline for the clinic.Method:A retrospective analysis on 108 patients diagnosed huge stomach ulcer fromJanuary 2007 to December 2013 were done.Result:Of all the 108 patients,44 were benign and 64 were malignant.Amongthe benign ulcer,the diameter of 86.36%(38/44) were in 3-3.5 cm,and 13.64%(6/44) were bigger than 3.5 cm.Andamong the malignant ulcer,the diameter of 31.25%(20/64) were in 3-3.5 cm, and 68.75%(44/64) were bigger than3.5 cm.For the infection of Hp(helicobacter pylori),the infection ratio of benign ulcer was 59.09% while the malignantulcer was 84.38%.Most of the patients were over 40 years old.Conclusion:Most of the stomach ulcer were malignant withHP infection,digestive symptoms,and the patients’ age were over 40.These patients had a greater potency of having a
history of alcohol abuse or family history of cancer.For the patients who were infected by Hp,a gastroscopy is necessary forearly diagnose.

2015 Vol. 12 (02): 47-49 [Abstract]( 427 HTML (1 KB)  PDF  (773 KB)  ( 172 )

REN Ling.

Objective: To explore the clinical effects of advanced cervical carcinoma by nedaplatin combinewith concurrent chemoradiotherapy. Method: 135 cases of patients with advanced cervical carcinoma were randomlydivided into group A, group B and group C,45 cases in each group. The group A was treated by nedaplatin combinewith concurrent chemoradiotherapy, the group B was treated by cisplatin combine with concurrent chemoradiotherapy,the group C was treated by radiation. The clinical effects and adverse reactions were compared. Result: There was nosignificant difference on the total effective rate for group A and group B(P>0.05). The total effective rate for groupA and group B were higher than group C, the difference was statistically significant(P<0.05). The rate of adversereactions of I~IV for the group A were lower than the group B,the difference was statistically significant( P<0.05).The rate of adverse reactions of I for the group A were lower than the group B,the difference was statistically significant(P<0.05). Conclusion: The clinical effects of advanced cervical carcinoma by nedaplatin combine with concurrentchemoradiotherapy is good, it has high clinical effects, with low adverse reactions. It is worthy of clinical promotion.

2015 Vol. 12 (02): 50-52 [Abstract]( 456 HTML (1 KB)  PDF  (775 KB)  ( 198 )

GAN Wen-yun,WANG Teng,LI Hai-ming,et all

Objective:To investigate the effects of inhaled Tiotropium on pulmonary function results in patientswith stable chronic obstructive pulmonary disease(COPD).Method:68 COPD patients were randomly divided intoexperimental group(tiotropium group) and control group.The pulmonary functio(FEVlFEVl/FVC,FEVl%) andinfiammatory cytokines(IL-8,TNF-α) were measured both before and 6 weeks after inhalation.Result:(1)Therewere no significant differences in the values of forced expiratory volume in FEV1,FEV1/FVC,FEV1%,IL-8 andTNF-α before treatment between two groups( P>0.05).(2)These were significantly improved in the values of forcedexpiratory volume in FEV1, FEV1/FVC,FEV1%(P<0.01 or P<0.05),the levels of IL-8,TNF-αin induced sputumcan be significantly decreased between two groups(P<0.01),and after treatment the experimental group were better thanthe control grou(P<0.01).Conclusion:Inhaled tiotropium can significantly improve the pulmonary functions,reducethe levels of inflammatory cytokines and airway inflammation in the treatment of COPD patients at stable stage.

2015 Vol. 12 (02): 53-55 [Abstract]( 587 HTML (1 KB)  PDF  (763 KB)  ( 198 )

LI Jian-ji,OU Zhao-xi,ZHANG Guang-hui.

Objective:To observe the clinical curative effect of combined traditional Chinese and Westernmedicine in treatment of wet age-related macular degeneration. Method:From January 2013 to January 2014 in ourdepartment,70 cases of wet age-related macular degeneration were selected.According to the completely random table,the patients were divided into combined group and control group,35 cases in each group.The control group were treatedwith single western medicine treatment, the control group were treated with traditional Chinese Medicine treatmentfoundation, the treatment effect of the two groups were compared after 2 months treatment. Result: The markedlyeffective, improved and invalid patients in combined group were 22 cases( 62.9%), 12 cases( 34.3%) and 1 cases(2.8%), the total effective rate was 97.2%; markedly effective, improved and ineffective patients in the control groupwere 18 case( 51.40%), 10 cases( 28.6%) and in 7 cases( 20%), the total efficiency was 80%. Combined treatmentwas better than that in control group, there was significant difference between the groups(P<0.05).Conclusion:Combining traditional Chinese and Western medicine treatment of age related macular degeneration of wet significantly,can significantly improve the treatment effect of the patients, promote significantly improve outcome quality, can be widely
used in clinic

2015 Vol. 12 (02): 55-58 [Abstract]( 506 HTML (1 KB)  PDF  (782 KB)  ( 204 )

HE Zhong-hong,DENG Shang-an,CHI Qi.

Objective:To explore the clinical research on patients with acute respiratory failure treated bynoninvasive positive pressure ventilation(NIPPV) and provide the clinical basis.Method:72 patients with acuterespiratory failure were selected randomly from July 2012 to December 2013 in our hospital. According to the application
of ventilation, they were divided into invasive mechanical ventilation group(the control group) and noninvasive positivepressure ventilation group( the observation group), which were 36 cases in each groups respectively. The main assessmentindexes of two groups were PaO2, PaCO2 and SaO2 after 4 h and 24 h ventilation; mechanical ventilation, VAPoccurrence rate.Result:In the observation group,4 h PaO2, PaCO2 ventilation and SaO2 were( 82.77±1.68)mm Hg,(57.80±1.13)mm Hg,(77.19±5.46)%;24 h PaO2, ventilation PaCO2 and SaO2 were( 92.48±1.41)mm Hg,(49.85±1.02)mm Hg,(93.83±6.07)%.In the control group,PaO2, PaCO2 4 h ventilation and SaO2 were(91.43±1.92)mm Hg,(52.37±0.81)mm Hg,(81.31±6.68)%,24 h PaO2,PaCO2 ventilation and SaO2 were(94.55±1.30)mm Hg,(50.34±0.89)mm Hg,(94.02±7.96)%,there was a statistically significant differencein ventilation 4 hours between the two groups(P<0.05), there was no significant differences in ventilation 24 hours.The
incidence of VAP in the observation group was 8.33%, which was lower than 27.78% in the control group, the differencewas statistically significant(P<0.05).Hospital stay in the observation group was( 17.19±0.46)d, which was lowerthan( 21.31±0.68)d in the control group, the difference was statistically significant(P<0.05).Conclusion:NIPPVcould effectively improve the gas exchange of the patients with acute respiratory failure, without the need for tracheotomy,effectively avoid various complications occurred.

2015 Vol. 12 (02): 58-60 [Abstract]( 488 HTML (1 KB)  PDF  (762 KB)  ( 220 )

XIANG Yi,ZHENG Zi-fu,SHEN Pei,et al.

Objective:To compare clinical effect of LMA (Supreme) laryngeal mask and tracheal intubationcombined with intravenous anesthesia used in the laparoscopic cholecystectomy.Method:Sixty patients with ASAⅠ-Ⅱ,no serious heart and lung function abnormalities, no oropharyngeal diseases and difficult airway,undergoing LCoperation, were randomly divided into two groups: 30 patients in each group. Blood pressure and heart rate changes wereobserved during intubation period, the operation period and the extubation( LMA) period.Oxygen saturation and end tidalcarbon dioxide partial pressure change during operation were also observed.Flatulence and postoperative complicationswere observed.Result:The two groups after induction of anesthesia, blood pressure during operation were compared withthe basic value decreased significantly, laryngeal mask group flatulence incidence( 0 cases) was significantly lowerthan that of endotracheal intubation group(18 cases)(P<0.01),laryngeal mask group extubation cough,bodymovement rate( 4 cases) was significantly lower than that of the trachea insert tube group( 16 cases)(P<0.01).Conclusion:LMA( Supreme) with laryngeal mask airway anesthesia hemodynamic composite vein smooth, comparison,and tracheal intubation has the advantages of simple operation, less complications, can be safely and effectively used inlaparoscopic cholecystectomy.

2015 Vol. 12 (02): 61-64 [Abstract]( 584 HTML (1 KB)  PDF  (782 KB)  ( 257 )

XUE Chuanpeng,LIU Yan.

Objective:To evaluate the clinical effects of three different mandible treatment methods in thecombined radical operation of tongue cancer. Method:37 cases of tongue cancer were collected and followed-up fromJanuary 2011 to December 2012. These patients were divided into three groups : Group A of 9 cases were treated withmandibular segmental resection; Group B of 15 cases were treated with mandibular rectangular resection and Group C of 13cases were treated with retaining of integrated dentition and mandible. Then,the feasibility of different mandible treatmentmethods in the radical operation of tongue cancer was evaluated,and the operation effects were observed. Result: Amongthe 37 cases of tongue cancer had been followed-up for 18 months after operation, there were 5 cases of local recurrence, 7cases of cervical lymph node metastasis, and 1 case of distant metastasis. However, tumor recurrence was not found in the
incision of homolateral mandibular buccal-lingual gingival mucosa or remained mandible. Moreover, there were no obviousrelations between different mandible treatment methods and recurrence rate or site of recurrence of tongue cancer, thedifference was statistically significant(P>0.05), and the oral function of Group C recovered best.Conclusion:Providedmandible and mucoperiosteum of lingual side are not invaded by primary foci of tongue cancer, the clinical evaluation ofmandibular rectangular resection is superior to that of mandibular segmental resection; and preservation of the integrality ofdentition and mandible is superior to that of mandibular rectangular resection.

2015 Vol. 12 (02): 64-67 [Abstract]( 580 HTML (1 KB)  PDF  (777 KB)  ( 155 )

ZHU Zi-xing,ZHENG Jian-wen.

Objective:To investigate the cognition and demand of patients for wound dressing after operation,for clinical nurses on postoperative patients with wound related health education and psychological support to providescientific basis.Method:90 patients those who were admitted to our hospital for surgical treatment were analyzed, closlyobserve the patients’ life testify after surgery,and ask the patients for the questionnaire which was our hospital drawn up
that including general information and patient patient’s wound cognition, demand dressing, the current health care givento five aspects of the surgical wound dressing, patient satisfaction, through it we can learn postoperative wound dressingawareness and demand.Result:67.2% of the patients understand the purpose and significance of wound was still small,94.4% incomplete understanding of factors affecting wound healing;patients want doctors "once a day" to give a view andchange the dressing wounds accounted for 67.8% and 71.1%, the current clinical with "once a day" frequency view woundsaccounted for 57.8%, change the dressing accounted for 43.3%, the actual frequency as "two days or more a" accountedfor 27.8% and45.7%. Postoperative patient satisfaction with wound dressing change for 71.4%.Conclusion:Most of thepatients on the cognitive level of wound after operation and the patients are given low, wound on the doctor’s expectedvalue higher than the current clinical practice, thus affecting the satisfaction of patients in a certain extent.

2015 Vol. 12 (02): 68-71 [Abstract]( 692 HTML (1 KB)  PDF  (800 KB)  ( 272 )

ZHANG Hong-xia,CHEN Li-fen,HE Xiong-xia,et al.

Objective: To investigate the standard maintenance practice of implantable venous access port( IVAP)in order to keep the catheter free of obstruction or infection to ensure successful treatment. Method: An evidence-basednursing team was established to evaluate the authenticity,reliability,and practicability of the evidence regarding themanagement of non-injured needle injection, flushing and sealing, catheter-related infection during maintenance ofIVAP in 129 patients in the department of Breast Surgery from October 2011 to April 2012. Result: The success rateof one-time non-injured needle injection was 99.4%.No obstruction or infection happened during catheter retention.Conclusion:Evidence-based is the basis of clinical care, applying evidence-based nursing to IVAP maintenance for
standard operation procedure and to guide clinical were great significance.

2015 Vol. 12 (02): 72-75 [Abstract]( 559 HTML (1 KB)  PDF  (780 KB)  ( 501 )

WU Yan.

Objective:To summary the nursing experience of BiPAP ventilator in the treatment of patients withrespiratory failure. Method:To retrospective analyze the whole process of BiPAP ventilator in the treatment of 82 patientswith COPD and type Ⅱ respiratory failure from 2011 to 2013.Result:67 patients were cured,15 cases were changedto racheal intubation,11 cases of them were recovered after extubation, 4 cases were undergone tracheotomy, and diedbecause ofpneumothorax or critical condition. Conclusion: Non-invasive ventilation has increased year by year , thesuccess rate is rising gradually.Correctly grasp the adaptations and operating procedures, strictly monitor and preventcomplications, good nursing of pre-treatment, during and post-treatment , all these are very important to use BiPAPventilator successfully.

2015 Vol. 12 (02): 76-79 [Abstract]( 561 HTML (1 KB)  PDF  (779 KB)  ( 776 )

LOU Ai-qing.

Objective:To summarize the first-aid nursing countermeasures of children with diabetic ketoacidosis.Method:40 children with DKA were carried out effective care with doctors and nurses.Result:(1)Through aggressivetreatment and careful nursing care, the blood glucose was good control,the ketone body was disappeard and the acidosiswas got correct. The therapy effective rate was 100%, and the great satisfaction and satisfaction rate of family member was
87.5%(35/40) and 12.5%(5/40).(2)The level of blood glucose,HbA1c,arterial blood gas index and AG aftertreatment and follow-up three month was lower than before treatment(P<0.05),but the change of electrolyte containedwas Unapparent(P>0.05).Conclusion:Treatment with nursing can significantly improve blood sugar levels,reduce theincidence of DKA.

2015 Vol. 12 (02): 79-81 [Abstract]( 430 HTML (1 KB)  PDF  (761 KB)  ( 158 )

ZENG Qiu-lian.

Objective: To investigate the effect of diet and life nursing intervention on blood glucose control inpatients with diabetes mellitus(DM).Method:68 patients with DM were randomly divided into the observation groupof 35 cases and the control group of 33 cases. Medcine treatment and routine nursing were given in two groups.What’smore, the observation group was given nursing intervention of diet,life and self monitoring of blood glucose. The changesof fasting plasma glucose(FPG), postprandial 2 h plasma glucose(2 h PG) and nd glycosylated hemoglobin( GHbA1c)in two groups were compared before and after intervention.Result:In observation group,the FPG,2 h PG and GHbA1cwere from(11.25±2.18)mmol/L,(18.94±3.15)mmol/L and( 9.42±1.16)%beforeintervention decreasedto( 6.35±1.42)mmol/L,(8.56±2.08)mmol/L and( 6.72±0.78)% after intervention ,the differences were
statistically significant( P<0.05); in control group, the FPG,2 h PG and GHbA1c were from(11.28±2.31)mmol/L,(19.03±3.42)mmol/L and(9.38±1.23)% before intervention decreased to(9.16±1.84)mmol/L,(12.92±2.34)mmol/Land(7.25±0.91)% after intervention( P<0.05);after intervention, all indexes in observation group were lower thanthose in control group, the difference was statistically significant( P<0.05).Conclusion: The diet and life nursingintervention can effectively control blood sugar, improve the life quality of the patients significantly.

2015 Vol. 12 (02): 84-86 [Abstract]( 533 HTML (1 KB)  PDF  (774 KB)  ( 602 )

ZENG Ling-fang,HU Cai-ru,LIShan-wen,et al.

Objective:To investigate the clinical application effect of nursing intervention in micro hand surgery,summarize nursing experience.Method:90 patients were randomly divided into control group and intervention group.45 patients of control group were treated with conventional care;the intervention group were treated with comprehensivenursing intervention.Relevant indicators of the two groups were compared.Result: The complication rate, recovery rate in the intervention group were 17.78%,73.33% ,which were better than 46.67%, 51.11% in the control group,hospitalization, patient compliance, patient satisfaction in the intervention group were( 16.83±7.43)d,(95.82±3.23)points,(94.36±4.53)points,which were better than( 19.36±11.47)d,(79.39±11.80)points,(84.25±5.35)points in the control group,the difference was statistically significant(P<0.05).Conclusion:The comprehensive nursing intervention applied in hand surgery microsurgery can effectively inhibit concurrency,improve the therapeuticeffect of rehabilitation,promote patient compliance,thereby improving patient satisfaction.

2015 Vol. 12 (02): 87-89 [Abstract]( 543 HTML (1 KB)  PDF  (795 KB)  ( 237 )

ZHAO Ying-xia LIU Yong-mei.

 Objective:To study the application effect of expectoration bat in nursing process of senile chronicbronchitis.Method:100 elderly patients with chronic bronchitis who were treated and followed in our hospital fromJanuary 2010 to January 2012 were collected, and randomly divided into two groups,the study group and the controlgroup,50 cases in each group. Patients of study group were cared with expectoration bat, while the control group patientswere received traditional hand patting-on-back by patients relatives. The successful expectoration cases of two groupsabout SaO2 were compared.Result:Compared the SaO2 levels, both groups elevated by patting-on-back, while the studygroup achieved better performance. In addition, the rate of successful expectoration were relatively higher in the study group.Compared the SaO2 levels of two groups, the difference was statistically significant(P<0.05).Conclusion: During nursing
process of elderly patients with chronic bronchitis in our hospital, expectoration is a significant part of the nursing work.But relatives who offer the nursing work usually cannot master the expectoration skills. Expectoration bat is convenient,efficient, and of lower skill requirements, and offers better nursing effect,should be widely used.

2015 Vol. 12 (02): 89-92 [Abstract]( 468 HTML (1 KB)  PDF  (795 KB)  ( 129 )

LIXiao-xiang,GUO Qi

Objective:To discuss the clinical application of quality care in laparoscopic cholecystectomy.Method:The clinical application of quality care in laparoscopic cholecytecystectomy was analyzed for reducing theincidence of complications was statistical significance.Result:The difference of hospital stays and degree of satisfactionof two groups was statistical significance(P<0.05).Conclusion:Using high-quality nursing care can effectively shortenhospital stays,improve satisfaction, and achieve good social effects.

2015 Vol. 12 (02): 92-94 [Abstract]( 340 HTML (1 KB)  PDF  (759 KB)  ( 277 )

LI Li.

Objective: To probe into the clinical effects and safety of Gegen Qinlian Decoction on patientswith acute enteritis. Method:68 patients who suffered from acute enteritis and accepted treatment in our hospital fromMarch 2010 to September 2013 were selected as the research objects, and these patients were randomly divided into thecontrol group and the observation group, with 34 patients in each group. In the control group, they were treated with theazithromycin tablets,while the observation group were treated with the Gegen Qinlian Decoction. Then, the curativeeffects of both groups after the treatment were compared.Result: The whole response in the observation group was 91.18%,comparing with 70.59% in the control group, and the differences had the statistical significance(P<0.05).In addition,after treatment, the symptom score of two groups also had marked significance, with the symptom score in observation
group evidently lower than that in the control group(P<0.05). Furthermore, in the control group, the rate of untowardeffects in the control group was 50.00% and that in the observation group was 2.94%, which also indicated that thedifferences had the statistical significance(P<0.05). Conclusion:The treatment effect of Gegen Qinlian Decoction onpatients with acute enteritis is evident, which can decrease the untoward effects, act on the lesions rapidly and improve the
symptoms.Thus,it is worth promoting further in the clinical applications.

2015 Vol. 12 (02): 99-101 [Abstract]( 617 HTML (1 KB)  PDF  (780 KB)  ( 215 )

LIU Hai-na,WU Jie.

Objective:To discuss the risk factors of nosocomial infection in NICU,study its preventivestrategies, and provide scientific basis for reducing the nosocomial infection rates. Method: A statistical analysis of theinfection rate, infective sites and pathogens of nosocomial infection among 1026 cases of neonatal inpatients in our hospitalfrom January 2013 to December 2013 was performed with retrospective analysis method. Result: Among 1026 neonatesunder the surveillance, there were 23 infection cases and 26 infection times. The nosocomial infection rate was 2.24%, thecase time infection rate was 2.53%, and the daily infection rate was 2.73‰ .We found that the infection rate was relatedto the birth weight. Furthermore, the lower respiratory tract and hematological system were the predominant infectionsites, which accounted for 26.92% and 23.08%, respectively. Among all the cases, the application rate of ventilator was
2.61% , and the incidence rate of ventilator-associated pneumonia was 22.73‰ . Conclusion:The targeted surveillanceis conducive to analyze the high-risk factors of nosocomial infection and to put forward effective prevention and controlmeasures for nosocomial infection.

2015 Vol. 12 (02): 102-104 [Abstract]( 563 HTML (1 KB)  PDF  (747 KB)  ( 211 )

LAN Hai-zhen,FU Shuai,OUYANG Yu-long.

Objective: To ensure the safety of drug use,through Quality Control Circle(QCC)to reduce theoutpatient pharmacy dispensing error rate. Method:It had been carried out to plan, implementation, verification andimprovement according to the ten steps of QCC activity. Various reasons causing dispensing errors was analyzed, thesolutions were explored and put them into effect, the tangible results( dispensing error rate) and the intangible results(circle ability) were evaluated.Result:After carrying out the QCC activity,the outpatient pharmacy dispensing errorrate was significantly reduced, from 6 ‰ dropping to 1.9 ‰, thecircle member get great improvement in the aspects ofdiscovering problems ability, communication and coordination ability and the group spirit. Conclusion:The developmentof QCC activity is feasible to reduce the the outpatient pharmacy dispensing error rate, suggesting the popularization andapplication.

2015 Vol. 12 (02): 105-107 [Abstract]( 712 HTML (1 KB)  PDF  (868 KB)  ( 429 )

WAN An-zhen.

In the hospital management, the application of clinical pathway of this management mode, is a revolution to the hospital medical management behavior model. For the medical record management workers, clinical pathway work will inevitably bring the management work of great challenge. The need for renewal and transformation of the existing medical record management concept and management mode, establish evidence-based medicine point of view, the theory and method of clinical pathway management were studied, and the master, through continuous learning,improve the management of medical record practitioners of professional quality and comprehensive quality, case data of scientific, effective screening, in order to provide reliable service for the hospital medical records management work to ensure the implementation of clinical pathway, clinical pathway in the implementation of hospital science, this is the actual problem in current medical record management workers face. In this paper, the medical record management in the introduction of clinical pathway management mode, analyzes the problems, discusses the new requirements in the medical record management of clinical pathway in the work, and put forward the countermeasures aiming at existing problems.

2015 Vol. 12 (02): 108-110 [Abstract]( 364 HTML (1 KB)  PDF  (745 KB)  ( 193 )

TAO Lin-jing.

Objective:To analyze the reasons of unqualified blood specimens in clinical test and put forward the corresponding prevention measures.Method:150 unqualified blood specimens form different departments in Nanyang Central Hospital from September 2010 to September 2012 were selected as the objects of this study.The error information of those clinical materials were sorted out and reported back to the corresponding departments.Then staff from the corresponding departments were invited to participate in this study, jointly analyzing the causes of errors and proposing countermeasures.Result:After analyzing the 150 specimens,it can be concluded that the common reasons of unqualified blood specimens were sample hemolysis,blood coagulation, late submission, in correct use of anticoagulant, influence of drugs,etc.Conclusion:According to the causes of the unqualified blood specimens, it is necessary to take preventive measures to reduce the unqualified blood samples, so that to improve the accuracy of clinical test.

2015 Vol. 12 (02): 111-114 [Abstract]( 455 HTML (1 KB)  PDF  (764 KB)  ( 427 )

WANG Hui-xia,MAO Guo-fu,FENG Yi-heng.

Objective:To probe into the perioperative use of antibiotics for patients undergoing type I incisionoperations in the hospital in which there was clinical pharmacists involvement,analyze the effect and outcome of clinicalpharmacists intervention on rational use of antibiotics.Method:Totally surgical records of patients undergoing type Iincision operations from January 2013 to June 2013 collected before intervention and another surgical records duringJanuary 2014 to June 2014 collected after intervention were compared regarding the use of antibiotics and analyzedregarding the rationality of antibiotic use.Result: After clinical pharmacists intervention on perioperative use of antibiotics,the antibiotic used was more rational in drug choice,time and duration of drug use, dosage and administration etc.Conclusion:Clinical pharmacists intervention on perioperative use of antibiotics in patients undergoing type I incisionoperations was proved to be effective and it significantly strengthened rational use of antibiotics with remarkable efficacyachieved.

2015 Vol. 12 (02): 114-116 [Abstract]( 385 HTML (1 KB)  PDF  (764 KB)  ( 142 )

HU Peng,LI Qiang.

Objective:To investigate the clinical character ,diagnosis and treatment of aortic dissection。Method:Clinical data of the pathogeny,inducement, clinical manifestation,accessory examination,diagnosticclassification,treatment methods and effect of 62 patients with aortic dissection were retrospectively analyzed.Result:Stanford type A in 18 cases,Stanford type B in 44 cases.Hypertension was the main high risk factor,the firstsymptom for most of patients was the Chest and back pain.Enhanced spiral CT scans and three dimensional reconstructionof aorta were benefit to diagnose definitely.Among 15 cases proceeded with cardiothoracic surgical treatment,2 cases(13.3%) died and one case(6.7%) happened paraplegia.41 cases were performed endoluminal stent-graft implantation,and 2 cases(4.9%) occurred endoleak,one case(2.4%) died and one case(2.4%) happened paraplegia.4 cases(6.4%) died of before operation,2 cases(3.2%) auto-discharged.By Follow-up the remaining patients ,we foundthat no one appeared the related complications of aortic dissection or operations and owned a good total life quality.Conclusion:Early diagnosis and reasonable treatment in time are the key to improve the prognosis of patients with aorticdissection.

2015 Vol. 12 (02): 117-120 [Abstract]( 466 HTML (1 KB)  PDF  (768 KB)  ( 139 )

XIAOZong-yu,CHEN Xiao-juan,PEI Jie,et al.

Objective:To explore water dissection technique of Toth for the treatment of hypertensive basalganglia hematoma. Method:From June 2009 to December 2013, 42 patients with hypertensive basal ganglia hematomaunderwent surgery management via transsylvian fissure approach by water dissection technique of Toth, the therapeuticeffect of the management was analyzed retrospectively. Result:Postoperative CT showed that the total evacuation ofhematomas was reached in 28 patients, subtotal evacuation in 10 patients and greatly part in 4. 42 patients were followedup and evaluated by Glasgow outcome scale for at least 3 months. Among them, 14 patients showed good recovery, 12patients showed moderate disability, 7 patients showed severe disability, 2 patients died. Conclusion:It is safe, effectiveand minimally invasive for the treatment of hypertensive basal ganglia hematoma via transsylvian fissure approach by waterdissection technique of Toth.

2015 Vol. 12 (02): 121-124 [Abstract]( 553 HTML (1 KB)  PDF  (793 KB)  ( 138 )

CHEN Zhihui,JIN Shang-li,ZHOU Jian-xin.

Objective: To analyze the therapeutic effect of endourologial technique treating calculouspyonephrosis. Method: There were 90 cases of calculous pyonephrosis. In this 90 cases, 45 cases of calculouspyonephrosis that was called treatment group were treated by endourological technique(22 cases by mini-percutaneous
nephrolithotomy,23 cases by transurethral ureteroscopy),45 cases of calculous pyonephrosis that was called controlgroup were treated by nephrectomy. Result:Total effective rate of treatment group was 92%, control group was 100%,there was no statistically significant between two groups(P>0.05). The incidence of complications of treatment groupwas 8%, the incidence of complications of control group was 20%, there was statistically significant between twogroups(P<0.05).Conclusion:It is feasible and effective to treat calculous pyonephrosis with endourologieal technique.Most ofthe kidneys in calculous pyonephrosis might be saved.

2015 Vol. 12 (02): 124-126 [Abstract]( 415 HTML (1 KB)  PDF  (764 KB)  ( 138 )

JIN Zhi-heng

Objective:To evaluate and analyze clinical curative effect and safety of probiotics treatment appliedin neonatal jaundice.Method:According to the method of random draw,68 cases of neonatal jaundice were dividedinto control group and treatment group, 34 cases in each. The control group were treated with blue light treatment;thetreatment group were treated with micro ecological dichotomous triple living bacteria preparation treatment on the basisof the control group. In before and 1, 4, 7 d treatment serum total bilirubin level detection of two groups of patients, thestatistics of two groups of clinical drug effect time and jaundice subsided and clinical curative effect and adverse reactions.Result: Before the treatment, two groups of serum bilirubin level comparison( P>0.05).Treatment of 1, 4, 7 d, twogroups of serum bilirubin level before treatment were significantly decreased(P<0.05).But 1 d, 2 way comparison(P>0.05);4, 7 d treatment group decreased more significantly, compared with the control group(P<0.05).Clinicaldrug treatment group effect and presented a time respectively( 1.0±0.5) d with the control group,(3.8±1.7)d,(2.6±0.6)d,(5.3±2.1)d comparison(P<0.05).Treatment of efficient treatment group was obviously higher thanthat of control group(P<0.05).Two groups were not obvious adverse reactions.Conclusion:Using probiotics to treatneonatal jaundice,and it canobviously reduce the patients’ serum bilirubin, and take effect quickly, accelerate the patients with jaundice subsided, and has high security, is worthy of popularization and application

2015 Vol. 12 (02): 129-131 [Abstract]( 483 HTML (1 KB)  PDF  (774 KB)  ( 237 )

HUANG Shan-bo.

Objective: To study the artery ligation and stripping outside internal plunge in parallel double surgeryfor the treatment of mixed hemorrhoids. Method:120 cases in our hospital after surgical treatment of multiple mixedhemorrhoid patients were retrospective analysised,and were randomly divided into the observation group and the controlgroup,60 cases in each group. The observation group was treated by hemorrhoid artery ligation and ligation outer peel. Thecontrol group was only treated by ligation outer peel.The differences of two groups were compared.Result: The observationgroup patients pain were( 3.1±0.9)d;healing time were( 11.2±1.9)d;3 cases of the bleeding number, accountingfor 5%;5 cases of bowel movements difficult, accounting for 8.3%;10 cases of anal margin edema, accounting 16.6%;the patients were no anal stenosis. The observation group patients in the preoperative, immediate postoperative,1 day, 3
days and 1 week VAS scores were respectively(7.5±1.9),(3.0±1.8),(3.1±2.3),(3.5±2.4)and( 3.0±2.5).The observation group of complications and pain scores were significantly lower than the control group ,the differencewas statistically significant(P<0.05).Conclusion: The traditional method of hemorrhoid artery ligation and milligan morgan hemorrhoidectomy multiple mixed hemorrhoids curative effect is better than that of single milligan morgan hemorrhoidectomy and is worth reference in clinical.

2015 Vol. 12 (02): 132-134 [Abstract]( 446 HTML (1 KB)  PDF  (761 KB)  ( 123 )

LIANGJing-lin, YANG Xue-qun, LI Shao-guang,et al.

Objective:To analyze the clinical value of NBNA and early intervention in application of neonatal brain injury disease.Method:468 cases of hospitalization neonates in our hospital were selected from May 2012 to May2014, 212 cases of non-brain injury neonates were selected as the normal group,154 cases of neonates with suspectedbrain injury to take early intervention were selected as the observation group,another 102 cases of neonates suspectedbrain injury not to take early intervention were selected as the control group .The neonates behavior nerve score andsequelae situation were compared in three groups.Result: Before intervention,the normal group of NBNA scores were(37.85±1.32) significantly higher than the observation group of( 34.13±1.58) scores and control group of( 32.81±1.74)scores ,the differences were statistically significant(P<0.05);after intervention, the observation group of NBNA scoreswere( 39.41±1.23) significantly higher than the control group of( 36.52±1.87)scores, the difference was statisticallysignificant( P<0.05); the observation group of sequelae incidence was significantly lower than the control group, thedifference was statistically significant( P<0.05).Conclusion:NBNA can understanding the behavior and capacityof neonatal clearly and find mild brain injury and brain cell abnormalities that clinically easily missed in time,earlyintervention can improve nervous system compensatory restoration,induce the incidence of disability,has worthy ofclinical promotion and application.

2015 Vol. 12 (02): 134-136 [Abstract]( 463 HTML (1 KB)  PDF  (760 KB)  ( 273 )

CHEN Xiao-fei,YIN Shan-lang,SHAO Jun-qing,et al.

Objective:To explore the clinical effects of stereotactic catheter drainage in treatment of deephypertensive intracerebral hemorrhage.Method:62 cases of patients with deep hypertensive intracerebral hemorrhagein our hospital from March 2008 to July 2014,received stereotactic duct drainage treatment,according to GOS scorethe therapeutic effect was analyzed.Result:24-72 h after extubation, 30 days after the fine was 79.03%; excellent after2-30 months was 91.93%.Conclusion: Deep hypertensive intracerebral hemorrhage take stereotactic catheter drainagetreatment,clinical efficacy can be further improve,especially for patients with less hematoma volume significantlybetter,with a clinical value.

2015 Vol. 12 (02): 137-139 [Abstract]( 505 HTML (1 KB)  PDF  (760 KB)  ( 127 )

ZHANG Lihua,DONG Zi-ping,MU Yan-shun,et al.

Objective:To explore clinical curative effect of the totally laparoscopic cholecystolithotomy intreatment of cholecystolithiasis.Method:From January 2008 to January 2011,the gall preserving lithotomy of 100patients were divided into treatment group( 50 cases) and control group (50 cases) .Treatment group were treated withlaparoscopic cholecystolithotomy, the control group using laparotomy after cholecystolithotomy. The average operationtime, peri operation period, postoperative exhaust time, hospitalization time, follow-up treatment and relapse of twogroups were recorded.Result: The average operation time in the treatment group was( 58.2±12.5) minutes and was(84.9±16.4)minutes in the control group, the differences was statistically significant(P<0.05). The postoperativeexhaust time in treatment group was( 23.7±1.8)hours and( 36.9±1.2)in the control group,the differences wasstatistically significant(P<0.05).Hospitalization time in the treatment group was( 5.1±0.9)days and( 8.3±1.6)daysin the control group, the differences was statistically significant(P<0.05). Complications occurred in 1 cases in thetreatment group and 7 patients in the control group,the differences was statistically significant(P<0.05). Recurrenceoccurred in 1 cases in the treatment group and 3 patients in the control group, the differences was no statistically significant(P>0.05).Conclusion:Laparoscopic cholecystolithotomy for gallbladder stones( polyP) is safe,reliable,small injury,quick recovery,less complications,and is suitable for popularization and popularization.

2015 Vol. 12 (02): 139-142 [Abstract]( 370 HTML (1 KB)  PDF  (780 KB)  ( 159 )

JING Xin-jian,HUAGN Wen-tong,WEI Na.

Objective:To study the atomization inhalation budesonide suspension liquid and compoundisopropyl bromide liquid atomization in chronic obstructive pulmonary monary disease( COPD) with pulmonary space-occupyinglesions under CT guided percutaneous puncture lung biopsy in patients with perioperative application of intraoperativecomplications. Method: 55 cases in accordance with conditions of randomly divided into two groups, includingconventional puncture group( control group) in 27 cases, 28 cases in treatment group, before the operation usingatomizing inhaled budesonide suspension liquid and compound isopropyl bromide atomized liquid, comparing the twocomplications.Result: The treatment group( cough, hemoptysis, hemothorax, pneumothorax and the incidence of pleuralreaction was reduced.Conclusion:Chronic obstructive pulmonary disease(COPD) with pulmonary space-occupyinglesions in patients before the operation application of atomizing inhalation budesonide suspension liquid and compoundisopropyl bromide liquid atomization can better ensure thatoperation is completed, reduce intraoperative complications.

2015 Vol. 12 (02): 142-144 [Abstract]( 490 HTML (1 KB)  PDF  (760 KB)  ( 134 )

SUN Yang

Objective: To investigate the clinical efficacy of autologous cartilage ear nose flat treatment.Method: In 64 routine flat nose rhinoplasty patients, 34 cases of autologous ear cartilage as the observation group, 30cases of application of septal cartilage as the control group, the results of operations and surgical time of two groups werecompared. Result: Comparison of the effect of surgery observation group and the control group, the difference was not
statistically significant(P>0.05). The average operation time of the observation group were significantly shorter than thecontrol group, the difference was statistically significant(P<0.05). The postoperative complications did not occur any,and expressed satisfaction with the tip of the nose shape. Conclusion: Autologous ear cartilage and autologous therapeuticeffect of septal cartilage of the nose are quite flat, but take ear cartilage is more convenient, simple,and shorter surgicaltime.

2015 Vol. 12 (02): 145-146 [Abstract]( 546 HTML (1 KB)  PDF  (740 KB)  ( 513 )

WU Cheng-ping,WANG Fang.

Objective:To evaluate the polycystic ovary syndrome( PCOS) with infertility were treated by invitro fertilization-embryo transfer( IVF-ET) curative effect and characteristics of assisted reproduction treatment.Method: 52 cycles PCOS infertility factor in IVF-ET medical records in 2013 year were analysed retrospectively as groupA, and 102 cycles tubal factor IVF-ET cases in the same period as controls of group B.Result:Compared PCOS groupand tubal factor group analysis: age, infertility time, BMI, the number of eggs, portable designed the Gn days, embryonumber and risk of OHSS cancel graft rate comparison, the difference was statistically significant(P<0.05). PCOSpatients compared with tubal factor group more young, shorter infertility time, higher body mass index( BMI),longer Gntime,more egg number, more corresponding portable embryos and OHSS risk increased significantly. But two groups ofdesigned the Gn dosage, endometrium thickness, 2 PN fertilization rate, cleavage rate, good embryo rate and the clinicalpregnancy rate were no statistically significant difference.Conclusion:PCOS patients of infertility with the IVF-ET assistreproduction can be obtained IVF-ET assist similar curative effect with the tubal factor, but should pay attention to preventthe risk of OHSS.

2015 Vol. 12 (02): 147-149 [Abstract]( 372 HTML (1 KB)  PDF  (762 KB)  ( 222 )

SANG Jie-yu,ZHENG Rui.

Objective:Itching is a common symptom of dermatology, is the result of the interaction of multiplefactors, which by the central and peripheral mechanisms of dual control occur, but the exact mechanism is not clear.Withthe deepening of research in recent years, a variety of substances such as histamine, acetylcholine, serotonin, proteasesand protease-related receptors, cytokines, opioid peptides, and other media play an important role in the generation
process of pruritus, these media by stimulating type C nerve fibers or nerve fibers directly mediate receptor binding andskin feel itchy. Nerve conduction and conduction article will pruritus medium reviewed.

2015 Vol. 12 (02): 150-152 [Abstract]( 466 HTML (1 KB)  PDF  (768 KB)  ( 233 )

DONG Huimin,LIU Chao-ying,LAI Yan-hui,et al.

The effective health education of gestational diabetes mellitus could improve the therapy compliance,improve the traetment of gestatonal diabetes mellitus with efficiency and reduce the perinatal complications .This paperintroduces application significance of health education in gestational diabetes mellitus ,summarizes recently developmentsof the requirement, content and effect of health education laser at home and abroad,increasing the level of health.

2015 Vol. 12 (02): 153-156 [Abstract]( 366 HTML (1 KB)  PDF  (799 KB)  ( 588 )

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