Objective： To analyze the therapeutic effect of endourologial technique treating calculouspyonephrosis. Method： There were 90 cases of calculous pyonephrosis. In this 90 cases， 45 cases of calculouspyonephrosis that was called treatment group were treated by endourological technique（22 cases by mini-percutaneous
nephrolithotomy，23 cases by transurethral ureteroscopy），45 cases of calculous pyonephrosis that was called controlgroup were treated by nephrectomy. Result：Total effective rate of treatment group was 92%， control group was 100%，there was no statistically significant between two groups（P>0.05）. The incidence of complications of treatment groupwas 8%， the incidence of complications of control group was 20%， there was statistically significant between twogroups（P<0.05）.Conclusion：It is feasible and effective to treat calculous pyonephrosis with endourologieal technique.Most ofthe kidneys in calculous pyonephrosis might be saved.