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Abstract Objective：To investigate the clinical value of combined detection of erythrocyte sedimentation rate （ESR），rheumatoid factor（RF），anti-cyclic citrullinated peptide antibody（anti CCP） and anti keratin antibody （AKA） in diagnosis of rheumatoid arthritis（RA）.Method： ESR， RF， anti CCP and AKA in 100 patients with RA and 70 patients with other autoimmune diseases were detected.Result： In RA group， positive rate of four indexs was obviously higher than those of other autoimmune disease group， individual testing RA diagnostic sensitivity for ESR>RF>CCP>AKA，the specificity of CCP>AKA>RF>ESR，combined detection of RA diagnostic sensitivity，specificity was elevated even higher amounts to 100%.Conclusion：Combined detection of ESR，RF，anti CCP and AKA can improve RA diagnostic specificity，has high value on early diagnosis of RA.
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