Abstract Objective：To investigate the effects of phytoestrogen isoflavone on balloon catheter-induced hyperplasia of carotid artery.Method：Forty-eight female New Zealand rabbits were randomly divided into four groups：control（ balloon-induced carotid artery injury only）； ovariectomy control（ ovariectomy and carotid artery injury），oestrogen（ ovariectomy， carotid artery injury and nilestriol， 5 mg/kg daily for 28 days）， and isoflavone（ ovariectomy，carotid artery injury and isoflavone 120 mg/kg daily for 28 days）. The arterial wall thickness was assessed by coloured ultrasonography.Rusult：The medial layer thickness in the isoflavone group was less than in the ovariectomy control group（0.28±0.03 vs.0.35±0.04 mm，P<0.01）， and the intimal/medial layer（ I/M） ratio was the isoflavone group was also less than in the ovariectomy control group（ 16.85±3.79 vs.48.94±8.92，P<0.01）.There was no statistically significant difference in the medial layer thickness or I/M ratio between the isoflavone and the oestrogen groups. Conclusion：Soybean
isoflavones can play a role of protecting blood vessels to inhibit neointimal hyperplasia and the proliferation of vascular smooth muscle cell in Vascular injury .
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