Objective：To investigate the correlation analysis on serum interferon regulatory factor（ IRF4） and disease activity index（DAI），anti SSA antibody in systemic lupus erythematosus（ SLE）.Method：60 systemic lupus erythematosus patients in our hospital from January 2012 to December 2014 were selected as the observation group，55 healthy cases were selected as the control group，the level of serum interferon regulatory factor was detected by Enzyme-Linked Immuno Sorbent Assay（ ELISA） method，the relationship between serum interferon regulatory factor and disease activity index，anti SSA antibody was analyzed by the Pearson correlation.Result：The level of serum interferon regulatory factor of the observation group was significantly higher than that of the control group，serum interferon regulatory factor level of disease activity index ≥ 6 points of systemic lupus erythematosus patients was higher than disease activity index<6 points of systemic lupus erythematosus patients，serum interferon regulatory factor level of anti SSA antibody positive in systemic lupus erythematosus patients was significantly higher than anti SSA antibody negative in systemic lupus erythematosus patients，there was statistically significant difference（P<0.05）.The Pearson correlation showed that，there was no significant relationship between serum interferon regulatory factor and disease activity index（ r=0.45，P<0.05），serum interferon regulatory factor had significant positive correlation with anti SSA antibody（ r=0.43，P<0.05）.Conclusion：The serum interferon regulatory factor of systemic lupus erythematosus is higher，it has obvious correlation with disease activity index and anti SSA antibody，interferon regulatory factor promote the occurrence and development of systemic lupus erythematosus.

2015 Vol. 12　(19):　6-8 [Abstract]（ 525 ） HTML (1 KB)  PDF  (1228 KB)  ( 201 )

Objective：To evaluate the association among levels of serum proinflammatory factors，ST-T abnormalities on electrocardiogram（ ECG），Rose questionnaire based angina pectoris，and Metabolic Syndrome in a rural population. Method：An analysis on the cross-sectional study data was performed，which 1100 subjects were sampled from a clustered sample of the total population（ n=3000） in adults aged 35-59 years，from Guizhou Community，Shunde，Guangdong，in 2003. Demographic information，personal and family histories of diseases and Rose questionnaire were collected.Physical examination and laboratory tests included high-sensitivity C-reactive protein（ hs-CRP） and serum lipids were done.Subjects underwent examination on resting 12-lead ECG.ECG tracings were coded with Minnesota Code and classified as ST-T abnormalities ECG or normal ST-T ECG，and ST-T abnormalities ECGs were classified as marked ST-T abnormalities ECG（ codes 4-1，4-2，5-1 and 5-2） or lesser degrees of ST-T abnormalities ECG（ codes 4-3，4-4，5-3 and 5-4）.Result：A total number of 1093 subjects（ 521 men and 572 women） were finally included in this analysis.The prevalence of Metabolic Syndrome was 17.4%.The average hs-CRP level was（ 3.46±1.14）mg/L.The Metabolic Syndrome patients had the highest mean hs-CRP level（ 4.72±0.38）mg/L followed by the Rose questionnaire based angina pectoris patients（ 4.63±0.47）mg/L，and then the ST-T abnormalities ECG patients（ 4.38±0.72）mg/L，successively.They had significantly higher hs-CRP level compared to the normal ST-T ECG patients（ P<0.05），which had the lowest hs-CRP level（ 3.21±0.89）mg/L.ST-T abnormalities ECG patients，Rose questionnaire based angina pectoris patients and the Metabolic Syndrome patients had significantly higher hs-CRP levels compared with their respective normal patients（ P<0.05）.The standardized prevalence of ST-T abnormalities ECG was
21.5％（ 9.0％ in marked ST-T abnormalities ECG group and 12.5％ in lesser degrees of ST-T abnormalities ECG group）.The prevalence of Rose angina was 15.2％ .The prevalence of Rose angina was significantly higher in ST-T abnormalities ECG group（47.7％） than in normal ST-T ECG patients（P<0.05）.It was found that the severer the ST-T abnormalities，the higher the hs-CRP levels in abnormal ST-T patients（ P<0.05）.The level of hs-CRP positively correlated with ST-T abnormalities.Conclusion：Level of serum proinflammatory factors is predictors of cardiovascular diseases.It is a contributor to detecting subjects at high risk of coronary heart diseases with hs-CRP combining ECG ST-T abnormalities and Rose questionnaire.

2015 Vol. 12　(19):　12-15 [Abstract]（ 614 ） HTML (1 KB)  PDF  (997 KB)  ( 282 )

Objective：To investigate the effect of atorvastatin on blood homocysteine and fibrinogen level in patients with diabetic nephropathy.Method：50 cases who were diagnosed with diabetic nephropathy were divided into group A（ normal lipid group） and group B（ elevated blood lipids group） according to their lipid levels.The A group were randomly divided into control group（ A1 group） and treatment group（ A2 group）.Group A1，A2 and group B were given basic treatment of diabetes.A2 group and B group were given oral atorvastatin on the basis treatment of diabetes.Changes in blood homocysteine，fibrinogen
level and other indicators before and after treatment were compared between the two groups.Result：Before treatment，blood Hcy and fibrinogen level of the group A were lower than those of the B group（P<0.05）.There were no differences between A1 and A2 about the blood Hcy and fibrinogen level before treatment.After treatment，blood Hcy level and fibrinogen level of group A2 were lower than those of group A1，Hcy level and fibrinogen level of group B were significantly lower than before treatment（P<0.05）.Conclusion：Atorvastatin can reduce blood homocysteine and fibrinogen level in diabetic nephropathy，it can not only lower blood lipid but also protect vascular，so as to delay the progression of diabetic nephropathy.

2015 Vol. 12　(19):　19-21 [Abstract]（ 662 ） HTML (1 KB)  PDF  (987 KB)  ( 310 )

Objective：To study the Radix Paeoniae Rubra granules on the pan drug resistant Acinetobacter Bauman in vitro antibacterial activity，for the treatment of infectious disease caused by the bacterium infection clinical exploration.Method：Clinical were collected from January 2013 to June 2014 in our hospital microbiology laboratory of pathogenic bacteria culture and drug-sensitivity specimens，the bacteria identification and drug sensitivity test of Pan drug resistant
Acinetobacter meets Bauman of 50 strains of bacteria，the determination of the minimal inhibitory concentration of the strain of aeoniae granules by micro broth dilution susceptibility test，in vitro antibacterial observed the effect of Radix Paeoniae Rubra ranules.Result：The OD value of Radix Paeoniae Rubra particle solution of different concentration on the pan drug resistant cinetobacter Bauman OD value were less than the positive control hole，and with the increase of drug concentration，the OD alue was smaller，indicating that the inhibition of Radix Paeoniae Rubra particle solution were，and with the increase of drug
concentration，the stronger bacteriostasis.Conclusion：Radix Paeoniae granules on the pan drug resistant Acinetobacter Bauman an inhibit its growth in vitro antibacterial test.

2015 Vol. 12　(19):　24-26 [Abstract]（ 401 ） HTML (1 KB)  PDF  (987 KB)  ( 185 )

　Objective：To explore the application effect of cognitive function training on stroke patients in community groups of rehabilitation training.Method：138 cerebral apoplexy patients in community were selected as the research objects，according to the digital method were divided into observation group（ 69 cases） and control group randomly（ 69 cases），the control group received body movement，balance and daily activities such as routine rehabilitation training.The observation group received cognitive function training based on control group.The simple mental state（ MMSE），daily life activities ability Barthel
index（ MBI） and the degree of nerve function defect（CSS） score of patients were assessed.Result：Before training，two group with MMSE score，MBI，CSS had no obvious difference（ P>0.05）.1 month，3 months after training and MMSE，MBI scores of the observation group was obviously higher than that of the control group，and score of the third month was significantly higher than that of the first month，the difference was statistically significant（ P<0.05）.1 month，3 months after training，CSS score of the observation group was obviously lower than that of the control group，and score of the third month was significantly higher
than that of the first month，the differences were statistically significant（ P<0.05）.Conclusion：Cognitive function training can significantly improve community stroke rehabilitation training in patients with cognitive function and neural function，promote the daily life ability enhancement，worth clinical promotion use.

2015 Vol. 12　(19):　30-32 [Abstract]（ 585 ） HTML (1 KB)  PDF  (986 KB)  ( 197 )

　Objective：To analyze the effect of different dose dexmedetomidine combined with sevoflurane on cognitive function of elderly patients after general anaesthesia.Method：75 elderly patients with operation were selected in our hospital and randomly divided into the control group and the different dose dexmedetomidine M0，M1，M2，M3 group，the patients of the dexmedetomidine groups were treated with dexmedetomidine loading dose of 0.8 g/kg，infusion time 10~15 min，at a rate of 0，0.2，0.4，0.6 μg/（kg·h）until the end of operation，the control group was given equal volume of physiological saline.
The effects on patients of five groups after anesthesia were analyzed and observed.Result：There was no significantly difference in statistics between the awake after 1 hours and 6 days after surgery in patients with MMES score（P>0.05）；while awake after 3 hours，after 1 days and 3 days operation in M2 and M3 groups，MMES score decreased significantly better than the other three groups，the difference was statistically tically significant（ P<0.05）；M3 group spontaneous breathing recovery time，extubation time and recovery time orientation of the eyes and respiratory time were significantly higher than M0，M1，M2 group，the differences were statistically significant（P<0.05）；M2 and M3 group in POCD were obviously lower than the other three groups，the
differences were statistically significant（P<0.05）.Conclusion：In the clinic utilizing，0.4 μg/（kg·h）dexmedetomidine combined sevoflurane can not only reduce the postoperative incidence of cognitive dysfunction early in elderly patients with general anesthesia and operation，but also it’s safe and feasible.It’s the best scheme of dexmedetomidine combined sevoflurane administration，it is worthy of clinical popularization and application.

2015 Vol. 12　(19):　36-38 [Abstract]（ 581 ） HTML (1 KB)  PDF  (1014 KB)  ( 310 )

Objective：To explore the effect of pantients upper gastrointestinal hemorrhage after endoscopic operation by intestinal administration of Rabeprazole（Pariet） through triple lumen feeding tube.Method：82 patients with actue nonvariceal upper gastrointestinal bleeding were treated hemostasis under endoscopy and were involved in this prospective random control test.The experimental group of 45 patients were treated with indwelling three cavity gastric tube and intestinal Pollitt applications，and the control group of 37 cases were treated with indwelling traditional stomach tube and intravenous omeprazole injection，the gastric pH，rebleeding rate and the complications rate of two groups were compared and observed.Result：The differences of gastric pH，rebleeding rate and incidence of upper gastrointestinal tract perforation of the two groups were no statistically significant（P>0.05）.The experimental group had lesser degree of complications，it could decrease the amount of intravenous fluids and stable blood sugar.Conclusion：The effect of the patients with upper gastrointestinal hemorrhage after endoscopic operation by intestinal administration of Rabeprazole（Pariet） through triple lumen feeding tube is satisfactory.It is especially suitable for application in patients with cardiac insufficiency and diabetes.

2015 Vol. 12　(19):　42-44 [Abstract]（ 522 ） HTML (1 KB)  PDF  (987 KB)  ( 170 )