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Abstract Objective： The present study clarified the characteristics of the intracranial vascular CoW in high-risk population of stroke. Method： High-risk volunteers of stroke underwent head computed tomography omography angiography（ CTA） scan，focusing on diameter of vessels. Anatomic variations in the Circle of Willis was analyzed， the data were subsequently compared to the literature. Result： The head images of 153 men（ 54.4%） and 128 women（ 45.6%） were analyzed. The percentage of subjects with incomplete CoW increased with age but not significantly（ P=0.78）. Compared to healthy Chinese people， the high-risk population of stroke had a higher percentage of incomplete CoW（ 39% vs.17%， P<0.01）. Subjects who suffered ischemic stroke were older than those who had not，（ 59.0±8.7） vs.（ 49.6±10.2） years old， P<0.001. Conclusion： The variations of the circle of Willis may be develop in the early embryonic stage， and the morphologies persist in post-natal life. Compared to healthy Chinese people， the population has a higher percentage of incomplete CoW. The cumulative effects of external factors become increasingly important with increasing age and similar genetic background in the development of stroke.
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