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| A Population-based Study on the Relationship of Serum Proinflammatory Factors with Abnormal ST-T on Electrocardiogram |
| Guangdong Cardiovascular Institute，Guangdong General Hospital，Guangdong Academy of Medical Sciences，Guangzhou 510080，China |
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Abstract Objective：To evaluate the association among levels of serum proinflammatory factors，ST-T abnormalities on electrocardiogram（ ECG），Rose questionnaire based angina pectoris，and Metabolic Syndrome in a rural population. Method：An analysis on the cross-sectional study data was performed，which 1100 subjects were sampled from a clustered sample of the total population（ n=3000） in adults aged 35-59 years，from Guizhou Community，Shunde，Guangdong，in 2003. Demographic information，personal and family histories of diseases and Rose questionnaire were collected.Physical examination and laboratory tests included high-sensitivity C-reactive protein（ hs-CRP） and serum lipids were done.Subjects underwent examination on resting 12-lead ECG.ECG tracings were coded with Minnesota Code and classified as ST-T abnormalities ECG or normal ST-T ECG，and ST-T abnormalities ECGs were classified as marked ST-T abnormalities ECG（ codes 4-1，4-2，5-1 and 5-2） or lesser degrees of ST-T abnormalities ECG（ codes 4-3，4-4，5-3 and 5-4）.Result：A total number of 1093 subjects（ 521 men and 572 women） were finally included in this analysis.The prevalence of Metabolic Syndrome was 17.4%.The average hs-CRP level was（ 3.46±1.14）mg/L.The Metabolic Syndrome patients had the highest mean hs-CRP level（ 4.72±0.38）mg/L followed by the Rose questionnaire based angina pectoris patients（ 4.63±0.47）mg/L，and then the ST-T abnormalities ECG patients（ 4.38±0.72）mg/L，successively.They had significantly higher hs-CRP level compared to the normal ST-T ECG patients（ P<0.05），which had the lowest hs-CRP level（ 3.21±0.89）mg/L.ST-T abnormalities ECG patients，Rose questionnaire based angina pectoris patients and the Metabolic Syndrome patients had significantly higher hs-CRP levels compared with their respective normal patients（ P<0.05）.The standardized prevalence of ST-T abnormalities ECG was
21.5％（ 9.0％ in marked ST-T abnormalities ECG group and 12.5％ in lesser degrees of ST-T abnormalities ECG group）.The prevalence of Rose angina was 15.2％ .The prevalence of Rose angina was significantly higher in ST-T abnormalities ECG group（47.7％） than in normal ST-T ECG patients（P<0.05）.It was found that the severer the ST-T abnormalities，the higher the hs-CRP levels in abnormal ST-T patients（ P<0.05）.The level of hs-CRP positively correlated with ST-T abnormalities.Conclusion：Level of serum proinflammatory factors is predictors of cardiovascular diseases.It is a contributor to detecting subjects at high risk of coronary heart diseases with hs-CRP combining ECG ST-T abnormalities and Rose questionnaire.
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