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| Correlation Analysis on Serum Interferon Regulatory Factor and Disease Activity Index，Anti SSA Antibody in Systemic Lupus Erythematosus Patients |
| Dafeng Hospital，Shantou 515154，China |
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Abstract Objective：To investigate the correlation analysis on serum interferon regulatory factor（ IRF4） and disease activity index（DAI），anti SSA antibody in systemic lupus erythematosus（ SLE）.Method：60 systemic lupus erythematosus patients in our hospital from January 2012 to December 2014 were selected as the observation group，55 healthy cases were selected as the control group，the level of serum interferon regulatory factor was detected by Enzyme-Linked Immuno Sorbent Assay（ ELISA） method，the relationship between serum interferon regulatory factor and disease activity index，anti SSA antibody was analyzed by the Pearson correlation.Result：The level of serum interferon regulatory factor of the observation group was significantly higher than that of the control group，serum interferon regulatory factor level of disease activity index ≥ 6 points of systemic lupus erythematosus patients was higher than disease activity index<6 points of systemic lupus erythematosus patients，serum interferon regulatory factor level of anti SSA antibody positive in systemic lupus erythematosus patients was significantly higher than anti SSA antibody negative in systemic lupus erythematosus patients，there was statistically significant difference（P<0.05）.The Pearson correlation showed that，there was no significant relationship between serum interferon regulatory factor and disease activity index（ r=0.45，P<0.05），serum interferon regulatory factor had significant positive correlation with anti SSA antibody（ r=0.43，P<0.05）.Conclusion：The serum interferon regulatory factor of systemic lupus erythematosus is higher，it has obvious correlation with disease activity index and anti SSA antibody，interferon regulatory factor promote the occurrence and development of systemic lupus erythematosus.
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