Abstract Objective：To investigate the effect of atorvastatin on blood homocysteine and fibrinogen level in patients with diabetic nephropathy.Method：50 cases who were diagnosed with diabetic nephropathy were divided into group A（ normal lipid group） and group B（ elevated blood lipids group） according to their lipid levels.The A group were randomly divided into control group（ A1 group） and treatment group（ A2 group）.Group A1，A2 and group B were given basic treatment of diabetes.A2 group and B group were given oral atorvastatin on the basis treatment of diabetes.Changes in blood homocysteine，fibrinogen
level and other indicators before and after treatment were compared between the two groups.Result：Before treatment，blood Hcy and fibrinogen level of the group A were lower than those of the B group（P<0.05）.There were no differences between A1 and A2 about the blood Hcy and fibrinogen level before treatment.After treatment，blood Hcy level and fibrinogen level of group A2 were lower than those of group A1，Hcy level and fibrinogen level of group B were significantly lower than before treatment（P<0.05）.Conclusion：Atorvastatin can reduce blood homocysteine and fibrinogen level in diabetic nephropathy，it can not only lower blood lipid but also protect vascular，so as to delay the progression of diabetic nephropathy.
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