|
|
|
| The Effect of Different Dose Dexmedetomidine Combined with Sevoflurane on Cognitive Function of Elderly Patients after General Anaesthesia |
| The Center People’s Hospital of Zhanjiang，Zhanjiang 524031，China |
|
|
|
Abstract Objective：To analyze the effect of different dose dexmedetomidine combined with sevoflurane on cognitive function of elderly patients after general anaesthesia.Method：75 elderly patients with operation were selected in our hospital and randomly divided into the control group and the different dose dexmedetomidine M0，M1，M2，M3 group，the patients of the dexmedetomidine groups were treated with dexmedetomidine loading dose of 0.8 g/kg，infusion time 10~15 min，at a rate of 0，0.2，0.4，0.6 μg/（kg·h）until the end of operation，the control group was given equal volume of physiological saline.
The effects on patients of five groups after anesthesia were analyzed and observed.Result：There was no significantly difference in statistics between the awake after 1 hours and 6 days after surgery in patients with MMES score（P>0.05）；while awake after 3 hours，after 1 days and 3 days operation in M2 and M3 groups，MMES score decreased significantly better than the other three groups，the difference was statistically tically significant（ P<0.05）；M3 group spontaneous breathing recovery time，extubation time and recovery time orientation of the eyes and respiratory time were significantly higher than M0，M1，M2 group，the differences were statistically significant（P<0.05）；M2 and M3 group in POCD were obviously lower than the other three groups，the
differences were statistically significant（P<0.05）.Conclusion：In the clinic utilizing，0.4 μg/（kg·h）dexmedetomidine combined sevoflurane can not only reduce the postoperative incidence of cognitive dysfunction early in elderly patients with general anesthesia and operation，but also it’s safe and feasible.It’s the best scheme of dexmedetomidine combined sevoflurane administration，it is worthy of clinical popularization and application.
|
|
|
|
|
|
|
|
|
