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中国医学创新

2015 Vol.12,No.7

Published 2016-03-05

KANG Ying-mei.

Objective: To evaluate the efficacy difference of different combination treatment programs in treatment of ulcerative colitis patients. Method: 90 ulcerative colitis patients were selected from our hospital gastroenterology during June 2011 and June 2013, they were divided into three groups. Group A: mesalamine enteric tablets treatment; Group B:enema treatment; Group C: oral medicine combined with enema therapy, each group contained 30 patients, WBC counts,C-reactive protein levels, hemoglobin concentration before and after treatment, and treatment efficiency was analyzed and compared.  Result:( 1) Before treatment, in WBC count, C-reactive protein level, hemoglobin concentration, the three groups had no significant difference( P>0.05). After treatment, in WBC count, C-reactive protein level, hemoglobin concentration, the difference between the three groups was statically significant( P<0.05), and Group C was better than Group A and Group B.( 2) The total effective rate of the Group A was 63.3%, Group B was 80.0%, Group C was 93.3%,there were significant differences( P<0.05). Between the Group A and the Group B in total effective rate, and Group C was significantly better than Group B( P<0.05). Conclusion: TCM has obvious advantages in the clinical treatment of ulcerative colitis, oral medicine combined with enema therapy is better than along enema therapy, and it can be more effective in improving symptoms and promote intestinal mucosal repair.

2015 Vol. 12 (7): 1-3 [Abstract]( 664 HTML (1 KB)  PDF  (668 KB)  ( 193 )

GAN Bei.

Objective: To explore the relationship of NF-κB in placenta with early-onset( gestational age <32 weeks)and late-onset(gestational age ≥ 32 weeks)preeclampsia. Method:40 PE women were selected and divided into early-onset PE group of 20 cases and late-onset PE group of 20 cases.The normal control group were 30 healthy normotensive pregnancy.Immunohistochemistry was employed to show the location distribution and quantity of NF-κBp65 in placenta of preeclampsia. Result:NF–κBp65 in placenta of preeclampsia was stronger expression than that of control group,and was stronger expression in early-onset preeclampsia than that in late-onset preeclampsia,the differences were statistically significant(P<0.05).Conclusion: It suggests that NF–κB participate in the pathogenesis of preeclampsia.Increasing NF–κB activity in placenta induces the immune inflammatory reaction,which may be related to the etiology of early-onset and late-onset preeclampsia.

2015 Vol. 12 (7): 4-6 [Abstract]( 401 HTML (1 KB)  PDF  (740 KB)  ( 178 )

XIE Jun-feng.

Objective: To study the pneumonia in children with heart failure of troponin nin I( cTnI) change and the correlation with cardiac function evaluation. Method: The children with pneumonia in heart failure were selected as the research object,from April 2013 to April 2014 in our hospital.40 cases as pneumonia heart failure group;40 cases as pneumonia of congenital heart failure group(hereinafter referred to as: first heart pneumonia group); 40 cases as general pneumonia group; 40 cases of healthy children as normal control group.Enzyme-linked immunosorbent assay( ELISA) for cTnI levels were determined in the peripheral blood application on cardiac function in children with ultrasonic diagnostic instrument,the clinical data was contrasted. Result: Compared normal control group and general pneumonia group with cTnI heart failure group( pneumonia of congenital heart failure group+pneumonia heart failure group) were obviously increased, the difference was statistically significant(P<0.05);PFVP, EF, PFVA, SF, significantly decreased,the difference was statistically significant(P<0.05). The cTnI rise first heart pneumonia group, PFVP, PFVA, SF, EF lower than pneumonia heart failure group, but no significant difference( P>0.05). EF falls, elevated cTnI 60 cases,normal 0 case; EF was normal, elevated cTnI 12 cases, 48 cases of normal, elevated cTnI total 72 cases, 48 cases properly. CTnI on EF sensitivity and specificity evaluation were 100% and 80%. Conclusion: Pneumonia in clinical has certain heart function damage, is associated with myocardial damage, of cTnI detection, can damage to myocardium and cardiac function in early diagnosis,to provide accurate reference basis for the establishment of early treatment and prevention for the occurrence of heart failure, to improve the prognosis to a great extent,ensure children survival quality.

2015 Vol. 12 (7): 7-10 [Abstract]( 533 HTML (1 KB)  PDF  (690 KB)  ( 464 )

LI Shi-yuan.

Objective: To observe the effect of prone position general anesthesia on postoperative cognitive function in patients with orthopaedic surgery, provide reference for clinical practice and guidance. Method: 40 patients ith orthopaedic surgery in our hospital were selected as the clinical research objects,according to operation position, they were randomly divided into the supine position group and prone position group, 20 cases in each group. The two groups of patients were given the same anesthesia method. The cognitive function of the two groups before and after anesthesia were mainly observed, the influence of postural differences on postoperative cognitive function of patients was analyzed. Result: The supine position group and the prone position group occurred after surgery postoperative cognitive impairment,but the incidence of cognitive dysfunction in prone position group was significantly higher than that of the supine position group, recovered more slowly, the differences were statistically significant( P<0.05). Conclusion: The prone and supine position under general anesthesia orthopaedic surgery may occur the postoperative cognitive dysfunction, but the incidence of cognitive dysfunction in prone position is significantly higher, cognitive function recovery time is also significantly slower, so should choose a more scientific and reasonable postures of patients with general anesthesia, to ensure the postoperative quality of life of patients.

2015 Vol. 12 (7): 10-13 [Abstract]( 693 HTML (1 KB)  PDF  (687 KB)  ( 156 )

Rats/QI Chao,LI Xia-qing,ZHANG Hong.

Objective:To investigate a lateral spinal cord injury model with less trauma and better replication.The model would be usefull for the study of various new medicines or stem cell therapy on spinal cord injury.Method: A modified self-made needle was used to insert into lumbar spinal cord of SD rats without opening the cavum medullare,the lateral spinal cord injury was established.The grasping ability( movement function) and sensory function by temprature of hind-limbs were measured and compared with contralateral side at different time points after injury for insure the model was successfully.Result:It showed that lateral spinal cord injury model of rats appeared obvious lateral paralysis ,but without incontinence of urine and defecation. Also none of them had infection locally or systemically. The model was successfully.Conclusion:The spinal injure model made by self-made modified needle insertion into SD rats lumbar spinal cord is easy to handle ,repeat,and induce obvious lateral paralysis without severe complications.Due to its advantage of connecting, some medicines or stem cells could be injected conveniently at the same time while surgery processed,then provides an experimental basis to explore the molecular mechanism of spinal cord injury regeneration difficulty.

2015 Vol. 12 (7): 14-17 [Abstract]( 587 HTML (1 KB)  PDF  (736 KB)  ( 335 )

ZHENG Gui-lang,WU Jia-xing.

Objective: To investigate the effect of UCP2 during the oxidative stress injury procedure of PM2.5 on the rat myocardial cells H9C2. Method: Rat cardiomyocytes H9C2 cell lines were cultured,and divided into 3 groups,the NC group was used of conventional medium stimulus,the PM2.5 group was used of PM2.5 medium stimulus and the PM2.5+siRNA group was used of PM2.5+siRNA medium stimulus. After 48 hours,the activity of reactive oxygen species (ROS) and superoxide dismutase( SOD), and the content of malonaldehyde( MDA) and glutathione( GSH),were determinated by colorimetric detection.Result:The PM2.5 group of intracellular ROS,MDA, the content of GSH,and the activity of SOD,were respectively( 69.2±6.3)U/Well,(68.33±1.96)nmol/mgprot,(533.05±10.83)mg/ gprot,(50.37±1.98)U/mgprot.Compared with PM2.5 group,the PM2.5+siRNA group of intracellular ROS was (90.2±6.2)U/Well increased greatly,MDA was(88.44±1.27)nmol/mgprot increased greatly,the content of GSH was( 421.17±16.90)mg/gprot and the activity of SOD was(30.09±2.02)U/mgprot. Compared the three groups,all the differences were statistically significant(P<0.05). Conclusion:PM2.5 can lead to myocardial cell damage by oxidative stress, and the silence of UCP2 by RNAi lead to aggravate the injury of H9C2 cells, indicating that UCP2 may play an protective effect during the oxidative stress injury procedure of H9C2 caused by PM2.5.

2015 Vol. 12 (7): 18-21 [Abstract]( 593 HTML (1 KB)  PDF  (712 KB)  ( 196 )

WANG Chang-xiong,WANG Qiao-ming,SONG Li-wei,et al.

Objective:To compare the clinical value of taking Jianweiyuyang pills and Rabeprazole capsules to repaire the iatrogenic ulcer after the Endoscopic therapy.Method:The patients who used the iatrogenic ulcer after the treatment of argon plasma coagulation,endoscopic mucosal resection and endoscopic submucosal dissection, let them take Jianweiyuyang pills and Rabeprazole capsules to make a clinical control treatment. Then drug efficacy were observed.Result:Two groups of patients during treatment did not be found complications such as gastric antrum mucosa hemorrhage, perforation. In Jianweiyuyang pills group, after 1 month of the last treatment review, there were 48 cases (90.6%) showed red ulcer scars( S1 period). After 3 month of the surgery review,there were 52 cases( 98.1%) showed white ulcer scars( S1 period). EUS appears as Sc of 50 cases( 94.3%) after 6 month of the surgery.In Rabeprazole capsules group, after 1 month of the last treatment review,there were 47 cases( 94.0%) showed red ulcer scars( S1 period). After 3 month of the surgery review, there were 45 cases( 90.0%) showed white ulcer scars( S1 period).EUS appears as Sc of 40 cases( 80.0%)after 6 month of the surgery.The quality of ulcer healing of Jianweiyuyang pills group with stage Sc was better than Rabeprazole capsules group, the difference was statistically significant( P<0.05).Conclusion:Short-term efficacy is quite of treating the Iatrogenic ulcer by taking Jianweiyuyang pills or Rabeprazole capsules. Long-term effects( the Sc period of ulcer healing quality) of taking Jianweiyuyang pills is better than Rabeprazole capsules . The author believes that Jianweiyuyang pills is an ideal drug for treating the artificial ulcer, and can be a selection for clinical application.

2015 Vol. 12 (7): 22-24 [Abstract]( 640 HTML (1 KB)  PDF  (670 KB)  ( 206 )

YANG Hong-mei, WANG Xuezhe.

Objective: To assess effect on ovarian adenocarcinoma cell HO-8910 by gallium nitrate, investigate the expression of Bcl-2, Bax and Caspase-3.  Method: The human ovarian cancer cell line HO-8910 was cultured and treated with drugs, expression of Bcl-2, Bax and Caspase-3 was analyzed by Western blot. Result: The expression of Bcl-2 protein was down regulated in gallium nitrate group, cisplatin group and combination group compare with control. Bax and aspase-3 protein was activated in gallium nitrate group and combination group compare with control.Conclusion: Effects of gallium nitrate on human ovarian cancer cells, may be associating with the expression of Bcl-2 levels is decrease, Bax, Caspase are up regulation.

2015 Vol. 12 (7): 25-27 [Abstract]( 566 HTML (1 KB)  PDF  (679 KB)  ( 241 )

LI Pu-qian,JIANG Min-qiao.

Objective: To investigated the level of application value of combined detection HE4 and CA125 in serum for the diagnosis of ovarian epithelial tumors. Method: 165 patients with ovarian tumor were selected,87 cases were ovarian epithelial cancers group,78 cases were benign ovarian tumors group and 50 cases were healthy women as control group,and all of them were detected by the methods of ELISA of CA125 in serum and HE4 in blood.Result: The level of HE4 in blood with epithelial ovarian cancer patients were significantly higher than that in benign ovarian tumor group and the control group,the difference was statistically significant(P<0.05). The sensitivity and accuracy of HE4 in blood were 87.3% and 92.3% respectively,the sensitivity and accuracy reached up to 96.5% and 97.4% by combined detection of HE4 in blood and CA125 in serum,the difference was statistically significant(P<0.05). Conclusion: The diagnostic rate of ovarian epithelial cancer can be improved significantly by combined detection of HE4 in blood and CA125 in serum.

2015 Vol. 12 (7): 28-30 [Abstract]( 508 HTML (1 KB)  PDF  (669 KB)  ( 220 )

WANG Juan, GAO Yong-gang.

Objective: To investigate the clinical value of noninvasive bi-level positive tive airway pressure( BiPAP)in the treatment of elderly patients with acute left heart failure on the basis of conventional drug treatment. Method: 55 elderly patients with acute left heart failure above 60 years old, after conventional nasal catheter oxygen and strong heart,diuresis drug treatment 40 min stilled invalid, then were treated with BIPAP. The symptoms and signs, serum brain natriuretic peptide( BNP) and partial pressure of oxygen in arterial blood( PaO2), partial pressure of carbon dioxide in arterial blood( PaCO2) and so on before and after the treatment of all patients were observed. Result: After the treatment with noninvasive ventilator,46 cases( 83.6%) of dyspnea improved obviously, double lung sound decreased, heart rate (HR), respiratory( R), the BNP declined, PaO2, arterial oxygens aturation( SaO2) increased, the differences were statistically significant( P<0.05). 9 patients due to illness were changed tracheal intubation mechanical ventilation treatment, 5 cases died. Conclusion: For the poor effect of drug treatment in elderly patients with acute left heart failure,BIPAP treatment can rapidly improve the arterial blood oxygen content, improve heart function, relieve edema, reduce the use of tracheal intubation invasive mechanical ventilation and related complications, reduce the patient’s pain and the effect is remarkable. It is a safe and effective method of first aid.

2015 Vol. 12 (7): 31-33 [Abstract]( 558 HTML (1 KB)  PDF  (680 KB)  ( 277 )

TAN Zhi-lin.

Objective: To explore and study of etomidate combined with fentanyl and etomidate dezocine scheme scheme comparison of application effect in anesthesia in painless artificial abortion. Method: From April 2014 to January 2015, 100 cases with painless induced abortion were selected, according to the odd and even number of admission, 50 patients in control group used etomidate combined with fentanyl anesthesia project, 50 patients in observation group used etomidate combined with dezocine scheme of anesthesia, the change of vital signs during operation sedation agitation scale, duration of anesthesia,recovery time, adverse reactions, postoperative pain score for statistical comparison between the two groups were compared. Result: The observation group patients were relatively stable, SAS score and the anesthesia recovery time compared between the two groups showed no significant difference, but the incidence rate of adverse reaction and surgery pain of the observation group was significantly lower than that of the control group, the differences were statistically significant( P<0.05). Conclusion: Etomidate composite decocine painless induced abortion can provide sedation, good analgesic effect on respiratory and circulatory system, interference small, which is a safe and effective anesthesia scheme.

2015 Vol. 12 (7): 34-36 [Abstract]( 500 HTML (1 KB)  PDF  (669 KB)  ( 235 )

DENG Jian.

Objective: To explore the clinical value of nephron carcinoma resection. Method: Our hospital from 2010 to 2010 nephron kidney cancer resection 41 cases and kidney cancer radical resection of 47 cases of medical records in kidney cancer radical resection were selected for control group, with nephron kidney cancer resection as the experimental group, to analyze the effect of the two groups. Result: Two groups successfully completed, and an average length of hospital stay of the two groups were both 11 d clinical stages were T1N0M0, and intraoperative blood loss in operation time and survival rate had no significant differences( P>0.05), but the experimental group had a good quality assessment( P<0.05). Conclusion: Retain the nephron kidney cancer resection of postoperative life quality is much better than that of radical excision group of patients, has higher clinical value and practical significance.

2015 Vol. 12 (7): 37-39 [Abstract]( 505 HTML (1 KB)  PDF  (667 KB)  ( 250 )

YIN Jian-bin, YANG Chuan-feng, YAO Yong-sheng.

Objective: To discusses narrow spectrum uvb rays in serum in patients with chronic urticaria of histamine and leukotriene meaning. Method: 40 chronic urticaria patients, were randomly involved into two groups,and were treated by Fexofenadine Hydrochloride Tablets( 60 mg, bid) accompanying with NB-UVB( biw) in the trial group, and Fexofenadine Hydrochloride Tablets( 60 mg, bid) alone in the control group respectively.Therapeutic courses in both groups were 2 months. Concentration of serum histamine and leukotriene was detected before and after treatments, and( USA) score and dermatological life quality index( DLQI) was used to evaluate the patients’improvements. Result:( 1) There was no statistical significance in the study group and the control group before treatment, but after 1 month and 2 months of treatment, there was statistically different( P<0.05).( 2) The comparison of serum histamine level before and after treatment of the two groups, the difference was statistically significant( P<0.05),but no significant difference between the two groups after treatment. Comparison of serum leukotriene B4 level before and after treatment in the two groups, the difference was statistically significant( P<0.05), but no statistically significant difference after treatment. Conclusion: Combination therapy of Fexofenadine Hydrochloride Tablets and NB-UVB is beneficial for chronic urticaria, with a significantly higher improvement effect than each single therapy.

2015 Vol. 12 (7): 40-44 [Abstract]( 535 HTML (1 KB)  PDF  (682 KB)  ( 161 )

ZHANG Bai-bing, LI Jian, YU Wen, et al.

Objective: To investigate the changes and significance of the receptor activator for osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand( RANKL) in gingival crevicular fluid( GCF) in postmenopausal women with periodontitis. Method: To follow careful sampling of GCF with moisture absorption paper point strips in patients. The level of OPG and RANKL was detected using ELISA technique. Result: The GI, PLI, PD,AL difference was significant between the two groups( P<0.01). There was significant difference in levels of RANKL,OPG and the ratio of RANKL/OPG in GCF between the two groups( P<0.01). Conclusion: The result suggests that the increasing production of RANKL and reducing production of OPG maybe associated with the initiation and progress of periodontitis.

2015 Vol. 12 (7): 42-44 [Abstract]( 609 HTML (1 KB)  PDF  (670 KB)  ( 259 )

DONG Xiao-yan.

Objective: To investigate the effects of menopause syndrome hormone replacement therapy compliance related factors and preventive measures. Method: 104 patients with climacteric syndrome according to individual condition used only estrogen supplement, progesterone supplementation alone and female pregnancy( male) hormone ties complement in three ways, to analyze climacteric syndrome clinical data, hormone replacement therapy compliance judgment of 104 cases, differences of compliance related factors between the two groups. Result: 104 patients with hormone replacement therapy compliance in 62 cases( 59.62%), hormone replacement therapy for treatment of 42 cases of poor compliance( 40.38%); single factor 字2 test culture degree, family support, place of residence, the psychological condition, economic income, the hormone replacement therapy, cognitive, hormone replacement therapy, medical adverse reaction cost, medical conditions of the 9 indexes had significant difference( P<0.05). Logistic regression analysis of the influence of climacteric syndrome hormone related factors of treatment compliance: hormone replacement therapy cognitive bias, hormone replacement therapy, adverse reactions and adverse psychological status and living in rural areas( OR=4.70,4.29,3.89,3.17). Conclusion:Menopausal compliance is poor syndrome hormone replacement therapy process, resulting in poor compliance effect of complex, should carry out some measures to improve the compliance of hormone replacement therapy.

2015 Vol. 12 (7): 45-48 [Abstract]( 625 HTML (1 KB)  PDF  (699 KB)  ( 208 )

ZHOU Yan-zhen.

Objective: To explore the curative effect of 45 Uncontrolled hemorrhagic shock patients treated with Restrictive liquid recovery, in order to provide experience for the clinical treatment of uncontrolled hemorrhagic shock. Method: To retrospectively analyze the clinical data of 77 uncontrolled hemorrhagic shock patients admitted in our hospital emergency clinic, they were divided into observation group and control group depending on the liquid recovery methods. 45 patients in the observation group were treated with restrictive liquid recovery treatment, 32 patients in the control group were treated with sufficient liquid recovery treatment. To compare the preoperative transfusion amount,prothrombin time, backlog of red blood cells, mortality, and survival in patients with acute renal failure( ARF) and multiple organ dysfunction syndrome( MODS) and acute respiratory distress syndrome( ARDS), diffuse intravascular coagulation( DIC), and other complications between the two groups. Result: The preoperative transfusion amount,prothrombin time in the observation group was significantly lower than that of the control group,while the backlog of red blood cells was significantly higher than that of the control group, the difference was statistical significance( P<0.05).The fatality rate of the observation group was 8.89%, it’s significantly less than 18.75% of the control group, the difference was statistically significant( P<0.05). Among survival patients, the complication rate of the observation group was 17.07%, it’s significantly less than 34.62% of the control group, the difference was statistically significant( P<0.05). Conclusion: Restrictive liquid recovery uncontrolled hemorrhagic shock with obvious therapeutic effect, can significantly reduce the mortality and complication rates, deserves further research.

2015 Vol. 12 (7): 48-50 [Abstract]( 543 HTML (1 KB)  PDF  (680 KB)  ( 172 )

ZHU Da-gao, WANG Hui.

Objective: To observe the efficacy of the combined raltitrexed plus oxalplatin in the treatment of senile advanced colorectal carcinoma. Method: Thirty-nine advanced colorectal cancer patients were divided into two groups. The treatment group( n=20) was administered intravenously raltitrexed plus oxaliplatin regimen. The control group (n=19) was administered S1 plus Oxaliplatin regimen. Result: All the patients in the treatment group and control group were evaluated. Effective rate of the treatment group and control group was 60.00% and 26.32%, respectively. Median TTP was 8.1 and 4.9 months, respectively. The significant statistical difference was found in the short-term efficacies of the two groups( P<0.05). Adverse reactions compared to the elevated transaminase enzymes of the treatment group was higher than that of the control group. There were more patients who reduced neutropenia in the treatment group( P<0.05). There were more patients who developed vomiting in the control group( P<0.05). Conclusion: The raltitrexed plus oxaliplatin regimen is effective and safe in senile patients with advanced colorectal carcinoma, which is worthy of clinical popularization and application.

2015 Vol. 12 (7): 51-53 [Abstract]( 563 HTML (1 KB)  PDF  (671 KB)  ( 350 )

HUANG Jian-wen.

Objective: To discuss the approach complication cause and precautionary measures by modified radical mastectomy. Method: 120 cases clinical data of breast cancer were analyzed in our hospital general surgery department from Janury 2010 to May 2014,which were divided into control group of 60 cases and observation group of 60 cases. The control group was used in longitudinal fusiform incision,observation group was used in transverse incision. Result: The postoperative complications、postoperative recurrence rate and transport rate of observation group were lower than control group, the difference were statistical significance(P<0.05). Conclusion: The complication cause by modified radical mastectomy are analyzed,the incidence of postoperative complications by precautionary measures are decreased,prognostic level is increased.

2015 Vol. 12 (7): 53-55 [Abstract]( 616 HTML (1 KB)  PDF  (667 KB)  ( 181 )

LAI Bao-yu,LIANG Guo-hua.//

Objective: To investigate the clinical effects of hypostatic pneumonia cured by Xue Bijing combined with antibiotics. Method: 82 patients who suffered from the hypostatic pneumonia and who accepted treatments in our hospital from March 2012 to February 2014 were taken as the research objects,and these patients were randomly divided into the control group and the observation group,41 patients in each group. In the control group, they were treated with the Cefoperazone sodium shu ba potassium sodium glucose while in the observation group, on the basis of the treatment in the control group, they were treated with the Xue Bijing injection. Then, the curing effects of these two groups of patients were compared.Result: The total effective rate of observation group was 92.68%, and the control group was 70.73%,the differences had the statistical significance((P<0.05). In addition, the disappearing time for symptoms and signs in the observation group were evidently shorter than that in the control group and the differences had the statistical significance (P<0.05). Conclusion: The clinical effects of hypostatic pneumonia cured by Xue Bijing combined with antibiotics are good enough, which can evidently improve the curing effects, shorten the disappearing time for symptoms and signs, and improve the long-term outcomes, thus should be promoted in the clinical application.

2015 Vol. 12 (7): 56-58 [Abstract]( 604 HTML (1 KB)  PDF  (669 KB)  ( 187 )

HU Shou-zhang.

Objective: To observe the changes of coagulation, fibrinolytic function and platelet parameter before and after interventional therapy for patients with lung cancer,and explore its clinical significance.Method: 37 patients with lung cancer were treated with selective bronchial artery catheterization and perfusion chemotherapy drugs by using Seldinger line of femoral artery intubation,at the same time 35 cases of normal medical clinic were selected as control group.The changes of coagulation,fibrinolytic function and platelet parameter of the control group and patients with lung cancer were compared before and after chemotherapy.Result:The expression level of serum PT, TT and APTT,FIB,D-D,PAI-Ⅰ of patients with lung cancer before interventional treatment were significantly higher than that of the control group,and the expression levels of serum PC, FPS were significantly decreased,the differences were statistically significant(P<0.05).The above indicators were significantly lower or higher after interventional therapy, compared with the control group had no significant difference(P>0.05).The expression levels of PLT, PCT and MPV of patients with lung cancer before interventional therapy were significantly higher than that of the control group,the difference was statistically significant(P<0.05).The above indicators were significantly lower after interventional therapy,the difference was statistically significant(P<0.05),but PDW had no significant change(P>0.05).Conclusion:The curative effect of interventional treatment of patients with lung cancer can be accurately assess according to blood coagulation, fibrinolytic function and platelet parameters.

2015 Vol. 12 (7): 58-60 [Abstract]( 657 HTML (1 KB)  PDF  (669 KB)  ( 195 )

LIU Guang-yuan, NA Min, PANG Juan, et al.

Objective: To investigate MR imaging features of missed diagnosis and misdiagnosis in small hepatocellular carcinoma( SHCC). Method: Thirty-eight missed diagnosis and misdiagnosis were analyzed, all the cases were confirmed as small hepatocellular carcinoma by pathology. Result: In all the cases, forty-three nidi were observed, and thirty-six nidi appear untypically. Conclusion: Some small hepatocellular carcinoma lack the specific MR imaging features, and are easy to misdiagnose, should be emphasized( 36/43).

2015 Vol. 12 (7): 61-63 [Abstract]( 613 HTML (1 KB)  PDF  (691 KB)  ( 426 )

HU Bo, WU Ying-chao.

Objective: To discuss and analyze the curative effect of levofloxacin hydrochloride combined with metronidazole in the treatment of pelvic inflammatory disease observation. Method: In our hospital from 2012 December to 2013 December during the pelvic inflammatory disease patients, randomly selected 74 patients as the research objects,and randomly divided them into observation group and control group( 37 cases in each group), the control group accepted Metronidazole Injection treatment, the observation group based on the Metronidazole Injection combined with levofloxacin hydrochloride carries on the treatment, after treatment, to compare the clinical efficacy and adverse reactions of the two groups. Result: The cure rate of the observation group and the total effective rate was 70.27%( 26 cases), 94.59%( 35 cases), which was significantly higher than 37.83%( 14 cases), 70.27%( 26 cases) of the control group; adverse reaction of the observation group was 5.40%( 2 cases), which was significantly lower than 24.32%( 9 cases) of the control group,with statistical significance( P<0.05). Conclusion: The use of pelvic inflammation patients is treated with levofloxacin hydrochloride combined with metronidazole, obvious effect, and less adverse reactions, got favorable comments from patients, is worthy of promotion and application in clinical.

2015 Vol. 12 (7): 63-65 [Abstract]( 550 HTML (1 KB)  PDF  (668 KB)  ( 171 )

NIAN Gui-xia, ZHAO Lan-di, ZHANG Li, et al.

Objective: To test the expression of Human placental lactogen( HPL) and CA125 in early missed abortion, and discuss its rationality, accuracy and feasibility of early diagnosis of missed abortion. Method: 41 patients who clear diagnosis of early missed abortion were selected as experimental group, and 40 patients with normal pregnancy at the same period were selected as control group. Human placental lactogen( HPL) was detected by enzyme-linked immunosorbent, CA125 was detected by automated chemiluminescent immunoassay Analyzer. Result:( 1) HPL and CA125: the detection value of the experimental group was significantly lower than that of the control group, the differences were statistically significant( P<0.05).( 2)After the relevant inspection, the human placental lactogen( HPL) in the experimental group was positively correlated with CA125. Conclusion: In missed abortion, the expression of HPL and CA125 in missed abortion is less than that of the normal pregnancy. The expression of HPL is positively correlated to the CA125.

2015 Vol. 12 (7): 66-68 [Abstract]( 550 HTML (1 KB)  PDF  (670 KB)  ( 337 )

WANG Xiao-jun.

Objective:To discuss the clinical effect of hemodialysis series blood perfusion in the treatment of uremia,summarized the clinical application value. Method: 40 cases of patients with uremia were selected in our hospital from June 2012 to June 2014,according to the double blind method,divided into the experimental group and control group,20 cases in each group.The control group were treated with hemodialysis,the experimental group were treated with hemodialysis series blood perfusion, 4 weeks after treatment,the clinical effect were compared. Result: Compared with the control group, experimental group had better effect to the treatment of patients with uremia, the experimental group after treatment of PTH( parathyroid hormone),and β2-MG( β2-microglobulin) level were respectively(231.6±63.8) ng/L、(4.3±1.8)ug/mL,lower than the control group,the difference was statistically significant  (P<0.05). In addition,the experimental group sleep,appetite and itchy skin to improved situation were better than that of control group, the difference was statistically significant(P<0.05).Conclusion: Hemodialysis series blood perfusion for the treatment of patients with uremia is better than that of hemodialysis filtration, tandem therapy is worth further application and popularization.

2015 Vol. 12 (7): 68-71 [Abstract]( 425 HTML (1 KB)  PDF  (691 KB)  ( 196 )

BAO Sheng-hua, LIU Yu, WU You-zhen.

Objective: To study the minimally invasive percutaneous ureteroscopy take renal nephrolithotomy (MPCNL) in clinical anesthesia methods and effect. Method: 77 patients in hospital accepted MPCNL were selected as the research objects, according to different anesthetic methods divided into general anesthesia group( 37 cases) and waist hard joint group( 40 cases), the general anesthesia group took tracheal intubation general anesthesia treatment,combined spinal epidural anesthesia group took lumbar anesthesia combined with epidural anesthesia treatment. To observe anesthesia effect, the time of anesthesia, and the adverse reactions of the two groups. Result: Combined with spinal epidural anesthesia group, the excellent and good rate of the general anesthesia group was obviously better than that of general anesthesia group, and adverse reaction incidence rate was significantly lower, the difference was statistically significant( P<0.05). Conclusion: Minimally invasive percutaneous ureteroscopy takes renal nephrolithotomy treatment,clinical application of waist hard joint anesthesia can obviously improve the effect of anesthesia, anesthesia time, and reduce adverse reactions, is worth using for reference.

2015 Vol. 12 (7): 71-73 [Abstract]( 612 HTML (1 KB)  PDF  (679 KB)  ( 211 )

CHEN Shi-you, LI Xiao-qi, CHEN Jian.

Objective: To through the detection rate of chronic disease for five years of medical staff in a tertiary comprehensive hospital, analyze the reasons and put forward effective health promotion strategies on the basis of the reasons. Method: The results of health examination of workers from 2009 to 2013 in a a tertiary comprehensive hospital of Jiangmen city were used. The 字2 test of multiple sample rate was used in the detection rate of disease for significance test analysis. Result: There were statistical differences among the detection rate of gallbladder disease, high blood pressure,blood glucose abnormalities, and fatty liver in five years( P<0.01). Conclusion: Health status of medical personnel is not optimistic, it should draw great attention of the related departments. On the basis of adopting comprehensive measures,emphasizing the comprehensive social forces is very important measure to ensure the medical personnel health promotion.

2015 Vol. 12 (7): 77-79 [Abstract]( 482 HTML (1 KB)  PDF  (667 KB)  ( 198 )

ZHANG Hai-ling,CHEN Qiong-fang, HUANG Ting-ting.

Objective: To analyze the damage control in application on attendance of orthopedic critically patients.Method: 80 orthopedic critically patients from October 2012 to October 2013 in our hospital, were random divided into observation group and control group with 40 cases in each group, the control group was treated with conventional nursing, the observation group was treated with nursing which according to the different stages of damage control surgery,the hospitalization time and curative effect was compared between the two groups. Result: The hospitalization time of the observation group was( 8.6±1.9) weeks, which was shorter than( 11.6±2.1) weeks of the control group, there were statistically significant differences( P<0.05). The complication rate, disability rate and mortality rate of the observation group was lower than that of the control group, there were statistically significant differences( P<0.05). Conclusion: DCO nursing can reduce the complication rate, disability rate and mortality rate effectively, to promote the recovery of patients, and has worthy of clinical application.

2015 Vol. 12 (7): 80-82 [Abstract]( 459 HTML (1 KB)  PDF  (690 KB)  ( 180 )

CHEN Li-bing,LIU Yu-qin,OU Hui-zhi,et al.

Objective: To explore the effect of systematic nursing intervention on external fixation stent therapy for patients suffering long-bone fracture of limbs to offer scientific guidance to help Clinical patients. Method: 68 cases of patients who received external fixation stent therapy after suffering long-bone fracture of limbs in our hospital from November 2011 to November 2012 were chosen as the objects, they were randomly divided into the observation group and the control group,34 cases in each group. The patients in the observation group were given routine nursing intervention and the others in the control group were given systematic nursing intervention.The clinical intervention effects, complication rates, the satisfaction degree and the information of nursing self-management evaluation in each group were observed and compared. Result:Clinical intervention effects, complication rates, the satisfaction degree and the information of nursing self-management evaluation in the observation group were significantly superior to those in the control group, the differences were statistically significant(P<0.05);clinical intervention had great effect on patients in both group, and the condition of the observation group was superior to that of the control group after offering systematic nursing intervention, the difference was statistically significant(P<0.05).Conclusion: Systematic nursing intervention in external fixation stent therapy for the patients suffering long-bone fracture of limbs has great effect on those patients, it can reduce the complications rates in patients, improve patients ’ satisfaction degree and clinical nursing effect. It is worthy of extensive clinical application.

2015 Vol. 12 (7): 83-85 [Abstract]( 647 HTML (1 KB)  PDF  (679 KB)  ( 222 )

PU Guang-min, SU Lian-chun, LI Xiao-qian, et al.

Objective: To observe the effect of standardized painless ward management applied in perioperation period of open operation for thoracolumbar burst fracture. Method: 80 cases were included in this study. 40 cases were selected randomly as study group, accepting standardized painless ward management in perioperation period. Meanwhile,40 patients were selected as control group, accepting routine nursing management in perioperation period. The observation indexes were pain visual analogue scale( VAS) and the Houston pain questionnaire( HPOI). Result: At the time of admission and the day of operation, there was no significant difference in pain score between the two groups. 1 day before operation, 3 days after operation and at discharge, pain score of study group was significantly lower than that of the control group( P<0.05). Mean score of pain satisfaction of study group was significantly higher than that of the control group,and the difference was statistically significant( P<0.01). Conclusion: The application of painless ward management in perioperation period of open operation for thoracolumbar burst fracture is successful. To provide more professional pain nursing service for patients, improvement of management is also necessary.

2015 Vol. 12 (7): 86-88 [Abstract]( 435 HTML (1 KB)  PDF  (668 KB)  ( 173 )

ZHOU Jie, LI Jin-long, ZHANG Yi-chuan, et al.

Objective: To discuss the importance of the first aid nursing to save liver trauma life and improve the cure rate. Method: We recorded and analyzed retrospectively more complete 96 cases with severe liver injury from August 2000 to April 2014. Result: 96 liver rupture patients, all hepatic artery ligation, simple hepatic wound debridement repair 30 cases, additional common bile duct and T tube drainage in 6 cases, hepatic artery ligation( HAL) and T-tube drainage 42 cases, 14 cases of irregular hepatectomy, right liver injury 18 cases. The bare area of liver of severe comminuted damage, unable to repair, average blood lost more than 2500 mL, in critical condition, with gauze with packing the injured part and inferior phrenic, using HAL and T tube drainage, all patients were in Prin-gle ’s method for processing.The blocking time was within 20 minutes, the average postoperative blood transfusion volume in the 1000-2400 mL. 19 cases of biliary tract bleeding, subphrenic infection in 12 cases, pulmonary infection, organs function failure in 15 cases,12 cases of death. Conclusion: Liver traumatic rupture patients need early correct diagnosis, with medical treatment, fast recovery of body fluid balance. In the emergency treatment and nursing process should be fast and accurate preoperative blood transfusion with all kinds of preparations, postoperative nursing. Hemorrhagic shock at the same time, operation treatment. First aid nursing positively has great effect on saving the patient’s life and improving the cure rate.

2015 Vol. 12 (7): 89-92 [Abstract]( 532 HTML (1 KB)  PDF  (688 KB)  ( 251 )

FENG Yu-fei.

Objective: To discuss influences of individualized nursing intervention on life quality of patients with malignant lymphoma after chemotherapy. Method: Fifty patients with malignant lymphoma admitted the Inpatient Department from January 1, 2011, to June 30, 2013 were selected as research subjects, who were divided into observation group and control group with 25 cases in each group with the method of control study, patients in the control group accepted routine nursing, and patients in the observation group accepted personalized nursing intervention, life quality scores and psychological evaluation of patients between the two groups were compared. Result: The comparisons of SAS score, SDS score and life quality index score of patients between the two groups showed that differences were statistically significant (P<0.05). Conclusion: The efficacy of personalized nursing intervention applied on patients with malignant lymphoma is significant, making for improving the nursing quality and life quality of patients after chemotherapy, imposing high clinical practice significance.

2015 Vol. 12 (7): 93-95 [Abstract]( 630 HTML (1 KB)  PDF  (667 KB)  ( 308 )

YU Sa-chen.

Objective: To analyze the nursing intervention auxiliary oxygen spray inhalation drug therapy the clinical treatment effect of children with asthmatic bronchitis. Method: From May 2012 to May 2014 in our hospital 268 children with asthmatic bronchitis were divided into two groups at random, control group accepted with oxygen spray inhalation budesonide and terbutaline sulfate treatment, observation group increased nursing intervention on the basis of the control group. Result: Treatment effectiveness of the observation group after nursing intervention was 94.8%,treatment effectiveness of the control group was 82.1%, children symptoms relieve time of the observation group was significantly shorter than that of the control group, the treatment effect between the two groups was different markedly, with statistical significance( P<0.05). Conclusion: The drug oxygen spray inhalation in the treatment of the clinical treatment of children with asthmatic bronchitis, increase nursing intervention measures, and can effectively improve the clinical therapeutic effect, make the healing fast, recommended in clinical use.

2015 Vol. 12 (7): 96-98 [Abstract]( 493 HTML (1 KB)  PDF  (680 KB)  ( 193 )

PENG Qiao-yun.

Objective: To investigate the application effect of intensive care nursing scoring system in nursing resources allocation of ICU. Method: 120 intensive patients admitted in ICU of our hospital were selected, 56 cases from January to June as control group, 64 cases from July to December as observation group. The patients of the control group were given routine care management, and were assigned to each tube bed nurse; patients of the observation group were given nursing resource allocation according to intensive care nursing scoring system. The hospital stay time, treatment costs, complications and nursing satisfaction of patients was compared, nursing quality score and nurses’ satisfaction were evaluated. Result: The hospital stay time of the observation group was shorter than that of the control group, hospital cost was lower than that of the control group, nursing satisfaction score was higher , the difference was significant( P<0.05). The pressure sore, unplanned extubation, nosocomial infection rate of the observation group was significantly lower than that of the control group( P<0.05). The nursing quality score and nurses’ satisfaction score of the observation group was significantly higher, the difference was statistically significant( P<0.05). Conclusion: In ICU, nursing resource allocation according to intensive care nursing scoring system can improve the efficiency and quality of nursing care, it is worth applications.

2015 Vol. 12 (7): 98-100 [Abstract]( 592 HTML (1 KB)  PDF  (678 KB)  ( 203 )

LI Qing.

Objective: To investigate the risk management in low birth weight children intravenous catheter care in the use. Method: First we chose our hospital NICU 480 low birth weight children, who were divided into two groups.With conventional treatments as well as risk management, we compared and analyzed the incidence of complications in the case of the two care methods. Result: Compared two fluid extravasation of low birth weight children, phlebitis,infection and the occurrence of skin induration, the risk management significantly reduced the risk of incidence( P<0.05). Conclusion: Risk Management Act in low birth weight children intravenous catheter care process is very important,which can reduce the incidence of complications, and strengthen risk management to ensure the safety of low birth weight children infusion skin plays a decisive role.

2015 Vol. 12 (7): 101-104 [Abstract]( 515 HTML (1 KB)  PDF  (698 KB)  ( 276 )

BI Yan-mei,SUN Xing-yun, LIU Feng-min.

Objective: To evaluate the effect of the implementation of community nursing intervention in patients with cerebral apoplexy, promote the community nursing work, improve the recognition of community residents for community nursing work. Method: 84 patients with cerebral apoplexy accepted community nursing intervention, including health education, diet guidance, psychology guidance, exercise guidance, medication guide, life guidance. Result: After 10 months community nursing intervention, patients’ awareness rate of related disease knowledge increased obviously, from 23.8% to 85.7%. And, according to the medical, reasonable movement, quit alcohol limit took a turn for the better,with significant difference compared before community nursing intervention. Conclusion: Community nursing intervention can promote physical recovery, prevent disease recurrence, improve treatment effect.

2015 Vol. 12 (7): 104-106 [Abstract]( 567 HTML (1 KB)  PDF  (678 KB)  ( 264 )

WU You-zhen.

Objective: To analyze quality of nursing in patients with cerebral thrombosis, the application of clinical nursing effect. Method: We chose 86 cerebral thrombosis patients, and randomly divided into two groups,controlled group which contained 42 cases was given basic nursing, 44 cases in observation group were given high quality on the basis of basic nursing care, compared patient care and nursing satisfaction of the two groups. Result: After nursing,SAS scores and SDS scores of the two groups were significantly lower, and that of the observation group was significantly lower than that of the control group. After nursing, patients daily life activities ability score of the two groups increased significantly, and daily life activities ability score of the observation group was significantly higher than that of the control group. Length of stay of the observation group was shorter than that of the control group, and nursing satisfaction was significantly higher than the control group, with significant difference( P<0.05). Conclusion: High quality nursing care for patients with cerebral thrombosis, is conducive to ease the anxiety, depression, and the bad mood, can significantly shorten the hospitalization time, promote the rehabilitation of patients daily life activities ability is worth popularization in clinical.

2015 Vol. 12 (7): 107-110 [Abstract]( 473 HTML (1 KB)  PDF  (687 KB)  ( 191 )

LI Shao-fang,FAN Lei,ZHAO Xiao-jing,et al.

Objective:To evaluate the quality of death case reporting in county and above level medical institution of Henan province in 2013.Method:The death cases information about reporting network system reported from county and above level medical institution of Henan province in 2013 were selected,county reporting rate,eligibility rate of reporting,auditing rate,eligibility rate of auditing, and the accuracy of underlying cause of death coding were applied to the assessment of reporting deaths.Result:The total county reporting rate was 95.27%,eligibility rate of reporting was 88.27%,average auditing rate was 99.9%,eligibility rate of auditing was 98.49%;the accuracy of underlying cause of death coding was 7.93 % .Conclusion:Although the quality of death case reporting in county and above levels medical institutes had greatly increased,quality of death coding is dissatisfactory,which indicated that the training on ascertainment and coding of underlying death causes were quite essential.

2015 Vol. 12 (7): 114-116 [Abstract]( 420 HTML (1 KB)  PDF  (655 KB)  ( 177 )

PENG Xi-an, LUO Man-yi.

Objective: To investigate the clinical curative effect of laparoscopic operation combined with drugs in the treatment of endometriosis of ovary. Method: 40 patients underwent laparoscopic operation treatment because of ovarian cyst, infertility, dysmenorrhea and other diagnosis in our department from January 2012 to January 2014 were reviewed, they were given triptorelin acetate treatment for 3-6 months. Result: The pathological of all operation specimens were diagnosed as endometriosis of ovary, regular followed up after operation, 3 cases of recurrence, 21 cases of dysmenorrhea relief, 8 cases of pregnancy  Conclusion: Laparoscopy combined with triptorelin acetate is a method of good curative effect for the treatment of endometriosis of ovary, can improve the pregnancy rate in infertile patients at the same time.

2015 Vol. 12 (7): 117-120 [Abstract]( 526 HTML (1 KB)  PDF  (687 KB)  ( 183 )

WANG Zhan-hua.

Objective: To study repeated urinary tract infection among long-term inpatients of disabled soldiers caused by E.coli and drug resistance of the bacterium. Method: A retrospective investigation was carried out. The E.coli isolated with routine method from urine specimens was analyzed, whose susceptibility to antimicrobial agents was tested. Whonet5.4 and Excel were used to deal with the data. Result: Urinary specimens of long-term urinary tract infection inpatients of disabled soldiers were cultured, 1214 Strains of bacteria(no-repeated strains)were obtained, including 384 E.coli( accounting to 31.63%). Repeated infection occurred among some patients, which was especially resistant to antibiotics. Conclusion: Bacteria culture should be carried out to treat the long-term inpatient of disabled soldiers with urinary tract infection, so as to give an instruction to rational use of antibiotics.

2015 Vol. 12 (7): 120-122 [Abstract]( 459 HTML (1 KB)  PDF  (667 KB)  ( 157 )

ZENG Ai-sheng,ZHOU Zhong-yi, YANG Zi-cai.

Objective: To analyze the reconstruction and repairing methods and effects of comminuted fractures of anterior skull base. Method: 60 patients who suffered from the comminuted fractures of anterior skull base and who accepted treatment in our hospital from May 2012 to August 2014 were taken as the research objects to take the retrospective analysis. According to the CT examine results, the osseous reconstruction and the membranous reconstruction repairing surgeries were conducted. In addition, taking the titanium mesh and patients’ own bones as the repairing materials, the recovery situation after surgeries and the CT re-examine results were observed and written down. Result: Among 60 patients, one of them died due to the serious injuries, two of them were conducted the interventional therapy because of the internal artery injuries and were conducted the reconstruction and repairing surgeries later on. Then, the surgeris of another 59 of them succeeded. During the follow-up period, two of them suffered from intracranial infection, one of them suffered from leakage of cerebrospinal, one of them suffered from infection after the cranial through surgery. After the second surgery and the treatment of lumbar continuous drainage of fluid, the repairing effects at the places of fracture were good, and the continuity of bones was good without the complications of cranial meningocede and the leakage of cerebrospinal.Conclusion: The application of the osseous reconstruction and the membranous reconstruction repairing on the patients who suffer from comminuted fractures of anterior skull base can effectively recover the defects of bone dura mater. In addition, the occurrence rate of complications is low and the effect of surgeries is good. Thus, it should be promoted in the clinic applications.

2015 Vol. 12 (7): 123-125 [Abstract]( 563 HTML (1 KB)  PDF  (666 KB)  ( 251 )

YANG Cun-zhen.

Objective: To investigate and compare the application value of the three-dimensional color Doppler and the nuclear magnetic resonance in the diagnosis of fetal malformation. Then, to provide some reliable theoretical basis for the early clinical diagnosis and the proposals of prenatal and postnatal care. Method: 120 pregnant women who came to our hospital for prenatal ultrasound and were diagnosed with abnormal results from March 2012 to March 2014 and investigated. Three-dimensional color Doppler and nuclear magnetic resonance were separately used in order to diagnose fetal malformation. The pregnant women were given follow-up to postpartum or confirmed cases of odinopoeia. To learn the differences between the three-dimensional color Doppler and nuclear magnetic resonance in the diagnosis of fetal malformation, the detection rate, sensitivity, specificity and positive predictive value of the two diagnostic methods were compared and analyzed. Result: During the diagnosis of fetal malformation, the detection rate of the three-dimensional color Doppler was 67.92%( 72/106), the specificity was 81.30%, the sensitivity was 100%, the positive predictive value was 79.60% and the negative predictive value was 100%. The detection rate of the nuclear magnetic resonance was 84.91%( 90/106), the specificity was 89.60%, the sensitivity was 100%, the positive predictive value was 88.20% and the negative predictive value was 100%. Conclusion: In the diagnosis of the fetal malformation, the nuclear magnetic resonance has more apparent advantages. It can be united with the three-dimensional color Doppler to conduct antenatal fetal malformations.

2015 Vol. 12 (7): 126-128 [Abstract]( 538 HTML (1 KB)  PDF  (667 KB)  ( 173 )

ZHOU Wei-zhong,ZHANG Zhi-yuan,CHEN Ming-zhi,et al.

Objective:To study the clinical effect of repairing serious scar contracture of axilla by applying scapular region flap. To summarize the experiences of clinical scapular region flap application, and discuss its feasibility. Method: 11 patients with 13 parts of serious scar contracture of axilla were organized scar release. All patients got repaired by transferring scapular region flap.Result:11 patients with 13 parts of serious scar contracture of axilla getting repair were totally successful. Among them,one patient’s distal subcutaneous fat of flap became fat liquefaction, and with 2 cm dehiscence,changed fresh dressing and suturing, the repaired part healed. Doctors and patients all satisfied with wood surface. Post-operation follow-up 6 monthes to 2 years, all patients wood surface looked good without edema and the axilla never happen scar contracture again. Shoulder joint work normally. Conclusion:The scapular region flap is one of the best way of repairing scar contracture of axilla,which with following advantages:scapular region flap with large area,reliable blood supply,without sacrifice main blood vessel can be easily get,and can be directly sutured and so on.

2015 Vol. 12 (7): 129-131 [Abstract]( 505 HTML (1 KB)  PDF  (711 KB)  ( 266 )

CHEN Fang.

Objective: To explore the application value of contrast-enhanced ultrasound in the evaluation of the stability of carotid atherosclerotic plaques. Method: 52 patients with carotid atherosclerotic plaques were divided into symptomatic group( 35 cases) and asymptomatic group( 17 cases) according to clinical symptoms, and divided into 20 cases of soft plaque, 18 cases of mixed plaque and 14 cases of hard plaque according to the ultrasonic echo. The plaque composition, contrast enhanced intensity( EI), plaque and lumen enhanced intensity ratio( ratio) and contrast enhancement degree classification of each groups were compared. Result: The ratio of soft plaque in symptomatic group was significantly higher than that of the asymptomatic group, and after contrast EI and ratio values was significantly higher than that of the asymptomatic group( P<0.05). The proportion of soft plaque imaging Ⅲ, EI and ratio values was higher than that of the mixed plaque and hard plaque, and the proportion of mixed plaque contrast Ⅲ, EI and ratio values was higher than that of hard plaque( P<0.05). Conclusion: Contrast enhanced ultrasound can enhance quantitative assessment of the stability of plaque through observing the neovascularization in carotid atherosclerotic plaques.

2015 Vol. 12 (7): 132-134 [Abstract]( 521 HTML (1 KB)  PDF  (668 KB)  ( 196 )

ZHU Jian-zhong.

Objective: To compare the clinical efficacy analysis of thoracolumbar fractures were treated by vertebral single segment and across the injured vertebra short segment fixation treatment. Method: 70 thoracolumbar fracture patients in our hospital were randomly divided into observation servation group( treated by vertebral single segment fixation treatment) and control group( with short segment fixation across the injured vertebra), and were observed and compared between the two groups before and after operation of operation treatment satisfaction, sagittal Cobb angle, injury vertebral front height changes,postoperative follow-up corrective and follow-up of loss. Result: The postoperative follow-up found that patients of the two groups after the sagittal Cobb angle decreased, and the vertebral front height increases, but the patients in the observation group were improved significantly than that of the control group( P<0.05). Two groups with sagittal Cobb angle, vertebral height of anterior surgical correction was not significantly different. The observation group patients were followed up for sagittal Cobb angle, vertebral front height loss degree were significantly lower than the control group( P<0.05). Conclusion: The vertebral single segment fixation for the treatment of thoracolumbar fractures of the clinical efficacy is significant, which can effectively restore the sagittal Cobb angle, vertebral height, also can reduce postoperative loss of correction, worthy of further promotion and application in clinical practice.

2015 Vol. 12 (7): 134-137 [Abstract]( 630 HTML (1 KB)  PDF  (701 KB)  ( 343 )

YANG Gang-hua,WANG Li-xun,LU Zeng-ting,et al.

Objective:To prospectively evaluate the effects of body position to the narcotrend index during intravenous anaesthesia.Method: 45 elective surgery patients aged from 20 to 60 years were selected in our hospital from July 2013 to December 2013,whom were 24 males and 21 females,with the BMI 17-23 kg/m2 and ASAI-Ⅱ level, the intravenous general anesthesia were underwent. Propofol and remifentanil anesthesia protocol was introduced and maintained with Target-controlled infusion(TCI) in supine position.5 min after reaching steady-state target concentration,the patients were changed in Trendelenburg position(30 degrees) and maintained about 10 min;10 min later,the position into anti-trendelenburg position were changed( 30 degrees),also maintained about 10 min. Narcotrend Index( NI), mean arterial pressure( MAP), heart rate( HR), end-tidal carbon dioxide partial pressure (PETCO2) were recorded separately at the time points of before trendelenburg position(T0),immediately(T1),1 min( T2) later, 3 min(T3) later,5 min(T4) later and 10 min(T5) later after in Trendelenburg position and antitrendelenburg position.Result:Compared the parameters in supine position(T0),patients’ MAP in Trendelenburg position at the time point of T2-5 increased,also the NI at the time piont of T2-4 ,the difference was statistically significant (P<0.05).While, they were decreased in anti-trendelenburg position..The MAP at the point of T2-5,NI at the point of T2-4 were significantly lower in Trendelenburg position than in anti-trendelenburg position,the difference was statistically significant( P<0.01).Conclusion:Patients’ body position during intravenous anaesthesia can affect the Narcotrend index, of which will affect the anesthesiologists to judgment patients’ anesthesia depth.

2015 Vol. 12 (7): 137-139 [Abstract]( 507 HTML (1 KB)  PDF  (692 KB)  ( 218 )

LI Xiang-fu, WANG Qi-ling, ZHAO Dong-gang, et al.

Objective: To investigate the microscopically craniotomy hematoma removal clinical effect in the treatment of hypertensive intracerebral hemorrhage. Method: A retrospective analysis treated 253 hypertensive cerebral hemorrhage patients with clinical data under a microscope craniotomy hematoma removal from May 2009 to May 2014,including the conventional decompressive craniotomy hematoma in 68 cases, a small bone window craniotomy hematoma removal in 185 cases. Result: 24 h after operation, all patients were scanned CT, 119 cases of hematoma cleared completely, 87 cases of residual hematoma volume ≤ 10 mL, 46 cases of 10 mL < residual hematoma volume ≤ 20 mL, 1 case of residual hematoma volume 25 mL. According to GOS scale, 5 points in 71 cases, 4 points in 95 cases, 3 points in 55 cases, 2 points in 24 cases, 1 point in 8 cases. Conclusion: Hypertensive cerebral hemorrhage is generally treated with nonsurgery treatment, the surgery treatment is applied when the hemorrhage is severe, accurately grasping the indication of surgery, microsurgery technique, operation time and handle of a variety of postoperation complications are the key points to reduce the mortality and improve the patients’survival rate.

2015 Vol. 12 (7): 140-142 [Abstract]( 485 HTML (1 KB)  PDF  (699 KB)  ( 151 )

LI Jiu-neng,ZHANG Zi-qing, MA Li-feng, et al.

The higher rate of deformity after the defect of peripheral nerve, serious influence patient’s quality of life. Short distant defected peripheral nerve can regenerate by repairing and stuturing, but the repairing of long distant nerve defect is a difficult problem in the area of surgery. The article reviewed the repairing method and the animal experimental model and the bridge materia of the peripheral nerve defect, the future study trends was discussed and developed.

2015 Vol. 12 (7): 143-145 [Abstract]( 371 HTML (1 KB)  PDF  (668 KB)  ( 184 )

HUANG Ke-min,XIONG Bo, LIU She-ting.

Instability of the atlanto-axial complexly caused by inflammatory, trauma, congenital neoplast or degenerative disorders. It was one of considerable challenges to the veterinary surgery and could lead to quadriplegia and even life-threatening. With the increasing level of modern surgical clinics, diagnosis and treatment for instability of the atlanto-axial achieved great progress. A variety of internal fixation methods were invented. Anterior fixation methods prior to passing atlantoaxial screw fixation( ATS), anterior plate fixation Currently there transoral atlantoaxial plate (Harms plate), anterior atlantoaxial joint locking plate( SAALP), transoral atlantoaxial reduction plate system( TARP),transoral anterior reconstruction plate( TORP). Posterior technology include Gallie technology and Brooks steel or titanium cable fixation techniques, Halifax or Apofix lamina clip fixation techniques, within Magerl by atlantoaxial facet screw steel or titanium cable joint posterior fixation method, C1- lateral mass and C2 pedicle screw or nail plate screwrod fixation techniques. Atlantoaxial instability in other major surgical include minimally invasive surgery, orthopedics dynamic fixation techniques of digital technology-oriented technology and to maintain atlantoaxial activity. But over several techniques used in experiments or preliminary clinical evaluation of the need for further study are still studying. In this paper, the progress of atlantoaxial instability surgery on reviewed.

2015 Vol. 12 (7): 146-149 [Abstract]( 594 HTML (1 KB)  PDF  (678 KB)  ( 426 )

AN Min, AN Rong-ze, WANG Zhao-jie, et al./

As the most abundant and the most widely distributed in bone tissue, osteocytes are dynamic cells, with complex function. Recent studies have revealed that osteocytes play multiple important physiological roles, secreting many regulatory factors, such as osteosclerosis protein, receptor activator of the NF-kB ligand( RANKL) and osteoprotegerin (OPG). These factors play important roles in regulating bone formation and bone resorption. The sclerostin, is expressed at significant levels by osteocytes, interacts with Lrp5 and Lrp6 and inhibits the canonical Wnt signaling pathway.Sclerostin monoclonal antibody ensures Wnt pathway conducting normally by inhibiting sclerostin, increasing bone formation, bone mineral density and bone strength. Osteocytes also secretes RANKL and OPG, both of which regulating differentiation and function of osteoclasts directly or indirectly, in Physiological and pathological conditions, regulating bone reabsorption. In this paper, we make a review about the research status and development direction.

2015 Vol. 12 (7): 150-153 [Abstract]( 510 HTML (1 KB)  PDF  (691 KB)  ( 470 )

QIN Huan, WEI Shan-ping.

Metacarpal neck fractures often suffer from shock when a fist metacarpal bones convey violence caused mostly transverse fracture, are unstable fracture, surgery should be reset, help restore hand function. Because of the need to complete the fine hand movements on fracture healing after the appearance, functions have higher requirement, to select appropriate method of treatment is important. Currently metacarpal neck fractures in patients, the use of external fixation, internal fixation method of treatment has been applied to routine clinical treatment, its efficacy has been clinically recognized. This paper reviews the concepts metacarpal neck fractures, surgical reduction mechanism, metacarpal neck fractures checks, external fixation, internal fixation, drug treatment, progress functional exercise, and other aspects of postoperative treatment and sequelae.

2015 Vol. 12 (7): 153-156 [Abstract]( 324 HTML (1 KB)  PDF  (686 KB)  ( 138 )

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