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Abstract As the most abundant and the most widely distributed in bone tissue， osteocytes are dynamic cells， with complex function. Recent studies have revealed that osteocytes play multiple important physiological roles， secreting many regulatory factors， such as osteosclerosis protein， receptor activator of the NF-kB ligand（ RANKL） and osteoprotegerin （OPG）. These factors play important roles in regulating bone formation and bone resorption. The sclerostin， is expressed at significant levels by osteocytes， interacts with Lrp5 and Lrp6 and inhibits the canonical Wnt signaling pathway.Sclerostin monoclonal antibody ensures Wnt pathway conducting normally by inhibiting sclerostin， increasing bone formation， bone mineral density and bone strength. Osteocytes also secretes RANKL and OPG， both of which regulating differentiation and function of osteoclasts directly or indirectly， in Physiological and pathological conditions， regulating bone reabsorption. In this paper， we make a review about the research status and development direction.
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