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| Narrow Spectrum Uvb Rays in Serum in Patients with Chronic Urticaria of Histamine and Leukotriene Meaning |
| Chongqing Shapingba District People’s Hospital， Chongqing 400030， China |
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Abstract Objective： To discusses narrow spectrum uvb rays in serum in patients with chronic urticaria of histamine and leukotriene meaning. Method： 40 chronic urticaria patients， were randomly involved into two groups，and were treated by Fexofenadine Hydrochloride Tablets（ 60 mg， bid） accompanying with NB-UVB（ biw） in the trial group， and Fexofenadine Hydrochloride Tablets（ 60 mg， bid） alone in the control group respectively.Therapeutic courses in both groups were 2 months. Concentration of serum histamine and leukotriene was detected before and after treatments， and（ USA） score and dermatological life quality index（ DLQI） was used to evaluate the patients’improvements. Result：（ 1） There was no statistical significance in the study group and the control group before treatment， but after 1 month and 2 months of treatment， there was statistically different（ P<0.05）.（ 2） The comparison of serum histamine level before and after treatment of the two groups， the difference was statistically significant（ P<0.05），but no significant difference between the two groups after treatment. Comparison of serum leukotriene B4 level before and after treatment in the two groups， the difference was statistically significant（ P<0.05）， but no statistically significant difference after treatment. Conclusion： Combination therapy of Fexofenadine Hydrochloride Tablets and NB-UVB is beneficial for chronic urticaria， with a significantly higher improvement effect than each single therapy.
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