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WANG Yu-mei.
Objective： To observe the curative effect of Succinic acid adenosine methionine and Ganciclovir combined treatment infant cytomegalovirus（ CMV） hepatitis. Method： 66 cases with infant cytomegalovirus hepatitis were randomly divided into two groups， treatment group contained 35 cases and control group contained 31 cases. The control group was given clear heat cholagogic， protect liver back yellow， vitamin supplements and other conventional treatment， the treatment group on the basis of the control group therapy plus with succinic acid adenosine methionine and Ganciclovir. 2 weeks after treatment， the liver to narrow， the changes of serum bilirubin and CMV overcast of the two groups were observed. Result： 2 weeks after treatment， the two groups in the liver to narrow， reduce serum transaminase and serum bilirubin and CMV turn before the treatment were improved. But the treatment group was better than control group， difference was statistically significant（ P<0.05）. Conclusion： Succinic acid adenosine methionine combined with Ganciclovir to treat infant cytomegalovirus（ CMV） hepatitis has a good effect， and no obvious adverse reactions.
2015 Vol. 12 (10): 1-3 [Abstract]（
540
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XIE Chang-fei， TAO Yun-ming.
Objective：To observe blood purification treatment of burn patients with sepsis， make a brief discussion of blood purification of efficacy and safety.Method：To select 50 hospitalized patients with severe sepsis burn in our hospital from October 2013 to October 2014， they were randomly divided into treatment group and observation group. The treatment group was treated with blood purification therapy， while the observer group was treated with routine clinical treatment.To compare vital signs and clinical efficacy of the two groups.Result：Comparing outcome and prognosis of the treatment group with the observation group， the former showed good effect， the difference was statistically significant （P<0.05）.Serum levels of the two groups after treatment were compared to those before treatment， the result turned out to be a certain degree of reduction， but the observation group showed minimized statistically significant compared to the previous treatment.The reduced level of post-treatment group was significantly lower compared to pre-treatment， the difference was statistically significant（ P<0.05）.Comparison between the two groups， the effect of the treatment group was better than that of the observation group， the difference was statistically significant（ P<0.05）.Conclusion：Blood purification technology to improve organ function has a good effect.And it can improve the hemodynamics of burn patients，
reducing as complicated with sepsis severity， therefore it can achieve improvements of burn patients with sepsis adverse stress reaction， which belongs to an effective treatment.The clinical course of treatment of this method can be popularized.
2015 Vol. 12 (10): 4-5 [Abstract]（
488
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WANG Jia-chang，WANG Jiu-li，GOU Pei-fang，et al.
Objective：To observe the clinical application effect of the BLX machine by nickel-titanium instrument in a root canal treatment.Method：200 patients who needed to do a root canal were selected according to the patients’willing， the machine with BLX nickel-titanium instrument root canal preparation or hand type with stainless
steel K file root canal preparation were selected， two methods of pain happening after root canal preparation filling were compared.Result：The incidence of acute pain during root canal therapy， machine with BLX nickel-titanium instrument root canal preparation filling group was 7%， hand type with stainless steel K file prepared root canal filling group was 37%， the difference was statistically significant（P<0.05）.Conclusion：The BLX nickel titanium machine system used
in root canal preparation， and improve the work efficiency， reduce the acute pain during root canal therapy，good for root canal filling treatment.
2015 Vol. 12 (10): 7-11 [Abstract]（
415
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LI Yong-fu，FENG Xing.
Objective：To study the effect of circadian rhythm disorder induced by HIE in clock genes through the comparison changes of hypoxic ischemic encephalopathy full-term neonates and normal neonates in the peripheral blood lymphocytes cell（ PBLC） in biological clock gene Clock mRNA， Bmal1 mRNA levels.Method：32 patients of HIE and 24 normal full-term newborns were determinated by semi quantitative reverse transcription polymerase chain reaction （RT-PCR） in PBLC Clock mRNA， Bmal1 mRNA，the difference between groups were compared.Result：In groups HIE the levels of Clock mRNA and Bmal1 mRNA displayed significantly lower than the control groups， the difference was statistically significant（P<0.05），the changes trend of Bmal1 mRNA and Clock mRNA in peripheral blood lymphocytes of HIE groups were basically in the same.Conclusion：The expression of Clock mRNA and Bmal1 mRNA were abnormal in PBLC of HIE group， which may plays a certain role in hypoxia and ischemia occurred after the disorder of circadian rhythm.
2015 Vol. 12 (10): 11-14 [Abstract]（
537
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GAO Feng，ZHANG Zhen，KANG Xiao-kui，et al.
Objective：To investigate the effect of Hes1 on adult neurogensis from the level of neurogenesis and Hes1 expression in dentate gyrus of hippocampus between neonatal mice and adult mice.Method：The C57BL/6 male mice were separated into two groups：the newborn mice was as control for neonatal group（10 days old，N group），and the adult mice（ 4 months old， A group） were assigned to adult group，8 mice in each group.The immunofluorescence staining of Hes1，Brdu，Doublecortin（ DCX） and NeuN were performed and the cell count was corresponding recorded，double positive cells types and level of expression were preliminary analyzed of Brdu，Hes1.The hippocampal dentate gyrus was separated in microscope，Hes1 protein levels were detected by Western blot， the differences of two groups’Hes1 protein expression levels were observed and compared.Result：（1）Hes1 protein levels of A group was hingher than the
N group from Western blot detection，the difference was statistically significant（P<0.05）；（2）Hes1 positive cells mainly distributed in the dentate gyrus granular cell lower， and most Hes1 positive cells expressed Brdu at the same time；（3）the group A of Hes1（+） cells significantly was more than N group， and BrdU（+） obviously less than N group，the difference was statistically significant（P<0.05）.Conclusion：The different expression of Hes1 from neonatal mice and
adult mice in dentate gyrus of hippocampus，lead to different neurons generated levels， indicating high expression of Hes1 may inhibit neurogenesis.
2015 Vol. 12 (10): 15-18 [Abstract]（
485
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LI Zong-han，TAN Si-min，KE Yi，et al.
Objective： To explore apoptosis of the fibroblast induced by Fas and Fas-L after trabeculectomy. Method： A total of 20 healthy white rabbits were randomly divided into the control group and observation group，10 cases in each group，and the rabbits in the observation group were given glaucoma trabeculectomy.Two groups of tissues in trabeculectomy filtration area， which contain conjunctiva， anadesma， sclera and limbus corneae were cut down， and the fibroblasts of the tissues were cultivated. 5 cases of fibroblasts in each group were randomly selected and treated by FasMcAb. At last， PI staining and flow cytometry were used for testing the apoptotic rate of all the fibroblasts.Result： The apoptotic rate of normal fibroblasts induced by FasMcAb was higher than that of normal fibroblasts without induced by FasMcAb， the difference was statistically significant（P<0.01）； the apoptotic rate of fibroblasts from tissues in trabeculectomy filtration area induced by FasMcAb was higher than that of fibroblasts from tissues in trabeculectomy filtration area without induced by FasMcAb，the difference was statistically significant（P<0.01）；the effect of FasMcAb on the apoptotic rate of fibroblasts from tissues in trabeculectomy filtration area was more significant than that on normal fibroblasts， the difference was statistically significant（P<0.01）.Conclusion：Fas/Fas-L can accelerate apoptosis of the fibroblast after trabeculectomy， and helps to find a new breakthrough to reduce the scar after glaucoma trabeculectomy.
2015 Vol. 12 (10): 18-20 [Abstract]（
539
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KONG Yuan-yuan， XUE Zhi-qiang， YAN Gong-hui， et al.
Objective：To analyze the impact of dyslipidemia ultrafiltration failure in peritoneal dialysis patients. Method：80 patients in our hospital with peritoneal dialysis were selected for the study， and treated with peritoneal dialysis treatment over 12 months， the patients’ ALB（ albumin）， Hb（ hemoglobin）， T-ch（ total cholesterol）， TG （triglycerides）， LDL-C（ low density lipoprotein）， HDL-C（ high density lipoprotein）， BUN（ blood urea nitrogen），Cr （creatinine），and GIu（ glucose） levels were measured to calculate the renal function in patients and detailed records of the two groups of dialysis time.According to their lipid results will be divided into two groups， dyslipidemia group of 39 cases， and lipid control group of 41 cases， the incidence of dialysis ultrafiltration failure were compared； patients were divided into ultrafiltration failure group of 22 cases and ultrafiltration normal group of 58 cases， two groups’ patients with kidney function， blood lipid levels， GIu， ALB and Hb were compared.Result：Through this observation can be seen，dyslipidemia ultrafiltration failure in peritoneal dialysis patients were higher than normal lipid group； ultrafiltration failure group’s ultrafiltration dialysis time for longer than the normal group； ultrafiltration failure group’s diastolic and systolic blood pressure were higher than the normal group； ultrafiltration failure group’s T-Ch and TG levels were higher than normal ultrafiltration group， ultrafiltration failure group HDL-C levels was significantly lower than the ultrafiltration normal group， compared the two groups， the differences were statistically significance（ P<0.05）.Conclusion：The patients with dyslipidemia are caused by one of the important factors of ultrafiltration failure in peritoneal dialysis， and dyslipidemia of patients with peritoneal dialysis of ultrafiltration failure has the close relationship with high TG， T-Ch levels，and low HDL-C levels.
2015 Vol. 12 (10): 21-23 [Abstract]（
551
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YANG Tian，FAN Zhi-qiang，WEN Shi-he.
Objective：To analyze the clinical curative of transurethral resection combined with pirarubicin intravesical chemotherapy in the treatment of superficial bladder cancer.Method：72 cases patients from June 2010 to June 2012 were selected and analyzed.With the random number table， the patients were divided into experimental group and control group，36 cases in each group.The experimental group was treated the transurethral resection combined with pirarubicin intravesical chemotherapy，the control group was treated with transurethral resection.The short-term efficacy of two groups were observed and followed up for 1 year.Result：The catheter indwelling time of experimental group patients were（3.7±0.5） d，which in control group patients were（6.3±0.7）d，the difference was statistically
significant（P<0.05）；after operation one year， the experiment group 6 patients occurred tumor recurrence，12 cases of control group relapsed，compared two groups of patients tumor recurrence rate ，the difference has statistically significant （P<0.05）.Conclusion：Electrovaporization combined with bladder instillation in treatment of superficial bladder cancer is better in effect.The patients’ short-term recurrence rate are significantly lower， and the patients’treatment satisfaction
improve， it is worth in the clinical application.
2015 Vol. 12 (10): 24-26 [Abstract]（
624
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LI Zhen-ping， GAO Xiao-feng，WANG Fei， et al
Objective： To evaluate the advantages and disadvantages of Narcotrend（ NT） in monitoring the depth of anesthesia when compared with the bispectral index（BIS）. Method： 60 patients（ ASA I or Ⅱ）， undergoing elective laparoscopic surgery， were randomly divided into two groups， NT group and BIS group. 1.0 μg/kg dexmedetomidine was injected with a micro infusion pump， fusion time was 10 minutes. 1.5 mg/kg propofol， 4 μg/kg fentanyl and 0.15 mg/kg
atracurium was injected intravenously after dexmedetomidine was injected 5 minutes. Tracheal intubation was placed after demedetomidine was injected 10 minutes. BIS， NT， mean arterial pressure（ MAP） and heart rate（ HR） were measured before induction（ T0）， before intubation（ T1）， instant time after intubation（ T2）， 1 minute（ T3）， and 5 minutes（ T4） after intubation. Result： The NT index was positively correlated to the BIS（ r=0.901，P<0.001）； HR， MAP， NT and BIS values were significantly lower after dexmeddetomidine administration（ P<0.05）. NT and BIS values significantly
decreased at loss of consciousness as compared with the baseline value（ P<0.01）. Compared with that before intubation，HR and MAP increased during intubation， and at l and 3 mins after intubation， while no significant change was found in HR， MAP， NT and BIS values. Conclusion： NT can monitor sedative effect induced by dexmeddetomidine accurately. NT and BIS are comparable no advantages.
2015 Vol. 12 (10): 26-28 [Abstract]（
475
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ZHAO Qing-mei.
Objective： To investigate the effect of sufentanil midazolam intraspinal anesthesia clinical effect and application value. Method： In our hospital 90 elective abdominal operation patients with intraspinal anesthesia，were randomly divided into two groups， 45 cases in each group， Ⅰ group sufentanil combined with midazolam， Ⅱ group and fentanyl combined with midazolam， analyze clinical effect of the two groups. Result： After induction of anesthesia，operation began， at the end of Ⅰ group patients with systolic blood pressure， diastolic blood pressure were significantly lower than that of the Ⅱ group， the difference was statistically significant（ P<0.05）. Analgesic and sedative effect of theⅠ group than that of the Ⅱ group， the Ⅱ group to maintain the dosage was small， the onset time of the Ⅰ group than in the Ⅱ group quickly， adverse reaction and inhibition of respiratory complications were less than the Ⅱ group， in the wash
and exploration on the abdominal cavity， Ⅰ group had the body movement， and cardiovascular fluctuations than the Ⅱgroup was significantly. Conclusion： As adjuvant of spinal anesthesia， the composite sufentanil midazolam sedation and anterograde amnesia effect is good， fast， safe and adverse reaction rate.
2015 Vol. 12 (10): 29-31 [Abstract]（
387
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LI Zhen-hua.
Objective：To investigate the effect of partial resection of bladder and transurethral resection of bladder tumor（ TURBT） for treatment of superficial bladder cancer.Method：A total of 100 patients with T1T2 bladder neoplasm were randomly divided into two groups， each contained 50 cases.The control group was treated with partial resection of bladder， while the treated group was treated with TURBT.The operative time， blood loss， catheterization time， incidence of postoperative complication and recurrence rate was compared.Result：The operative time， blood loss， catheterization time of the observation group was significance of the indicators between the two groups（ P<0.05）. The incidence of postoperative complication of the observation group（ 2.1%） was significantly lower than that of the control group（ 16.8%）（ P<0.05）.There was no significant difference in the recurrence rate between the two groups. Conclusion：This study shows that the TURBT and partial resection of bladder have the similar recurrence rate.But TURBT has the advantage of shorter operative time， less trauma， less bleeding， faster recovery and low incidence of postoperative complication.
2015 Vol. 12 (10): 31-33 [Abstract]（
541
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ZHANG Hai-feng，SHEN Pei-lei.
Objective： To analyze the clinical results of Su Huang cough capsules combined Aspen in cough variant asthma.Method： 80 patients with cough variant asthma were selected in our hospital from January 2013 to October 2014 ，and randomly divided into observation group and control group，40 cases in each group.The observation group was treated by Su Huang cough capsule combined Aspen treatment， the control group was given Aspen treatment，two groups of clinical outcomes， including clinical efficacy， symptoms remission time and disappear time，and changes in lung function were compared. Result： The total effective rate was 85.0% in observation group，and the control group was 62.5%， the total effective observation group was higher， the difference was statistically significant（P<0.05）；observation group like remission time and disappear time，and relapse rates were lower than the control group， the differences were statistically significant（P<0.05）；the changes in lung function in the observation group were better than the control group， the difference was statistically significant（P<0.05）.After treatment，patients eosinophil counts were improved，but the degree of improvement in patients in the observation group was better than the control group（P<0.05）.Conclusion：The clinical outcomes of Su Huang cough capsule joint Aspen in cough variant asthma has significantly
improves symptoms remission and disappear in a faster time， improve patients’ lung function in good condition.
2015 Vol. 12 (10): 34-37 [Abstract]（
647
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SUN Yun-xia， GUO Qian， GUO Xiang-rong， et al.
Objective：To explore the role and significance of psychological intervention and music therapy in liver dynamic enhancement scanning with 3.0 T MRI.Method：230 patients who underwent liver dynamic enhancement scanning from June 2012 to June 2014， and were randomly divided into three groups， the first experimental group received routine nursing care， the second experimental group used psychological intervention nursing and routine nursing care， the third experimental group used psychological intervention nursing and music therapy nursing.Changes of vital signs were observed and compared before and after examination（ blood pressure， heart rate， respiration， pulse），symptoms， psychological and time.Result：（1） The first experimental group had statistical differences before and after MRI examination； the second experimental group had slightly increased than the third experimental group before and after MRI examination.（2） The first experimental group need（ 25.5±6.7）min than the second experimental group （20.5±4.1）min and the third experimental group（ 18.3±2.1）min.Conclusion：The psychological intervention and music therapy could alleviate the physiological and psychological changes of patients before and after MRI examination，relieve anxiety and depression， and it was helpful to get a satisfactory results.
2015 Vol. 12 (10): 37-40 [Abstract]（
519
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LIN Bai-han， WU Li-li， ZHANG Ji-yong.
Objective： To compare static intensity-modulated radiation therapy（ IMRT） technique with various arcs of volumetric-modulated arc radiation therapy（ VMAT） techniques in patients with cervical cancer treated with definitive bone morrow-sparing whole pelvic radiotherapy， and to explore a better treatment management. Method：9 CT image sets of staged ⅡA-ⅢB cervical cancer patients， treated in Cancer Hospital of Shantou University Medical College， were included. Nine fixed-field IMRT（ FF-IMRT） plans and two arcs， three arcs， four arcs VMAT plans（ 2AVMAT，3A-VMAT， 4A-VMAT） were created and compared for each patient. Plans were evaluated on parameters of tumor target volume， pelvic bone marrow（ PBM）， other pelvic organs， plan MUs and delivery time. Result： Four groups of 2A-VMAT， 3A-VMAT， 4A-VMAT and IMRT plans provide equivalent tumor target volume coverage， conformity，
homogeneity and sparing of PBM respected to V10，V20，V40. Three VMAT plans demonstrate the similar organs sparing. VMAT was slightly superior to FF-IMRT with the sparing of bowel. However， FF-IMRT showed better rectum sparing than that of 3A-VMAT. The monitor units of IMRT， 2A-VMAT， 3A-VMAT and 4A-VMAT were（ 1850.3±227.8）MU， （848.4±58.8）MU，（ 835.0±76.2）MU and（ 910.8±43.3）MU， respectively， while delivery time were（ 353.2±25.1）
s，（ 136.2±3.6）s，（ 211.2±3.5）s and（ 286.2±3.4）s， respectively. There were significant differences of monitor units （MUs） and treatment time among four plans. IMRT plan had more MUs and treatment time than that of VMAT plans， and two arcs VMAT plan had the least MUs and treatment time. Conclusion： Considering the physical factors and biological effects during the cervical cancer definitive radiotherapy with pelvic bone marrow-sparing， 2 arcs VMAT plan would be the best choice for the treatment planning.
2015 Vol. 12 (10): 41-45 [Abstract]（
535
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GUO He-fu， DONG Ying-xia， YANG Fang-e.
Objective：To observe the clinical curative effect of Naoxintong capsule combined with atorvastatin calcium in the treatment of carotid atherosclerotic plaque.Method：300 patients with carotid atherosclerotic plaques，were randomly divided into two groups：group A was given Naoxintong capsule 4 grain， 3 times /d， Atorvastatin Calcium Tablets 20 mg， 1 times/d.Group B was given Atorvastatin Calcium Tablets 20 mg， 1 times/d， period of treatment 12 weeks. Before and after the treatment of carotid artery intima-media thickness（ IMT）， patch area， total plaque score， serum lipid and C reactive protein（ CRP）were compared.Result：After 12 weeks treatment， compared the IMT of carotid artery，the total area and plaque score， blood lipid level， the level of serum CRP in patients of the group A were lower than those of the group B， the difference was statistically significant（ P<0.05）.Conclusion：Naoxintong capsule combined with atorvastatin calcium has better anti atherosclerotic plaque， reversal， lipid-lowering effect.It is worthy of clinical promotion.
2015 Vol. 12 (10): 45-47 [Abstract]（
607
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HU Bo， WU Ying-chao.
Objective： To discuss the clinical curative effect of using different treatment method of azithromycin treatment of children with Mycoplasma infection. Method： 166 patients with mycoplasma infection in our hospital from 2013 January to December were randomly selected as the objects， and randomly divided into observation group and control group， the control group contained 83 cases， which was given treatment of azithromycin based conventional treatment methods： the first dose of 20 mg/kg Azithromycin injection， intravenous infusion of the drug， sustained 5D， 1 time/d， after 4D dosage for the first half， after 4D of withdrawal， again in the treatment of 3D by using this method； the observation group contained 83 cases， which carries on the treatment method using the same control group based on the conventional treatment， difference was that， stop drug 4D in children， again in the treatment of 5D using this method.
At the end of treatment， the clinical efficacy， duration of hospitalization， and various symptoms disappear time of the two groups was compared. Result： The cure rate and total effective rate of the observation group p was 84.3%（ 70 cases），95.1%（ 79 cases）， and that of the control group was 79.5%（ 66 cases）， 91.5%（ 76 cases）， there was no statistically significant difference. The hospitalization time and a variety of diseases disappear time of the observation group was lower than that of the control group， there was statistically significant difference（ P<0.05）. Conclusion： The use of azithromycin intravenous infusion therapy for children with 5D after stopping drug， 4D， again in the treatment of 5D by using this method， can effectively shorten the symptom disappearance time， get favorable comments from the families of the children， worthy of promotion and application in clinical.
2015 Vol. 12 (10): 48-50 [Abstract]（
414
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XU Mao-xing.
Objective：To investigate the rosuvastatin and fluvastatin clinical efficacy of statin lipid-lowering effects of unstable angina.Method：98 cases were randomly divided into observation group and control group， 49 cases in each group.In the conventional treatment including nitrates， anti-platelet drugs， calcium antagonists and anti-clotting drugs on the basis of that，the control group was took fluvastatin 20 mg， orally once every night；observation group was took rosuvastatin 10 mg， orally once every night，the observation times of two groups were 8 weeks.The clinical efficacy and changes of before and after treatment of lipid and C--reactive protein（ C-response protein， CRP） concentrations in both groups were Observed.Result：The clinical improvement in symptoms of both groups，compared with the control group，the response rate was respectively 93.88% and 79.59%（P<0.05）；total cholesterol， triglycerides， LDL and CRP levels of observation group were significantly lower，the differences were statistically significant（ P<0.05）；serum highdensity lipoprotein of observation group significantly increased， the difference was statistically significant（ P<0.05）. Conclusion：Aosuvastatin and fluvastatin can improve clinical symptoms in patients with unstable angina， lipid effects obvious， and rosuvastatin are better than fluvastatin.
2015 Vol. 12 (10): 50-53 [Abstract]（
541
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LIN Lin， XU Fei-peng， HUANG Zhe， et al.
Objective：To retrospectively analyze the several common methods of laparoscopic appendectomy （LA） applied for the handling of appendix stump and compare the superiority and inferiority with them.Method：A total of 352 patients of（ LA） in the treatment of appendicitis， according to appendix stump processing mode were divided into simple ligation of pure silk（ group A， 113 cases）， simple ligation thread ligation（ group B， 137 cases）， plus pouch suture embedding after silk thread ligation or ligation thread ligation（ group C， 102 cases）， compared the operation time，intraoperative blood loss， bowel function recovery time， hospital stay， complications with the three groups.Result：Three groups operation smoothly， no transfer laparotomy， the operation time of pouch suture embedding group was obviously longer than pure silk thread ligation group and simple ligation thread ligation group（ P<0.05）， but the operation time of
pure silk ligation group and simple ligation thread ligation group was not statistically significant， intraoperative blood loss，bowel function recovery time， hospital stay， differences of serious complications of the three groups were not statistical significant.Conclusion：Simple ligation of pure silk， simple ligation thread ligation and plus pouch suture embedding after silk thread ligation or ligation thread ligation all are safe and reliable applied for the handling of appendix stump， the most reasonable treatment is in according to the residual root of appendix.
2015 Vol. 12 (10): 53-55 [Abstract]（
664
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AI Ming-yang， HUANG Su-hua， ZHOU Jia-feng， et al.
Objective：To research the difference in clinical effect between skin flap repair for pulp defect at the free dorsal nerve ring finger ulnar artery and pedicled skin flap repair.Method：32 patients who came to our hospital forrepair of pulp defect from August 2013 to August 2014 were chosen with their approval.They were divided into group A and group B， 16 cases in each group.Patients in the group A were given skin flap repair for pulp defect at the free zone dorsal digital nerves of ulnar ring finger artery while， and those in the group B were repaired by digital artery flap， dorsal fascial flap， pro finger flap and so on.Engraftment rate and degree of satisfaction of the two groups were compared.Result：The total effective rate of the group A was 81.25%， while that of the group B was 68.75%.Conclusion：Skin flap repair for pulp defect at the free zone dorsal digital nerves of ulnar ring finger artery is more suitable for finger pulp tissue defect.
2015 Vol. 12 (10): 56-59 [Abstract]（
398
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YU Nian-en，LI Ping，LI An-xue.
Objective：To observe the restlessness and pain effects caused by preoperative parecoxib sodium injection on resection of gallbladder patients Method：56 cases of cholecystolithiasis patients were treated in our hospital from May 2013 to November 2014 as research object，and were randomly divided into two groups，29 cases in the observation group and 27 cases in the control group.The observation group with preoperative parecoxib sodium， control group with intravenous injection of flurbiprofen axetil， the same of other drugs were used by the two groups.Two groups of patients’ VAS scores after 1， 2， 4， 12， 24 h， the incidence of agitation，and the incidence of adverse reaction were compared.Result：The observation group patients’ VAS scores after 1， 2， 4， 12， 24 h were significantly lower than those in control group， suggested that the pain was lighter，the difference was statistically significant（P<0.05）.The incidence
of agitation rate of patients in observation group was 6.8%（ 2/29），significantly lower than the control group of 29.6% （8/27）， the difference was statistically significant（P<0.05）.In addition， observation group of adverse reaction of nausea and vomiting，and itch of skin were also significantly lower than control group， the difference was statistically significant （P<0.05）.Conclusion：Parecoxib sodium has good effect of analgesia in laparoscopic cholecystectomy surgery， sedative effect of analepsia period is significant， but also effectively in prevent restlessness， nausea and vomiting adverse reaction，wide application prospect， is worthy of promotion.
2015 Vol. 12 (10): 59-62 [Abstract]（
456
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SUN Zheng-hai， ZHAO Yu-huan， WANG Wen-lin， et al.
Objective：To investigate the characteristic and significance of the brain function and the brain neurotransmitter changes in Alzheimer’s disease.Method：19 patients with clinically diagnosed AD were selected from the city proper of Qiqihar as the case group.According to the same community， sex， age（ ±3 years）， and the educational level， 19 healthy elderly were selected as control group.To use the Encephal of lutuograph technology to test the brain function and the levels of their brain neurotransmitter， compare and analyze the brain function and the characteristic of the brain neurotransmitter changes in Alzheimer’s disease.Result：The anterior-posterior reversal rates of dominant power in encephal of lutuograph were higher in the case group than those of the control group（ P<0.01）.Compared with the control group， three neurotransmitters of the γ-GABA， Glu， and Ach in the case group were significantly lower（P<0.05）.Comparison of three neurotransmitters of the 5-HT， NE， and the DA in the case group and the control group，the difference was not statistically significant.Conclusion：AD Brain power reversal rates are higher in Alzheimer’s disease than the case group.The brain neurotransmitter of γ-GABA， Glu， and Ach in Alzheimer’s disease changes lower.The Encephal of lutuograph technology can test the levels of brain neurotransmitter， provide reference for the diagnosis of Alzheimer’s disease.
2015 Vol. 12 (10): 62-64 [Abstract]（
548
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YI Ai-lian.
Objective：To study the effect of humanistic nursing care in conscious patients with physical restraint in ICU.Method：90 conscious patients with physical restraint in ICU were selected and divided into the control group and the experimental group，45 patients in each group.The control group was given conventional nursing care， while the experimental group was given humanistic nursing care besides the same basis.The changes of physical restraint rate，extent of satisfaction of nursing and the occurrence of adverse results were observed and compared between two groups. Result：The physical restraint rate， extent of satisfaction of nursing and adverse results in the experimental group were better than those in the control group， the differences were statistically significant（P<0.05）.Conclusion：Humanistic nursing care is helpful to decreasing physical restraint for conscious patients in ICU， thus reducing the occurrence of nursing adverse results and improving the satisfaction of nursing.
2015 Vol. 12 (10): 65-67 [Abstract]（
548
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YANG Zhi-lan，TENG Shu-yan.
Objective：To explore the methods of nursing care in the treatment of infertility by hysteroscopy combined with laparoscopy.Method：80 cases were diagnosed as infertile patients， the diagnosis and treatment of hysteroscopy combined with laparoscopy operation.The patients were randomly divided into two groups，the intervention group and control group，40 cases in each group.The intervention group was trested perfect operation during in hospital preparation， careful postoperative nursing and the whole psychological support；the control group was treated conventional nursing.Result：The intervention group 28 cases of successful pregnancy， included 9 cases of primary infertility and 19 cases of secondary infertility， pregnancy of the shortest time was 2 months after the operation， with the longest up to 23 months after operation； 28 cases of successful pregnancy in patients with 4 cases of successful pregnancy after assisted
reproductive technology， the rest were the natural pregnancy； abortion 1 cases， the other 27 cases were belong to full-term normal neonates.The control group 18 cases of successful pregnancy， included 5 cases of primary infertility and secondary infertility in 13 cases， the pregnancy time is the shortest 2.5 months postoperatively， the longest for 24 months after operation； 18 cases of successful pregnancy in patients with 6 cases of successful pregnancy after assisted reproductive technology， the rest were natural pregnancy； 2 cases of ectopic pregnancy， abortion 3 cases， the other 13 cases were belong to full-term normal neonates.two sets of ectopic pregnancy after statistics processing，the rate and abortion rate had no statistical significance.Conclusion：Hysteroscopy combined with laparoscopy for treatment of infertility can improve the effectiveness of diagnosis and treatment， psychological support of nurses nursing and full preoperative and postoperative therapy are the key to success.
2015 Vol. 12 (10): 68-71 [Abstract]（
398
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WANG Ni
Objective：To investigate the application effect of high-quality nursing in leukemia nursing.Method：100 cases of leukemia patients were selected in our hospital from May 2013 to May 2014.100 patients were randomly divided into two groups， 50 cases in each group， the control group was treated routine nursing intervention
and the observer group was treated high-quality nursing intervention，then the effect of two groups were compared.Result：Compared the control group， the observer group patients’ satisfaction and quality of care score were higher ，the complication rate was lower，the differences were statistically significant（P<0.05）.Conclusion：Strengthing the application of high-quality nursing concept in leukemia nursing， can improve patient satisfaction， ensure clinical safety，and it has significance to safeguard the long-term prognosis and quality of life.
2015 Vol. 12 (10): 71-73 [Abstract]（
503
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ZENG Hui，WANG Hong-li.
Objective：To analyze the nursing intervention authentication function on the basis of Alzheimer’s patients， we propose to enhance the therapeutic effect in patients with Alzheimer’s suggestions.Method：The disease status was evaluated according Mini Mental State Exam（ MMSE）， activity scale（ ADL） of the two groups of patients before treatment and after the intervention.Result：After nursing intervention study group， 56 patients with cognitive standards，but only received usual care control group the number of standard cognitive ability only 23 cases.In addition， the quality of the life of the patients study group scores were higher than the control group， the differences were statistically significant（P<0.05）.Conclusion：Nursing intervention for the treatment of Alzheimer’s disease work a positive impact， it can help older patients recover the ability to basic social behavior， daily living，and cognitive things.
2015 Vol. 12 (10): 74-77 [Abstract]（
429
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COPD/ZHENG Xi-yan， ZHOU Huan， TIAN Yu-jie， et al.
Objective：To investigate the effect of nursing intervention to incidence of depression in patients with COPD.Method：60 patients with COPD were divided into intervention group（ n=30） and control group（ n=30） from Feb 2011 to Feb 2013.Incidences of depression， 1-year survival rate and satisfaction rate of nursing were compared.Result：Incidence of depression of the intervention group was significantly lower than that of the control group.Incidence of severe depression of the intervention group was significantly lower than that of the control group.There was no significant difference in 1-year survival rate between two groups.Satisfaction rate of nursing of the intervention group was significantly higher than that of the control group.Conclusion：Nursing intervention could decrease incidence of depression and improve satisfaction rate of nursing in patients with COPD， but not improve prognosis in patients with COPD.
2015 Vol. 12 (10): 77-79 [Abstract]（
352
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YANG Rui，HUO Li-li，ZHANG Chun-xiao，et al.
Objective：To explore the diagnosis and treatment under arthroscopy assisted habitual patellar dislocation perioperative nursing intervention and rehabilitation training on the clinical effect.Method：The medial and revascularization of 27 patients with habitual patellar dislocation in arthroscopy were assisted descending of the lateral retinaculum release.Perioperative according to different patients， psychological guidance，a comprehensive system of health knowledge education and comprehensive function rehabilitation training were given for them.Result：26 cases recovered well postoperatively，1 cases with delayed healing of incision（ 18 days）.No hypostatic pneumonia， complications such as deep vein thrombosis of lower limbs.Postoperative patients in hospital 5-18 d， average of 12.5 d.Follow-up of 12 to 24 months， an average of 18.5 months.1 patient because of fear pain in knee joint adhesion，active flexion was 20°and passive flexion was 110°.The rest of the patients with follow-up period without patellar dislocation relapse again， no limited knee joint activities， patellar stability was better preoperative， postoperative effect was satisfactory.Conclusion：Arthroscopic treatment of habitual patellar dislocation patients perioperative science， system，and targeted nursing intervention，which can effectively prevent the occurrence of postoperative complications， restore the knee joint function， improve patients
quality of life，and improve exercise capacity in general.
2015 Vol. 12 (10): 80-83 [Abstract]（
466
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WANG Xue-yun， HUANG Xiao-yan.
In the normal operation of the hospital nursing management and nursing play an important role in the development of the career， and effective nursing management can significantly enhance the core competitiveness of hospitals in the medical market.Nurse took the double tasks of medical providers and medical coordinator， and nursing work throughout the whole process of diagnosis and treatment of patients， so to strengthen the construction of nursing team and improve can play a positive role in improving the nursing management level.This article mainly from the basic requirement of modern nursing management of nursing staff and higher requirements， provide certain theoretical basis for clinical nursing management.
2015 Vol. 12 (10): 83-86 [Abstract]（
330
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CHEN Li，MENG Chang-xiu， XUE Jun， et al.
Objective： To know the risk factors of occupational exposure among nursing staff， in order to provide some effective protective measures for them and reduce the risk of occupational exposure. Method： Through the analysis and summary which contrapose to the 37 occupational exposure registration of nurses in our hospital. Result： Among total 364 nurses（ including student nurses）， 37 nurses suffered the occupational exposure（ 37/364，10.16％）. The exposure
categories include sharp injuries， skin injuries and the others. 89.19% was sharp injuries（ needle stick injuries account for 94.12% in sharp injuries） and skin injuries account for 10.81%， 5.58% for the others. 15 cases（ 14 person-time） were exposed to hepatitis B cases blood（ 39.47％） ，3 cases were exposed to hepatitis C patient blood（ 7.89％）， 2 cases were exposed to the HIV-positive cases blood（ 5.26 ％）， 2 cases were exposed to the treponemapallidum（ 5.26%）， 3 cases were not exposed to the pathogens of hematogenous infection（ 10.53%） and the rest were not sure（31.58%）. 27 in the 37 nurses who suffered the occupational exposure haven’t been infected by occupational exposure during more than six months’follow-up. The others haven’t been infected by occupational exposure during more than three months’ follow-up. Conclusion： Nurses are the high-risk group of sharp injuries， especially needle stick injuries. So we must take a further effective measure to prevent occupational exposure.
2015 Vol. 12 (10): 86-88 [Abstract]（
637
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TONG Ya-juan.
Objective：To explore the application of flurbiprofen axetil in patients with mechanical ventilation associated lung injury and the effect of nursing measures.Method：60 patients needed mechanical ventilation treated in ICU in our hospital in 2014 January-2014 June were selected as the research objects， all patients were given flurbiprofen and they were randomly divided into two groups.The control group was given conventional care， monitoring of body temperature， pulse， the observation group was given targeted nursing， nursing of airway management and comfortable nursing etc.To compare effect between the two groups.Result：In the observation group VAP， UEX occurred in 4 cases（13.3%）， 2 cases（ 6.7%）， and was lower than that of the control group（ P<0.05）.The observation group was significantly better than the control group in comfortable degree（ P<0.05）.Group spirit， sleep， diet， mental status scores was observed for（ 4.51±0.38），（ 4.41±0.35），（ 4.55±0.36），（ 4.46±0.33）， and was higher than that of the control group（ P<0.05）. Conclusion：Flurbiprofen axetil used in mechanical ventilation related lung injury patients should pay attention to the implementation of clinical nursing measures， taking comfort care and airway care helps to reduce complication， so it has important clinical value.
2015 Vol. 12 (10): 89-91 [Abstract]（
482
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JIN Xiang-hua， LIU Ying-qi， LI Ling.
To expound the importance of the method of strengthening the body resistance to eliminate of traditional Chinese medical science in the treatment of the systemic lupus erythematosus of fire excess from yin deficiency from the theoretical basis， meaning of the rules of treatment， clinical application value and using of the Chinese herbal medicine.
2015 Vol. 12 (10): 92-94 [Abstract]（
315
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WU Chang-gang.
Objective：To explore the curative effect and its effect on serum procalcitonin level of flavored Shuanghuanglian Injection in the treatment of bronchial pneumonia.Method：80 cases of patients with Bronchial pneumonia were selected from January 2012 to June 2014，and divided into observation group and control group according to random number table method， 40 cases in each group.The control group was given conventional western medicine treatment， the observation group was used flavored Shuanghuanglian Injection treatment on the basis of the control group，the course of the two groups were 10 d.The clinical efficacy and serum procalcitonin level of two groups were observed and compared.Result：The clinical total effective rate of the observation group were better than that in control group，the difference has statistical significance（ P<0.05）；the temperature stability，cough， wheeze， lung’s rale disappear，X-ray inflammation absorption and the average healing time of the observation group were significantly better than the control group， the difference has statistical significance（P<0.05）；after treatment the blood leukocyte count， neutrophil percentage，and serum procalcitonin level of the observation group were significantly lower than the control group， the difference has statistical significance（P<0.05）.Conclusion：The curative effect of flavored Shuanghuanglian Injection in the treatment of bronchial pneumonia is distinct， worthy of clinical popularization and application.
2015 Vol. 12 (10): 95-97 [Abstract]（
553
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DU Zhen-sheng， ZHANG Shan-shan.
Objective： To observe the clinical effect and the expression of Survivin and Fas of Jianpi Liqi Formula on patients with precancerous lesions of chronic atrophic gastritis. Method： 66 patients with precancerous lesions of chronic atrophic gastritis were equally randomized into two groups， which were the control group and the treatment group（ n=33）. In the treatment group Jianpi Liqi Formula decoction was given to the patients and in the control group Weifuchun tablets was given. Treated for 12 weeks， the total effective rate， clinical symptoms， gastroscopic images，pathological changes of gastric mucous membranes， Hp-eradicating rates ， the expression of Survivin and Fas were observed. Result： The total effective rate， clinical symptoms， gastroscopic images， pathological changes of gastric mucous membranes and Hp-eradicating rates of the treatment group was better than that of the control group（ P<0.05）.
The expression of Survivin was suppressed and the expression of Fas was enhanced in the treatment group（ P<0.05）. Conclusion： Jianpi Liqi Formula can improve the symptoms in patients with precancerous lesions of chronic atrophic gastritis and prevent the development of precancerous lesions of chronic atrophic gastritis. The mechanism of the clinical effect is probably due to down-regulate Survivin expression and up-regulate Fas expression.
2015 Vol. 12 (10): 98-102 [Abstract]（
590
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WANG Guo-fan，WU Guo-qing，HAO Zhi-jun.
Objective：To discuss the clinical curative effect of combining traditional Chinese and western medicine treatment of colorectal cancer，and to provide the theory basis for improving the quality life of patients and prolong life.Method：112 patients with colorectal cancer were selected in our hospital for treatment from January 2012 to January 2013，and randomly divided into study group and the control group on average in the two groups， each group of 56 patients.The control group patients were given western medicine chemotherapy in the treatment of patients with simple， the study group patients with traditional Chinese medicine treatment based on Western medicine chemotherapy，two groups of patients with recent effective rate， recurrence rate， adverse reaction rate， time to progression， quality of life score and pain score were compared.Result：In study group the effective rate was 80.36%， recurrence and metastasis rate was 17.86%，the rate of adverse reaction was 21.43%， for the time of disease progression were（12.84±1.03） months， pain scores were（3.41±1.01）， quality of life scores were（ 144.51±3.59）， the study group was significantly better than the control group，the difference was statistically significant（P<0.05）.Conclusion：Combining traditional Chinese and western medicine treatment of colorectal cancer can improve efficiency in recent years and patients’ life quality， prolong patients life.
2015 Vol. 12 (10): 102-104 [Abstract]（
501
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ZHANG Li-na.
Objective： To observe the curative effect of combination treatment of high fever. Method： 42 cases in the treatment group were given combination drug therapy， control group was treated with simple treatment， the two groups were 7 days to 1 course of treatment， to judge the curative effect of treatment after 2 courses. Result： The total effective rate of the treatment group was 80.95%， which was significantly higher than 50.0% of the control group， the difference was significant（ P<0.05）. Conclusion： The therapeutic effect of combined therapy in the treatment of exogenous high fever certainly， can effectively shorten the course of disease， safe and reliable.
2015 Vol. 12 (10): 105-107 [Abstract]（
479
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HONG Hou-yun.
Objective：Advocates of chronic obstructive pulmonary disease（ COPD） patients with long-termoxygen therapy can improve the survival rate of the family.Method：Using the questionnaire survey and through telephone follow-up of patients with chronic obstructive pulmonary disease about 450 cases， to understand the family oxygen therapy of oxygen time， oxygen consumption and oxygen use device， put forward the oxygen therapy in family matters needing
attention.Result：Family patients every day adhere to the oxygen in 15 h above， can improve lung function， strengthen the body immunity， has a significant effect on improving the function of the system.Conclusion：Chronic obstructive pulmonary disease patients every day adhere to long-term home oxygen therapy， can reduce the economic burden of patients， to improve the quality of life of the patients， to reduce the medical cost and expenses， improve the survival rate.It
is worth the community health promotion.
2015 Vol. 12 (10): 108-111 [Abstract]（
610
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CAO Zheng， WANG Chun-yan，CAO Jian-ping， et al.
Objective：To evaluate the value of Anti-tissue transglutaminase antibodies and Anti-gliadin antibodies detection on the diagnosis of celiac disease.Method：Serum tTG antibodies and AGA were measured in 198 chronic diarrhea patients.Endoscopic and pathological findings were compared.Result：Among 15 CD patients who were confirmed by endoscopic and pathological diagnosis， 14 cases were tTG antibodies positive and 15 cases were AGA positive.5 cases showed tTG antibodies and 28 cases showed AGA in 183 non-CD patients.Conclusion：ROC curve analysis indicated that positive predicted value（PPV）and negative predicted value（NPV）of tTG antibodies were higher than of AGA.It might be used as a useful mark for screening and diagnosis CD.
2015 Vol. 12 (10): 111-113 [Abstract]（
331
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YU Qian，FANG Yuan.
Objective：To improve pharmacy service quality，then trying to implement the QCC in the hospital pharmacy personnel.Method：From January 2014 to June，QCC in PIVAS was first tried to implement，and it was used in processes evaluation and management.Result：Through the QCC，it improved the cognition rate of drug instructions.The drug instructions cognitive problems from 127 cases reduced to 55 cases.Conclusion：Carrying out quality in pharmacy personnel management circle activities is feasible.It improves the pharmacy service quality.
2015 Vol. 12 (10): 114-117 [Abstract]（
374
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LIU Hong-qun.
Case management information system has been widely used in hospitals， it is an effective way to take advantage of network technology and computer systems to modernize medical record information management.Data quality defects are recurring problems of information system operation， causing many adverse effects to the hospital staff and managers.This paper starting from the characteristics of medical record information， brief analyzes the problems of data quality， and discusses in detail the impact of data quality problems for hospital case management information system， and put forward some measures to solve the data quality problems.
2015 Vol. 12 (10): 117-120 [Abstract]（
587
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LU Jing，YANG Li-ping.
Objective：To summarize the neonatal congenital hypothyroidism（ CH） and phenylketonuria（ PKU）incidence and clinical experience.Method：9654 cases of hospitalized neonates with CH and PKU in our hospital were selected from January 2013 to July 2014.CH was tested by time-resolved immunofluorescence assay，PKU was tested by Guthrie bacteria inhibitory test.Result：Totally screening 9654 cases of neonates， 9 neonates were classified as definite CH， the incidence was 0.932‰， and 2 neonates as definite PKU， the incidence was 0.207‰ .Conclusion：It is necessary to understand the pathogenesis of CH and PKU， and the NICU children are the high-risk group.The birth population quality can effectively improved by neonatal screening，early detection and diagnosis.
2015 Vol. 12 (10): 121-123 [Abstract]（
382
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ZHANG Qing，LI Juntang，ZHANG Jin-feng，et al.
Objective：To analyze the problems in diagnosing renal oncocytoma by spiral CT and pathology， in order to improve the accuracy of diagnosis.Method：The imaging features of CT of 12 lesions confirmed by pathology were analysed retrospectively and correlated by pathologic diagnosis.Result：11 cases were single nodule， accompanying with the diameter of lesion was 20-87.0 mm， average 53.5 mm.ON plain CT scan，1 lesion showed a little higher density than the renal parenchyma，central stellate scar showed low density shadow.In the cortical phase， 5 cases displayed inhomogeneous enhancement，and 6 cases displayed homogeneous enhancement in part.The enhanced degree of all lesions were higher than that of medulla， and lower than that of cortex.In parenchymal phase， the enhanced degree of all lesions were lower than that of medulla.In excretory phase， the density of solid part of tumor was equation， and below that of the renal parenchyma， which was corresponding with the pathological feature：the tumor was less of hemorrhage，necrosis and cystic degeneration.The case of bilateral multiple renal lesions also followed the strengthening method.6 cases showed central slit shaped or stellate shaped scar，and all cases showed no calcification.Conclusion：Since renal oncocytoma is a kind of benign renal tumor， which has some imaging features in enhanced spiral CT scan， taking renal biopsy before operation or surgery frozen biopsy will be useful to make therapy plan for the benefits of patients.
2015 Vol. 12 (10): 124-129 [Abstract]（
473
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WANG Xu-yao，QUAN Ming-tao，LI Xiao-juan，et al.
Objective：To know the effect of comprehensive interventions on the compliance of rising the bed head of patients with mechanical ventilation in the intensive care unit.Method：The comprehensive interventions in a tertiary hospital were used to improve the compliance of rising the bed head，then the differences of the compliance of rising the bed head at 4∶00，10∶00，17∶00，23∶00 before and after the intervention were analyzed.Result：The compliance of rising the bed head ≥ 30° before and after the comprehensive intervention were respectively 70.55%，94.54%， four time points of 4∶00，10∶00，17∶00，23∶00 after intervention respectively was 59.73%，84.09%，67.70% and 68.95%， higher than before intervention of 91.91%，94.76%，94.82% and 96.47%，the differences had statistical significance（P<0.05）.Conclusion：The comprehensive intervention of rising the bed head in the intensive care unit can improve
recognition of the importance of the nurse in the intensive care unit， then improve the compliance of rising the bed head.
2015 Vol. 12 (10): 129-132 [Abstract]（
435
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WU Yue-hua，LIU Kai，XIAO Ya-juan，et al.
Objective：To compare the level of C-reactive protein and Fibrinogen in the cerebral infarction patients with bone fracture and cerebral infarction patients without bone fracture.Method：The patients in advanced neurology and orthopedic department were selected， including the old bone fracture patients developed cerebral infarction patients，and divided into patients with bone fracture group and patients without bone fracture group，70 cases in each group.The second day after admission the blood was collected， the level of C-reactive protein and Fibrinogen were measured，then statistic analysis of them was used.Result：The level of C-reactive protein and Fibrinogen in patients with bone fracture were higher than patients without bone fracture，they were significiant correlation with cerebral infarction volume，in the same cerebral infarction volume，the level of C-reactive protein and Fibrinogen in patients with
bone fracture were higher than patients without bone fracture.Level of CRP and FIB had positively correlated with nerve function damage degree（light，medium，heavy），and the same nerve function damage degree of combined fracture significantly higher than the unincorporated fracture group，the two groups were compared， the difference was statistically significant（P<0.05）.So，higher level of C-reactive protein and Fibrinogen in the old patients after bone fracture were danger factors， they could lead to cerebral infarction.Conclusion：C-reactive protein and Fibrinogen were involved in the pathologic process of cerebral infarction，level of C-reactive protein and Fibrinogen may be helpful as objective guides to judging the size of infarction area， nerve function damage degree and prognosis.At the same time， orthopedic surgeon can measure them to prevent the happen of cerebral infarction.
2015 Vol. 12 (10): 133-135 [Abstract]（
523
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/SU Li-jun， LIU Yufa，CHEN Guang-xin.
Objective：To study Subclinical hypothyroidism’s influence on coronary artery atherosclerosis
patients.Method：These coronary artery atherosclerosis patients were divided into control group and experimental group according to random number table， these coronary artery atherosclerosis patients whose thyroid function did not decline belonged to control group， while these coronary artery atherosclerosis patients whose thyroid function declined belonged to experimental group， compared two group’s blood fat situations and their coronary artery atherosclerosis conditions. Result：Compared with the control group， the experimental group’s thyrotropic hormone， triglyceride， low density lipoprotein-cholesterol and cholesterol in blood serum raised a lot， high density lipoprotein-cholesterol significantly decreased（ P<0.05）， it had statistics meaning.Experimental group’s coronary artery atherosclerosis ratio was higher than control group’s （P<0.05）， it had statistics meaning.Conclusion：Subclinical hypothyroidism is one of the potential risk factors for coronary artery atherosclerosis patients， it is worthy of our attention and should prevent and improve it positively.
2015 Vol. 12 (10): 136-138 [Abstract]（
520
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LI Kun-lun， CHEN Xin， LI Bo， et al.
Objective：To investigate the security， indications and methods of the primary suture of common bile duct after exploration under choledochoscope.Method：The therapeutic effectiveness of primary suture of common bile duct in 103 cases having the indications subject to exploration of common bile duct under choledochoscope was retrospectively analyzed.Result：All the 103 cases fully recovered.The bile leakage occurred in 5 cases and biliary calculi recurrence occurred in 3 cases.During the follow up of 3 month to 3 years，no residual calculus or stricture of bile duct was seen.No serious obstructive jaundice， cholangitis， pancreatitis or abdominal cavity infection was occurred. Conclusion：If the indication and the technology of bile duct suturation are prepefly mastered， the primary suture of common bile duct after exploration under choledochoscopy is safe.
2015 Vol. 12 (10): 138-140 [Abstract]（
421
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ZHANG Ji-hong， TANG Tian-jun.
Objective：To research and analyze the effect of liver placeholder lesions in clinical diagnosis and treatment using Percutaneous liver biopsy under the guide of ultrasound.Method：80 cases with liver occupying lesions in the hospital were selected from April 2013 to August 2014， with CT inspection respectively， conventional ultrasonic testing and ultrasonic guided percutaneous liver biopsy examination， and the proportion of three type diagnosis of lesions was compared.The sensitivity， specificity and accuracy of clinical diagnosis were compared.Result：The results of percutaneous liver biopsy pathology inspection under the guide of ultrasound was 22 cases（ 2.75%）， 18 cases of chronic hepatitis B（ 2.25%）， 16 cases of cirrhosis（ 20.00%）； 8 cases of hepatocellular carcinoma（ 10.00%）； 7 cases of non alcoholic fatty liver（ 8.75%）； 5 metastases cases（ 6.25%）； 2 cases of chronic hepatitis（ 2.50%）； 1 case of alcoholic liver disease（ 1.25%）； 1 case of nodular hyperplasia（ 1.25%）.Test sensitivity of ultrasound guided percutaneous
liver biopsy was 81.25%， 85.00% of specificity， 92.50% of accuracy was significantly higher than those of conventional ultrasonic inspection， and the difference was statistical significant（ P<0.05）.Conclusion：Ultrasound guided percutaneous liver puncture biopsy is a safe and effective clinical application in liver occupying lesions diagnosis means， which can improve the accuracy of diagnosis， early diagnosis is advantageous to the treatment and prognosis of patients.
2015 Vol. 12 (10): 141-144 [Abstract]（
554
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LIU Fang-yu，DING Cun-shan.
Objective：To investigate clinical application，aesthetics，stability and bio-compatibility of zirconia all-ceramic crowns.Method：Computeraided design and computer aided manufacturing（CAD/CAM）techniqueswere used to make zirconia all-ceramic crowns for 78 teeth on 59 patients.After one year follow-up,the esthetics,stability biocompatibility were investigated by examining oral adaptability of crow color，breakage ratio，losing ratio and gingival health.. Result：The effect of the 59 patients to repair the overall satisfaction. Conclusion：The esthetics,stability and biocompatibility of zirconia-veneered crowns were enhanced by CAD/CAM technique.
2015 Vol. 12 (10): 144-146 [Abstract]（
573
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TANG Rong-zhi，LAI Hai-biao，ZHONG Liang，et al.
Objective：To investigate the surgical skills and the clinical effect of L5-L3 impacted ureteral stones treated with transureteroscopic holmium YAG laser lithotripsy.Method：56 patients from march 2013 to October 2014 diagnosed with impacted ureteral stones were treated with transureteroscopic holmium YAG laser lithotripsy.the size of stones were from 0.7 cm×0.5 cm to 1.6 cm×0.8 cm.Result：The fragmentation rate in single procedure was 92.9% （52/56），one case was conversed to open surgery due to the severity tortuosity of ureter that led to failed ureteroscope insertion。The stones of three cases slipped into the renal in the process because of stones harder.the mean operation time were 28 min。the mean postoperation hospital stay time were three days。The complications did not take place in and after operations such as ureter perforation、ureterodialysis、renal rupture、hyperthermia and sepsis。Conclusion：The clinical result of the L5-L3 impacted ureteral stones that were treated with transureteroscopic holmium YAG laser lithotripsy is satisfactory.If you want to avoid the operative complications and enhance clinical effect，you should play attention to surgical skills.
2015 Vol. 12 (10): 147-150 [Abstract]（
462
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ZHENG Yong-gang,LI Xia.
Objective：To study the efficacy of Roxithromycin Sustained Release Capsulesin（RSRC） in treating stable Chronic Obstructive Pulmonary Disease（COPD） patients.Method：Totally 113 patients with stable COPD were randomly divided into the treatment group and the control group. All the patients were treated with basic therapy（including oxygen,eliminating phlegm to smooth wheezing,immune regulation,support treatment and health education）.The treatment group in the basic therapy combined with RSRC 0.15 g,1/d oral for 6 months.Dyspnea score,pulmonary function（FEV1/ FVC）,6-MWT,the quality of life（QOL） and the times of exacerbations were observed.Result：The indicators of FEV1/ FVC（%）,6-MWT and QOL were higher than those before the treatment（P<0.05）.The times of exacerbations and dyspnea score were smaller than those before the treatment（P<0.05）.The indicators of FEV1/FVC（%）,6-MWT and QOL in the treatment group were higher than those in the control group after the treatment（P<0.05）.The times of exacerbations and dyspnea score in the treatment group were smaller than those in the control group after the treatment （P<0.05）.Conclusion：Long-term treatment for stable COPD patients with RSRC is an effective means in relieving dyspnea,improving pulmonary function and QOL and preventing recurrence.
2015 Vol. 12 (10): 150-152 [Abstract]（
571
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YANG Wei-huang， HUANG Ping.
Exhaled breath condensate（ EBC） is a new method for the detection of respiratory system diseases.Detecting real-time biomarkers in EBC evaluates acute and chronic airway inflammation and oxidative stress level.Since the EBC has non-invasive， real-time monitoring， simple， repeatable advantages， it can be used as diagnosis of lung disease， severity assessment， evaluation of drug efficacy and prognostic marker，and has good application prospects. EBC has extensive application in COPD， asthma， lung cancer and interstitial lung disease.In this paper， we review the advances of EBC in COPD， asthma， lung cancer and interstitial lung disease.
2015 Vol. 12 (10): 153-156 [Abstract]（
594
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