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| Comparison on Effect of Dexmedetomidine between Narcotrend and BIS |
| Huizhou the First People’s Hospital， Huizhou 516000， China |
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Abstract Objective： To evaluate the advantages and disadvantages of Narcotrend（ NT） in monitoring the depth of anesthesia when compared with the bispectral index（BIS）. Method： 60 patients（ ASA I or Ⅱ）， undergoing elective laparoscopic surgery， were randomly divided into two groups， NT group and BIS group. 1.0 μg/kg dexmedetomidine was injected with a micro infusion pump， fusion time was 10 minutes. 1.5 mg/kg propofol， 4 μg/kg fentanyl and 0.15 mg/kg
atracurium was injected intravenously after dexmedetomidine was injected 5 minutes. Tracheal intubation was placed after demedetomidine was injected 10 minutes. BIS， NT， mean arterial pressure（ MAP） and heart rate（ HR） were measured before induction（ T0）， before intubation（ T1）， instant time after intubation（ T2）， 1 minute（ T3）， and 5 minutes（ T4） after intubation. Result： The NT index was positively correlated to the BIS（ r=0.901，P<0.001）； HR， MAP， NT and BIS values were significantly lower after dexmeddetomidine administration（ P<0.05）. NT and BIS values significantly
decreased at loss of consciousness as compared with the baseline value（ P<0.01）. Compared with that before intubation，HR and MAP increased during intubation， and at l and 3 mins after intubation， while no significant change was found in HR， MAP， NT and BIS values. Conclusion： NT can monitor sedative effect induced by dexmeddetomidine accurately. NT and BIS are comparable no advantages.
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