Objective： To investigate the diagnostic value of serum CEA， SCC and SF as analyzed with Logistic vegression and ROC curve in patients with lung cancer lymph nodes metastasis. Method： Serum CEA， SCC， and SF were detected in 100 patients with lung cancer， and in those cases， 65 cases were identified as lymph nodes metastasis group and 35 as non-metsatasis group. Result： The positive rate of CEA and SCC of metastais group was evidently higher than that of non-metastasis（ P<0.01，P<0.05）， but there was no significant difference for SF between the two groups. According to regression equation Y=1/[1+EXP（1.584X1+0.935X2-0.425）]， and the AUC of variable Y was higher than any of the three tumor markers. Conclusion： The combination of CEA and SCC is useful as indicator of lung cancer lymph nodes metastasis. Applications of Logistic regression and ROC curve increase diagnostic accuracy in lung cancer.

2015 Vol. 12　(13):　1-3 [Abstract]（ 507 ） HTML (1 KB)  PDF  (664 KB)  ( 342 )

Objective： To discuss the effect of fortified nutrition on facilitating wound healing of patients in endoscopic therapy for cirrhosis and esophageal varices. Method： 136 patients in endoscopic therapy for cirrhosis and esophageal varices were randomly divided into two groups. The control group was adopted the way of normal therapy. The treatment group was adopted the way of intervention of fortified nutrition on that basis. Result： After the treatment， the whole effective rate of wound healing in the treatment group was 97.06%， evidently higher than that of 83.82% in the control group. In addition， the treatment group was better than the control group in the respect of the plasma albumin and prothrombin time. In the treatment group， there were 28 patients with visible injection site anabrosis， which was obviously less than the 52 patients in the control group. There were 15 patients with slight bleeding on injection site anabrosis in the control group， which was obviously more than the 2 patients in the treatment group. The difference between the two groups was statistically significant（ P<0.05）. Conclusion： Adopting the intervention of fortified nutrition on patients in endoscopic therapy for cirrhosis and esophageal varices can effectively accelerate the speed of wound healing and improve liver functions.

2015 Vol. 12　(13):　7-10 [Abstract]（ 551 ） HTML (1 KB)  PDF  (682 KB)  ( 266 )

Objective： To explore the relationship of elderly patients with hypertension and blood pressure variability in patients with type 2 diabetes and cognitive function. Method：A retrospective　analysis　was performed on clinical data of 120 elderly patients from March 2011 to November 2014，and were divided into two groups. Hypertensive patients were control group only， elderly hypertensive patients with type 2 diabetes mellitus patients were the observation group， with 60 cases in each group. Two groups of patients in general， cognitive ability and the 24 hours ambulatory blood pressure（ 24 h ABPM） changes were observed and compared.Result： The observation group of patients with 24 h systolic blood pressure standard deviation， 24 h systolic blood pressure variation coefficient， systolic blood pressure standard deviation during the day， during the systolic blood pressure variation coefficient， nocturnal systolic blood pressure standard deviation and nighttime systolic blood pressure variation coefficient were higher than the control group patients，statistically significant difference （P<0.05）. While the rest of the 24 hours ambulatory blood pressure index compared with the control group had no obvious difference， no statistical significance（P>0.05）.The observation group of patients with cognitive ability was better than control group， the difference is statistically significant（P<0.05）. Conclusion： The blood pressure variability in elderly hypertensive patients with diabetes increased， and there is a close relationship between
the increase of loss and cognitive function.

2015 Vol. 12　(13):　14-16 [Abstract]（ 553 ） HTML (1 KB)  PDF  (660 KB)  ( 145 )

Objective： To summarize clinical characteristics and intervention measures of peptic ulcer paitents infected by helicobacter pylori，to improve the clinical treatment of these patients， reduce the relapse rate， reduce the relapse rate.Method： 240 paitents with peptic ulcer caused by helicobacter pylori infection were selected from September 2009 to August 2011，their clinical characteristics and intervention measures were summarized. 240 paitents with peptic ulcer caused by Helicobacter pylori infection were selected from September 2012 to August 2014，they were randomly divided into control group and observation group，120 cases in each group，the control group was treated with conventional therapy treatment，the observation group was treated by intervening measure on the basis of conventional therapy，then the recent clinical results and long-term recurrence rate were compared between two groups. Result： The proportion of males caused by helicobacter pylori infection in patients with peptic ulcer disease higher than women；different ages compared to the proportion，the population aged 20-50 years was significantly higher than others， duodenal ulcer patients were significantly higher than gastric ulcer patients，compared all the indicators， the differences were statistically significant （ P<0.05）.Two groups of a short-term effect were observed， the difference was not statistically significant （P>0.05）； but the long-term recurrence rate of observation group was significantly lower than that in the control group， the difference was statistically significant（ P<0.05）. Conclusion： Patients with peptic ulcer caused by helicobacter pylori infection with a more specific clinical features， targeted interventions take countermeasures against its features， which can effectively reduce the relapse rate of patients and improve treatment levels.

2015 Vol. 12　(13):　20-22 [Abstract]（ 556 ） HTML (1 KB)  PDF  (661 KB)  ( 203 )

Objective： To assess the relationship between　subtypes of ischemic stroke and insulin resistance. Method：101 enrolled patients diagnosed with cerebral infarction were divided into 3 groups，atherothrombotic infarction group（AT group ）；acute perforating small artery occlusion group（APSAO group） and cardioembolic infarction group（CE group）.We investigated the relationships between ischemic stroke subtypes and the prevalence of insulin resistance used by homeostasis model assessment for insulin resistance（HOMA-IR）.Result： The mean of HOMA-IR was significantly increase in the AT group with AGM compared to the CE group， the difference was statistically significant （P<0.01）.The mean of HOMA-IR was also higher in the APSAO group with AGM than the CE group， the difference was statistically significant（P<0.05）. The mean of HOMA-IR was significantly increase in the AT group with AGM compared to the NGT，the difference was statistically significant（P<0.01）. The mean of HOMA-IR was also higher in the APSAO group with AGM than the NGT，the difference was statistically significant（P<0.05）. Conclusion： insulin resistance is not only associated closely with atherothrombotic infarction， but also has a close relationship with acute perforating small artery occlusion infarction.Early intervention and treatment for insulin resistance seems to be important for the secondary prevention of ischemic stroke.

2015 Vol. 12　(13):　26-28 [Abstract]（ 512 ） HTML (1 KB)  PDF  (662 KB)  ( 299 )

Objective： To study the curative effect of dual antiplatelet aggregation and intensive lipid lowering on posterior circulation infarction patients with basilar artery stenosis. Method： Fifty posterior circulation infarction patients with basilar artery stenosis were randomly allocated into control group and observation group. Patients in the control group were treated by antiplatelet aggregation and conventional lipid lowering treatment. Observation group was given dual antiplatelet aggregation and intensive lipid lowering treatment. Course of treatment lasted three weeks. National Institutes of Health Stroke Scale（ NIHSS） was tested before therapy and after the treatment of 1， 2， 3 weeks. Result： Efficiency was 92.0% in the observation group， nerve function defect treatment effect of the observation group was better than that of the control group（ P<0.01）. Both of the two groups had no severe hemorrhage and muscular aches. Conclusion： Short time of aspirin， clopidogrel dual antiplatelet aggregation combined with intensive lipid lowering treatment on posterior circulation infarction patients with basilar artery stenosis is better than aspirin alone and conventional lipid lowering group； and no severe hemorrhage happens.

2015 Vol. 12　(13):　32-34 [Abstract]（ 575 ） HTML (1 KB)  PDF  (662 KB)  ( 168 )

Objective： To observe the effect of hydrocolloid dressing with wet heat compression in preventing mechanical phlebitis of peripherally inserted central catheter（ PICC）. Method： 135 patients were randomly divided into three groups， experimental group 1（ 45 cases）， experimental group 2（ 45 cases）， and control group（ 45 cases）. The experimental group 1 used hydrocolloid dressing after PICC for 7 days， received wet heat compression after 24 hours， had
been covered for 7 days（ 30 min/times， 2 times/d）. The experimental group 2 received wet heat compression after 24 hours， had been covered for 7 days（ 30 min/times， 2 times/d）. The control group received routine nursing. Result： The incidence of phlebitis in the experimental group 1 was significantly lower than that in the experimental group 2 and control group， with significant difference（ P<0.05）. Conclusion： Hydrocolloid dressing with wet heat compression can prevent mechanical phlebitis of peripherally inserted central catheter（ PICC）.

2015 Vol. 12　(13):　39-41 [Abstract]（ 640 ） HTML (1 KB)  PDF  (663 KB)  ( 204 )

Objective： To explore the application of detection of ultrasonic beckoning diagram on blood flow spectrum of fetal ductus arteriosus. Method： To select 156 patients with normal singleton birth for prenatal ultrasonography in our hospital from September 2012 to September 2014 as the research objects， application of color doppler ultrasound beckoning diagram， detection of normal fetal ductus arteriosus， variation rules of dynamic observation of the fetal period with different development. Result： 156 patients with normal fetal ductus were obtain two-dimensional ultrasound relatively clear beckoning with color Doppler flow spectrum， transcatheter arterial pulse doppler spectrum showed a bimodal pattern； through regression analysis， related to gestational age and AT，PFVd， PFVs positive（ P<0.05）. Conclusion： The application of graph is of vital significance of beckoning detected in normal fetal ductus arteriosus blood flow spectrum in quantitative study of ultrasound， fetal circulation system can provide physiological information， early assessment of fetal risk value， timely intervention， clinical attention should be paid.

2015 Vol. 12　(13):　44-47 [Abstract]（ 534 ） HTML (1 KB)  PDF  (704 KB)  ( 268 )

Objective： To explore the relationship between the level of NT-ProBNP before and after cardioversion treatment in patients with the recurrence of atrial fibrillation（ AF）. Method： 50 patients with AF were tested NTProBNP before and after admission. NT-ProBNP was compared between the successful cardioversion group and the failure group， coupled with that between the Maintenance of sinus rhythm group and the recurrence of atrial fibrillation group.  Result： NT-ProBNP before and after treatment in failure group was significantly higher than the successful group （P<0.01）. NT-ProBNP after treatment in the recurrence of atrial fibrillation group was significantly higher than the maintenance of sinus rhythm group（ P<0.01）. Conclusion： The probability of successful cardioversion for those who had higher level of NT-ProBNP before and after cardioversion treatment is lower while controlling ventricular rate was desirable； it is easier to maintain sinus rhythm for those whose NT-ProBNP rapid returned to normal after treatment. The content of NT-ProBNP after treatment in patients with AF can act as the index to predict the recurrence of atrial fibrillation.　

2015 Vol. 12　(13):　50-53 [Abstract]（ 478 ） HTML (1 KB)  PDF  (684 KB)  ( 194 )

Objective：To investigate the level and influencing factors of uncertainty in illness among preoperative patients with total hip arthroplasty（THA）. Method：Totally 100 patients with THA were investigated by a self-designed demographic questionnaire，Mishel uncertainty in illness scale（ MUIS）， social support scale rating scale and Connor-Davidson resilience scale in the preoperative 1 day.Result：The total score of MUIS was（ 102.01±14.35） and it is at the middle level，the average score of item in unpredictability dimension was the highest， and the score in complexity dimension was the lowest. Multiple stepwise regression showed the influencing factors of uncertainty in illness were educational level， family economic burden， social support and resilience.  Conclusion：Uncertainty in illness is at a middle level of preoperative patients with THA，which is influenced by individual factors， nurses should give nursing intervention to reduce their uncertainty in illness.

2015 Vol. 12　(13):　56-59 [Abstract]（ 470 ） HTML (1 KB)  PDF  (681 KB)  ( 230 )

Objective： To explore influences of behavioral guidance on curative effects of chronic cough caused by laryngopharyngeal reflux.  Method： 87 laryngopharyngeal reflux induced chronic cough patients were randomly divided into control group and intervention group， the control group was treated with Omeprazole combined with Domperidone treatment， nursing intervention in the intervention group was treated with the same drugs at the same time to the behavior guide， curative effect and RSI score of the two groups were observed. Result： After 8 weeks treatment， the total efficiency was 72.09% in the control group， the intervention group was 88.64%； the RSI score of the control group was（ 8.12±3.04），the intervention group was（ 7.11±2.31）， two items of data through the comparison， the difference was statistically significant（ P<0.05）. Conclusion： The laryngopharyngeal reflux induces chronic cough and guides to behavior in drug treatment， which can improve the curative effect.

2015 Vol. 12　(13):　62-65 [Abstract]（ 608 ） HTML (1 KB)  PDF  (683 KB)  ( 155 )

Objective：To analyze the patients with acute cerebral infarction after simvastatin treatment using serum interleukin-6（IL-6）， and serum C-reactive protein（ CRP） level changes in circumstances。Method：60 patients of acute cerebral infarction（ ACI） in our hospital were selected from March 2013 to September 2014，and randomly divided into treatment group and control group，30 cases in each group.The treatment group was treated in the routine based on symptomatic treatment with simvastatin，the control group was treated by conventional integrated symptomatic treatment alone.Before and after treatment，the rate nephelometry and radioimmunoassay were respectively used to measured the groups’ CRP and IL-6 levels.Result：The total effective rate of treatment group was 90%，the total effective rate of control group was 70%， the total efficiency of the treatment group compared with the control group was significantly higher，the difference was statistically significant（P<0.05）. Before treatment，the difference of two groups’ IL-6 and CRP levels had no statistically significant（P>0.05）；after treatment， the patients via the corresponding IL-6 and CRP levels were decreased compared with before treatment，the difference was statistically significant（ P<0.05），but the treatment group’s patients with IL-6 and CRP levels were lower than the control group， the difference was statistically significant comparison（P<0.05）. Conclusion：In patients with acute cerebral infarction using simvastatin has significant clinical effect， can effectively reduce serum levels of IL-6 and CRP， anti-inflammatory effect is good.

2015 Vol. 12　(13):　68-71 [Abstract]（ 497 ） HTML (1 KB)  PDF  (685 KB)  ( 154 )

Objective： To investigate the anesthesia management of continuous cyclic peritoneal perfusion chemotherapy in gastric cancer radical resection of Narcotrend assisted laparoscopic. Method： 40 continuous cyclic peritoneal perfusion chemotherapy with gastric cancer radical resection patients from 2013 March to 2014 November in our hospital were selected as the research objects. They were randomly divided into observation group and control group， with 20 cases in each group， the control group achieved anesthesia according to the experience of anesthesia doctor’s clinical experience， the observation group was treated by Narcotrend anesthesia depth monitoring to guide the implementation，compared two groups’ each stage hemodynamic indexes and anesthesia effect. Result： The observation group’s operation time， anesthesia time had no significant differences compared with the control group， and its dosage of drugs， wake time was significantly better than the that of the control group（ P<0.05）， with statistical significance. The control group’s SBP，DBP and HR in T2， T3， T4， T5 had increased compared with T0 time（ P<0.05）， there was no significant difference between the two groups’ SBP， DBP， HR in T0 and T1 stage， but the control group’s SBP， DBP， HR in T2， T3， T4， T5 were higher than the observation group（ P<0.05）， with statistical significance.  Conclusion： Using Narcotren anesthesia depth monitoring to guide the implementation of anesthesia in gastric cancer radical surgery can better maintain the hemodynamics of patients， it uses less anesthesia drug to achieve better anesthesia effect and is beneficial to the patients’ recovery， so it has clinical value of application and popularization.

2015 Vol. 12　(13):　74-77 [Abstract]（ 566 ） HTML (1 KB)  PDF  (684 KB)  ( 297 )

Objective： To explore the value of MRI in diagnosis and differential diagnosis of female ovarian lesion. Method： Reviewed the characteristics of MRI in 68 ovarian lesions proved by pathology. Result： 60 patients had 68 lesions. Among these， 21 cases were ovarian cystadenoma， 12 cases were endometriosis， 11 cases were ovarian teratoma，7 cases were ovarian cancer， 5 cases were ovarian cyst or parovarian cyst， 2 cases were ovarian thecoma， 3 cases were sactosalpinx， 4 cases were subserous uterine myoma， 3 cases were other disense. Ovarian lesion mainly performed cystic or cystic-solid or solid masses. Among these， benign lesions were 58. Misdiagnosis of MRI was 5， the rate was 7.4%. Conclusion： MRI image of ovarian lesions has certain characteristics， MRI has high value for diagnosis and differential diagnosis of ovarian lesions.

2015 Vol. 12　(13):　80-84 [Abstract]（ 491 ） HTML (1 KB)  PDF  (810 KB)  ( 489 )

Objective： To investigate the role of the hydrocolloid dressings in intravenous infusion of sodium aescinate， the function of sodium aescinate is to reduce the lymph exudation caused by the radical resection of laparoscopic gynecologic malignant tumor. Method： August 2011 to August 2014， in our departments who dad undergone the radical resection and hale intravenous infusion of sodium aescinate were included of which 56 patients with cervical cancer，10 patients with endometrial cancer. They were randomly divided into two groups， 36 cases in the experimental group，received relevant measures of nursing staff， including the use of hydrocolloid dressings to protect the vein， the application of the precise filter to reduce the influence of the infusion particles and psychological intervention. 32 cases were in the control group， just used the precise filter. Then to compare the incidence of phlebitis， the comfort and satisfaction of patients in the two group. Result： Compared with the control group， the incidence of phlebitis was lower， the comfort and satisfaction of patients were higher in the experimental group. Conclusion： According to the clinical research， nurses use the hydrocolloid dressings to reduce the influence of infusion particles， adjust the infusion rate and have psychological intervention for patients can reduce the incidence of phlebitis， alleviate the suffering of patients and improve the
satisfaction of patients.

2015 Vol. 12　(13):　87-89 [Abstract]（ 410 ） HTML (1 KB)  PDF  (660 KB)  ( 142 )

Objective： To investigate the implications of laparoscopic cholecystectomy patients’mental status and satisfaction which nursed by human care. Method： To select 100 patients with laparoscopic cholecystectomy which admitted in our hospital in recent years， then randomly divided them into control group and observation group. The control group was cared by basis model， the observation group was cared by humane care model. The mental status of the two groups was rated by SCL-90 scale. The satisfaction of patients was investigated by an anonymous questionnaire survey. Result： After care， the mental status of the two groups were improved. But by contrast， the score of the observation group after care was significantly lower than that of the control group， the difference had statistically significant（ P<0.05）.About satisfaction， the observation group reached 100%， the control group was only 92.0%， with significant difference （P<0.05）. Conclusion： The implementation of humane care model can help patients with laparoscopic cholecystectomy adjust their attitude better， enhance the nursing satisfaction. It has clinical promotional value.

2015 Vol. 12　(13):　93-96 [Abstract]（ 577 ） HTML (1 KB)  PDF  (680 KB)  ( 226 )

Objective：To study clinical therapeutic effect of the two types of external treatment in patients with acute gouty arthritis. Method： Based on the data and treatment of the diagnosis and treatment of 80 cases of patients with acute gouty arthritis， the patients were divided into two groups. one is control group whose joint outside were washed by gout detergent， and the other group is test group whose joint outside　were apply Heat dispersion.The treatment effects were compared between the two groups.Result：The total efficiency of test group 95% was higher than that of control group 85%（P<0.05）.The satisfaction rate of　test group 95% was higher than that of control group 65%（P<0.05）. The recurrence rate of　test groupis 2.5% after 4 weeks，and will increase to 5% after 12 weeks. these data is lower than that of the control group.Serum uric acid level of test group was（ 409.34±56.01）μmol/L，（345.06±40.57）μmol/L，（310.84±44.75）μmol/L in 1，4，12 weeks. These data was lower than that of the control group（P<0.05）. Conclusion： Gouty arthritis in clinical disease incidence rate is high， clinical use of heat arthralgia scattered ideal external joint lesion effect， is worthy to be popularized.

2015 Vol. 12　(13):　100-102 [Abstract]（ 478 ） HTML (1 KB)  PDF  (660 KB)  ( 176 )

Objective：To investigate the compliance of atrial fibrillation patients under community management plan， provide the basis for the development of atrial fibrillation community standardized management scheme. Method：Two communities with far geographically distance of 220 AF patients were randomly selected and divided into the experimental group of 109 cases and control group of 110 cases.A standardized management plan was implemented in experimental group.Conventional treatment was conducted in control group. Duration of follow-up was at least 12 months.Patients’ compliance were analyzed between two groups.Result：After 12 months follow-up，the compliance of medical treatment and life style change was better in experimental group than that in control group， the differences were statistically significant（P<0.05）.Conclusion：The community management plan for patients with atrial fibrillation is superior to usual care in terms of patients’ compliance.

2015 Vol. 12　(13):　106-108 [Abstract]（ 555 ） HTML (1 KB)  PDF  (663 KB)  ( 208 )

Objective： To analyze the characteristics and drug resistance of pathogenic bacteria in operative incision infection of orthopedics patients， to provide reference of controlling the operation incision infection incidence in department of orthopedics and clinical rational drug use. Method： 300 incision infectious patients as the research objects in department of orthopedics in our hospital from August 2011 to October 2014， were collected the surgical incision infection specimens， isolated pathogenic bacteria， using automatic analyzer in detection of bacterial pathogens and analysis of drug resistance. Result： 300 cases with a total of 920 strains of pathogenic bacteria cultured in department of orthopedics， patients with surgical incision infection and pus secretion specimen source： 818 strains accounted for 88.9%，33 from blood， accounted for 3.6%， drainage of 32 strains， accounted for 3.5%， 27 cases of joint effusion， accounted for 2.9%， other 10 strains， accounted for 1.1%. 920 strains of pathogenic bacteria， 597 strains of gram negative bacilli，accounted for 64.9%； 171 strains of gram positive coccus， accounted for 18.6%； 152 strains of fungi， accounted for 16.5%； incision infection in department of orthopedics was mainly pathogenic bacteria of gram negative bacilli， which pseudomonas aeruginosa ranked first， accounting for 32.6%， followed by Acinetobacter baumannii， accounted for 13%.Gram positive coccus was the second pathogens caused operation incision in department of orthopedics infection， including Staphylococcus aureus was the leading pathogen infection， accounted for 12.4%. The fungus was the third bacteria caused operation incision infection in department of orthopedics， which infected with Candida albicans， accounted for 7.8%； gram negative bacilli had higher rate to Amikacin， aztreonam， Pi La Shilling， cefepime， ticarcillin， resistant to levofloxacin， cefazolin， gram positive coccus had high resistance rate on the left ofloxacin， cefoxitin， penicillin，clindamycin. Conclusion： In application of antibiotic therapy in department of orthopedics must strictly according to pathogenic bacteria detection results， to determine the clinical medication types according to the result of drug sensitivity test， launch targeted， individual treatment， in order to optimize the anti infection treatment effect， reduce the incidence of postoperative infection.

2015 Vol. 12　(13):　112-115 [Abstract]（ 574 ） HTML (1 KB)  PDF  (677 KB)  ( 184 )

Objective： To discuss the curative effect of the operation which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large）. Method： The operation clinical data which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large） of 46 cases were reviewed. Result： There were 46 cases of the operation which TUPKEP combined with bladder lithotomy for prostatic hyperplasia with bladder multiple calculi（ large） were successful simultaneous therapy， the success rate of lithotomy was 100%. Operation time was 60-155 min， average（ 90.54±19.75） min. The bleeding was 50-300 mL， average（150.42±55.46）mL. The patients were in hospital 7-9 days， average（ 7.53±0.68）days after operation. No patient dead in operation or hemorrhage or blood transfusion or bladder perforation or（ TURS） or urinary fistula or infection of incision complications. The time follow-up was 6-24 months， average（ 16.76±5.11）months， IPSS， QOL， PVR was improved before operation， a statistically significant difference（ P<0.05）， IPSS from preoperative average（ 26.48±2.54） points to（ 5.63±1.22） points， QOL from preoperative average（ 4.63±1.12） points to（ 1.23±0.94） points， PVR from preoperative average（ 208.38±35.53）mL to（ 13.52±3.47）mL. All patients were urinate unobstructed with no really urinate incontinence or no bladder calculi recurrence or urethral stricture. Conclusion： TUPKEP combined with bladder lithotomy for benign prostatic hyperplasia with bladder multiple calculi（ large） simultaneous therapy is safety and simple method with good effect and little trauma，especially fit for the patients which aged high-risk with larger bladder prostate and multiple stones and other basis of disease.

2015 Vol. 12　(13):　119-122 [Abstract]（ 525 ） HTML (1 KB)  PDF  (681 KB)  ( 350 )

Objective： To probe into the MRI parting of knee recessive traumatic fractures and its clinical diagnosis values. Method： 60 patients who suffered from the knee recessive traumatic fractures and who accepted treatment in our hospital from January 2013 to January 2014 were taken as the research objects， and these patients were randomly divided into control group and observation group， with 30 patients in each group. In the control group， they were treated with the Spiral CT， while in the observation group， patients were treated with the MRI scanning. Then， the finding rate of the positive occult fracture and the injured parts were compared. Result： Among 30 patients in the observation group who were treated by the MRI scanning， 29 of them（ 96.67%） occurred the abnormal positive， comparing with 26 patients（ 86.67%） in the control group. The differences had the statistical significance（ P<0.05）. Conclusion： For these patients suffering from knee recessive traumatic fractures， the preferred method is the Spiral CT. After the adoption of this method， for these patients who do not have certain results， they can be treated with MRI. Combining with these two methods can evidently improve the correctness of the diagnosis of knee recessive traumatic fractures and can clearly see the injured extents and types of patients， which is good for the clinical diagnosis and treatment. Thus， it should be promoted in the clinic applications.

2015 Vol. 12　(13):　127-130 [Abstract]（ 491 ） HTML (1 KB)  PDF  (681 KB)  ( 180 )

Objective： To study the clinical value of early diagnosis and treatment of endoscopic in the digestive tract tumor， and to provide reference for the early diagnosis and treatment of digestive tract tumors. Method： 110 patients with suspected alimentary canal tumor were collected and analyzed from January 2011 to June 2014， and patients with endoscopic examination and serum tumor markers were examined and two groups of diagnostic coincidence rate were compared. Patients under endoscopic treatment were diagnosed， and the effect of the treatment were observed and recorded. Result： 32 patients were positive for by pathological examination， 30 cases positive by endoscopy， 2 cases of misdiagnosis， the diagnosis coincidence rate was 93.75%； serum tumor markers detection were 23 cases positive， 9 cases of misdiagnosis，the diagnosis coincidence rate was 71.875%； the difference of two test modes was statistically significant（P<0.05）. Before the treatment， patients’ life quality score of （ 53.8±5.4）， after treatment， the patients quality life score of（ 85.1±6.5）， before and after treatment the difference in the quality of life was statistically significant（P<0.05）. 32 patients after endoscopic therapy had achieved good curative effect， no adverse reaction and complications occurred， CR of 10 cases， PR of 12 cases， SD of 5 cases， PD of 5 cases， the total effective rate was 68.75%.Conclusion： The application of endoscopy in early diagnosis and treatment of digestive tract tumor has important clinical significance， diagnosis coincidence rate is high， the treatment effect， less adverse reaction， and quality of life in patients with increased significantly，it is worth clinical promotion.

2015 Vol. 12　(13):　133-136 [Abstract]（ 418 ） HTML (1 KB)  PDF  (682 KB)  ( 289 )

Objective： To investigate the main clinical features and treatment of elderly patients with epilepsy secondary effect. Method： Our department of elderly patients with epilepsy from January 2008 to December 2012 54 patients hospitalized， the basic clinical data were retrospectively analyzed patients， medical history， as well as the onset of characteristic radiographic findings， treatment， etc.， summary the clinical features， explore effective control measures. Result： 54 patients cause categories of secondary epilepsy， 46 cases（ 85.2%） for secondary epilepsy after stroke， 38 cases of cerebral ischemic stroke， including 33 cases of cerebral infarction， cerebral embolism in 5 cases， 8 cases of hemorrhagic stroke， including 7 cases of brain hemorrhage，subarachnoid hemorrhage in 1 case. Proportion of ischemic cerebral apoplexy was significantly higher than hemorrhagic stroke. The remaining patients respectively， 3 cases of traumatic brain injury， brain tumor（ incidence of brain metastases） in 2 cases， metabolic encephalopathy in 2 cases，intracranial infection， 1 case. General stiffness matrix that big twin sex seizures 28 cases（ 51.9%）， status epilepticus in 2 cases（ 3.7%）， 9 cases of simple partial seizure（ 16.7%）， complex partial seizure in 11 cases（ 20.4%）， 4 cases were not classified attack（ 7.4%）， tip - secondary epilepsy with systemic rigidity matrix twin sex hair as the most common type. 38 ischemic stroke patients， late-onset epilepsy（ 2 weeks after stroke recovery and sequelae of epilepsy） 29 cases， 9 cases of early-onset epilepsy， including 1 case with epilepsy as first symptoms. In 8 patients with hemorrhagic stroke， the early onset of epilepsy in 5 cases within 48 h after the onset of patients with cerebral hemorrhage， tended to secondary epilepsy，directly affects the primary disease type secondary epilepsy onset time. Are head CT or MRI data， all patients with multifocal lacunar infarction， brain atrophy and brain white matter demyelination changes， such as cerebral hemorrhage，cerebral metastases performance. Conclusion： Elderly patients with secondary epilepsy highest incidence of stroke as the primary disease， the cause clear， but the primary disease is different， a different time of onset. To give appropriate treatment according to the patient’s primary disease， seizure type， seizures time. Early anticonvulsant therapy will focus on controlling symptoms also need to be given to maintain long-term oral antiepileptic drugs reduce mortality.

2015 Vol. 12　(13):　139-142 [Abstract]（ 512 ） HTML (1 KB)  PDF  (681 KB)  ( 189 )

Objective：To summarize the clinical experience of treating urethral disruption by urethral reunion traction operation in ureteroscope combined with bladder puncture fistulation.Method： 15 cases with urethral disruption who received urethral reunion traction operation combined with bladder puncture fistulation were selected and the clinical data was summarized. Result：15 cases all successed，the mean operation time was（ 22±8）minutes，the amount of bleeding in operation was（ 18±4）mL，the average time of urethral sustained traction was（ 8±2）days，and the hospitalization time was（ 12±2）days.After a follow up of 12 months，the treatment effect was satisfactory，and no obvious urinary incontinence and erectile dysfunction.2 patients with dysuria were cured by urethral dilation. Conclusion：The operation of urethral reunion traction operation in ureteroscope combined with bladder puncture fistulation to treat urethral disruption is effective for treating urethral disruption and it is worth popularizing.

2015 Vol. 12　(13):　146-149 [Abstract]（ 623 ） HTML (1 KB)  PDF  (668 KB)  ( 269 )

p38 mitogen-activated protein kinase（ p38MAPK） is an important member of the mitogen-activated protein kinase（ MAPK） superfamily， which is mainly distributed in the cytoplasm and a serine/threonine kinase. It plays an important role in the pathogenesis of diabetic cardiomyopathy（ DCM）， such as microvascular disease， myocardial fibrosis， cardiac hypertrophy， myocardial apoptosis and so on， which can be activated by a variety of factors. Studying the role of p38MAPK is helpful to further clarify the pathogenesis of DCM， as well as to provide new target for DCM treatment.

2015 Vol. 12　(13):　153-156 [Abstract]（ 624 ） HTML (1 KB)  PDF  (672 KB)  ( 297 )