Objective: To investigate and compare the influence of intra-articular injection of Sodium Hyaluronate by two point puncture for survival status and functional recovery of patients with knee osteoarthritis. Method: A total of 120 patients with knee osteoarthritis admitted to the Orthopaedic Surgery Clinic of Wuzhou Red Cross Hospital from July 2020 to June 2021 were divided into control group (60 cases) and observation group (60 cases) according to random number table method. Both groups were treated with intra-articular injection of Sodium Hyaluronate. Four-point puncture method was used in the control group, and two-point puncture method was used in the observation group. The time of pain relief, duration of treatment effect, WOMAC scale scores, visual analogue scale (VAS) scores and WHOQOL-BREF scores before and after treatment were compared between the two groups. Result: The time of pain relief of observation group was shorter than that of control group, the duration of treatment effect was longer than that of control group,the differences were statistically significant (P<0.05), the WOMAC scale scores, VAS scores and WHOQOL-BREF scores of two groups before the treatment were compared, the differences were not statistically significant (P>0.05). WOMAC scale scores, VAS scores and WHOQOL-BREF scores of the observation group were better than those of the control group at 3, 6 and 12 months after treatment, the differences were statistically significant (P<0.05). Conclusion: Two point puncture injection of Sodium Hyaluronate in joint cavity has a relatively good effect on the survival state and functional recovery of patients with knee osteoarthritis, which is more suitable for the treatment of patients with knee osteoarthritis.

2023 Vol. 20　(7):　1-5 [Abstract]（ 186 ） HTML (1 KB)  PDF  (1024 KB)  ( 206 )

Objective: To investigate the effect of Roxadustat Capsules in the treatment of renal anemia in maintenance hemodialysis patients and its influence on biochemical indexes. Method: A total of 120 patients with renal anemia in maintenance hemodialysis who were admitted to People's Hospital of Yangjiang from July 2021 to March 2022 were divided into a control group and a treatment group according to the random number table method, with 60 cases in each group. The control group was treated with Recombinant Human Erythropoietin Injection, and the treatment group was treated with Roxadustat Capsules. The effective rate, hemoglobin (Hb), red blood cell count (RBC), hematocrit (HCT), iron metabolism indexes [serum iron (SI), transferrin (TRF) and transferrin saturation (TS)] and mean arterial pressure (MAP) before and after treatment were compared between the two groups. Result: After 1 month and 3, 6 months of treatment, the effective rates in the treatment group were higher than those in the control group, the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in Hb, RBC, HCT, iron metabolism indexes and MAP levels between the two groups (P>0.05). After 1 month and 3, 6 months of treatment, the Hb, RBC, HCT and iron metabolism indexes in the treatment group were significantly higher than those in the control group, the differences were statistically significant (P<0.05), but there was no statistical difference between the two groups in MAP (P>0.05). Conclusion: Roxadustat Capsules is effective in the treatment of renal anemia in maintenance hemodialysis patients, and it is helpful to improve the biochemical indexes of patients, so it has high clinical application value.

2023 Vol. 20　(7):　11-14 [Abstract]（ 248 ） HTML (1 KB)  PDF  (951 KB)  ( 133 )

Objective: To explore the clinical value of uterine artery pulsatility index (PI) combined with fetal hemodynamic parameters in predicting severe preeclampsia in early pregnancy. Method: The clinical data of 104 pregnant women with regular prenatal examination and delivery in Gao'an Maternal and Child Health Hospital from January 2020 to May 2022 were retrospectively analyzed. 52 patients with severe pre-eclampsia were taken as the observation group, and 52 pregnant women with normal prenatal examination were taken as the control group. The uterine artery PI, umbilical artery PI, resistance index (RI), ratio of systolic peak velocity to diastolic velocity (S/D),

2023 Vol. 20　(7):　19-23 [Abstract]（ 155 ） HTML (1 KB)  PDF  (1251 KB)  ( 28 )

Objective: To investigate the clinical effect of ultrasound-guided cervical nerve root block (CNRB) in the treatment of acute herpes zoster neuralgia (HZN). Method: A total of 60 inpatients with acute HZN from July 2020 to June 2022 in Leping Tianhu Hospital were selected as observation subjects and divided into a medication group and a CNRB group according to the random number table method, with 30 cases in each group. The medication group was given medication, and the CNRB group was given ultrasound-guided CNRB treatment on the basis of medication. The curative effect, serum pain substances, complications and incidence of post-herpetic neuralgia (PHN) were compared between the two groups. Result: The total effective rate of 93.33% in the CNRB group was higher than 73.33% in the medication group (P<0.05). After the treatment, the levels of serum substance P (SP) and tumor necrosis factor-α (TNF-α) in the CNRB group were lower than those in the medication group (P<0.05). The complication rates of the CNRB group and the medication group respectively was 16.67%, 13.33%, there was no significant difference between the two groups (P>0.05). The patients were followed up for three months and found that the incidence of PHN in the CNRB group and the medication group respectively was 3.33% and 13.33%, there was no significant difference between the two groups (P>0.05). Conclusion: Ultrasound-guided CNRB combined with medication has a significant effect in the treatment of acute HZN, which can reduce the level of pain substances and relieve the pain symptoms of patients, with few complications and high safety, but it has no obvious effect in reducing the incidence of PHN in the near future.

2023 Vol. 20　(7):　28-32 [Abstract]（ 172 ） HTML (1 KB)  PDF  (981 KB)  ( 68 )

Objective: To compare and analyze the effects of nasal vestibular cyst uncovering, labial sulcus approach nasal vestibular cyst resection and temperature-controlled ablation radio-frequency coblation in the treatment of nasal vestibular cyst. Method: A total of 90 patients with nasal vestibular cyst who were admitted to the Sixth Affiliated Hospital of South China University of Technology from January 2018 to June 2022 were selected and divided into group A, B and C by random number table method. group A was treated with nasal vestibular cyst uncovering, group B was treated with labial sulcus approach nasal vestibular cyst resection, and group C was treated with temperature-controlled ablation radio-frequency coblation. The operation indicators, postoperative recovery indicators, complication rates and recurrence rates were compared among the three groups. Result: The operation time and intraoperative bleeding volume in the group A, C were better than those in the group B (P<0.05), but there were no statistical differences between the above indexes in group A and C (P>0.05). The incision healing time and hospitalization time in the group A, C were shorter than those in the group B (P<0.05), but there were no significant differences in incision healing time and hospitalization time between group A and C (P>0.05). The complication rates and recurrence rates in the group A, C were significantly lower than those in the group B (P<0.05), but there were no significant differences between between group A and C (P>0.05). Conclusion: Nasal vestibular cyst uncovering and temperature-controlled ablation radio-frequency coblation in the treatment of nasal vestibular cyst are both effective and have similar effects. However, considering the higher cost of the cryogenic plasma ablation instrument, which is not conducive to the promotion in primary hospitals, nasal vestibular cyst uncovering can be taken as the preferred treatment.

2023 Vol. 20　(7):　38-41 [Abstract]（ 132 ） HTML (1 KB)  PDF  (1003 KB)  ( 154 )

Objective: To investigate the effect of Labetalol combined with Aspirin in the treatment of preeclampsia and its influence on vascular endothelial function. Method: A total of 60 preeclampsia patients admitted to Ganzhou People's Hospital from August to December 2021 were selected, they were divided into control group (Aspirin) and observation group (Labetalol + Aspirin) according to different medication methods, with 30 cases in each group. Blood pressure, urinary protein, vascular endothelial function, adverse reactions and pregnancy outcomes were compared. Result: After 2 weeks of treatment, the levels of systolic blood pressure, diastolic blood pressure, urinary protein, endothelin (ET-1) and nitric oxide (NO) in both groups were better than those before treatment, and those in the observation group were better than those in the control group (P<0.05). There were no significant difference in the incidence of adverse reactions, adverse pregnancy outcomes and cesarean section between the two groups (P>0.05). Conclusion: The treatment of preeclampsia with Labetalol combined with Aspirin is beneficial to reduce blood pressure and urinary protein levels, promote the recovery of vascular endothelial function, with high safety.

2023 Vol. 20　(7):　46-49 [Abstract]（ 224 ） HTML (1 KB)  PDF  (991 KB)  ( 75 )

Objective: To explore the influence of Sevoflurane for blood indexes of postoperative inflammatory stress and cognitive state of elderly patients with abdominal surgery. Method: A total of 80 elderly patients with abdominal surgery in Nanjing Meishan Hospital from December 2019 to December 2020 were chosen as the research object, and they were divided into control group and observation group with 40 cases in each group. The control group was treated with Propofol, the observation group was treated with Sevoflurane. Then the cognitive state (MMSE score) at 1st and 7th day after operation, serum inflammatory stress indexes [interleukin-1β (IL-1β) and interleukin-6 (IL-16)] and cognitive state related indexes [Tau protein (Tau), neuron specific enolase (NSE) and S100B protein (S100B)] before the operation and at 1st, 3rd and 7th day after the operation of two groups were compared. Result: The MMSE scores showed that the total incidences of cognitive dysfunction in the observation group were lower than those in the control group at 1 d and 7 d after operation, the differences were statistically significant (P<0.05), the serum inflammatory stress indexes and cognitive state related indexes of two groups before operation were compared, the differences were not statistically significant (P>0.05), those serum inflammatory stress indexes and cognitive state related indexes of observation group at 1st, 3rd and 7th day after the operation were significantly lower than those of control group, the differences were statistically significant (P<0.05). Conclusion: The Sevoflurane can significantly control the blood indexes of postoperative inflammatory stress and cognitive state of elderly patients with abdominal surgery, so it is helpful for patients to recover after operation.

2023 Vol. 20　(7):　54-57 [Abstract]（ 120 ） HTML (1 KB)  PDF  (1070 KB)  ( 221 )

Objective: To compare and analyze the application effect of loop electrosurgical excisional procedure (LEEP) and common electrosurgical knife conization (EKC) in patients with high-grade cervical intraepithelial neoplasia (CIN). Method: A prospective randomized controlled study was used in this study, 84 cases of high-grade CIN patients admitted to the Zhangshu Third People's Hospital from January 2018 to June 2021 were selected, they were divided into LEEP group (received LEEP treatment) and EKC group (received EKC treatment) by random number table method, with 42 cases in each group. The general data, operation time, intraoperative blood loss, conization height, conization area and the status of incision margin were compared between the two groups; human papillomavirus (HPV) infection, lesion residual, recurrence and complications were compared between the two groups. Result: There were no significant differences in operation time and intraoperative blood loss between the two groups (P>0.05). The cone-cutting area in LEEP group was lower than that in EKC group, and the cone-cutting height in LEEP group was lower than that in EKC group, the differences were statistically significant (P<0.05). The positive rate of incisal margin in LEEP group was higher than that in EKC group, the difference was statistically significant (P<0.05). Before operation, there was no significant difference in HPV infection rate between the two groups (P>0.05). After 6 months of operation, the infection rate of HPV in both groups were lower than those before operation, the differences were statistically significant (P<0.05). However, there was no significant difference in HPV infection rate between the two groups after 6 months of operation (P>0.05). There was no significant difference in lesion residual rate between the two groups (P>0.05). The recurrence rate in LEEP group was higher than that in EKC group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: The operation time and intraoperative bleeding volume of LEEP and EKC in the treatment of high-grade CIN are similar, but EKC has more advantages in maintaining the cutting depth, removing the focus and reducing the positive rate of the cutting edge, and LEEP and EKC have better safety in the treatment of high-grade CIN.

2023 Vol. 20　(7):　62-66 [Abstract]（ 143 ） HTML (1 KB)  PDF  (1068 KB)  ( 65 )

Objective: To investigate the effect of Triptorelin Acetate combined with laparoscopic surgery in the treatment of endometriosis and its influence on inflammatory factors. Method: A total of 98 patients with endometriosis from October 2016 to April 2022 in Rushan Hospital of Traditional Chinese Medicine were selected and divided into a control group (n=49) and an observation group (n=49) using the random number table method. The control group received laparoscopic surgery, and the observation group received Triptorelin Acetate combined with laparoscopic surgery. The oxidative stress state [reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px)], ovarian function indexes [follicle stimulating hormone (FSH), estradiol (E2)], pain symptom scores (dyspareunia, pelvic pain) and inflammatory factor indexes [tumor necrosis factor-α (TNF-α) and recurrence rate were compared between the two groups. Result: Before treatment, there were no significant differences in the levels of POS, MDA, SOD, GSH-Px, FSH, E2, TNF-α, IL-18, VEGF, and the scores of dyspareunia and pelvic pain between the two groups (P>0.05). After treatment, POS, MDA, FSH, E2, TNF-α, IL-18 and VEGF in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, SOD and GSH-Px were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). The recurrence rate in the observation group (2.04%) was lower than that in the control group (20.41%) (P<0.05). Conclusion: Patients with endometriosis receiving Triptorelin Acetate combined with laparoscopic surgery can reduce the level of oxidative stress, improve ovarian function, reduce the degree of pain and inflammatory factor levels, and the recurrence rate is low.

2023 Vol. 20　(7):　71-75 [Abstract]（ 173 ） HTML (1 KB)  PDF  (1181 KB)  ( 42 )

Objective: To investigate and analyze the residents and common pathogenic factors of diabetes in Anningqu Town, Urumqi city, Xinjiang Uygur Autonomous Region, and lay a foundation for diabetes prevention and intervention in agricultural and pastoral areas. Method: From March to October 2015, a total of 3 519 people living in Anningqu Town of Urumqi for health checkup were selected as the subjects. According to the National Basic Public Health Standards (2011 edition), the unified personal information table was used for the cross-sectional survey. The epidemiological study method and multi-stage stratified random sampling method were used to investigate the prevalence of diabetes in local residents. Regression analysis was used to explore the risk factors of diabetes. Result: The number of diabetes patients among the 3 519 residents was 519 cases, accounting for 14.75% of the total population. Statistical analysis of the basic information of all patients showed that there were no significant differences in the prevalence of diabetes among different genders, nationalities, BMI, central obesity, physical exercise adherence, smoking, meat and vegetable intake, and high total cholesterol and low density lipoprotein (P>0.05). The incidences of diabetes in patients with age 51-59 years and 60-69 years, salt addiction, sugar addiction, drinking and high triglyceride were higher, the differences were statistically significant (P<0.05). According to the results of multivariate logistic regression analysis, the risk factors of diabetes patients were age, drinking, salt addiction, sugar addiction and high triglycerides (P<0.05). Conclusion: The prevalence of diabetes mellitus in the residents of Anningqu Town of Urumqi is higher than the national level. Age, salt, sugar, alcohol and high triglyceride are the risk factors for diabetes mellitus in Anningqu Town. Therefore, the township health centers of the region should standardize the management of the above pathogenic factors, so as to effectively prevent and control the prevalence of diabetes mellitus in the town residents.

2023 Vol. 20　(7):　79-83 [Abstract]（ 244 ） HTML (1 KB)  PDF  (1217 KB)  ( 113 )

Objective: To explore and analyze the evaluation of the effect of home-based self-management under the health belief model after modified Bacon surgery in patients with middle and low rectal cancer. Method: A total of 120 patients with rectal cancer who received modified Bacon surgery and were treated in Jiangxi Cancer Hospital from May 2018 to February 2021 were selected, they were divided into the control group and the observation group by random number table method, with 60 cases in each group, excluding those who dropped out or discontinued the study, transferred to a hospital, or had missing clinical data, a total of 111 patients were included in the final study there were 53 cases in the control group and 58 cases in the observation group. The control group was given routine management, and the observation group was given home-based self-management under the health belief model. Self-care ability scores, health belief scores, complication rate and satisfaction were compared between the two groups. Result: After management, the scores of self-concept, self-care skills, health knowledge level and sense of self-care in the observation group were higher than those in the control group, and the scores of health motivation, benefits, self-efficacy, susceptibility, severity and disorder were higher than those in the control group, the differences were statistically significant (P<0.05). The complication rate in the observation group was lower than that in the control group, and the satisfaction rate was higher, the differences were statistically significant (P<0.05). Conclusion: The application of home-based self-management under the health belief model to the modified Bacon surgery for the treatment of cancer patients significantly improves the patients' self-care ability, improves their health behaviors and health beliefs, and reduces the incidence of complications, overall satisfaction is high.

2023 Vol. 20　(7):　89-93 [Abstract]（ 179 ） HTML (1 KB)  PDF  (1236 KB)  ( 159 )

Objective: To analyze the effect of Orem self-care model combined with enteral nutrition support on intestinal mucosal barrier function in elderly patients with esophageal cancer undergoing chemotherapy. Method: A total of 110 patients with advanced esophageal cancer treated in the Hongda Hospital of Jiamusi University from February 2019 to February 2021 were selected and divided into control group and study group according to different intervention methods. The control group was given simple enteral nutrition intervention, and the study group was given Orem self-care model based on the control group. The changes of self-care ability, quality of life, nutritional indexes, intestinal mucosal barrier function indexes and complications were compared between the two groups. Result: After the intervention, the scores of self-care ability and quality of life in the two groups increased, and the scores of self-care ability and quality of life in the study group were higher than those in the control group (P<0.05); after the intervention, the levels of serum ALB, PA and TF decreased and the levels of ET, DAO and DLA increased in the two groups. Compared with the control group, the levels of serum ALB, PA and TF in the study group were higher and the levels of ET, DAO and DLA were lower (P<0.05). The incidences of adverse reactions in the two groups were 14.55% and 3.64% respectively, the difference was statistically significant (P<0.05). Conclusion: Orem self-care mode combined with enteral nutrition can effectively improve the intestinal mucosal barrier function and prognosis of patients with advanced esophageal cancer after chemotherapy, with less adverse reactions.

2023 Vol. 20　(7):　98-102 [Abstract]（ 99 ） HTML (1 KB)  PDF  (1317 KB)  ( 169 )

Objective: To explore the clinical effect of Kuntai Capsules on menopausal syndrome after endometrial carcinoma surgery. Method: A total of 94 patients with menopausal syndrome after endometrial carcinoma radical surgery who visited the Gynaecology Clinic of Qingyuan People's Hospital from January 2021 to May 2022 were selected and divided into two groups according to the random number table method, with 47 cases in each group. The control group was given general treatment, and the observation group was treated with Kuntai Capsules on the basis of the control group. The clinical effects, symptom improvement, sleep quality, life quality, neuro-endocrine indexes changes and adverse reactions were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group (P<0.05). After 4, 8 and 12 weeks of treatment, the Kupperman menopausal index (KMI), menopause-specific quality of life questionnaire (MENQOL) and Pittsburgh sleep quality index (PSQI) in the observation group were lower than those in the control group, while the levels of 5-hydroxytryptamine (5-HT) and β-endorphin (β-EP) were higher than those in the control group (P<0.05). There were no significant differences in the levels of estradiol (E2) and follicle stimulating hormone (FSH) between the two groups before and after treatment (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Kuntai Capsules has achieved good results in the treatment of menopausal syndrome after endometrial carcinoma surgery, and the clinical symptoms of patients have been significantly alleviated, and the neuroendocrine function has been significantly improved, which has high clinical significance.

2023 Vol. 20　(7):　107-111 [Abstract]（ 185 ） HTML (1 KB)  PDF  (1229 KB)  ( 214 )

Objective: To observe the clinical effect of Pinggan Ningxin massage combined with sensory integration in the treatment of children with tic disorder (TD). Method: A total of 60 children with TD who were admitted to the Department of Traditional Chinese Medicine Pediatrics and Rehabilitation of Baogang Hospital of Inner Mongolia from April 2019 to May 2020 were divided into a control group and an observation group according to random number table method, with 30 cases in each group. The control group was treated with Tiapride Hydrochloride Tablets, and the observation group was treated with Pinggan Ningxin massage combined with sensory integration. Yale globle tic severity scale (YGTSS) and TCM symptom scores were used to evaluate the condition of children before and after treatment, and the curative effects of the two groups were compared. Result: The total effective rate in the observation group was 90.00%, which was higher than 56.67% in the control group (P<0.05). After treatment, the motor twitch, vocal twitch, overall injury scores, total scores of YGTSS and TCM symptom scores of the two groups were lower than those before treatment, and the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). Conclusion: Pinggan Ningxin massage combined with sensory integration has good clinical effect on children with TD, and it is worthy of clinical application.

2023 Vol. 20　(7):　117-121 [Abstract]（ 145 ） HTML (1 KB)  PDF  (1255 KB)  ( 40 )

Objective: To investigate the clinical effect of irritable bowel syndrome (constipation type) of Deficiency of lung-spleen Qi with Huangqi Decoction and Shenling Baizhu Powder. Method: From January 2021 to January 2022, 72 patients with irritable bowel syndrome (constipation type) of deficiency of lung-spleen Qi were selected from the Second Affiliated Hospital of Hunan University of Chinese Medicine, 72 patients were randomly divided into treatment group and control group with 36 cases each. The treatment group was given Huangqi Decoction and Shenling Baizhu Powder, two times a day, one dose each time. The control group was given Linaclotide Capsules, and one capsule was taken 30 minutes before the first meal every day. Both groups were treated continuously for 4 weeks and followed up 4 weeks after drug withdrawal. The main symptom scores and quality of life scores of the two groups before and after treatment were observed, and the clinical efficacy of the two groups was evaluated. Result: Compared with the scores before treatment, the scores of abdominal pain discomfort, the average number of abdominal pain episodes within 10 days, abdominal distension at the time of assessment, stool satisfaction and life distress in the two groups decreased significantly after treatment (P<0.05), the quality of life score decreased significantly (P<0.05). After treatment, the scores of symptoms and quality of life in the treatment group were lower than those in the control group (P<0.05). The total effective rate was 94.4% (34/36) in the treatment group and 72.2% (26/36) in the control group. The treatment group was significantly better than the control group (P<0.01). Conclusion: Huangqi Decoction and Shenling Baizhu Powder can improve the main symptoms of patients with irritable bowel syndrome (constipation type) of Deficiency of lung-spleen Qi, improve their quality of life, and has satisfactory clinical efficacy, which is worth promoting.

2023 Vol. 20　(7):　126-130 [Abstract]（ 196 ） HTML (1 KB)  PDF  (1265 KB)  ( 181 )

Objective: To explore the clinical effect of acupoint catgut embedding treated by winter disease summer treatment of traditional medicine on stable chronic obstructive pulmonary disease (COPD) with lung and kidney qi deficiency. Method: A total of 84 COPD patients treated in the Department of Pulmonary Diseases of Guigang Hospital of Traditional Chinese Medicine from July 2018 to August 2019 were selected, they were divided into control group and traditional Chinese medicine group according to the random number table method, with 42 cases in each group. The control group was treated with basic drug therapy + exercise lifestyle intervention, and the traditional Chinese medicine group was treated with acupoint catgut embedding for winter disease summer treatment on the basis of the control group. The treatment course was 3 years. The peripheral blood T lymphocytes, serum immunoglobulin, pulmonary function parameters [peak expiratory flow (PEF), percentage of forced expiratory volume in the first second to expected value (FEV1%pred), ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC%)], 6 min walking distance and the total effective rate of the two groups were compared before and after the treatment. Result: 2 cases were shed in each group, and 40 patients were eventually included in each group. Before treatment, there were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+ between the two groups (P>0.05); compared with those before treatment, CD3+, CD4+ and CD4+/CD8+ in the traditional Chinese medicine group after treatment were higher, while CD8+ was lower, CD3+, CD4+ and CD4+/CD8+ in the traditional Chinese medicine group were higher than those in the control group, and CD8+ was lower than that in the control group (P<0.05). After treatment, CD4+/CD8+ in control group was higher than that before treatment, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in serum IgA, IgG, IgM and IgE levels between the two groups (P>0.05); compared with those before treatment, IgA levels were higher and IgE levels were lower in both groups after treatment, serum IgA and IgG levels in the traditional Chinese medicine group were higher than those in the control group, while IgE levels were lower (P<0.05). After treatment, there was no significant difference in IgM between the two groups (P>0.05). After treatment, IgG in traditional Chinese medicine group was higher than that before treatment, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in PEF, FEV1%pred, FEV1/FVC% between the two groups (P>0.05); compared with those before treatment, the PEF and FEV1/FVC% levels in the traditional Chinese medicine group after treatment were higher than those before treatment, those in the traditional Chinese medicine group were higher than those in the control group (P<0.05). After treatment, FEV1%pred in both groups were higher than those before treatment, the differences were statistically significant (P<0.05). After treatment, there was no significant difference in FEV1%pred between the two groups (P>0.05). Before treatment, there was no significant difference in 6 min walking distance between the two groups (P>0.05); compared with those before treatment, the 6 min walking distance after treatment were longer in both groups, that in the traditional Chinese medicine group was longer than that in the control group (P<0.05). The total effective rate in traditional Chinese medicine group was higher than that in control group (P<0.05). Conclusion: Acupoint catgut embedding treated by winter disease summer treatment of traditional medicine in the treatment of stable chronic obstructive pulmonary disease can improve immune function and lung function, which is of obvious value for improving the therapeutic effect.

2023 Vol. 20　(7):　135-140 [Abstract]（ 181 ） HTML (1 KB)  PDF  (1459 KB)  ( 77 )

Objective: To explore the effect of Weisu Granules on inflammatory factors and gastric mucosal protective function in elderly patients with chronic gastritis. Method: A total of 200 elderly patients with chronic gastritis who were admitted to the Meishan Branch of Nan'an General hospital from February 2019 to February 2021 were selected as the research subjects, and they were divided into a research group and a control group according to the random number table method, with 100 cases in each group. The control group was given routine triple therapy, and the research group was given Weisu Granules on the basis of the control group. The indexes of inflammatory factors, gastric mucosal protective function and clinical efficacy were observed and compared between the two groups. Result: Before treatment, there were no significant differences between the two groups in the indexes of inflammatory factors and gastric mucosal protective function (P>0.05). After treatment, the indexes of inflammatory factors and gastric mucosal protective function in the research group were better than those in the control group, the differences were statistically significant (P<0.05). The total effective rate of the research group was 94.00%, which was higher than 72.00% of the control group, the difference was statistically significant (P<0.05). Conclusion: The treatment of elderly chronic gastritis with Weisu Granules can effectively improve the inflammatory state of patients, improve the gastric mucosal protective function and clinical efficacy, which is one of the ideal schemes in clinical treatment practice.

2023 Vol. 20　(7):　145-148 [Abstract]（ 223 ） HTML (1 KB)  PDF  (1316 KB)  ( 36 )

Objective: To investigate the current status of acute ST-segment elevation myocardial infarction (STEMI) in different age groups after the establishment of a region chest pain center. Method: A total of 275 patients with acute STEMI were enrolled in Anning First People's Hospital from January 2017 to December 2020. According to the age, the subjects were divided into the young group, the middle-aged group, and the elderly group. The general information, ways of coming to the hospital, symptom onset-to-first medical contact (S2FMC) time, treatment plan, double bypass, door-to-balloon (D2B) time, angiography results, reasons for reperfusion delay, prisoners' blood vessels and blood flow information were collected. Statistical methods were used to analyze and describe the current situation of reperfusion treatment at different age groups and its influencing factors in chest pain centers in counties. Result: (1) STEMI patients were most commonly elderly and male patients. (2) Patients came to the hospital by themselves, network hospital transfer, 120 call and in-hospital onset, and the difference in the mode of arrival between different groups was not statistically significant (P>0.05). (3) The differences in double bypass, treatment plan, offender vessel and blood flow information between different groups were not statistically significant (P>0.05). (4) All enrolled The shortest visit time after onset was 13 min and the longest was 1 956 min. 235 patients were seen within 12 h. More patients in the youth group had S2FMC time >12 h than in the middle-aged and elderly group had S2FMC. (5) The median D2B of STEMI patients was 82.10 min, and the main reasons for delayed reperfusion included: family non-arrival, long informed consent time, intraoperative complications delay, delayed preoperative complications and delayed physician decision making, and the differences in the distribution of D2B time among different groups of patients were not statistically significant (P>0.05). Conclusion: The duration of S2FMC is significantly longer in young STEMI patients than in the middle and old age groups, suggesting that patients in the old age group were better educated about myocardial diseases. The next step is not only to actively strengthen community education, but also to expand the scope of education and promote it among the young population.

2023 Vol. 20　(7):　153-157 [Abstract]（ 176 ） HTML (1 KB)  PDF  (1464 KB)  ( 58 )

Objective: To systematically evaluate the main risk factors of acute myocardial infarction in young adults, and to provide evidence for preventive decision-making. Method: PubMed, Embase, Web of Science, Cochrane, Library, Wanfang Data, China National Knowledge Network (CNKI), VIP, and China Biomedical Literature Database (CBM) were searched for all literatures from the date of database establishment to April 2022, comprehensively collect all case-control studies related to risk factors for acute myocardial infarction in young adults. The data were initially screened and independently extracted by two evaluators, and the methodological quality was evaluated. For the research that meets the requirements, RevMan 5.3 and Stata 14.0 statistical software are used to analyze the extracted relevant data. Result: A total of 7 case-control studies were included, including 1 061 cases in the case group and 1 627 cases in the control group. The results of meta-analysis showed that smoking [OR=2.40, 95%CI (1.84, 3.13)], family history of cardiovascular disease [OR=1.97, 95%CI (1.53, 2.55)], hyperlipidemia [OR=1.79, 95%CI (1.52, 2.12)], hypertension [OR=2.17, 95%CI (1.61, 2.92)], diabetes mellitus [OR=1.99, 95%CI (1.11, 3.56)] were associated with acute myocardial infarction in young adults. Conclusion: Smoking, family history of cardiovascular disease, hyperlipidemia, hypertension and diabetes are risk factors for acute myocardial infarction in young adults.

2023 Vol. 20　(7):　162-167 [Abstract]（ 209 ） HTML (1 KB)  PDF  (2259 KB)  ( 100 )

Metabolomics is a new emerging biological detection technology that can describe the biological phenotype and comprehensively analyze metabolites. It has been widely used in basic and clinical research because it can visually reflect the physiological or pathological conditions of the body. In recent years, with the continuous improvement of neonatal survival rate, paying attention to the short-term and long-term healthy life of neonates has become a hot research topic for pediatricians. This paper reviews the application of metabolomics in prenatal diagnosis, prediction of neonatal premature birth, growth and development, nutritional strategies and early recognition, diagnosis, and efficacy evaluation of common neonatal diseases, in order to provide a theoretical basis for the guidance of neonatal nutritional strategies and disease prevention and treatment.

2023 Vol. 20　(7):　172-177 [Abstract]（ 203 ） HTML (1 KB)  PDF  (1496 KB)  ( 110 )

Colorectal cancer has a high incidence of perioperative hypoproteinemia, which easily leads to decreased plasma colloid osmotic pressure, decreased tissue perfusion, infection, increased incidence of postoperative anastomotic leakage, and even causes serious complications such as acute kidney injury. There are many reasons of hypoproteinemia after colorectal cancer surgery. For the treatment of hypoproteinemia, careful albumin supplementation, nutritional risk screening and nutritional assessment, preoperative nutritional support for high-risk patients and early postoperative enteral nutrition program can effectively improve the postoperative albumin level, reduce the occurrence of complications and significantly improve the prognosis of patients. In addition, reasonable drugs, anesthesia and surgical selection can reduce the release of inflammatory factors, reduce stress response, reduce capillary permeability, and then reduce albumin leakage, which is an effective measure to prevent and treat hypoproteinemia after colorectal cancer surgery.

2023 Vol. 20　(7):　182-188 [Abstract]（ 235 ） HTML (1 KB)  PDF  (1662 KB)  ( 79 )