Objective：To explore the expression and correlation of RhoE and EGFR in esophageal squamous cell carcinoma， and analyze its clinical significance.Method：59 patients with esophageal carcinoma were collect from the in our hospital from Jan 2011 to Jan 2012. The method of RT-PCR was used to examine the expressions of RhoE and EGFR in esophageal carcinoma and normal esophageal tissues. The results and other relevant clinical parameters were used for statistical analysis.Result：（1）The relative expression of EGFR in esophageal squamous cell carcinoma and normal esophageal tissues were（ 0.581±0.174） and（ 0.347±0.136），the difference between them was significant （P<0.05）.（2）The relative expression of RhoE in esophageal squamous cell carcinoma and normal esophageal tissues were（ 0.346±0.241） and（ 0.673±0.142）， the difference between them was significant（ P<0.05）.（3）The expressions of them were closely related to expression of tumor pathological staging， differentiation degree， lymph metastasis and high tumor infiltration（ P<0.001），but had no relationship with other factors such as tumor type， size and location （P<0.01）.（4）It had a negative correlation between the expression of RhoE and EGFR in esophageal squamous cell carcinoma（ P<0.01）.Conclusion：The expression level of EGFR gene in esophageal squamous cell carcinoma is higher，while the RhoE expression level is lower； it has a negative correlation between them. The expressions of them have a closely relationship with the expression of tumor pathological staging， differentiation degree， lymph metastasis and high tumor infiltration.Thus，it can be seen that，the expressions of RhoE and EGFR plays a vital role in the occurrence and development of esophageal squamous cell carcinoma. Testing the expressions of esophageal squamous cell carcinoma tissue will help us to evaluate the prognosis.

2015 Vol. 12　(6):　5-8 [Abstract]（ 568 ） HTML (1 KB)  PDF  (718 KB)  ( 177 )

Objective：To discuss the effect on nucleus pulposus cells morphology about the tensile experiment by using the degenerative nucleus pulposus cells.To provide the oretical basis for the traction treatment of lumbar disc prolapse.Method：The nucleus pulposus specimens were collected from patients with intervertebral disc protrusion， who were all volunteers.Nucleus pulposus cells were inoculated the cultured into the BioFlex culture plate.The morphological changes of the cells were observed at high magnification after stretched for twenty-four hours with the tensile range of 5%，10% and 15%. The patient was given the lumber traction by using 20%， 30% and 35% of his body weight and the patient，s lumbar lateral radiographs were shot before and after traction. The changes of intervertebral space height were measured and calculated.Result：For the morphology of the degenerative nucleus pulposus cells，it improved mildly under the tensile range of 5%，it was close to normal nucleus pulposus cells under the tensile range of 10% and it deteriorated under the tensile range of 15% after twenty-four hours.There was significant difference between the number of cells（P<0.05）.The number of cells showed that 10% tensile range group>5% tensile range group>the control group>15% tensile range group.Compared with the increasing range of intervertebral space before and after traction，there was significant difference （P<0.05）.The increasing range of intervertebral space showed that 20% weight group<30% weight group<35% weight group.Conclusion：The restoration of degenerative nucleus pulposus cells is slow by using the tensile range of 5%.It is no good for the restoration of degenerated nucleus pulposus cells by using the tensile range of 15%.The restoration of degenerative nucleus pulposus cells is fast by using the tensile range of 10%.It is suitable for the patients with lumbar disc herniation by using the weight of 30% of their body weight.

2015 Vol. 12　(6):　12-15 [Abstract]（ 361 ） HTML (1 KB)  PDF  (723 KB)  ( 188 )

Objective：To observe the effect of insulin Determir combined with miglitol in treatment of secondary failure-to sulfonylureas in type 2 diabetes mellitus.Method：72 cases were randomly divided into group A and group B，36 cases of each group.The group A was treated with insulin Determir combined with Miglitol， while group B was given subcutaneous injection of insulin Aspart 30R.Both groups were treated for 12 weeks. The fasting plasma glucose（FBG），2-hour postprandial plasma glucose（2 h PG），glycosylated hemoglobin（HbAlc）， the control rate and incidence of low blood glucose before and after treatment of the two groups were compared.Result：After treatment， the FBG， 2 h PG and HbAlc of two groups were remarkably decreased，and the differences were statistically significant（P<0.05）. But there were no statistical significance between two groups after treatment（P>0.05）.And in the A group ，the rate of hypoglycemia was lower than in B group（P<0.05）.Conclusion：Insulin Determir combined with Miglitol is convenient，safe and effective with secondary failure of Sulphonylureas in type 2 diabetes mellitus.

2015 Vol. 12　(6):　20-22 [Abstract]（ 651 ） HTML (1 KB)  PDF  (683 KB)  ( 138 )

Objective：To explore the histopathologic and histochemistic changes of amniotic membrane and placenta with oligohydramnios in term pregnancy.Method：Amniotic membrane and placenta with normal amount amniotic fluid and oligohydramnios 15 cases in each group.The martial undergone fixation with 10% formaldehyde and routine paraffin section， HE staining and AB-PAS reaction.The slices were observed under light microscope and some index of the morphomatry acquired.Result：The amniotic cells of oligohydramnios became shriek and vesicle， even stratified metaplasia， PAS granules were reduced in their cytoplasm.Syncytail knots increased.AB-PAS reaction became weaken because of glycogen granules in cytoplasm were rare， the basement membrane of the capillaries at the villi became vary thinker， all these changes point on aging and disfunction.Conclusion：The histopathologic changes and glycogen reduce in amniotic cells， and number of syncytail knot raise， thinker vasculosyncytial membrane and rare glycogen et al in placenta villi take part in the pathological and physiological process of the oligohydramnios.

2015 Vol. 12　(6):　26-29 [Abstract]（ 578 ） HTML (1 KB)  PDF  (752 KB)  ( 156 )

Objective： To analyze the serum progesterone testing and adjustment in the value of clinical diagnosis and treatment of ectopic pregnancy. Method： 80 cases of ectopic pregnancy were selected from January 2012 to June 2014 and randomly divided into the experimental group and control group，40 cases in each group，at the same time 40 cases of normal pregnancy were selected as the normal group.The control group was treated with serum β-HCG detection and analysis and guided further treatment，the experimental group was detection and analysis on the basis of combined progesterone and guided subsequent treatment work. Two groups diagnostic accuracy，diagnostic time and the treatment outcome were compared， the test results of experimental group and normal group were compared.Result： The patients with ectopic pregnancy progesterone average detection level were（ 3.49±1.02）ng/mL，significantly lower than normal pregnancy progesterone levels，the difference was statistically significant（P<0.05）. Accurately diagnosed the experimental group was 97.5%，significantly higher than control group； the time of diagnosis（ 24.92±2.08）d，shorter than the control group，the difference was statistically significant（P<0.05）.After treatment the mean progesterone levels in the experimental group was（ 7.98±1.28）ng/mL，better than before treatment，the difference was statistically significant（ P<0.05）.After treatment，the experimental treatment group blood β-hCG was（ 2616.12±52.81）IU/L，better than the control group；repeating the treatment rate was lower than in the control group，pregnancy and bleeding mass diameter was less than the control group，the differences were statistically significant（P<0.05）.Experimental group were very satisfied with the clinical services in 28 cases，12 cases of satisfaction，overall satisfaction，100% higher than the control group， the difference was statistically significant（P<0.05）.Conclusion： Conventional testing methods combined progesterone analysis helps to quickly and accurately detect and diagnose an ectopic pregnancy carry out active and effective treatment，gets satisfactory clinical results.

2015 Vol. 12　(6):　32-35 [Abstract]（ 633 ） HTML (1 KB)  PDF  (704 KB)  ( 378 )

Objective：To investigate the therapeutic effect of combination of peritoneal dialysis and hemodialysis for end-stage renal disease.Method： 90 patients of end-stage renal disease were selected in our hospital as the research object from May 2012 to May 2014 and divided into three groups，combination group，peritoneal dialysis group and hemodialysis group， 30 cases in each group. One year follow-up，the three groups of patients’ complications ，biochemical indexes during hospitalization，and statistics of all patients with in one year survival rate and cause of death were observed， according to the quality of life of 1.2 KDQOL-SFTM scores of quality life on the survival of patients with analysis.Result：There were not statistically significant differences between combination group and peritoneal dialysis group and hemodialysis group in serum potassium and blood glucose level（P>0.05）. The combination group of urea nitrogen and creatinine levels compared with hemodialysis group had no significant difference（P>0.05），and compared with peritoneal dialysis group significantly decreased， the difference was statistically significant（P<0.05）.Combination group of hemoglobin and albumin levels were significantly higher than that of peritoneal dialysis group and hemodialysis group， the differences were statistically significant（P< 0.05）， between peritoneal dialysis group and hemodialysis group had no significant difference（ P>0.05）.The rate of complication in the combination group was significantly less than peritoneal dialysis group and hemodialysis group，the difference was statistically significant（P< 0.05），peritoneal dialysis group complication rate was higher than the hemodialysis group， there was significant difference between two groups （P<0.05）.Combination group of the survival rate of the patients was significantly higher than that of peritoneal dialysis group and hemodialysis group， the difference was statistically significant（P<0.05）， peritoneal dialysis group of the survival rate was lower than the hemodialysis group， but the difference had no statistical significance（P>0.05）.The combination group patients symptoms and discomfort of 12 items， affect daily life of 8 items， the working condition of 2 items， 3 items of social quality， function of 2 items，social function of 2 items， the energy status of 4 items were better than peritoneal dialysis group and hemodialysis group， the differences were statistically significant（P<0.05）， in which the blood dialysis group scored higher than peritoneal dialysis group， there was not significant difference between two groups （P<0.05）. The combination group 2 scores of pain was significantly less than peritoneal dialysis group and hemodialysis group， the difference was statistically significant（P<0.05）， but between peritoneal dialysis group and hemodialysis group was no statistical significance difference（P>0.05）.Conclusion： The combination group patients can stable internal environment condition， good effect， less complications，and it is worthy of clinical application.

2015 Vol. 12　(6):　38-41 [Abstract]（ 449 ） HTML (1 KB)  PDF  (703 KB)  ( 158 )

Objective：To investigate the change of plasma osteopontin（ OPN） level before and after treatment in cervical cancer patients and in cervical cancer recurrence.Method：The plasma OPN levels of 238 cervical cancer patients before and after treatment were measured by ELISA and followed for up to 5 years. The relations of between plasma OPN level and clinical variables， recurrence were analyzed.Result：Plasma OPN levels was associated with differentiation degree and metastasis in patients with stage Ⅰb-Ⅱa cervical cancer（P<0.05）and not associated with age， clinical stage and pathological type（P>0.05）. Plasma OPN expression level decreased obviously after treatment（P<0.05）.When cervical cancer recurrence plasma OPN level was significantly higher than without recurrence（P<0.05）.Conclusion：The evaluation of plasma level of OPN may be helpful to predict the recurrence of cervical cancer patients in advance.

2015 Vol. 12　(6):　44-46 [Abstract]（ 540 ） HTML (1 KB)  PDF  (683 KB)  ( 184 )

Objective：To study the clinical value of the CT plain scan and enhanced scan is applied to cor pulmonale pulmonary hypertension.Method： 40 patients with cor pulmonale in the hospital from November 2012 to November 2013 were selected as the research object， one of the group of 20 patients with radiation chest check the radiographic inspection group， another group of 20 cases by chest CT scan and enhanced scan CT inspection group， two groups of patients were checked before and after therapy. before and after treatment the main pulmonary artery， left and right pulmonary artery diameter changes of the two groups were compared.Result：The diameter of the pulmonary artery， left and right pulmonary artery： diagnosis by radiation measurement results compared before and after the treatment lines had significant difference（ P<0.01）， but lower right pulmonary artery of stem diameter of 15 mm were 12 cases（ 60%）， show the X-ray measurement right pulmonary artery stem diameter for diagnosis of lung pulmonary hypertension was of certain clinical value， but its specificity was poor. CT plain scan and enhanced scan results all lines had significant difference （P<0.01）， in the lower right pulmonary artery all stem diameter 15 mm or higher， significantly higher than that of radiographic inspection group（ P<0.01）， and strong specificity.Conclusion：CT examination is applied to the diagnosis of pulmonary hypertension and cor pulmonale therapeutic effect evaluation of clinical value.

2015 Vol. 12　(6):　51-53 [Abstract]（ 548 ） HTML (1 KB)  PDF  (683 KB)  ( 241 )

Objective：To explore 1.5 T Whole Body Diffusion Weighted-Imaging and its clinical application value. Method：4 volunteers， 9 cancer patients and 4 health examination in our hospital were collected for 1.5 T whole body diffusion weighted imaging of volunteers， with maximum intensity projection method and anti window view， got a total body thin diffusion weighted and 3D images， and found the suspicious positive lesions to bureau of the Ministry of the conventional MRI or CT scanning， analysis and evaluation and statistics on the image.Result：16 cases got clear threedimensional images， image evaluation was 91.1%， of which 3 volunteers and 2 patients tested negative， 1 cases were detected in testicular hydrocele， 2 cases were cystic lesions， 8 cases of tumor patients with metastasis detection， the positive rate was about 68.8%， the detection of malignant the tumor was 88.9%， the diagnostic effect on tumor and normal MRI or CT consistency was good， no statistical significance（ P>0.05）.Conclusion：Magnetic resonance whole body diffusion weighted imaging with the sensitivity for detection of disease， can basically meet the clinical medical screening and diagnosis， can be used for routine physical examination，diagnosis and curative effect evaluation of malignant tumor is of high clinical value.

2015 Vol. 12　(6):　56-59 [Abstract]（ 500 ） HTML (1 KB)  PDF  (760 KB)  ( 328 )

Objective：To explore diagnostic value of nasopharyngoscope combining NMR on changes in disease conditions of patients with nasopharyngeal carcinoma， and to look for the most accurate method for the re-examination on patients.Method：80 patients with nasopharyngeal carcinoma upon radiotherapy from January 2014 to January 2015 were selected as research subjects， all patients were subjected to indirect nasopharyngeal endoscope+nasopharyngeal NMR （control group） and nasopharyngoscope+nasopharyngeal NMR examination（ observation group），the diagnostic value of changes in patients’ conditions was explored.Result：The detection rate of nasopharyngoscope+nasopharyngeal NMR examination on the change total of nasopharynx in patients was significantly higher than that of indirect nasopharyngeal endoscope+nasopharyngeal MRI， and it was better than that of indirect nasopharyngeal endoscope+nasopharyngeal MRI in the nose， sinuses and vocal cord change，the differences were statistically significant（P<0.05）.Conclusion：The re-examination of nasopharyngoscope combining nasopharyngeal NMR in patients with nasopharyngeal carcinoma after radiotherapy is capable of effectively providing quantitative and qualitative information cellular level，and sensitively identify conditions of residues of nasopharyngeal carcinoma after radiotherapy，fibrosis plaque and tumor recurrence，delivering high clinical value.

2015 Vol. 12　(6):　62-64 [Abstract]（ 585 ） HTML (1 KB)  PDF  (683 KB)  ( 265 )

Objective：To explore the application effect of comprehensive healthy transmission in oral hygiene instruction and further reduce the prevalence of gingivitis. Method：540 adult gingivitis patients were randomly selected in our center from Aug 2013 to Oct 2013. After received the same diagnosis and remedy， all participants were asked to finish a questionnaire， Meanwhile， an oral hygiene instruction was conducted among the participants through mass communication and inter-personal communication combination method. Comprehensive communicational intervention as further enhanced when participants paid return visits 3 months later. 6 months later， all participants underwent an oral check and completed the same questionnaire. We evaluated the communication effects by contrast the oral hygiene condition and awareness of each participants 6 months later to the beginning.Result： Participants gained more knowledge about gingivitis and oral hygiene after received comprehensive healthy transmission， and the compliance to the oral hygiene instruction had been significantly improved（ P<0.001）. Additionally， the dental plaque index（ PI）， gingival index （GI） and sulcus bleeding index（ SBI） were all significantly lower after the intervention（P<0.001）.Conclusion：The comprehensive healthy transmission method could effectively improve the compliance of oral hygiene instruction and may further reduce the gingivitis prevalence.

2015 Vol. 12　(6):　68-71 [Abstract]（ 507 ） HTML (1 KB)  PDF  (700 KB)  ( 173 )

Objective：To investigate the influence of postpartum continued nursing intervention on life quality of parturient.Method：120 parturient were randomly divided into study group and control group. People in control group were conducted by maternal and child health care personnel about traditional family visit. The study group on the basis of routine postpartum nursing by the research team in the maternity hospital after 7 days and 28 days postpartum visit to the new mode of continuing nursing intervention of postpartum. The quality of life of the two groups was compared.Result：The incidence of maternal postpartum depression of the control group was 15.3%， the study group was 3.27%， with significant difference （ χ²=5.17，P<0.05）. The puerperal complications rate of the study group was significantly lower than that of the control group（ χ²=16.69，P<0.01）.Conclusion：Postpartum continuity nursing intervention has a promoting effect on maternal improved quality of life.

2015 Vol. 12　(6):　75-77 [Abstract]（ 534 ） HTML (1 KB)  PDF  (680 KB)  ( 493 )

Objective：To understand the application effect of individualized psychological intervention on initial artificial abortion.Method：202 cases of proposing to artificial abortion were chosen， they were randomly divided into intervention group（ n=101） and control group（ n=101）.The control group was given routine nursing， and the intervention group was given preoperative psychological intervention， the psychological interventions included preoperative education，breathing relaxation training， music therapy.measurement SAI were repeating accepted by each group during the operation，5 minutes before the operation ，30 minutes after the operation；And the blood pressure， pulse were measured 5 minutes before the operation .Postoperative pain score was measured when the patient was fully awake.Result：the anxiety of the abortion group（ the intervention group and the control group） was significantly higher than the norm（P<0.01）.The anxiety value of the intervention group after intervention was less than the control group， postoperative pain score was significant lower than the control group（P<0.05）. The preoperative anxiety and the postoperative pain were positively correlated.Conclusion：Individualized psychological intervention has lower abortion subject anxiety level and the effect postoperative pain.

2015 Vol. 12　(6):　85-88 [Abstract]（ 492 ） HTML (1 KB)  PDF  (717 KB)  ( 174 )

Objective：To discussion the influence of contact personalized midwifery model of early maternal birth outcomes.Method： 220 cases produced by admission time primiparous women were selected in our hospital from January 2012 to September 2013，and randomly divided into experimental and control groups，110 cases in each group. The control group was treated by traditional midwifery model， the experimental group was treated by individualized midwifery model. Two groups mothers of pain， birth outcomes and family satisfaction produced were compared.Result：When the two groups of mothers produce pain， labor， neonatal apgae and family satisfaction scores were not the same， the experimental group was better than the control group， the differences were statistically significant（P<0.05）.Conclusion：Personalized mode of connection to the relative ease of midwifery can relief pain， increased family satisfaction， enhance the quality of delivery，and can be popularized in production of clinical.

2015 Vol. 12　(6):　91-92 [Abstract]（ 441 ） HTML (1 KB)  PDF  (662 KB)  ( 160 )

Objective：To investigate the influence of clinical nursing intervention on clinical curative effects in the patients with chronic gastritis.Method：70 patients with chronic gastritis treated in our hospital from Jan 2010 to June 2014 were chosen as the research subjects and randomly divided into the observation group and the control group. Two groups were all based on the holistic nursing.The control group took the conventional nursing methods. The observation group adopted the clinical nursing intervention and performed nursing care by conducting the planned，targeted and individualized nursing scheme. Treatment effect and incidence rate of complications were observed and recorded in the two groups.Result：After a period of nursing， the total effective rate of the observation group was 97.1%， which was significantly higher than 80% of the control group， the difference was statistically significant（ P<0.05）；the degree of patient satisfaction after nursing intervention was 97.1%， which was significantly higher than 85.7% of the control group， the difference was statistically significant（ P<0.05）.Conclusion：The nursing intervention can obviously improve the relationship between nurses and patients， improve the effect of clinical treatment and nursing service satisfaction， worthy of clinical popularization and application.

2015 Vol. 12　(6):　96-98 [Abstract]（ 568 ） HTML (1 KB)  PDF  (682 KB)  ( 214 )

Objective：To explore the efficacy of Huoxuetongluo method in treatment of chronic atrophic gastritis precancerous lesions.Method：80 cases of chronic atrophic gastritis were selected from our hospital from October 2012 to October 2013， they were randomly divided into observation group and control group， 40 cases in each group， observation group were treated with Huoxuetongluo treatment， the control group were treated with Weifuchun， after treatment，therapy efficacy and CEA， CA199， CA125 levels before and after treatment were compared.Result：（1）In observation group，the number of cured patients　were 22 cases（55.00%），the total efficiency was 87.50%；in control group，the number of cured　patients were 14 cases（35.00%），the total efficiency was 87.50%，the differences were statistically significant（P<0.05）；（2）Before treatment，CEA，CA199，CA125 value of observation group were respectively（34.1±4.5）μg/mL，（57.4±16.1）U/mL，（55.4±14.2）U/mL；CEA，CA199，CA125 value of contorl group were respectively（34.3±4.6）μg/mL，（58.1±8.5）U/mL，（55.6±13.4）U/mL，the difference were not statistically significant（P>0.05）.After treatment，CEA，CA199， CA125 value of observation group were respectively（5.9±1.3）μg/mL，（22.1±7.8）U/mL，（15.4±4.5）U/mL；CEA，CA199，CA125 value of contorl group were respectively（12.5±2.6）μg/mL，（36.5±6.5）U/mL，（19.6±6.2）U/mL，the differences were statistically significant（P<0.05）.Conclusion：Huoxuetongluo method has a good effect in the treatment of chronic atrophic gastritis precancerous lesions， can significantly reduce CEA， CA199， CA125 levels，has a positive effect on the prevention of precancerous lesions or partially reversed.

2015 Vol. 12　(6):　101-103 [Abstract]（ 500 ） HTML (1 KB)  PDF  (682 KB)  ( 194 )

Objective：To observe the clinical effect on postoperative patients with thyroid cancer treated mainly by strengthening body resistance and eliminating evil method.Method：67 cases with thyroid cancer took Fuzheng Xiaoying decoction for two months after receiving surgery and endocrine treatment. The change of thyroglobulin（TG）level and the main clinical symptoms of patients were observed respectively before and after treatment.Result：The rate of decrease of TG level of 67 cases was 91.04%， and the rate of remission of symptoms was 79.10%.Conclusion：The postoperative patients with thyroid cancer were accepted by adjuvant therapy of traditional Chinese medicine， the side-reaction due to endocrinotherapy of thyroid cancer of them was alleviated， and TG level of them was decreased. The clinical symptoms and quality of life of patients were improved.

2015 Vol. 12　(6):　106-108 [Abstract]（ 443 ） HTML (1 KB)  PDF  (669 KB)  ( 220 )

Through literature review， the article summarizes the effectiveness of the reform of public hospitals in Sanming of Fujian Province， the core idea of the reform， the key links of the reform， and the breakthrough on policy， so as to provide reference for the reform of public hospitals in other provinces.

2015 Vol. 12　(6):　112-114 [Abstract]（ 364 ） HTML (1 KB)  PDF  (668 KB)  ( 209 )

Objective：To research and explore the imaging features and the classification of lateral collateral ligament injury of knee joint with the use of MRI.Method：24 patients with injury of lateral collateral ligament of knee joint were chosen as the objective of study.Their injured areas were scanned with the application of MRI.Then， their imaging features were researched and analyzed.The patients were also given arthroscopy.At last， the diagnosis of MRI was compared with that of arthroscopy.At the same time， the accuracy of MRI diagnosis was calculated.Result：Through MRI，29 pieces of lateral collateral ligament injury of knee joint were detected in the 24 patients.， included three conditions，the tibial collateral ligament injuries of 20 pieces，lateral collateral ligament injury of 7 pieces and dual lateral collateral ligament injury of 2 pieces.According to injury of knee lateral collateral ligament injury class，class Ⅰ knee ligament were 16 pieces，class Ⅱ lateral collateral ligament of knee joint injury were 8 pieces，class Ⅲ the ruptured collateral ligament of the knee joint were 5 pieces.With arthroscopy result as the standard， the overall accuracy rate of MRI was 89.7%，3 pieces of ligament fiber breakage misdiagnosed as completely broken.The patients complications were joint effusion of 14 cases，meniscus injury of 4 cases， anterior cruciate ligament injury of 5 cases（ 6 pieces）， after cruciate ligament injury of 4 cases（ 6 pieces）， and fracture of 1 case.Conclusion：With good space resolution and high accuracy during the diagnosis of lateral collateral ligament injury of knee joint， MRI should be spread.

2015 Vol. 12　(6):　118-121 [Abstract]（ 566 ） HTML (1 KB)  PDF  (702 KB)  ( 288 )

Objective： To study the treatment of intramedullary nail fixed femoral shaft middle fracture effects.Method：145 cases of internal fixation failure situation bone graft were selected， The needle method， expanding intramedullary or not and fixed way were used by depending on the patient's specific conditions.Result： The operatio of different nail ways， the average blood loss and infection chance compared， the difference was statistically significant （P<0.05）；in the expansion of pulp or not， the average blood loss and fat embolism comparison difference was statistically significant（P<0.05）；fixed way without influence the fracture healing， and there was no statistically significant difference （P>0.05）. Conclusion： For midway through femoral fractures，especially comminuted fracture with intramedullary nail fixation surgery procedures is now more classic surgical internal fixation method.

2015 Vol. 12　(6):　124-127 [Abstract]（ 510 ） HTML (1 KB)  PDF  (702 KB)  ( 170 )

Objective： To investigate the effect of non-classical antipsychotic drugs on bone mineral density in male patients with schizophrenia. Method： The bone mineral density between the two groups were determinated with absorptiometry to learn bone mineral density. General situation was surveyed， combined with the general situation to analyze the related factors associated with bone density. Result： The normal BMD values in the case group and the control group was 30.00%， 81.25%， respectively， the osteoporosis in the case group and the control group was 52.50%，6.25%， respectively. There were significant differences on BMD values between the two groups（ P<0.05）. There was no difference on age， body mass index between the two groups， there were differences in smoking， milk factors（ P<0.05）.Conclusion： Compared with the healthy population， the BMD on patients with the long-term use of antipsychotic drug significantly.

2015 Vol. 12　(6):　130-132 [Abstract]（ 546 ） HTML (1 KB)  PDF  (683 KB)  ( 207 )

Objective：To analyze the effectiveness of interventional therapy for the patients with ectopic pregnancy under the ultrasound guidance.Method：53 patients with ectopic pregnancy were chosen in our hospital and divided into two groups， 26 in control group and 27 in observation group.The patients in the control group were given a single intramuscular injection of Methotrexate and 4 pieces of oral Mifepristone.The patients in the observation group were given puncture injection of Methotrexate on the gestation sac and 4 pieces of oral Mifepristone.Result：After seven - day treatment， the serum b-hCG value of the patients in the two groups declined， but it declined much more in the observation group than that in the control group.The gestation sac of the patients of both the two groups shrank.However， the efficiency of the observation group was higher than that of the control group， the contrast difference was statistically significant（P<0.05）.Conclusion：The interventional therapy effect of the ectopic pregnancy patients who are given puncture injection of Methotrexate on the gestation sac and 4 pieces of oral Mifepristone is remarkable.This therapy is saver with little harm.Thus， it should be spread.

2015 Vol. 12　(6):　135-137 [Abstract]（ 547 ） HTML (1 KB)  PDF  (683 KB)  ( 153 )

Mitochondria apoptosis pathway is a central link in the process of apoptosis ， and the releasing of cyt-c from mitochondria plays key role. The interaction of apoptosis-promoting and survival- promoting proteins of Bcl-2 protein family controls the releasing of cyt-c et al from mitochondria， and has distinctly important regulating effect on mitochondria apoptosis pathway. Apoptosis plays important role in many diseases. It is hopeful to interdict apoptosis by acting on target spots of regulating proteins of mitochondria apoptosis pathway， and accordingly treat related diseases.

2015 Vol. 12　(6):　143-146 [Abstract]（ 756 ） HTML (1 KB)  PDF  (694 KB)  ( 511 )

The incidence of brain metastases is exceedingly rare in pediatric patients. The prognosis of pediatric brain metastases is poor and the most common tumors that develop brain metastases include leukemia， lymphoma， Ewing’s sarcoma，etc. There are rare case reports on other much less common tumors，inculding malignant germ cell tumors，melanoma， malignant rhabdoid tumor of the kidney，etc.This article reviews recent domestic and international research of the diagnosis， treatment and prognosis of the rare pediatric brain metastases.

2015 Vol. 12　(6):　150-153 [Abstract]（ 394 ） HTML (1 KB)  PDF  (703 KB)  ( 274 )