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中国医学创新

2015 Vol.12,No.26

Published 2016-09-15

SU Li-jun,LIU Yu-fa,GAO Li,et al.

Objective:To study the efficiency of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning.Method:87 cases of delayed encephalopathy caused by carbon monoxide poisoning admitted to our department, were randomly divided into two groups:the control group( n=42) was given conventional hyperbaric oxygen,preventing platelet aggregation,improving microcirculation,improving cerebral metabolism and other conventional treatment;the experimental group( n=45) was given Ganglioside( 100 mg, intravenous drip 1/d), Edaravone( 30 mg,intravenous drip 2 /d) for 21 days on the basis of the control group. The efficiency of two groups were observed and their cognitive function and daily life activity with the mini-mental state examination( MMSE) and modified Barthel index( MBI) before treatment and after treatment were evaluated.Result:The efficiency of the control group was 76.2%, the efficiency of the experimental group was 93.3%(P<0.05). MMSE score and MBI score of the control group and experimental group after treatment were higher than those of before treatment(P<0.05);MMSE score and MBI score of the experimental group were obviously higher than those of the control group after treatment(P<0.05). Conclusion:Application of Ganglioside plus Edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning can obviously improve the prognosis of delayed encephalopathy, and significantly improve the patients’ cognitive ability and daily life ability.

2015 Vol. 12 (26): 1-3 [Abstract]( 582 HTML (1 KB)  PDF  (678 KB)  ( 238 )

BAO Sharina.

Objective:To investigate the change and significance of cytokines IL-6,IFN-γ,TNF-α in the patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis.Method:The serum levels of cytokines IL-6,IFN-γ,TNF-α in the patients with COPD complicated with TB were measured by double antibody sandwich enzyme-linked immunosorbent assay(ELISA),whose patients were including 152 patients with COPD complicated by pulmonary tuberculosis(COPD and TB group),150 patients with pulmonary tuberculosis (TB group),as well as 157 patients with COPD(COPD group) and 50 healthy volunteers( healthy control group) in the department of respiratory medicine of our hospital from March 2011 to December 2013 were selected.The data were analyzed by SPSS 13.0 statistic software.Result:Compared to the healthy control group,the serum levels of cytokines IL-6,IFN-γ,TNF-α in the patients with COPD complicated with TB and TB group were increased,the differences were statistically significant(P<0.05).Compared to the COPD and TB group,the serum levels of cytokines IL-6,IFN-γ,TNF-α in the patients with COPD complicated with TB group were increased,the differences were statistically significant(P<0.05),however,there were no statistically significant differences in the serum levels of cytokines IL-6,IFN-γ,TNF-α between the patients with COPD and TB group(P>0.05).Conclusion:There are different extents of imbalance of some serum cytokines IL-6,IFN-γ,TNF-α in the patients with COPD complicated by TB.It suggests that there are important roles of these cytokines in immune pathogenesis of COPD complicated with TB and will provide theoretical evidence to immune intervention.

2015 Vol. 12 (26): 4-7 [Abstract]( 539 HTML (1 KB)  PDF  (701 KB)  ( 311 )

ZHU Xiao-hong,GONG Li,LU Yong-jia,et al.

Objective:To observe the clinical curative effect of ear acupoints application therapy on female climacteric syndrome with the type of incoordination between heart and kidney.Method:69 female climacteric syndrome patients were randomly divided into the pure medicine group for 35 cases and the ear acupoints application therapy group for 34 cases.The pure medicine group was given Huanglian Ejiao Decoction,the ear acupoints application therapy group was given ear acupoints application therapy on the basis of the control group.Treatment for 12 weeks,TCM symptom score and serum sex hormone levels(FSH,LH,E2) before and after treatment and clinical efficacy of traditional Chinese Medicine in TCM symptoms improvement between the two groups were observed. Result:TCM symptom scores and sex hormone levels of the two groups after treatment had significant differences(P<0.05),compared with the items before treatment.Compared with the pure medicine group,TCM symptom scores and sex hormone levels in ear acupoints application therapy group after treatment had significant differences(P<0.05).The ear acupoints application therapy group in improving the symptoms of menopause,secondary disease had obvious advantages.Two groups of TCM syndrome efficacy comparison(rank sum test),among them,effective and excellent,the differences were statistically significant(P<0.05).The total effective rate of TCM Syndrome improvement in the ear acupoints application therapy group was 94.12%,which was slightly higher than 88.57% in the pure medicine group,there was no statistically significant difference(P>0.05). Conclusion:The ear acupoint application therapy can significantly improve female climacteric syndrome with the type of incoordination between heart and kidney in patients with clinical symptoms and adjust the sex hormone levels in the body.What’s more the ear acupoints application therapy is simple,safe,feasible and worth promoting in clinic.

2015 Vol. 12 (26): 7-10 [Abstract]( 602 HTML (1 KB)  PDF  (698 KB)  ( 359 )

HE Bing.

Objective:To investigate the changes and clinical significance of plasma B-type natriuretic peptide level in patients with intrusive acute myocardial infarction after emergency percutaneous coronary intervention. Method:316 patients with acute myocardial infarction admitted to our hospital from March 2009 to March 2013 were divided into the observation group and the control group according to the random number table method,158 cases in each group.The observation group was treated with emergency PCI within 12 hours of onset,the control group was only given conventional therapy without emergency PCI.The plasma BNP level changes of the two groups on admission and 1 day,7 and 30 days after admission were compared and analyzed,the myocardial damage index such as serum CK-MB,troponin I(cTnI) and MYO of the two groups were determined.The left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume index(LVEDVI) and left ventricular end systolic volume index(LVESVI),after 6 months of follow-up,the occurrence of adverse cardiovascular events were observed. Result:There were no significance differences in the levels of CK-MB,cTnI,MYO,plasma BNP,LVEDVI,LVESVI and LVEF between the two groups on admission(P>0.05). Compared with on admission,the BNP concentration of observation group decreased but that in the control group increased 7 days after admission,the differences were statistically significant(P<0.01).30 days after admission,the BNP concentration of the two groups were significantly lower than on admission(P<0.01).Besides,the level of plasma BNP,LVEDVI,LVESVI and LVEF in the observation group were significantly lower than those of the control group 7 and 30 days after admission,the differences were statistically significant(P<0.01).Postoperative follow-up of 6 months,the incidence of major adverse cardiovascular events(MACE) in the observation group was 18.35%(29/158),which was significantly lower than 34.18%(54/158) in the control group,the difference was statistically significant(χ2=10.2125,P<0.01). The BNP had positive correlation with CK-MB,cTnI,MYO,LVEDVI,LVESVI and MACE(P<0.01),and negatively related with LVEF(P<0.01). Conclusion:Plasma BNP can serve as a predictor of acute myocardial infarction after emergency percutaneous coronary intervention,it is also a valuable index for prognosis monitoring and curative effect.

2015 Vol. 12 (26): 11-14 [Abstract]( 591 HTML (1 KB)  PDF  (701 KB)  ( 230 )

ZHANG Jian,CHEN He,KANG Jian,et al.

Objective:To investigate the clinical significance of early identification of severe hand foot and mouth disease( HFMD) and its prognosis by the serum levels of S-100β protein combined with cranial magnetic resonance. Method:50 cases diagnosed with HFMD were collected from the women’s and children’s hospital of Ganzhou from May 2013 to May 2014. The effective cases were divided into the common group and the severe group according to clinical manifestations,25 cases in each group. At the same time,20 cases of non HFMD without neurological infections were collected as a negative control group. Serum levels of S-100β protein in acute and recovery stage of severe HFMD group and common HFMD group were detected by the ELISA kit of human S-100β protein. Acute phase serum S-100βprotein was detected in the negative control group. The cranial magnetic resonance was used by the severe HFMD group and common HFMD group. Result:The S-100β protein in acute stage of severe HFMD group was higher than that of the negative control group,the difference was statistically significant(P<0.001).The S-100β protein both in acute and recovery stage of severe HFMD group were higher than those of common HFMD group, the differences were statistically significant(P<0.001).The occurrence of abnormal cranial magnetic resonance in severe HFMD group was 72.0%,which was higher than 16.0% of common HFMD group,the difference was statistically significant( χ2=15.909,P<0.001).The occurrence of sequela in severe HFMD group was 24.0%,which was higher than that of common HFMD group,the difference was statistically significant( χ2=4.735,P=0.030).The acute and recovery phase of S-100βprotein in cranial magnetic resonance abnormalities group were significantly higher than those of cranial magnetic resonance normalities group, the differences were statistically significant(P<0.001).The occurrence of sequelae in abnormal cranial magnetic resonance examination group was 27.3%,which was higher than that of normal cranial magnetic resonance group, the difference was statistically significant(P=0.012). Conclusion:The levels of S-100β protein can be used to early judge whether the HFMD combined with central nervous system infection and early identification whether the HFMD developed to severe cases.The serum levels of S-100β protein combined with cranial magnetic resonance test can evaluate the degree of brain damage and the prognosis of HFMD.

2015 Vol. 12 (26): 14-17 [Abstract]( 534 HTML (1 KB)  PDF  (699 KB)  ( 222 )

ZHOU Yue-jun,CHEN Yu-cui.

Objective:To observe the influence of Zhiyixiao on experimental non-alcoholic fatty liver disease(NAFLD) rats liver tissue pathology and visfatin protein expression and investigate the mechanism of action of Zhiyixiao in the treatment of NAFLD. Method:High fat diet were prepared for NAFLD rat model.60 rats were divided into low, medium and high Zhiyixiao of treatment group,Yishanfu capsule in the positive control group,saline control group,normal control group,10 rats in each group.The rat liver tissue homogenate TC and TG level were detected;fatty degeneration of liver cells and the liver tissue inflammatory changes were microscopically observed by HE staining in all groups;the rat liver tissue visfatin levels were detected by ELISA. Result:The levels of TC and TG in the rats’ liver homogenate of treatment group compared with the model group,the differences were statistically significant(P<0.05); the liver cell inflammation activity was significantly improved, liver tissue visfatin protein expression was significantly decreased, the differences were statistically significant( P<0.05),but compared with the Yishanfu group, each dose treatment group were not statistically significant differences( P>0.05). Conclusion:Zhiyixiao can inhibit the production of TC and TG in the liver cells,improve liver steatosis and liver tissue inflammatory diseases, improve liver tissue visfatin expression level and has similar efficacy with Yishanfu,the mechanism of NAFLD may be related to the expression of visfatin protein in liver tissue.

2015 Vol. 12 (26): 18-21 [Abstract]( 521 HTML (1 KB)  PDF  (797 KB)  ( 189 )

QIAO Fen,CHENG Qiao,FAN Zhe-lu.

Objective:To evaluate the effect of Dezocine and Dezocine combined with Ropivacaine on healing of incision and the expression of GM-CSF. Method:One-hundred healthy and clean male Kunming mice were randomly divided into Normal Sline group(group NS),0.5% Ropivacaine group(group L),Dezocine roup(group D) ,0.5% Ropivacaine and Dezocine group(group Y),each group had 25 mice. 10 minutes before incision , group L was injected subcutaneously with 0.5% Ropivacaine(1 mL/kg), group D was injected by intraperitoneal injection with Decoine(5 mL/kg) , group Y was injected with 0.5% Ropivacaine(1 mL/kg) and Dezocine(5 mL/kg).The equal volume of Normal Saline was injected into the no injection sections of group L,D,NS.Five mice in each group were chosen for recording the healing time,twenty mice were taken in each group for recording the wound area about 72 hours after operation(measured the rate of wound healing).The skin tissues around the incision were removed in order to determine the concentration of GM-CSF. Result:The healing time, the rate of wound healing and the concentration of GM-CSF in group L,D,Y were all better than those in group NS,the differences were statistically significant(P<0.05).The differences in the indexes above between group D and group L were not statistically significant(P>0.05). The healing time, the rate of wound healing and the concentration of GM-CSF in group Y were all better than those in group L and group D,the differences were statistically significant(P<0.05) . Conclusion:Both 0.5% Ropivacaine and Dezocine can promote the expression of GMCSF and the wound healing of incision.The combination of the two drugs have better effects on promoting the expression of GM-CSF and the wound healing of incisions.

2015 Vol. 12 (26): 22-25 [Abstract]( 674 HTML (1 KB)  PDF  (700 KB)  ( 257 )

CHEN Hong-qin.

Objective:To explore the protective effect mechanism of thrombin inhibitor nexin-1 on brain edema after intracerebral hemorrhage.Method:90 rates were randomly divided into the control group, the model group and the intervention group.The model of cerebral hemorrhage was made by caudate nucleus injection of autologous arterial blood. In the modeling process,the intervention group was injected with thrombin inhibitor nexin-1 in the caudate nucleus,the rest group were injected with Normal Saline.12 hours, 24 hours and 36 hours after the injection,the PAR-1 in brain tissues was detected by immunohistochemistry, the Caspase-3,Claudin-5 and ZO-1 in brain tissues were detected by western blotting method.Result:The PAR-1 and Caspase-3 in brain tissues of the model group were significantly higher than those of the control group and the intervention group,the differences were statistically significant(P<0.05). The Claudin-5 and ZO-1 in brain tissues of the model group were significantly lower than those of the control group, the Claudin-5 and ZO-1 in brain tissues of the intervention group were significantly higher than those of the model group,the differences above were all statistically significant(P<0.05).Conclusion:The protective effect mechanism of thrombin inhibitor nexin-1 on brain edema after intracerebral hemorrhage may through reducing the expression of PAR-1,Caspase-3 and increasing the expression of Claudin-5 and ZO-1 to achieve.

2015 Vol. 12 (26): 25-28 [Abstract]( 549 HTML (1 KB)  PDF  (715 KB)  ( 174 )

WU Tie-ying,LI Gai-lan,HUANG Yu-sheng,et al.

Objective:To study the curative effect,living quality and side effect of body-gamma knife radiotherapy in treating with early-stage non-small cell lung cancer.Method:The clinical data of 58 non-small lung cancer patients who were treated with rotary body gamma knife in our hospital from October 2004 to March 2011 were retrospectively analyzed.Result:All the 58 cases completed the treatment on schedule.The recent complete remission rate of the primary lesion was 56.8%,partial remission rate was 20.7% and the stability rate was 1.7%.The overall response rate was 79.3%.The survival rates of 1,2 and 3-year after the treatment were 86.2%,75.9% and 67.2%.3 years after the treatment,there were 23 cases with neoplasm local recurrence and metastasis.19 cases died,among them,12 cases died of recurrence and metastasis and 7 cases didn’t die of neoplasm.The amount of patients with anxiety,expiratory dyspnea and cough after the treatment were less than before treatment,the differences were statistically significant(P<0.05). The complications of radiotherapy were less,24.1%(14/58) of the patients were with radiation pneumonitis,13.7%( 8/58)of the patients were with radiation esophagitis and 15.5%(9/58) of the patients were with stage Ⅰ leucopenia.Conclusion:With good sort-term effects and survival rate,less radiotherapy complications,body-gamma knife is an useful and safety nonsurgical treatment in treating with early-stage non-small cell lung cancer.

2015 Vol. 12 (26): 29-32 [Abstract]( 707 HTML (1 KB)  PDF  (701 KB)  ( 457 )

GUO Ji-lu,LI Yuan,NIU Jun-bo,et al.

Objective:To investigate the correlations between ultrasonographic features and molecular biological indexes such as ER(estrogen receptor),,PR(progesterone receptor),C-erbB-2( human epidermal growth factor receptor 2)and Ki-67 in invasive duct carcinoma of breast(IDC).Method:The data of 107 IDC patients who were in our hospital from January 2012 to June 2014 were collected.Their ultrasonographic data and immunohistochemical pathologic results were analyzed.Result:The positive expression rates of ER,PR in patients with spiculation were higher than those in patients without spiculation,the positive expression rates of ER,C-erbB-2 and Ki-67 in patients with microcalcification were higher than those in patients without microcalcification,the positive expression rate of C-erbB-2 in patients with suspicious lymph node was higher than that in patients without suspicious lymph node,the positive expression rate of C-erbB-2 in patients with rich blood flow signals was higher than that in patients with poor blood flow signals,the differences above were all statistically significant(P<0.05). Conclusion:There is a certain correlation between ultrasonographic features and molecular biology markers in invasive duct carcinoma of breast. The expression results of ER,PR,C-erbB-2 and Ki-67 of IDC can be predicted according to the ultrasonographic features,which can provide a basis for the biologic behavior assessment,prognosis and clinical treatment.

2015 Vol. 12 (26): 32-35 [Abstract]( 731 HTML (1 KB)  PDF  (785 KB)  ( 890 )

LI Qing,YANG Xue-rong,WANG Shan-shan,et al.

Objective:To investigate the compliance of statins in secondary prevention of ischemic cerebrovascular disease,and to identify the factors influencing the compliance of statins.Method:Data were prospectively collected on consecuffvely encountered 199 ischemic stroke or transient ransient ischemic attacks( TIA) patients.The compliance of statins was investigated at 3,6 months and 1,2,3 years follow-up.The Logistic regression analysis was used for the analysis of influence factors of the compliance of statins.Result:The application rate of statins at 3 months and 3 years was 57.7% and 41.9%,respectively.Logistic regression analysis showed that good compliance of statins was associated with the Han nationality(OR=2.15,95% CI:1.10-4.20),the patients with the basic medical insurance system for urban employees or free medical service( OR=3.43,95% CI:1.21-9.69)and ischemic stroke( OR=4.47,95% CI:1.24-16.05). Conclusion:In Xinjiang minority nationality areas, the Han nationality, the patients with the basic medical insurance system for urban employees or free medical service and ischemic stroke have better statins compliance.

2015 Vol. 12 (26): 36-38 [Abstract]( 629 HTML (1 KB)  PDF  (695 KB)  ( 334 )

YANG Rui, CHEN Xiang-yun, XIE Zhao-yang, et al.

Objective: To assess the clinical efficacy of suture anchor nail repair renal failure associated with spontaneous femoral quadriceps tendon patellar check point of fracture.Method: From January 2007 to January 2012,21 renal failure patients with spontaneous femoral quadriceps tendon rupture were given the nail line of patella femoral quadriceps tendon suture anchor check point repair suture. Preoperative routine laboratory examination was taken by lateral knee X-ray films and MRI. With a protection within 6 weeks, after 6 weeks bend knees practice was taken, and knees angle was measured 2 years later. Result: 21 patients were all followed up and in the end they were not loose bolts and emergence. The effect was evaluated by Kujala and Lysholm knee scoring standards and showed significant difference before and after operation( P<0.05). Conclusion: Selecting appropriate cases and using suture anchors is renal failure associated with spontaneous femoral quadriceps tendon patellar fracture effective method of check point.

2015 Vol. 12 (26): 39-42 [Abstract]( 492 HTML (1 KB)  PDF  (765 KB)  ( 233 )

JI Na,ZHAO Li,FENG Xin,et al.

Objective:To investigate the clinical therapeutic effects of laparoscopic myomectomy and abdominal myomectomy.Method:35 patients with laparoscopic myomectomy from December 2012 to December 2014 were selected as the observation group,36 cases of uterine fibroids with open operation treatment in our hospital were selected as the control group.The operation condition and postoperative complications between the two groups were compared.Result:All patients in the observation group were successfully completed laparoscopic myomectomy,no transfer laparotomy.Intraoperative no vice injury occurred,such as bleeding complications.The operation process of control group were all smoothly,eliminated fibroid number up to seven,maximum diameter was 20 cm,but 20 cm fibroids of myomectomy had more blood loss,injected 2 U erythrocyte suspension.No intraoperative injury,1 case of incomplete intestinal obstruction after operation and recovered after conservative treatment.The operation time of the observation group was significantly longer than the control group,operative blood loss and hospitalization expenses were significantly less than the control group,the anus exhaust time and hospitalization days were significantly shorter than the control group,the operative incision was significantly shorter than the control group,the usage rate of postoperative analgesia was significantly lower than the control group,the differences were statistically significant(P<0.05).Two groups of patients were no serious complications occurred,the observation group of patients with all the grade A healing of incision,the healing rate was 100%.In the control group,there were 3 cases with wound infection,after the related treatment,all recovered to normal.There were 2 cases of complications in the observation group,and 5 cases in the control group,there was no statistically significant difference in the complication rate(P>0.05).Postoperative pathological returns were uterine fibroids.The patients were followed up for 1 months after operation and followed up every 6 months.All patients recovered to normal menstrual cycle in 1 month to 3 months after surgery,and the normal size of the uterus was recovered by B ultrasonic examination.Conclusion:For uterine fibroids patients with laparoscopic surgery,with small trauma,greatly reducing the patients’ pain and reduce the probability of postoperative complications,patients recover faster,is worthy of clinical popularization and application.

2015 Vol. 12 (26): 42-45 [Abstract]( 544 HTML (1 KB)  PDF  (698 KB)  ( 341 )

BAI Ying,LU Qun,LI Qiao-ping.

Objective:To investigate the association between serum lipocalin-2 and the pathogenesis of preeclampsia.Method:82 pregnant women with preeclampsia admitted to our hospital from January 2012 to January 2014 were selected as research objects,and they were divided into the mild preeclampsia group for 32 cases and the severe preeclampsia group for 50 cases according to the severity of the disease,in the same period,30 pregnant women were selected as the control group.The serum lipocalin-2 and endothelin level were detected in the above three groups.Result:The serum lipocalin-2 level in the severe preeclampsia group was( 73.98±15.68)ng/mL,which was significantly higher than( 52.01±13.26)ng/mL of the mild preeclampsia group,all of them were significantly higher than( 23.11±7.27)ng/mL in the control group.The endothelin levels in the two groups were significantly higher than the control group,the differences were statistically significant(P<0.05).Mild and severe preeclampsia were positively related to the serum lipocalin-2 and endothelin level(r=0.587,P<0.05;r=0.417,P<0.05),the serum lipocalin-2 and endothelin level of the control group were not related(r=0.178,P>0.05). Conclusion:Serum lipocalin-2 in maternal with preeclampsia is associated with the pathogenesis of preeclampsia,and increased with the severity of illness.

2015 Vol. 12 (26): 46-47 [Abstract]( 533 HTML (1 KB)  PDF  (657 KB)  ( 263 )

LI Guo-quan,DENG Ying-jun,DENG Zi-xiang.

Objective:To analyze the effect of Diprospan intralesional injection combined with chemical exfoliation in the treatment of cystic acne.Method:158 patients with cystic acne admitted to our hospital from October 2012 to October 2014 were selected as research objects,they were divided into the observation group and the control group according to the random sampling method,79 cases in each group.The control group was given conventional therapy,the observation group was given Diprospan intralesional injection combined with chemical exfoliation treatment on the basis of the control group.The treatment effect,recurrence and adverse reactions between the two groups were observed and compared.Result:The total effective rate of the observation group was 100%,which was significantly higher than 67.91% of the control group,the difference was statistically significant(P<0.05).The recurrence rate of the observation group was 2.53%,the incidence of adverse reactions was 12.66%,and the recurrence rate of the control group was 6.33%,the incidence of adverse reactions was 11.39%,there were no statistically significant differences between the two groups(P>0.05).Conclusion:The effect of Diprospan intralesional injection combined with chemical exfoliation in the treatment of cystic acne is significant,with high safety and feasibility,is worthy of clinical promotion and use.

2015 Vol. 12 (26): 48-51 [Abstract]( 600 HTML (1 KB)  PDF  (699 KB)  ( 197 )

GUO Jian-jun,NI Xiao-jun,SHI Li,et al.

Objective:To discuss the relevance of occurrence and development with high uric acid hematic disease and acute cerebral infarction.Method: 120 patients with acute cerebral infarction in our hospital were selected from September 2013 to September 2014, according to the fasting serum uric acid level, they were divided into high uric acid hematic disease group( acute cerebral infarction patients with high uric acid hematic disease, 40 cases) and normal uric acid group( acute cerebral infarction patients with normal serum uric acid level,80 cases), according to a 1995 cerebral apoplexy clinical nerve function defect degree grading standard,the nerve function defect ratio of moderate and severe degree and light degree before treatment, concomitant disease incidence and clinical curative effect after treatment of two groups were observed and compared. Result: Before treatment, moderate and severe degree nerve function defect ratio of high uric acid hematic disease group was higher than normal uric acid group, light degree nerve function defect ratio of high uric acid hematic disease group was lower than normal uric acid group, the differences were statistically significant(P<0.05). Before treatment, obesity, the incidence of high blood pressure, abnormal glucose tolerance and hyperlipidemia in high uric acid hematic disease group were higher than normal uric acid group,the differences were statistically significant (P<0.05). After treatment,the total effective rate of high uric acid hematic disease group was lower than normal uric acid group, the difference was statistically significant(P<0.05).Conclusion: High uric acid hematic disease has correlation with disease progression in acute cerebral infarction patients,it is an important predictor of poor prognosis.

2015 Vol. 12 (26): 51-53 [Abstract]( 705 HTML (1 KB)  PDF  (677 KB)  ( 242 )

SUN Jin-lei,WANG Zhen-chang.

Objective:To investigate the imaging findings of maxillary sinus tumors in order to improve the levels of diagnosis and differential diagnosis.Method:CT and MRI data of 89 cases with maxillary sinus tumors confirmed histopathologically were analyzed retrospectively.Result:Inverted papilloma,25 cases were connected with the nasal mass.CT:72.7% showed moderate soft-tissue density,13.6% visible calcification,close to 72.7% compression deformation of bone,45.5% bone absorption,18.2% bone destruction.MRI:The leisions showed isointensity or slight hypointensity on T1WI and isointensity or slight hyperintensity on T2WI.Postcontrast MR showed heterogeneous enhancement and 83.3% showed“ cerebriform” enhancement.Hemorrhagic and necrotic polyps,6 cases were lobulated and located in the maxillary sinus fontanelle Department.CT:heterogeneous density.MRI:T1WI showed slightly lower signal,T2WI showed high signal central area with a low signal intensity rim.Postcontrast MR showed obviously heterogeneous enhancement.Squamous cell carcinoma,23 cases showed the masses along the outside wall of the maxillary sinus formed invasive irregular thickening or tumors.CT:52.4% asymmetrical density,4.8% visible calcification,associated with bone destruction of sinus walls,of which 82.4% could be seen inwall bone destruction.MRI:T1WI showed hypointensity,isointensity or slight hyperintensity,T2WI showed isointensity or hypointensity,and postcontrast MR showed inhomogeneous enhancement.Of adenoid cystic carcinoma in 9 cases,CT:57.1% uneven density.MRI:The leisions showed hypointensity,isointensity or slight hyperintensity on T1WI and hyperintensity or inhomogeneous intensity on T2WI.Postcontrast MR showed inhomogeneous enhancement.Other rare tumor had its own characteristics. Conclusion:CT provides clear view of bone changes and has an important value in benign and malignant.MRI which can show the pathological features of tumors and demonstrate optimally the extent of the lesions suggests the diagnosis and clinical stage.Combined imaging commodities can provide more comprehensive information for the tumor in maxillary sinus.

2015 Vol. 12 (26): 54-58 [Abstract]( 810 HTML (1 KB)  PDF  (826 KB)  ( 596 )

LIU Wei.

Objective:To investigate the effect of Suhuangzhike Capsule on efficacy and immune factors of patients with cough variant asthma.Method:102 patients with cough variant asthma admitted to our hospital from October 2010 to October 2014 were selected as research objects,they were divided into the observation group and the control group according to the random number table method,51 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with Suhuangzhike Capsule on the basis of the conventional treatment. They were treated for four weeks.The FEV1,FVC,PEF and interleukin-4(IL-4),interferon γ(IFN-γ),interleukin-17(IL-17) were measured before and after treatment.The clinical curative effect between the two groups were compared.Result:After treatment,the total effective rate of the observation group was 96.1%,which was significantly higher than 82.4% of the control group,the difference was statistically significant( 字2=4.9930,P=0.0255).The FEV1,FVC,PEF of the two groups after treatment were significantly increased compared with before treatment(P<0.05 or P<0.01),and compared with the control group after treatment,the observation group improved more significantly after treatment(P<0.05).The serum IL-4,IFN-γ,IL-17 showed no significant differences of the two groups before treatment(P>0.05).The serum IL-4,IL-17 of the two group after treatment were significantly reduced,and compared with the control group after treatment,the patients in the observation group were decreased significantly(P<0.05). Serum IFN-γ were significantly higher in the two groups after treatment,and compared with the control group after treatment,the patients in the observation group were significantly higher(P<0.05). Conclusion:Patients with cough variant asthma treated with Suhuangzhike Capsule not only can significantly improve the curative effect,but also can improve the expression of immune factors.

2015 Vol. 12 (26): 59-62 [Abstract]( 703 HTML (1 KB)  PDF  (701 KB)  ( 425 )

ZENG Fan-zeng,ZHONG Zhi-qiang,ZHU Qiang.

Objective:To evaluate the application effect of laparoscopic operation in the early treatment of elderly patients with acute abdomen.Method:120 patients with acute abdomen admitted to our hospital from May 2013 to March 2014 were selected as research objects,they were divided into the control group and the observation group according to the random number table method,60 cases in each group.The two groups were given basis drug treatment,the control group was given traditional operation method for treatment on the basis of basis drug treatment,the observation group was given laparoscopic operation for treatment on the basis of basis drug treatment.The surgical treatment effect between the two groups were observed and compared.Result:After treatment,the total effective rate of the observation group was 96.7%,which was significantly higher than 80.0% of the control group,the times of body temperature recovery,abdominal pain,defecation,abdominal distension disappeared,operation time and hospitalization time in the observation group were significantly shorter than those in the control group,the intraoperative blood loss was significantly less than the control group,the nursing satisfaction rate of the observation group(88.3%) was significantly higher than 71.7% of the control group,the complication rate of the observation group( 5.0%) was significantly lower than 30.0% of the control group,the differences were statistically significant(P<0.05).Conclusion:Laparoscopic operation for the treatment of elderly patients with acute abdomen is minimally invasive and safety,with high diagnosis rate,the treatment effect is significant,is worthy of clinical promotion.

2015 Vol. 12 (26): 62-65 [Abstract]( 564 HTML (1 KB)  PDF  (697 KB)  ( 171 )

TONG Jian-lin,RAO Chang-hong,HUANG Bo.

Objective:To study the application of mycobacterium tuberculosis-DNA in BALF by FQ-PCR for the diagnosis of pulmonary.Method:110 cases with tuberculosis in our hospital were randomly selected from December 2013 to November 2014 as the objects of the study, all patients were given the fiberoptic bronchoscopy, biopsy, brush biopsy,mycobacterium tuberculosis DNA in bronchoalveolar lavage fluid( BALF) was detected by FQ-PCR,the examination results were analyzed. Result: In this study,44 cases of pulmonary tuberculosis, accounted for the proportion to 40.00%(44/110);the sensitivity of FQ-PC detection was significantly higher than that of conventional smear microscopy,the difference was statistically significant(P<0.05). Conclusion:In the diagnosis of pulmonary tuberculosis,the FQ-PCR detection has high sensitivity, simple operation and the detection speed faster,it is an important examination method of mycobacterium tuberculosis DNA in BALF and has important application value.

2015 Vol. 12 (26): 66-67 [Abstract]( 797 HTML (1 KB)  PDF  (658 KB)  ( 322 )

ZHAO Qing-wei,LYU Dao-xian.

Objective:To observe the efficacy of combined Tongxiening granule and Golden Bifid for the treatment of patients with dominant-diarrhea irritable bowel syndrome.Method: Randomized and parallel-group study method was used, 75 IBS-D patients who met the inclusion criteria were divided into three groups: group A( combined Tongxiening granule and Golden bifid tablets study group), group B( Tongxiening granule alone control group) and group C( Golden bifid tablets alone control group), 25 cases in each group. The symptoms of abdominal pain, diarrhea and global symptom were scored. The efficacy was determined by the changes of symptom scores. Result:After treatment for 4 weeks,compared the abdominal pain scores, diarrhea symptoms scores and total symptoms scores of three groups before and after treatment, the differences were statistically significant(P<0.01). After treatment,compared the symptoms scores of three groups patients, group A had statistically significant differences with the other two groups(P<0.01), but had no statistical differences between the group B and C(P>0.05).Compared the effect of three groups, group A had statistically significant difference with the other two groups(P<0.05), but had no statistical differences between the group B and C(P>0.05).Conclusion:Adjunctive therapy of Tongxiening granule and Golden Bifid tablets for IBS-D obviously improve the core symptoms of patients, has a better curative effect and no adverse reaction.

2015 Vol. 12 (26): 68-71 [Abstract]( 931 HTML (1 KB)  PDF  (701 KB)  ( 374 )

FENG Xin-huan.

Objective: To explore the effect of optimizing lamina CT imaging quality of abdominal vein and decreasing radiation dosage by model-based iterative reconstruction( MBIR), to improve MBIR’s imaging quality and guarantee patients safety. Method:30 cases underwent abdominal CT examination were selected,they were given abdominal plain scan and enhanced scan by GE HD750 type CT,then they were respectively given image reconstruction by filtered back projection( FBP), adaptive statistical iterative reconstruction(ASiR) and MBIR by GE AW4.5 workstation. Subjective score of image quality, noise value(SD) and contrast noise ratio( CNR) of three groups image were compared. Result:Three groups’ reconstruction image all could meet diagnosis requirements, subjective ratings of FBP, ASiR and MBIR group were respectively( 3.20±0.55)scores,(3.72±0.49)scores and( 4.65±0.27)scores,there were statistical differences among three groups(F=6.10,P<0.05).SD values of back muscle,liver,spleen and kidney essence in FBP,ASiR and MBIR group were decreased successively,CNR values of portal vein, pancreatic vein,splenic vein and inferior vena cava were increased successively,the differences were statistically significant(P<0.05). Compared with FBP group, SD reduction rate in ASiR group and MBIR group were respectively 27.86%-32.17% and 56.61%-64.05%,CNR increased rate were respectively 26.57%-53.66% and 140.85%-183.25%.Conclusion:MBIR can further reduce noise value of abdominal lamina CT,it reduces the radiation dose about 60% and still get good image quality, shows clear and detailed vein, also has better contrast enhancement effect, and it is significantly better than FBP and ASiR.

2015 Vol. 12 (26): 71-74 [Abstract]( 640 HTML (1 KB)  PDF  (701 KB)  ( 367 )

YAO Chuang,LI Guang-chen,XU Jian-guo.

Objective:To discuss the impact of dust weather on respiratory infectious diseases in Khorchin district,Tongliao city,Inner Mongol.Method:Khorchin district,Tongliao city,Inner Mongol was selected as the research site.The meteorological materials from 2011 to 2014 were obtained by contacting Tongliao meteorological department,incidence information of respiratory infectious diseases were obtained with the help of Tongliao Infectious Disease Hospital and two large and middle sized hospitals.The correlations between meteorological factors and incidence rates of infectious diseases were analyzed.Result:The outpatient quantity of respiratory tract infections was significantly higher after dust weather.The incidence rates of influenza,measles,mumps and tuberculosis had a positive correlation with the occurrence of dust weather.Conclusion:Areas with higher-frequency dust-weather have stronger fitting and forecasting capability toward respiratory infectious diseases,which has a significant impact on further learn,prevent and control the outbreak of respiratory infectious diseases.

2015 Vol. 12 (26): 75-77 [Abstract]( 579 HTML (1 KB)  PDF  (665 KB)  ( 236 )

Objective:To explore the incidence of metabolic syndrome(MetS) in junior middle school students of Shizhong district Ji’nan city in order to provide evidence for its prevention.Method:From 2008 to 2013,health checkup were given to 6862 junior middle school students in Shizhong district of Ji’nan city.The detection rates of MetS and its associative signs were analyzed and compared.Result:The detection rate of MetS was 1.4%.The difference in detection rates of MetS between boys and girls was not statistically significant(P>0.05).Boys with hypertension were more than girls with hypertension,boys with low HDL were less than girls with low HDL,the differences above were all statistically significant(P<0.01).The differences in detection rates of MetS in different ages were not statistically significant (P>0.05).The differences in detection rates of central obesity,high TG,low HDL and hypertension in different ages were statistically significant(P<0.01).The highest detection rate of central obesity was 15-year-old students.The detection rates of high TG,low HDL,hypertension and hyperglycemia in central obesity students were higher than those in non-central obesity students,the differences were all statistically significant(P<0.01).Conclusion:Intervention measures for adolescent obesity shall be conducted to prevent MetS in adolescent.

2015 Vol. 12 (26): 78-80 [Abstract]( 444 HTML (1 KB)  PDF  (678 KB)  ( 208 )

LIU Li.

Objective:To understand the situation and analyze the existing problems in the application of scene simulation method in emergency triage teaching of higher vocational nursing students, and to find out the countermeasures to improve the teaching effect.Method:The issuance of a self-made questionnaire was used,the effect of the scene simulation teaching of 240 vocational nursing students in our hospital were investigated.Result:Over 90% of nursing students thought that the application of scene simulation method stimulated the students' learning interest, improved the critical thinking ability of nursing students, and cultivated the ability of communication and team spirit. In the factor investigation of the effect of scene simulation, 79.17% of nursing students considered that the content of scene simulation was not enough; 87.50% of nursing students considered that the teaching case was too typical;69.58% of nursing students considered that teachers were not made in a timely manner.Conclusion: Through the application of scene simulation in emergency triage teaching, change the traditional way of teaching and cultivate the nursing students learning ability,it has good teaching effects.

2015 Vol. 12 (26): 81-83 [Abstract]( 551 HTML (1 KB)  PDF  (665 KB)  ( 234 )

LIU Lu,KANG Feng-ying,XUE Ning-ning,et al.

Objective:To investigate the effective methods of reducing the risk factors of falls in hospitalized patients.Method:According to failure mode and effect analysis(FMEA) method,the management process of fall prevention,failure mode/the reasons of potential risk and risk priority number were analyzed,on the analysis results,the falls prevention management process were improved,and the quality control of fall prevention was adopted. Result:After the implementation of intervention measures and improve the process,the RPN value of six failure mode were decreased compared with before the implementation,the differences were statistically significant(P<0.05),and after the implementation,the incidence of falls in high-risk patients was 0.57%(4/696),which was significantly lower than 3.41%(10/293) before the implementation,the difference was statistically significant(χ2=9.956,P=0.002).Conclusion:The fall prevention management process which is improved by the combination of“ 5E” injury prevention strategies and FMEA is helpful to reduce the risk of falls among the inpatients,as well as providing experience for addressing the risk factors and reducing the probability of falls.

2015 Vol. 12 (26): 84-88 [Abstract]( 666 HTML (1 KB)  PDF  (714 KB)  ( 259 )

LI Shun-ying.

Objective:To investigate the effect and prognosis of comfort care for patients with femoral neck fracture. Method:60 patients with femoral neck fracture admitted to our hospital from 2012 to 2014 were selected and divided into the control group and the experimental group according to the random number table method,30 cases in each group.The control group was given routine care,the experimental group was given comfort care on the basis of the control group. The patient care satisfaction and occurrence of complications between the two groups were observed and compared.Result:After nursing,the patient care satisfaction of the experimental group was 96.67%,which was significantly higher than 73.33% of the control group,the difference was statistically significant( χ2=4.7059,P=0.0301).The complication rate of the experimental group was 6.67%,which was significantly lower than 26.67% of the control group,the difference was statistically significant(χ2=4.3200,P=0.0377).Conclusion:Comfort care for femoral neck fracture care can significantly improve the prognosis,efficacy and nursing satisfaction of patients,is worthy of clinical application of the promotion.

2015 Vol. 12 (26): 89-92 [Abstract]( 616 HTML (1 KB)  PDF  (696 KB)  ( 223 )

WANG Le-le, YANG Hui.

Objective: To develop a appropriate assessment scale of hospitalized cancer patients’ family status and provide a good measurement tool to assess the hospitalized cancer patients’ family status in our country. Method: Using the third edition of“ nursing outcomes classification” as a framework, determined the alternative index by reviewing literature and interviewing experts, then formed the expert advisory questionnaire after the research team’s discussion, used the Delphi method( Delphi Method) to do two rounds’ letter inquiry on 22 experts. Result: After two rounds’ expert inquiry, we finally developed an assessment tool with 53 items classified in 5 dimensions named as family normalization, family function, family economic and health status, family involvement professional care and family support during treatment. The expert inquiry positive coefficient of two rounds were 96% and 100%, the experts authority coefficient both was 0.84, the coordination indexes were 0.305 and 0.437. Conclusion: The family status scale for hospitalized cancer patients developed by using Delphi method has high reliability and can improve the cancer patients’ quality of life, it can be applied in clinical practice.

2015 Vol. 12 (26): 92-95 [Abstract]( 546 HTML (1 KB)  PDF  (697 KB)  ( 184 )

SUN Hua-wei.

Objective:To investigate the effect of short-term prognosis of early enteral nutrition combined with parenteral nutrition for acute severe cerebral vascular disease patients with conservative treatment.Method:150 acute severe cerebral vascular disease patients with conservative treatment from January 2012 to June 2014 were selected,they were divided into the observation group and the control group A and the control group B according to the random number table method,50 cases in each group.The observation group was given early enteral nutrition combined with parenteral nutrition,the control group A was given early enteral nutrition,the control group B was given conventional family feeding,the observation time of the three groups was 21 days.The nutritional status:triceps skinfold(TSF) and arm muscle circumference(AMC),triglyceride(TG),serum total protein(TP),albumin(ALB),hemoglobin(Hb) were observed and compared.The incidence of the infection in the three groups were recorded.The nerve function defect(NIHSS score) and daily life ability( BI) in the three groups before and after treatment were evaluated and compared. Result:There were no statistically significant differences in the nutrition index,NIHSS score,BI index of the three groups before treatment(P>0.05).The various nutrition index of the three groups after treatment were significantly decreased than before treatment,the control group B had the greatest reduction,the control group A took second place,the observation group decreased minimum,the differences were statistically significant(P<0.05).The incidence of infection respectively was 12.00%,26.00%,36.00%,the difference was statistically significant( χ2=8.726,P=0.007),the NIHSS score after treatment respectively was( 11.51±2.68)scores,(13.22±2.71)scores,(14.48±2.55)scores,the difference was statistically significant(F=7.934,P=0.009).There was no statistically significant difference in the BI of the three groups(P>0.05).Conclusion:Early enteral nutrition combined with parenteral nutrition can obviously improve the nutritional status of acute severe cerebral vascular disease patients with conservative treatment,reduce the incidence of infection,improve the short-term prognosis of patients.

2015 Vol. 12 (26): 96-99 [Abstract]( 516 HTML (1 KB)  PDF  (698 KB)  ( 188 )

WANG Gui-qin,LIANG Jia-zhi,TIAN Xiao-na.

Objective:To investigate the application effect of high quality nursing methods in VSD negative pressure drainage technology,improve the nursing ability of nurses in VSD.Method:25 patients with open fractures with skin and soft tissue defects admitted to our hospital from January 2013 to November 2014 were treated with VSD negative pressure drainage,combined with high quality nursing service,used the method of nursing program,nurse in charge of the responsibility,the assessment-plan-implementation-evaluation-optimization of nursing path was implemented,the use of preoperative "targeted nursing",after the "eight key links of nursing" concrete method.Statistical methods were used for the cases of last 2 years,checked the problems before operation and postoperative,the implementation of the results of nursing care,the patient satisfaction rate,the average length of hospital stay were counted,the science and effectiveness of nursing method was verified.Result:25 cases of VSD preoperative issue were involved five aspects,postoperative problems were involved eight aspects,the settlement rate was 100% after nursing care.Data showed that the tangible assets:the satisfaction of patients was 99.98%;shorten the hospital stay of patients with an average of 9.97 days,the results were optimized compared with the group before the statistical data.Intangible assets:the nurses’ awareness of responsibility and care skills and methods were improved.Conclusion:VSD combined with operation nursing methods of high quality nursing service,using the nursing procedure,take the key link of preoperative nursing and postoperative nursing is an effective nursing method and is worthy of reference in the industry.

2015 Vol. 12 (26): 100-102 [Abstract]( 500 HTML (1 KB)  PDF  (664 KB)  ( 194 )

CHEN Su-xia.

Objective:To investigate the effect of community nursing process on the quality control of community nursing in stroke patients. Method:100 stroke patients who received treatment in our hospital from January 2013 to December 2013 were selected as research objects,they were randomly divided into the observation group and the control group,50 cases in each group.The two groups of patients were given symptomatic treatment,on this basis,the control group was given routine nursing,and the observation group was given nursing according to community nursing process.The knowledge awareness of disease,satisfaction of community nursing service and Activities of Daily Living( ADL scores) before and after nursing between the two groups were compared. Result:After nursing,the total understanding rate of disease knowledge in the observation group was 80.0%,which was significantly higher than 44.0% in the control group,the community nursing service satisfaction of the observation group was 90.0%,which was significantly higher than 72.0% of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the ADL scores of the two groups before nursing(P>0.05),the ADL scores of the observation group after nursing were significantly higher than those of the control group,the differences were statistically significant(P<0.05). Conclusion:For stroke patients with nursing according to community nursing process,can effectively improve the quality of patient care,and promote physical and psychological recovery of the patient.This kind of care model is feasible and effective,should be popularized in clinical practice,in order to help more patients benefit.

2015 Vol. 12 (26): 103-107 [Abstract]( 552 HTML (1 KB)  PDF  (718 KB)  ( 179 )

ZHANG Li-xia.

Objective: To evaluate and analyze the influence of the implementation of seamless care and clinical quality of care in the operating room. Method: In our hospital from December 2013 to December 2014, 210 patients were selected into the study, according to random number table method, all the patients were divided into the study group and the control group, each group contained 105 cases. The control group was given conventional nursing in operation room,the study group was given seamlessnuring method in operation room. The psychological comfort, heart rate change, blood pressure, cortisol, postoperative pain,nursing care and satisfaction indicators, etc of the two groups were compared. Result: Before anesthesia, SAS score, SDS score, heart rate, low blood pressure, cortisol index of the study group were lower than those of the control group; postoperative pain score of the study group was significantly lower; in addition, doctors,patients care satisfaction scores of the study group were higher than those of the control group, a higher degree of recognition obtained seamless care model, with statistically significant differences( P<0.05). Conclusion: Implementation of the operating room for surgical patients throughout seamless care,improve their negative emotions and stress response to surgery before surgery has a positive impact, and can reduce the level of postoperative pain, improve nurse satisfaction rate.

2015 Vol. 12 (26): 107-110 [Abstract]( 569 HTML (1 KB)  PDF  (696 KB)  ( 181 )

CHEN Xiao-ling,XIE Juan,FU Hua-jing.

Objective:To investigate the clinical significance of multi-slice spiral CT coronary angiography in special care for elderly patients.Method:1282 elderly patients came to our hospital for medical examination from January 2014 to March 2015 were selected and randomly divided into the control group and the observation group,641 cases in each group.The control group was given usual care,the observation group was given special care.The results of multi slice spiral CT coronary angiography in the elderly patients between the two groups were observed and its clinical significance were analyzed.Result:After nursing,the rates of heart rate variation,poor breath and poor image quality ratio in the elderly patients of observation group before and after the examination were 10.1%,6.7% and 8.4%,which were significantly lower than 45.4%,31.7% and 30.7% of the control group,the differences were statistically significant(P<0.05). Conclusion:After elderly patients with special care,can significantly reduce the phenomenon of heart rate variation,poor breath and poor image quality of elderly patients before and after examination,ensure the clinical diagnosis of multi slice spiral CT coronary angiography,is worthy of clinical promotion.

2015 Vol. 12 (26): 111-112 [Abstract]( 616 HTML (1 KB)  PDF  (656 KB)  ( 181 )

LI Jie.

Objective: To compare the clinical effect and life quality influence of Weisu granule combined with Western medicine in the treatment of elderly patients with chronic gastritis. Method: 98 elderly patients with chronic gastritis in our hospital were selected,in accordance with the sequence of its admission,they were divided into the control group and the experimental group, 49 cases in each group.The experimental group was given Weisu granule combined with Western medicine( Omeprazole+Amoxicillin)treatment and the control group was given only Western medicine( Omeprazole+Amoxicillin)treatment. After treatment, the effect and quality of life of two groups were compared. Result: After treatment,the total effective rate, physical function, social function, body pain, mental health,physical function, the function of emotion, general health and the vitality of life of experimental group were obviously better than in the control group,the differences were statistically significant(P<0.05).Conclusion:Elderly patients of chronic gastritis with Weisu granule combined with western medicine treatment, the clinical efficacy is significant, significantly improve the life quality of the patients, should be popularized in clinical.

2015 Vol. 12 (26): 113-116 [Abstract]( 552 HTML (1 KB)  PDF  (698 KB)  ( 184 )

ZHANG Hai-yan,ZHAO Zhen-tao,GAO Jian-jiao.

Objective:To observe the clinical curative effect of traditional Chinese medicine(TCM) combined with acupuncture in the treatment of cardiac neurosis. Method:157 outpatients and inpatients with cardiac neurosis admitted to our department from October 2012 to January 2015 were selected as research objects.They were treated with psychological intervention and randomly divided into the control group(the Deanxit group) for 68 cases and the treatment group((the Chinese medicine group) for 89 cases.The treatment group was treated with traditional Chinese medicine( TCM) combined with acupuncture,the control group was treated with oral Deanxit, the course of treatment was 8 weeks.The clinical curative effect,TCM symptom score and psychological mood before and after treatment between the two groups were observed,the psychological mood including Hamilton anxiety scale( HAMA) and Hamilton depression scale( HAMD) scores.Result:After treatment,the total effective rate of the treatment group was 50.56%,which was significantly higher than 29.41% of the control group,the difference was statistically significant(  χ2=7.1075,P=0.0077).The TCM symptom score of the two groups after treatment were significantly lower than before treatment(P<0.001),and the TCM symptom score of the treatment group was significantly lower than the control group,the difference was statistically significant(P<0.01).The HAMA and HAMD scores of the two groups after treatment were significantly lower than before treatment,and those of the treatment group were significantly lower than the control group,the differences were statistically significant(P<0.01 or P<0.001).Conclusion:Traditional Chinese medicine combined with acupuncture on cardiac neurosis has good clinical curative effect,is worthy of promotion.

2015 Vol. 12 (26): 116-120 [Abstract]( 676 HTML (1 KB)  PDF  (718 KB)  ( 397 )

WAN Rui,PAN Xiao-bo,WANG Fang.

Objective:To investigate the effect of transcranial Doppler(TCD) for screening and diagnosis of intracranial artery stenosis,whether it can be used as a screening method for cerebral vascular stenosis in the physical examination of pilots.Method:The bilateral middle cerebral artery(MCA),anterior cerebral artery( ACA) and posterior cerebral artery(PCA) of the 97 patients were examined by transcranial Doppler ultrasonography. Systolic blood flow velocity(Vs),mean blood flow velocity(Vm) and pulse index(PI) of above arteries and blood flow direction and Doppler spectrum of each artery were observed.At the same time,simultaneous nuclear magnetic resonance angiography(MRA) was performed.Result:The results showed that,transcranial Doppler sonography and MRI results had a very significant compliance(P<0.001).The ACA consistency of the two methods was 82.47%,the MCA consistency was 83.51%,the PCA consistency was 80.92%,the total consistency was 82.31%.The specificity of TCD was 86% and the sensitivity was 77%.Conclusion:The evaluated result of TCD and MRA head for intracranial artery stenosis is good.TCD examination is simple and feasible, and can be used as a screening method for the diagnosis of intracranial artery stenosis.In the pilot physical examination,if the TCD examination is normal,you can not need to do MRA inspection;MRA can be checked when TCD suggests that the narrow blood vessel.

2015 Vol. 12 (26): 121-123 [Abstract]( 598 HTML (1 KB)  PDF  (677 KB)  ( 262 )

YAO Qi.

Objective:To explore the clinical effects of gastric and duodenal perforation by laparoscopic herniorrhaphy.Method:128 patients with gastric and duodenal perforation in our hospital were selected from April 2012 to March 2015,they were divided into the experiment group and the control group,64 cases in each group. The control group was treated by traditional laparotomy, the experiment group was treated by laparoscopic herniorrhaphy.The operation time, intraoperatve blood soss, postoperative anal exhaust time for the first time, post operation hospitalization duration,postoperative complication, postoperative recurrence and abnormal body temperature of two groups were compared. Result:The operation time of the experiment group was longer than the control group, the difference was statistically significant(P<0.05).The intraoperatve blood soss, postoperative anal exhaust time for the first time and post operation hospitalization duration of the experiment group were lower than the control group, the differences were statistically significant(P<0.05).The postoperative complication of experiment group was 9.38%,which was lower than 28.13% of the control group, the difference was statistically significant(P<0.05).The postoperative recurrence and abnormal body temperature of experiment group were lower than the control group,the differences were statistically significant(P<0.05). Conclusion:It has good clinical effects for the patients with gastric and duodenal perforation by laparoscopic herniorrhaphy, it can reduce the intraoperatve blood soss, postoperative anal exhaust time for the first time, post operation hospitalization duration and postoperative complication, but it takes longer operation time.

2015 Vol. 12 (26): 124-126 [Abstract]( 637 HTML (1 KB)  PDF  (678 KB)  ( 252 )

XU Mao-xing.

Objective:To analyze the hospital anti-infectives adverse reactions( ADR) characteristics, and targeted analysis.Method:Outpatients collected 162 cases of anti-infective ADR reports, by patient sex and age, mode of administration, drug type, clinical presentation and outcome were analyzed.Result:The result in 162 cases of ADR, the administration of intravenous fluids caused ADR was 124 cases( 76.54%) in the first place, cephalosporins class caused ADR was 106 cases( 65.43%) in the first place, in the clinical manifestations, skin and its annexes damage was 63 cases(38.89%). Cured in 145 cases( 89.51%), improved in 17 cases( 10.49%);no sequelae and deaths occurred. Causality assessment:positive in 7 cases( 4.32%), most likely in 115 cases( 70.99%), the possible in 41 cases( 25.31%). Conclusion:On clinical anti-infective drugs must be used with caution in order to avoid and reduce the ADR for serious adverse reactions should always anti-infectives make emergency preparations.

2015 Vol. 12 (26): 127-130 [Abstract]( 619 HTML (1 KB)  PDF  (697 KB)  ( 180 )

SHI Jing-mei.

Objective:To investigate the effect of Erxieting in the prevention of antibiotic-associated diarrhea. Method:230 children with pneumonia in our hospital from June 2013 to December 2013 were selected and randomly divided into two groups.118 cases in the prevention group were given Erxieting on the basis of antibiotics and symptomatic treatment.112 cases in the control group were given antibiotics and symptomatic treatment,Erxieting was given to them after the diarrhea occurred.The incidence of diarrhea and its severity,curative effect,duration of diarrhea,treatment course of diarrhea and the incidence rates in different time were compared between the two groups.Result:The incidence of diarrhea and its severity in the prevention group was lower than those in the control group,the curative effect of the prevention group was better than that of the control group,the duration and treatment course of diarrhea in the prevention group were shorter than those in the control group,the incidence rates in different time of the prevention group were lower than those of the control group,the differences above were all statistically significant(P<0.05).There were no adverse reactions in the two groups.Conclusion:Erxieting can be used to prevent antibiotic-associated diarrhea in infants,its early application can reduce the duration and treatment course of diarrhea.It is good for patients’ speedy recovery.

2015 Vol. 12 (26): 130-132 [Abstract]( 455 HTML (1 KB)  PDF  (679 KB)  ( 181 )

XU Wei,ZHAN Sheng-fu.

Objective:To study the application efficacy of Dezocine combined with Propofol in elderly patients with painless gastroscopy.Method:95 elderly patients with painless gastroscopy admitted to our hospital from June 2012 to June 2014 were selected as research objects in the study,the observation group was given Dezocine combined with Propofol for anesthesia,the control group was given Remifentanil Hydrochloride combined with Propofol for anesthesia.The anesthetic effect,the signs of indicators and adverse reactions between the two groups were observed and compared. Result:Compared with T1 time point,the MAP and HR values of the observation group at T2 time point were significantly lower,the MAP of the observation group was significantly higher than the control group,the differences were statistically significant(P<0.05),while the MAP and SpO2 of the control group were significantly lower,the differences were statistically significant(P<0.05).At T3 time point,the HR of the observation group was significantly lower than the control group,and the SpO2 value was slightly higher than the control group,the differences were statistically significant(P<0.05).The average onset time of anesthesia,anesthesia awake time in the observation group were significantly shorter than the control group,the VAS score was significantly lower than the control group,the total incidence of adverse reactions in the observation group was 10.42%,which was significantly lower than 38.30% in the control group,the differences were statistically significant(P<0.05).Conclusion:The anesthetic effect of Dezocine combined with Propofol in elderly patients with painless gastroscopy is better,intraoperative anesthetic effect quickly,with little pain,is conducive to the implementation of endoscopic surgery,shorter anesthesia awake time,less postoperative adverse reactions,with high safety,is recommended to be widely used in clinic.

2015 Vol. 12 (26): 133-135 [Abstract]( 595 HTML (1 KB)  PDF  (678 KB)  ( 228 )

HE Wei-xuan,PANG Da.

Objective:To investigate the prenatal diagnosis value of using the two-dimensional and threedimensional ultrasound application in fetal malformation.Method:445 cases of fetal malformation in 22-28 weeks were found by the combined application of two-dimensional and three-dimensional ultrasound from January 2009 to December 2014,their prenatal examination ultrasonic image and the clinical data were retrospective analyzed. Result:The brain development abnormality were 71 cases( 16%), facial deformity were 44 cases( 10%), cardiac anomalies were 82 cases( 18%), thoracic dysplasia were 17 cases( 4%), urinary system abnormalities were 52 cases(12%), abnormal gastrointestinal and abdominal wall were 53 cases( 12%), skeletal dysplasia were 45 cases( 10%),multiple malformations were 40 cases( 9%), fetal edema were 41 cases( 9%);and abnormal fetal appendages were 52 cases. All the diagnosis were tested and verified by the provincial maternal and child care service centre,or all the fetus malformation features were the same as the clinic cases in our hospital.Conclusion:The two-dimensional ultrasound and the three-dimensional ultrasound combined application,has a high accuracy rate in diagnose the fetal malformation, and it is superior than one-way examining method. Rationally using the two kinds of examining methods has a great clinic value for improving the accuracy rate in prenatal diagnosis.It is an effective method for antenatal screening.

2015 Vol. 12 (26): 136-139 [Abstract]( 505 HTML (1 KB)  PDF  (768 KB)  ( 191 )

WANG Qi-rui,XING Chang-wei,LIU Ying.

Objective:To investigate the operative key points and surgical treatment effect of small bone flap craniotomy combined with lateral fissure-insular approach under the microscope in the treatment of hypertensive basal ganglia hemorrhage. Method:48 patients with hypertensive basal ganglia hemorrhage admitted to our hospital from January 2011 to January 2014 were selected,at the early stage,they were given evacuation of hematoma treatment via small bone flap craniotomy combined with lateral fissure-insular approach under the microscope.Its clinical efficacy was analyzed.Result:The CT re-examination after postoperative immediately showed that the hematomas was removed all in 43 patients,over 80% in 5 patients,postoperative died in four patients. After 6 to 18 months follow-up,the GOS was good in 30 patients,mild disability in 10 patients,severe disability in 3 patients and 1 patient died.Conclusion:The treatment of hypertensive basal ganglia hemorrhage via a small bone flap craniotomy combined with lateral fissure-insular approach under the microscope has advantages such as minimal invasive,good exposure,comparatively complete hematomas removal,desirable effect stopping the blood flow,can effectively reduce intracranial pressure,while reducing the temporal lobe cortex and vascular injury,with low morbidity and mortality,is worth popularizing in the grassroots.

2015 Vol. 12 (26): 139-142 [Abstract]( 583 HTML (1 KB)  PDF  (685 KB)  ( 223 )

ZHAO Hui-ya.

Objective:To investigate the clinical treatment methods and effects of neonatal breast milk jaundice(BMJ). Method:50 neonates with breast milk jaundice admitted to our hospital from February 2012 to February 2015 were selected in the study.Their clinical data were retrospectively analyzed,and were divided into the control group and the research group according to the different treatment,25 cases in each group.The control group was given routine treatment,the research group was given blue light irradiation on the basis of the control group.The clinical effect,total serum bilirubin before and after treatment,the cure time and the length of hospital stay between the two groups were observed and compared.Result:The clinical total effective rate of the research group was 96.00%,which was significantly higher than 68.00% of the control group,the cure time and the length of hospital stay were significantly shorter than the control group,the differences were statistically significant(P<0.05). The serum total bilirubin of the two groups after treatment were decreased significantly(P<0.05),but the research group was significantly decreased(P<0.05). Conclusion:The effect of blue light irradiation in the treatment of neonatal breast milk jaundice on the basis of routine treatment is obvious,and it can shorten the length of hospital stay and promote the recovery of patients,is worthy of clinical promotion for reference.

2015 Vol. 12 (26): 143-144 [Abstract]( 536 HTML (1 KB)  PDF  (658 KB)  ( 173 )

LI Jun-fei,LI Qing-lin.

“Serum Medicinal Chemistry” is one of the most effective ways to research the potential basis of TCM in this stages.Material basis of pharmacodynamic is the primary basis for accurate assessment of TCM quality,for the modernization of Chinese medicine has great significance.In this paper,we reviewed the research reports of using the way of serum Medicinal Chemistry to control the TCM quality,to provide a reference for the establishment of a more accurate and reasonable quality control of TCM models and approaches.

2015 Vol. 12 (26): 145-147 [Abstract]( 721 HTML (1 KB)  PDF  (666 KB)  ( 400 )

ZHANG Qing-chun,LI Ren-hong.

H-type hypertension is defined as primary hypertension accompanied by hyperhomocysteinemia.It is closely associated with stroke and other cardiovascular diseases,may be an important and independent risk factor.Now,people’s awareness of the harm,prevention and treatment of H-type hypertension isn’t high enough.This paper analyses the high incidence and harm of H-type hypertension and puts forward the scientific strategies of prevention and treatment of H-type hypertension based on the related literatures.Current evidence-based medicine studies have confirmed the application of enalapril maleate folic acid tablets for H-type hypertension. However,the larger,prospective,multicentre and randomized controlled trials still need to assess the effect and safety of enalapril maleate folic acid tablets for H-type hypertension.

2015 Vol. 12 (26): 154-156 [Abstract]( 556 HTML (1 KB)  PDF  (678 KB)  ( 280 )

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