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Abstract Ozone therapy be just unfolding，the clinical application results show that the medical ozone treatment of many diseases has significant advantages， recognised by doctors of different level，but why hasn’t really promotion in China? One important reason is that there are some people questioned the safety of medical ozone therapy.Patients acceptance of ozone therapy in a certain extent， which become an obstacle for the popularization and application of medical ozone. In this paper， the current medical ozone safety related research were reviewed， in order to make reference for the safety of medical ozone applications.
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