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| The Changes of Bone Metabolism Index in Postmenopausal Patients with Type 2 Diabetic Nephropathy |
| The Provincial Hospital Affliated to Anhui Medical University |
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Abstract Objective：To study bone metabolism index changes of postmenopausal patients with type 2 diabetic nephropathy combined osteoporosis. Method：based on bone mineral density was divided into 36 cases of type 2 diabetic nephropathy and osteoporosis，34 cases of type 2 diabetic nephropathy and normal bone mineral density ，and 33 cases of type 2 diabetic mellitus were selected. Calcium，phosphorus，ALP，PTH，PINP，and β-CTX and 25-OHD of three groups were determined.Result：ALP，PTH，PINP and β-CTX in diabetic nephropathy osteoporosis group and bone mass normal group were significantly higher than those in diabetic group（P<0.05 or P<0.01）.25-OHD in diabetic nephropathy osteoporosis group and bone mass normal group were lower than that in diabetes group（P<0.05 or P<0.01）. There were no statistical difference in blood phosphorus and blood calcium among groups.Conclusion：ALP and PTH in patients with type 2 diabetic nephropathy are elevate，PINP and β-CTX are sensitive indexs of osteoporosis.
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