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Abstract Objective：To investigate the influence of different single-lung ventilation on respiratory function and sevoflurane FA/FI.Method：45 patients underwent thoracotomy lobectomy and one-lung ventilation（OLV）in our hospital from January 2012 to January 2014 were selected，they were divided into the group A，B and C according to the random number table method，15 cases in each group.The group A underwent volume-controlled ventilation，the group B underwent pressure-controlled ventilation，the group C received small tidal volume and PEEP ventilation.The changes in vital signs and airway pressure after 10 min total lung ventilation（TLV）and after 20，45，70 min OLV of the three groups were compared.The three groups were received inhalation of 1.5% sevoflurane 20 min when OLV 20 min，and the FA/FI of the 3 groups were compared.Result：After OLV，T2-T4，the peak airway pressure of 3 groups were increased， but the group A and B were significantly increased（P<0.05），and lung compliance of the 3 groups were reduced，but the group A and group C were significantly reduced（P<0.05），intrapulmonary shunt fraction of the 3 groups were significantly increased，but the group C was significantly lower than group A and group B（P<0.05），arterial oxygen tension were significantly decreased（P<0.05），but there was no significant difference between groups（P>0.05）.In the early 8 min，the FA/FI of group B was higher than group C，over time，the three groups FA/FI converge.Conclusion： Pressure-controlled ventilation in single-lung ventilation status can improve the lung compliance，but it has no significant effect for narcotic drugs FA/FI.
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