Objective: To explore the clinical efficacy of intestinal flora transplantation intervention on children with autism complicated with gastrointestinal symptoms. Method: A total of 80 children with autism and gastrointestinal symptoms admitted to Yichun People's Hospital from January 2022 to July 2022 were enrolled as the subjects. According to admission sequence, the children were divided into observation group and control group by the random number table method, with 40 cases in each group. The control group received routine rehabilitation training, and the observation group was given intestinal flora transplantation intervention on this basis. The efficacy, gastrointestinal symptoms [gastrointestinal symptom rating scale (GSRS)], autism symptoms [childhood autism rating scale (CARS), autism behavior checklist (ABC)], intestinal flora status (abundance of flora phylum) and adverse reactions were compared between the two groups. Result: The effective rates at 1 month and 2, 3, 6 months in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). After 1 month and 2, 3, 6 months of treatment, the total scores of GSRS, CARS and ABC in the observation group were better than those in the control group, the differences were statistically significant (P<0.05). After 1 month of treatment, the richness of firmicutes in the observation group was higher than that in the control group, with statistical significance (P<0.05), while there were no statistical significance in the abundance of other phyla between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions within 6 months between the two groups (P>0.05). Conclusion: Intestinal flora transplantation intervention has a significant efficacy in the treatment of children with autism and gastrointestinal symptoms. It can improve autism and gastrointestinal symptoms in children by regulating and restoring intestinal microbial balance.

2023 Vol. 20　(17):　1-5 [Abstract]（ 318 ） HTML (1 KB)  PDF  (927 KB)  ( 106 )

Objective: To investigate the value of less invasive surfactant administration (LISA) in the treatment of neonatal respiratory distress syndrome (NRDS). Method: A total of 80 children with NRDS admitted to Jingdezhen Maternal and Child Health Hospital from May 2019 to August 2022 were selected and divided into the traditional group and the LISA group with 40 cases in each group according to random number table method. The traditional group was treated with endotracheal intubation, pulmonary surfactant (PS) perfusion and extubation (INSURE), while the LISA group was treated with LISA technology. Mechanical ventilation time, oxygen inhalation time, hospital stay and PS dosage were recorded in the two groups. The arterial partial pressure of carbon dioxide (PaCO2), oxygenation index (OI), partial oxygen pressure (PaO2), oxygen saturation (SaO2), pulmonary vascular resistance (PVR), extra vascular lung water (EVLW), mean pulmonary artery pressure (mPAP), right ventricular stroke work index (RVSWI) and serum advanced oxidation protein products (AOPPs), 8-hydroxydeoxyguanylate (8-OHdG) levels were compared between the two groups before and after administration. Adverse reactions and complications were recorded. Result: The duration of mechanical ventilation and hospital stay in the LISA group were shorter than those in the traditional group, and the dose of PS in the LISA group was lower than that in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of PaCO2 in two groups were lower than those before administration, the levels of PaO2, SaO2 and OI were higher than those before administration, and the level of PaCO2 in the LISA group was lower than that in the traditional group, the levels of PaO2, SaO2 and OI were higher than those in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of PVR, EVLW and mPAP in two groups were lower than those before administration, and the level of RVSWI in two groups were higher than those before administration, the levels of PVR, EVLW and mPAP in the LISA group were lower than those in the traditional group, and the level of RVSWI was higher than that in the traditional group, the differences were statistically significant (P<0.05). 24 h after administration, the levels of serum AOPPs and 8-OHdG in the two groups were lower than those before administration, the LISA group were lower than those in the traditional group, the differences were statistically significant (P<0.05). The percentages of bradycardia, mechanical ventilation and re-administration of PS in LISA group were 5.00%, 12.50% and 30.00%, which were lower than 20.00%, 32.50% and 52.50% in traditional group, the differences were statistically significant (P<0.05). Conclusion: LISA technology can improve the oxygenation function and pulmonary circulation function in children with NRDS, reduce the incidence of bradycardia, mechanical ventilation and re-administration of PS, and regulate the levels of serum AOPPs and 8-OHdG.

2023 Vol. 20　(17):　11-16 [Abstract]（ 207 ） HTML (1 KB)  PDF  (1016 KB)  ( 78 )

Objective: To explore the effectiveness of surgical internal fixation in the treatment of ankle joint fractures combined with lower tibiofibular ligament injury. Method: This study prospectively selected 84 patients with ankle fracture combined with lower tibiofibular ligament injury treated in Bijie Hospital of Traditional Chinese Medicine from December 2020 to January 2023 as the test subjects. The patients were divided into study group and control group by random number table method, 42 cases in each group. The control group received conservative treatment after joint reduction, and the study group received surgical internal fixation. The therapeutic effect, fracture healing effect, visual analogue scale (VAS) score and ankle joint function Ogilvie-Harris ankle joint score before and after treatment were observed and compared between the two groups, while the occurrence of adverse reactions was recorded. Result: The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P<0.05). The excellent and good rate of fracture healing in the study group was significantly higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the VAS score and Ogilvie-Harris ankle joint score of the two groups were significantly improved compared to before treatment, the differences were statistically significant (P<0.05); the VAS score of the study group was significantly lower than that of the control group, the difference was statistically significant (P<0.05), while the Ogilvie-Harris ankle joint score was significantly higher than that of the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P<0.05). Conclusion: The application of surgical internal fixation for the treatment of ankle joint fracture combined with lower tibiofibular ligament injury has a definite effect. This treatment method can better improve the ankle joint injury of patients, promote fracture healing efficiency, alleviate pain, have fewer adverse reactions, and is safe and reliable.

2023 Vol. 20　(17):　21-24 [Abstract]（ 224 ） HTML (1 KB)  PDF  (974 KB)  ( 72 )

Objective: To investigate the application effect of ultrasound-guided transverse abdominis plane block in laparoscopic cholecystectomy. Method: A total of 60 patients undergoing laparoscopic cholecystectomy admitted to the First Hospital of Nanchang from January 2020 to December 2022 were selected and divided into control group and experimental group according to random number table method, with 30 cases in each group. Both groups were given anesthesia induction with 1.5-2 mg/kg Propofol, 0.1-0.2 μg/kg Sufentanil, 0.02 mg/kg Midazolam and 0.2 mg/kg Atracurium. The experimental group received ultrasound-guided transverse abdominis plane block and 10 mL of 0.25% Ropivacaine was injected, while the control group injected the same dose of normal saline. The mean arterial pressure (MAP), heart rate (HR) and percutaneous arterial oxygen saturation (SpO2) of the two groups were recorded before skin incision (T0), during skin incision (T1), 15 min after skin incision (T2), 30 min after skin incision (T3) and immediately after operation (T4). The total amount of Propofol and Remifentanil used, the first postoperative exhaust time and eating time in the two groups were recorded. Visual analogue scale (VAS) scores of the two groups were recorded at 0.5, 1, 2, 6, 12 and 24 h after awakening, and the occurrence of adverse reactions were recorded in both groups. Result: At T0 time point, there were no significant differences in MAP and HR levels between the two groups (P>0.05). At T1, T2 and T3 time point, the levels of MAP and HR in the two groups showed a downward trend, but those in the experimental group were higher than those in the control group (P<0.05). At T4 time point, the levels of MAP and HR in both groups were higher than those at T3, and those in the experimental group were higher than those in the control group (P<0.05). There were no significant differences in SpO2 levels between the two groups at T0, T1, T2, T3 and T4 time point (P>0.05). The dosage of Propofol and Remifentanil in the experimental group were less than those in the control group, and the first postoperative exhaust time and eating time in the experimental group were shorter than those in the control group (P<0.05). The VAS scores of the experimental group were lower than those of the control group at each time point after awakening (P<0.05). The incidence of adverse reactions in the experimental group (6.67%) was lower than that in the control group (26.67%) (P<0.05). Conclusion: The application of ultrasound-guided transverse abdominis plane block in laparoscopic cholecystectomy can reduce hemodynamic fluctuation, and has the advantages of less anesthetic dosage, rapid postoperative recovery, light pain and low incidence of adverse reactions.

2023 Vol. 20　(17):　29-33 [Abstract]（ 136 ） HTML (1 KB)  PDF  (1013 KB)  ( 35 )

Objective: To investigate the effects of electroencephalobionic electrical stimulation combined with Pramipexole on non-motor symptoms and sleep quality in patients with Parkinson disease (PD). Method: A total of 88 PD patients admitted to Nanchang People's Hospital from January 2021 to June 2022 were selected and divided into the control group and the observation group by random number table method, with 44 cases in each group. The control group was treated with oral Pramipexole, and based on this, the observation group was treated with electroencephalobionic electrical stimulation, non-motor symptoms, sleep quality and adverse events were compared between the two groups. Result: There were no significant differences in the scores of non-motor symptoms and sleep quality between the two groups before treatment (P>0.05); after treatment, the scores of non-motor symptoms and sleep quality of the two groups were lower than those before treatment, and the observation group were lower, the differences were statistically significant (P<0.05). Both groups successfully completed the treatment, and no obvious discomfort occurred during the treatment. Conclusion: The combination of electroencephalobionic electrical stimulation and Pramipexole has a definite effect on PD patients, which can improve the non-motor symptoms and sleep quality of patients without inducing adverse events.

2023 Vol. 20　(17):　38-41 [Abstract]（ 77 ） HTML (1 KB)  PDF  (1006 KB)  ( 54 )

Objective: To explore the clinical effects of rigid neuroendoscopy assisted hematoma removal surgery and double hole irrigation and drainage surgery in the treatment of separated chronic subdural hematoma. Method: A retrospective analysis was analyzed on 69 patients with partitioned chronic subdural hematoma admitted to Xiamen Fifth Hospital from January 2019 to December 2022. A total of 31 patients treated with rigid neuroendoscopic assisted hematoma removal surgery were selected as the study group, and 38 patients treated with double hole irrigation and drainage surgery were selected as the control group. The related therapeutic indicators, neurological function indicators, daily living ability, and postoperative complications the two groups were compared. Result: The midline displacement in the study group was less than that in the control group, and the drainage time and hospitalization time were shorter than those in the control group, the surgical time was longer than that in the control group, and the hematoma clearance rate was higher than that in the control group, the differences were significant (P<0.05). The levels of central nervous system specific protein S100β in two groups at 30 days after surgery were all lower than those before surgery, and the study group was lower than that of the control group (P<0.05). 30 days after surgery, the ADL scores of both groups were higher than those before surgery, and the study group was higher than that of the control group (P<0.05). 30 days after surgery, the CSS scores of both groups were lower than those before surgery, and the study group was lower than that of the control group (P<0.05). The incidence of pneumatosis, fluid accumulation, hematoma recurrence, and infection in the study group were lower than those in the control group (P<0.05). There were no statistically significant differences in the incidences of epilepsy and brain parenchymal injury between the two groups (P>0.05). Conclusion: Compared to double hole irrigation and drainage surgery, rigid neuroendoscopy assisted hematoma removal surgery can better remove hematoma, improve neurological function and daily living ability, and reduce the risk of complications in the treatment of separated chronic subdural hematoma.

2023 Vol. 20　(17):　46-50 [Abstract]（ 146 ） HTML (1 KB)  PDF  (1055 KB)  ( 9 )

Objective: To investigate the effect of intensity-modulated radiotherapy combined with surgery for medium to low locally progressive rectal cancer and the effect on tumor markers. Method: Ninety-eight patients with medium to low locally progressive rectal cancer treated in Ganzhou People's Hospital from January 2019 to January 2020 were selected and divided into observation group and control group using the random number table method, with 49 cases each. Both groups received laparoscopic radical rectal cancer treatment, and the control group was treated with neoadjuvant radiotherapy before surgery, while the observation group was treated with full neoadjuvant therapy before surgery. The near and long-term efficacy, complication rate, serum tumor marker levels and immune function indexes of the two groups were compared. Result: The objective remission rate of the observation group was higher than that of the control group (P<0.05), and the 2-year local recurrence rate and distant metastasis rate were lower than those of the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Before treatment, the levels of serum tissue polypeptide specific antigen (TPS), cytokeratin 19 fragment (CYFRA21-1), fatty acid synthase (FAS) and tumor-type M2 pyruvate kinase (TuM2-PK) were not significantly different between the two groups (P>0.05); after treatment, the levels of each index were reduced in both groups, and the observation group were lower than those of the control group (P<0.05). Before treatment, the levels of CD3+, CD4+ and CD8+ in the two groups were not significantly different compared (P>0.05); after treatment, the levels of CD3+ and CD4+ decreased in both groups, but the observation group were higher than those of the control group (P<0.05), and CD8+ increased in both groups, but the observation group was lower than that of the control group (P<0.05). Conclusion: Full neoadjuvant treatment for middle to low locally progressive rectal cancer before laparoscopic radical resection of rectal cancer has significant near and long-term effects, without increasing complications, and can significantly reduce the level of serum tumor markers, with a low degree of damage to immune function.

2023 Vol. 20　(17):　55-59 [Abstract]（ 86 ） HTML (1 KB)  PDF  (1123 KB)  ( 46 )

Objective: To study the value of Pingchong Jiangni Tongluo Decoction + Letrozol in the treatment of endometriosis. Method: A total of 80 patients with endometriosis admitted to the Affiliated Hospital of Jiangxi University Chinese Medicine from August 2021 to May 2022 were selected and divided into groups by simple random distribution method, with 40 cases in each group. The study group was treated with Pingchong Jiangni Tongluo Decoction + Letrozol, and the control group was treated with Letrozol. The total effective rate, luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone (P), estradiol (E2), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-1β (IL-1β), interleukin-6 (IL-6), T lymphocyte (CD4+, CD3+, CD8+, CD4+/CD8+), ovarian volume, antral follicle count, TCM symptoms scores in the two groups were observed. Result: The total effective rate of the study group (92.50%) was higher than that of the control group (75.00%), the difference was statistically significant (P<0.05). There were no significant differences in gonadal hormone levels between the two groups before treatment (P>0.05); LH, FSH, P and E2 in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in inflammatory indexes between the two groups before treatment (P>0.05); the levels of TNF-α, IL-8, IL-1β and IL-6 in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in ovarian function between the two groups before treatment (P>0.05); the ovarian volume and the antral follicle count in the study group were better than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in TCM symptoms scores between the two groups before treatment (P>0.05); the scores of TCM symptoms in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in immune indexes between the two groups before treatment (P>0.05); CD4+, CD3+ and CD4+/CD8+ in the study group were higher than those in the control group, CD8+ was lower than that of control group, the differences were statistically significant (P<0.05). Conclusion: The therapeutic effect of Pingchong Jiangni Tongluo Decoction + Letrozol is more ideal, which can effectively improve gonadal hormone and ovarian function, reduce inflammatory reaction, and at the same time quickly relieve related symptoms and regulate patients' immune function.

2023 Vol. 20　(17):　63-67 [Abstract]（ 101 ） HTML (1 KB)  PDF  (1178 KB)  ( 21 )

Objective: To investigate the effect of Jiaomu Gualou Decoction in the treatment of chronic heart failure and its influence on myocardial microcirculation. Method: This study was conducted from November 2019 to November 2022. 92 patients with chronic heart failure treated in Tai’an Second Hospital of Traditional Chinese Medicine during this period were selected and divided into a control group (n=46, treated with conventional western medicine) and a study group (n=46, treated with conventional western medicine combined with Jiaomu Gualou Decoction) by applying the random number table method. The TCM symptoms scores (shortness of breath, phlegm, chest and rib swelling, fatigue), cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD)], inflammatory factors [interleukin-8 (IL-8), interleukin-17 (IL-17), hypersensitive C reactive protein (hs-CRP )], myocardial microcirculatory indexes (ST-segment drop frequency, duration, total myocardial ischemic load) and oxidative stress indexes [lipid peroxidation (LPO), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px)]. Result: Before treatment, there were no significant differences in the scores of shortness of breath, phlegm, chest and rib swelling and fatigue between the two groups (P>0.05). After treatment, the scores of shortness of breath, phlegm, chest and rib swelling, and fatigue decreased in both groups, and those in the study group were lower than those in the control group (P<0.05). Before treatment, there were no significant differences in LVEF, LVESD and LVEDD between the two groups (P>0.05). After treatment, LVEF increased, LVESD and LVEDD decreased in both groups, and LVEF in the study group was higher than that in the control group, LVESD and LVEDD in the study group were lower than those in the control group (P<0.05). Before treatment, there were no significant differences in the levels of IL-8, IL-17 and hs-CRP between the two groups (P>0.05). After treatment, the levels of IL-8, IL-17 and hs-CRP decreased in both groups, and those in the study group were lower than those in the control group (P<0.05). Before treatment, there were no significant differences in the frequency, duration and total myocardial ischemia load of ST-segment between the two groups (P>0.05). After treatment, the frequency, duration and total myocardial ischemia load of ST-segment decreased in both groups, and those in the study group were lower than those in the control group (P<0.05). Before treatment, there were no significant differences in LPO, SOD, MDA and GSH-Px between the two groups (P>0.05). After treatment, the levels of GSH-Px and SOD increased, LPO and MDA decreased in both groups, and the levels of GSH-Px and SOD in the study group were higher than those in the control group, and the levels of LPO and MDA were lower than those in the control group (P<0.05). Conclusion: Treatment of patients with chronic heart failure with Jiaomu Gualou Decoction can improve patients' cardiac function, myocardial microcirculation and reduce the degree of inflammatory response and oxidative stress.

2023 Vol. 20　(17):　72-76 [Abstract]（ 130 ） HTML (1 KB)  PDF  (1241 KB)  ( 31 )

Objective: To investigate the effect of Maitland joint mobilization combined with traditional Chinese medicine fumigation on joint function and pain mediators of patients with rotator cuff injury. Method: A total of 68 inpatients with rotator cuff injury from September 2020 to September 2022 in the Department of Rehabilitation Medicine, Central Hospital of Xinyu Iron and Steel Group Co., Ltd. were included and randomly divided into two groups. The control group (n=34) was treated with Maitland joint mobilization alone, and the research group (n=34) was treated with Maitland joint mobilization combined with traditional Chinese medicine fumigation. Both groups were treated for 6 weeks. The shoulder joint range of motion, shoulder joint function, and pain mediator [substance P (SP)] and prostaglandin E2 (PGE2)] levels before and after treatment in the two groups were compared, and the clinical effects of the two groups were compared. Result: The total effective rate of the research group (94.12%) was significantly higher than that of the control group (70.59%), the difference was statistically significant (P<0.05). After treatment, the range of abduction, flexion, external rotation and internal rotation of the shoulder joint in both groups increased than those before treatment, and those in the research group were higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, the pain, muscle strength, range of motion, daily life scores and total scores of the two groups were higher than those before treatment, and those in the research group were higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, serum PGE2 and SP in both groups were lower than those before treatment, and those in the research group were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Maitland joint mobilization combined with traditional Chinese medicine fumigation can significantly improve the clinical efficacy of rotator cuff injury, improve the shoulder joint function and range of motion, and effectively reduce the levels of pain mediators.

2023 Vol. 20　(17):　82-86 [Abstract]（ 95 ） HTML (1 KB)  PDF  (1186 KB)  ( 68 )

Objective: To explore the effect of evidence-based nursing model on the degree of disease pain and quality of life in patients with multiple myeloma. Method: A total of 90 patients with multiple myeloma who received treatment in the First Hospital of Putian City from January 2020 to June 2022 were selected as research objects, and were divided into the experimental group and the control group according to random number table method, with 45 patients in each group. The control group was given routine nursing mode, and the experimental group was given evidence-based nursing mode. The degree of bone pain, exercise of self-care agency scale (ESCA)scores, negative psychological emotion and quality of life scores were compared between the two groups before and after intervention. Result: After intervention, the degree of bone pain in the experimental group was significantly lower than that in the control group (P<0.05). After intervention, the scores of each dimension of ESCA in the experimental group were significantly higher than those in the control group (P<0.05). After intervention, the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the experimental group were significantly lower than those in the control group (P<0.05). After intervention, the scores of each dimension of the MOS 36-item short-form health survey (SF-36) in the experimental group were significantly higher than those in the control group (P<0.05). Conclusion: Evidence-based nursing model is effective in patients with multiple myeloma, which can effectively reduce the degree of bone pain, strengthen the self-care ability of patients, alleviate negative psychology and improve the quality of life.

2023 Vol. 20　(17):　91-95 [Abstract]（ 113 ） HTML (1 KB)  PDF  (1283 KB)  ( 47 )

Objective: To investigate the application effect of Fuzheng Qiangdu moxibustion in patients with postmenopausal osteoporosis (PMOP). Method: A total of 68 patients with PMOP treated in the Osteoporosis Clinic and Pain Clinic of Mindong Hospital of Ningde City from June 2021 to June 2022 were selected and divided into experimental group (n=34) and control group (n=34) according to random number table method. The control group was treated with modern medical routine nursing intervention, and the experimental group was treated with Fuzheng Qiangdu moxibustion intervention on the basis of the control group, all of which were treated for 1 month. Gonadal hormone, bone metabolism indexes and TCM symptoms scores were observed between the two groups before and after intervention. Result: After 1 month of intervention, serum estradiol (E2) level of experimental group was higher than that of control group, and the levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), osteoprotegerin (OPG), C-terminal peptide of type Ⅰ collagen (CTX-Ⅰ) and bone alkaline phosphatase (BALP), and the scores of lumbago and back pain, lumbago and knee weakness, lower limb tics, walking difficulty and difficulty in carrying weight were lower than those of control group, the differences were statistically significant (P<0.05). Conclusion: Fuzheng Qiangdu moxibustion intervention can effectively regulate the level of Gonadal hormone in PMOP patients, correct the abnormal bone metabolism, promote the balance between bone formation and bone resorption, and alleviate the clinical symptoms of patients.

2023 Vol. 20　(17):　99-103 [Abstract]（ 126 ） HTML (1 KB)  PDF  (1303 KB)  ( 67 )

Objective: To analyze the role of of CT data hip bone 3D model reconstruction in hip replacement. Method: A total of 80 patients with hip arthroplasty admitted to the Department of Bone and Joint Surgery of Pingxiang People's Hospital from January 2020 to January 2022 were selected and divided into two groups with 40 patients in each group by random number table method. The 2D group was evaluated by traditional 2D image before and after surgery, and the 3D group was evaluated by 3D image reconstruction of hip bone based on CT data before and after surgery. Imaging measurements (proximal femur matching degree, femoral offset, anteversion angle, abduction angle) before and after surgery, surgical indicators, excellent and good rate of postoperative hip function, and total incidence of complications were compared between the two groups. Result: Six months after surgery, anteversion angle and abduction angle of the 3D group were lower than those of the 2D group, the differences were statistically significant (P<0.05). The matching degree and femoral offset of proximal femur in the 3D group were higher than those in the 2D group, the differences were statistically significant (P<0.05). All surgical indexes in the 3D group were better than those in the 2D group, the differences were statistically significant (P<0.05). Three months after surgery, the excellent and good rate of hip joint function in 3D group (95.00%) was higher than that in 2D group (80.00%), the difference was statistically significant (P<0.05). One months after surgery, the total complication rate of the 3D group (2.50%) was lower than that of the 2D group (20.00%), the difference was statistically significant (P<0.05). Conclusion: The introduction of hip bone 3D model reconstruction technology based on CT data before and after hip replacement can effectively improve hip joint function, reduce blood loss and drainage volume, shorten operation and recovery time, reduce the incidence of complications, and improve surgical safety.

2023 Vol. 20　(17):　108-111 [Abstract]（ 124 ） HTML (1 KB)  PDF  (1235 KB)  ( 30 )

Objective: To study the effect of Mimics simulation-assisted bronchoscopic cryotherapy in the treatment of bronchial tuberculosis. Method: A total of 68 patients with bronchial tuberculosis admitted to Third People's Hospital of Jiujiang City from January 2020 to June 2022 were selected, they were divided into observation group (n=34) and reference group (n=34) by random number table method. The reference group received bronchoscopic cryotherapy, and the observation group received Mimics simulation-assisted bronchoscopic cryotherapy. The total effective rate, negative conversion rate of deep sputum and immune function indexes were compared between the two groups. Result: After treatment, the total effective rate in the observation group was higher than that in the reference group (P<0.05). The negative conversion rate of deep sputum in the observation group was higher than that in the reference group (P<0.05). After treatment, CD3+, CD4+, CD4+/CD8+ in the observation group were higher than those in the reference group, and CD8+ in the observation group was lower than that in the reference group (P<0.05). Conclusion: The application of Mimics simulation-assisted bronchoscopic cryotherapy has better effect on patients with bronchoscopy than single bronchoscopy cryotherapy, which can effectively improve the negative conversion rate of deep sputum and immune function of patients, and can be used for reference in clinical practice.

2023 Vol. 20　(17):　116-119 [Abstract]（ 156 ） HTML (1 KB)  PDF  (1159 KB)  ( 26 )

Objective: To investigate the changes of serum indicators of hepatic fibrosis and ferritin levels in patients with non-alcoholic fatty liver disease (NAFLD) complicated with type 2 diabetes mellitus (T2DM) and their clinical significance. Method: A total of 88 patients with T2DM admitted to the Affiliated Tai’an City Central Hospital of Qingdao University from January 2021 to October 2022 were selected and divided into 31 patients in T2DM group (T2DM patients alone) and 57 patients in NAFLD group (NAFLD patients combined) according to the results of color Doppler ultrasound, and 32 healthy patients in the hospital during the same period were selected as control group. Serum indicators of hepatic fibrosis [collagen type Ⅳ (C-Ⅳ), hyaluronic acid (HA), laminin (LN)], and serum ferritin (SF) were compared among the three groups. According to the severity of NAFLD, patients in the NAFLD group were divided into 25 cases in the mild group (patients with mild NAFLD), 22 cases in the moderate group (patients with moderate NAFLD), and 10 cases in the severe group (patients with severe NAFLD). The correlation between hepatic fibrosis indexes and SF and the severity of NAFLD in patients with T2DM was determined. Result: Total cholesterol, triglyceride, LDL-C, fasting blood glucose and 2 h PG in T2DM group and NAFLD group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). HA in NAFLD group was significantly higher than that in control group, the difference was statistically significant (P<0.05). The level of SF in NAFLD group was higher than those in T2DM group and control group, and that in T2DM group was higher than that in control group, the differences were statistically significant (P<0.05). The levels of SF and HA in severe group and moderate group were significantly higher than those in mild group, the differences were statistically significant (P<0.05). Conclusion: In patients with T2DM complicated with NAFLD, there are abnormal expression of serum hepatic fibrosis indexes and SF levels, and with the aggravation of NAFLD, abnormal expression of fibrosis indexes and SF becomes more obvious.

2023 Vol. 20　(17):　124-128 [Abstract]（ 121 ） HTML (1 KB)  PDF  (1414 KB)  ( 44 )

Objective: To explore the effect of Quetiapine combined with Sodium Valproate Sustained Release Tablets in patients with bipolar affective disorder. Method: A total of 75 patients with bipolar disorder admitted to Jiangxi Provincial Psychiatric Hospital from January 2020 to November 2022 were selected as the research subjects, and they were divided into a control group (n=37) and an observation group (n=38) using numbered singular and even forms. The control group was treated with Sodium Valproate Sustained Release Tablets, while the observation group was treated with a combination of Quetiapine and Sodium Valproate Sustained Release Tablets. The scores of the Bech-Rafaelsen mania rating scale (BRMS), neurotransmitter levels and quality of life scores were compared between the two groups. Result: Before treatment, there was no statistically significant difference in BRMS scores between the two groups (P>0.05); after 8 weeks of treatment, the BRMS scores of both groups were lower than those before treatment, and the observation group was lower than that of the control group, the differences were statistically significant (P<0.05). Before treatment, there were no statistically significant differences in the levels of 5-HT, NE and DA between the two groups (P>0.05); after 8 weeks of treatment, the levels of 5-HT, NE, and DA in both groups were lower than those before treatment, and the observation group were lower than those of the control group, the differences were statistically significant (P<0.05). Before treatment, there were no statistically significant differences in physiological function, energy, emotional function, physiological function, mental health, social function, physical pain and overall health scores between the two groups (P>0.05); after 8 weeks of treatment, the physiological function, energy, emotional function, physiological function, mental health, social function, physical pain and overall health scores of the two groups of patients were higher than those before treatment, and the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion: The combination of Quetiapine and Sodium Valproate Sustained Release Tablets can reduce the BRMS score of patients with bipolar affective disorder, regulate the expression levels of NE, 5-HT and DA, and improve the quality of life of patients.

2023 Vol. 20　(17):　132-136 [Abstract]（ 141 ） HTML (1 KB)  PDF  (1394 KB)  ( 73 )

Objective: To analyze the effect of free hand fetal position transfer on cesarean section rate and perineal lateral resection rate of gestational diabetes mellitus complicated with dystocia during labor analgesia. Method: A retrospective analysis was made on the clinical data of 124 cases with gestational diabetes mellitus complicated with dystocia who received delivery in Quanzhou Women's and Children's Hospital from January to December 2020. According to different treatment methods, 45 cases were divided into forceps assisted delivery group (forceps assisted delivery) and 79 cases were divided into free hand transfer group (free hand fetal position transfer under labor analgesia). The vaginal delivery rate, cesarean section rate, lateral perineal resection rate, perineal laceration and laceration degree, perineal pain degree, neonatal conditions and complications were compared between the two groups. Result: Compared with the forceps assisted delivery group, the vaginal delivery rate, cesarean section rate, perineal pain degree and complication rate were higher than those in the free hand transfer group (P<0.05). Compared with the vaginal delivery patients in forceps assisted delivery group, the lateral perineal incision rate and perineal laceration rate of vaginal delivery patients in the free hand transfer group were lower (P<0.05), but there was no statistical significance in the perineal laceration degree of patients with perineal laceration in the two groups was compared (P>0.05). Conclusion: On the basis of labor analgesia for gestational diabetes complicated with dystocia using free hand transfer of fetal position, the rate of cesarean section and perineal lateral resection decreased significantly, effectively relieve perineal pain.

2023 Vol. 20　(17):　141-144 [Abstract]（ 157 ） HTML (1 KB)  PDF  (1305 KB)  ( 29 )

Objective: To study the clinical effect of Amiodarone combined with Metoprolol in the treatment of patients with chronic heart failure and ventricular arrhythmia, and to provide clinical guidance for the recovery of patients. Method: A total of 80 patients with chronic heart failure and ventricular arrhythmia who were admitted to Fuzhou Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the research subjects. The patients were divided into a study group and a control group according to the random number table method, with 40 cases in each group. The control group was treated with Amiodarone, and the study group was treated with Amiodarone combined with Metoprolol. Before and after treatment for 3 months, the left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and left ventricular ejection fraction (LVEF) were compared between the two groups. After treatment for 1 month, 2 and 3 months, the sinus rhythm maintenance rate of the two groups were recorded. After treatment for 3 months, the total effective rate and adverse reactions of the two groups were recorded. Result: The total effective rate of the study group was 92.5%, which was significantly higher than 72.5% of the control group, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in LVEDV, LVSV and LVEF between the two groups (P<0.05). After 3 months of treatment, LVEDV and LVSV in the two groups were significantly decreased, and those in the study group respectively was (131.3±30.6), (67.3±18.4) mL, which were significantly lower than those in the control group (149.5±32.5), (85.4±19.8) mL, LVEF in the study group was significantly increased, and that in the study group group was (48.7±6.4)%, which was significantly higher than (42.9±5.7)% that of the control group, the differences were statistically significant (P<0.05). After 1, 2 and 3 months of treatment, the sinus rhythm maintenance rate in the study group respectively was 77.5%, 87.5% and 90.0%, which were significantly higher than 47.5%, 60.0% and 62.5% in the control group, the differences were statistically significant (P<0.05). The incidence of adverse reactions in the two groups respectively was 5.0% and 10.0%, the difference was not statistically significant (P>0.05). Conclusion: Amiodarone combined with Metoprolol in the treatment of chronic heart failure with ventricular arrhythmia has a significant effect, it can effectively improve the cardiac function of patients, maintain the sinus rhythm of patients, and has high safety.

2023 Vol. 20　(17):　149-152 [Abstract]（ 68 ） HTML (1 KB)  PDF  (1209 KB)  ( 178 )

Objective: To investigate the effect of Ziprasidone in the treatment of patients with refractory schizophrenia and its effect on the scores of the positive and negative syndrome scale (PANSS) and serum cytokine levels in patients with schizophrenia. Method: A total of 82 patients with refractory schizophrenia admitted to Third People's Hospital of Ganzhou from January 2019 to January 2022 were selected as the research objects and divided into the observation group (n=41) and the control group (n=41) by random number table method. The control group was treated with Olanzapine, and the observation group was treated with Ziprasidone based on the control group. Both groups were treated for 6 weeks. The clinical efficacy after treatment was compared between the two groups. PANSS score, serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), 5-hydroxytryptamine (5-HT), glial fibrillary acidic protein (GFAP), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) before and after treatment and the occurrence of adverse reactions during treatment were compared. Result: After treatment, the total clinical effective rate of patients in the observation group was higher than that in the control group (P<0.05); positive symptoms, negative symptoms, general psychopathological symptoms and total score, the levels of serum GFAP, IL-2, IL-6, TNF-α, IL-17 in the observation group were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05); the levels of serum BDNF, NGF and 5-HT in the two groups after treatment were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). During the treatment, the total incidence of adverse reactions in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). Conclusion: The application of Ziprasidone in the treatment of refractory schizophrenia can effectively improve the psychiatric symptoms, relieve neuronal stress response, reduce neuronal damage, reduce inflammation, with significant efficacy and high safety.

2023 Vol. 20　(17):　157-161 [Abstract]（ 126 ） HTML (1 KB)  PDF  (1383 KB)  ( 186 )

Objective: To investigate the influencing factors of immature autologous internal arteriovenous fistula and construct a prediction model. Method: A total of 1 001 patients with stage 5 chronic kidney disease who had established autologous internal arteriovenous fistula in Pingxiang People's Hospital from June 2016 to June 2021 were selected as the research subjects. According to whether the patients' internal fistula had mature, they were divided into mature internal fistula group (n=735) and immature internal fistula group (n=266). The clinical data of patients were collected, and the influencing factors of immature autologous internal arteriovenous fistula were analyzed by multivariate logistic regression, and a prediction model was constructed, and its predictive value was evaluated. Result: Obesity (OR=2.542), diabetes (OR=4.923), hypoproteinemia (OR=3.408), diameter of radial artery (OR=0.416), diameter of cephalic vein (OR=0.587) and C reactive protein (OR=3.487) were influencing factors of immature autologous internal arteriovenous fistula (P<0.05). The prediction model was constructed: Y=1/(1+e-x), X=-2.958 + 0.933×obesity + 1.594×diabetes + 1.226×hypoalbuminemia - 0.877×diameter of radial artery -0.533×diameter of cephalic vein + 1.249×C reactive protein. The area under the ROC curve was 0.820 [95%CI (0.794, 0.846), P<0.001], the sensitivity was 81.55%, and the specificity was 67.26%. Conclusion: Obesity, diabetes, hypoproteinemia, diameter of radial artery, diameter of cephalic vein and C reactive protein are closely related to immature autologous internal arteriovenous fistula, the model constructed in this study has good prediction value and can be used for clinical reference.

2023 Vol. 20　(17):　166-171 [Abstract]（ 148 ） HTML (1 KB)  PDF  (1585 KB)  ( 115 )

Neonatal pulmonary hemorrhage (PH) refers to massive pulmonary hemorrhage during the neonatal period, which is one of the major critical diseases of neonates with a high mortality rate. How to identify the risk factors of PH early and taking effective measures to reduce the mortality rate is a hot spot in clinical research. This paper reviews the literature on the risk factors and treatment of neonatal pulmonary hemorrhage.

2023 Vol. 20　(17):　175-179 [Abstract]（ 129 ） HTML (1 KB)  PDF  (1515 KB)  ( 180 )

Non-acquired hemolytic disease of newborn is a common disease in neonatal period, its etiology is complex and diverse, and it often leads to missed diagnosis or misdiagnosis due to its similar clinical manifestations. It is mainly hemolytic disease caused by congenital defects of red blood cells, including enzyme defects of red blood cells, morphological abnormalities of red blood cells, hemoglobin disease and hemolytic disease of newborn. This article reviews the research progress in the pathogenesis of non-acquired hemolytic diseases in newborns.

2023 Vol. 20　(17):　183-188 [Abstract]（ 129 ） HTML (1 KB)  PDF  (1682 KB)  ( 145 )