Objective: To analyze the practical application effect of Dexmedetomidine preoperative nasal drip combined with combined intravenous and general anesthesia in laparoscopic hernia surgery in children. Method: A total of 100 children with oblique inguinal hernia who underwent surgical treatment in Jiujiang Maternal and Child Health Hospital from April 2020 to April 2022 were selected and divided into two groups according to the random number table method, 50 cases in each group. The control group was given combined intravenous and general anesthesia. On the basis of this, the observation group was given Dexmedetomidine preoperative nasal drip. The anesthesia effect, analgesic effect, stress response, the incidence of negative postoperative behavioral changes (NPOBC) and adverse reactions were compared between the two groups. Result: The extubation time [(6.03±1.18) min], anesthesia awakening time [(18.31±1.53) min] and residence time in the anesthesia recovery room [(60.53±5.28) min] in the observation group were shorter than those in the control group [(9.43±1.69), (27.58±2.67) , (83.69±7.31) min], the differences were statistically significant (P<0.05). The visual analogue scale (VAS) scores of the observation group 15 min after wakefulness after surgery and 24 h after surgery [(3.25±0.97), (1.53±0.42) scores] were lower than those of the control group [(4.61±1.06), (2.31±0.65) scores], the differences were statistically significant (P<0.05). 24 h after surgery, the cortisol (Cor), norepinephrine (NE) and epinephrine (E) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). 1 day after surgery, the incidence of NPOBC in the observation group was lower than that in the control group, the differences was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dexmedetomidine preoperative nasal drip combined with combined intravenous and general anesthesia is effective in laparoscopic hernia surgery in children, with strong anesthetic and analgesic effects, which can effectively reduce the stress response of children and reduce the incidence of NPOBC without serious adverse reactions.

2023 Vol. 20　(16):　5-8 [Abstract]（ 158 ） HTML (1 KB)  PDF  (926 KB)  ( 16 )

Objective: To explore the correlation between peripheral blood neutrophil/lymphocyte ratio and renal injury in patients with type 2 diabetic nephropathy (T2DN) and its early diagnosis efficiency. Method: The study subjects were selected from 70 patients with type 2 diabetes mellitus (T2DM) and 130 patients with T2DN who were hospitalized in the Endocrinology Department of Ganxian District People's Hospital, Ganzhou City from June 2021 to March 2022. Patients with T2DM were included in group C. According to the urine albumin creatine ratio (UACR), patients with T2DN were divided into group A and group B, with 65 cases in each group, and 105 healthy people in our hospital served as group D in the same period. The expression situation of neutrophil/lymphocyte ratio (NLR), glycosylated hemoglobin (HbA1c), creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), cystatin C (Cys C) and homocysteine (Hcy) were observe in the four groups, and the correlation between NLR and other indexes and its early diagnosis efficiency of T2DN were analyzed. Result: There were significant differences in NLR, HbA1c and Hcy among all groups (P<0.05), and the NLR, HbA1c, Hcy, Cr, BUN, and UA in group A, B and C were significantly higher than those in group D, Cys C and Hcy in group A and B were significantly higher than those in group C, and the NLR in group A was significantly higher than that in group B and C, the differences were statistically significant (P<0.05). There were significant differences in Cr, BUN and UA among all groups (P<0.05), and Cr, BUN and UA in group A and B were significantly higher than those in group C, and Cr, BUN and UA in group A were significantly higher than those in group B (P<0.05). Pearson correlation analysis showed that NLR had a strong correlation with Cr, BUN, and UA, and a certain correlation with Cys C (P<0.05). The ROC curve shows that when NLR 2.625, the maximum area under the curve obtained, with sensitivity=88.50%, specificity=84.30% and AUC=0.590. Conclusion: NLR in patients with T2DM showed an increasing trend, and the expression of NLR increased continuously with the progress of the disease in patients with T2DN, and it shows a correlation with renal function related indicators. NLR shows certain value in the auxiliary diagnosis and prognosis of patients with T2DN.

2023 Vol. 20　(16):　13-17 [Abstract]（ 178 ） HTML (1 KB)  PDF  (1049 KB)  ( 11 )

Objective: To investigate the efficacy of Famciclovir in the prevention of herpes zoster in multiple information myeloma and its effect on cytokines interleukin-2 (IL-2) and interleukin-10 (IL-10). Method: A total of 60 patients with multiple myeloma admitted to First Affiliated Hospital of Gannan Medical University from February 2020 to February 2021 were retrospectively selected and divided into observation group and control group according to the treatment methods, with 30 cases in each group. The control group received Bortezomib combined with Cyclophosphamide and Dexamethasone (BCD) regimen chemotherapy, while the observation group received Famciclovir orally on the basis of the control group. The adverse reactions, incidence of herpes zoster during chemotherapy, laboratory indicators, pain degree, clinical efficacy and satisfaction of the two groups were statistically analyzed. Result: The rate of adverse reactions during chemotherapy in the observation group was 10.00% (3/30), which was lower than 33.33% (10/30) in the control group (P<0.05); the incidence of herpes zoster was 3.33% (1/30), which was lower than 20.00% (6/30) in the control group (P<0.05). After treatment, the level of IL-10 in the observation group was lower than that in the control group (P<0.05), and the level of IL-2 in the observation group was higher than that in the control group (P<0.05). After treatment, the VAS score of the observation group was lower than that in the control group (P<0.05). There was no significant difference in clinical efficacy between the two groups (P>0.05). The satisfaction of patients in the observation group was 93.33%, which was higher than 66.67% in the control group (P<0.05). Conclusion: Famciclovir can effectively reduce the incidence of herpes zoster during the treatment of multiple myeloma, and effectively increase the level of cytokine IL-2 and reduce the level of IL-10.

2023 Vol. 20　(16):　23-26 [Abstract]（ 171 ） HTML (1 KB)  PDF  (1002 KB)  ( 91 )

Objective: To investigate the clinical effect of colonoscopic cold loop resection in microscopic polyps of the colon. Method: A total of 122 patients with microscopic colon polyps treated in Xuzhou Tongshan District Hospital of Traditional Chinese Medicine from January 2019 to January 2022 were selected, they were divided into observation group (n=61) and control group (n=61) by applying the random number table method. The control group received high-frequency electrocoagulation resection under colonoscopy and the observation group received colonoscopic cold loop resection. The procedure-related indexes (operation time, treatment cost), serum pain factor level and complication rate of the two groups were compared. Result: The operation time of the observation group was shorter than that of the control group, and the treatment cost was lower, the differences were statistically significant (P<0.05). Before surgery, there were no significant differences in the levels of prostaglandin E2 (PGE2) and nerve growth factor (NGF) between the two groups (P>0.05); 1 day after surgery, NGF and PGE2 in both groups were higher than those before surgery, but those in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The complication rate of the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: The operation of colonoscopic cold loop resection in microscopic colon polyps is simple, with clear efficacy and high safety.

2023 Vol. 20　(16):　30-34 [Abstract]（ 192 ） HTML (1 KB)  PDF  (1022 KB)  ( 17 )

Objective: To investigate the effect of Wiltse approach for transforaminal lumbar interbody fusion in the treatment of degenerative change of lumbar intervertebral disc. Method: A total of 100 patients with degenerative change of lumbar intervertebral disc admitted to China Aerospace Science and Industry Group 731 Hospital from January 2019 to November 2022 were divided into two groups according to random number table method. The control group (n=50) was treated with traditional approach for transforaminal lumbar interbody fusion, while the observation group (n=50) was treated with Wiltse approach for transforaminal lumbar interbody fusion. The intraoperative bleeding volume, postoperative drainage, postoperative hospitalization time, before and after treatment of lumbar and lower limb pain [visual analogue scale (VAS)], functional status [Oswestry dysfunction index (ODI)] and lumbar related parameters (intervertebral space height and lumbar lordosis) were compared between the two groups. Result: The intraoperative bleeding volume and postoperative drainage in the observation group were significantly less than those in the control group, and the postoperative hospitalization time was significantly shorter than that in the control group, the differences were statistically significant (P<0.05). There were no significant differences in VAS scores, ODI and lumbar related parameters between the two groups before operation (P>0.05). 1 and 3 months after operation, the VAS scores of lumbar vertebrae and lower limb and ODI in the observation group were significantly better than those in the control group, and the related parameters of lumbar vertebrae were significantly higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Wiltse approach for transforaminal lumbar interbody fusion is effective in the treatment of degenerative change of lumbar intervertebral disc, which can significantly improve the lumbar function and vertebral body parameters of patients and accelerate postoperative rehabilitation.

2023 Vol. 20　(16):　39-42 [Abstract]（ 150 ） HTML (1 KB)  PDF  (1050 KB)  ( 11 )

Objective: To analyze and discuss the application of acupotomy in improving pain degree and function rating scale (FRS) and Japanese orthopaedic association scores (JOA) scores in patients with lumbar disc herniation. Method: A total of 174 patients with lumbar disc herniation who were admitted to the Sixth People's Hospital of Jiujiang from April 2020 to April 2022 were selected as the control group and the experimental group according to the random number table method, with 87 cases in each group. The control group was treated with hot compress with traditional Chinese medicine + manipulative reduction, and the experimental group was treated with acupotomy on the basis of the treatment of the control group. The patients were assessed with visual analogue scale (VAS), JOA and FRS for low back pain. The evaluation results and clinical efficacy of the two groups were compared. Result: The total effective rate of the experimental group was 97.70%, which was significantly higher than 80.46% of the control group (P<0.05). After 2 weeks of treatment and after treatment, the VAS scores of the experimental group respectively was (3.28±1.02), (2.02±0.28) scores, which were significantly lower than those of the control group (5.34±1.35), (3.65±0.85) scores at the same period (P<0.05). After 2 weeks of treatment and after treatment, the scores of JOA and FRS in both groups were significantly improved (P<0.05), and the scores of JOA and FRS in the experimental group were significantly better than those in the control group at the same period (P<0.05). Conclusion: Acupotomy therapy can relieve the pain of patients with lumbar disc herniation, improve the lumbar function and symptoms such as muscle strength decline and numbness.

2023 Vol. 20　(16):　47-51 [Abstract]（ 141 ） HTML (1 KB)  PDF  (1067 KB)  ( 19 )

Objective: To investigate the application value of recurrent laryngeal nerve exposure in peroral total endoscopic thyroidectomy, so as to find a reliable surgical approach to reduce postoperative complications. Method: A total of 40 patients who underwent peroral total endoscopic thyroidectomy in the Second Affiliated Hospital of Gannan Medical College from January 2021 to April 2022 were selected. According to whether the recurrent laryngeal nerve was dissected or not, the patients were divided into the control group (thyroid lobectomy without recurrent laryngeal nerve dissection) and observation group (thyroid lobectomy after recurrent laryngeal nerve dissection), with 20 cases in each group. The occurrence and severity of postoperative hoarseness and recovery time of voice were compared between the groups, the operation time, intraoperative blood loss, postoperative wound recovery time, length of hospital stay and wound bleeding were recorded, postoperative recurrent laryngeal nerve injury was objectively evaluated. Result: The incidence of hoarseness in the observation group was significantly lower than that in the control group (P<0.05), the GRBAS grading of hoarseness assessment proposed by Japanese society for logopedics and phoniatrics was better than that in control group (P<0.05), and recovery time of voice was shorter than that in control group (P<0.05). The amount of intraoperative bleeding in the observation group was more than that in the control group, operation time was significantly longer than that in the control group (P<0.05), the postoperative wound bleeding was less than that in the control group (P<0.05), postoperative wound recovery time and length of hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). There was a statistically significant difference in the total incidence of recurrent laryngeal nerve injury between the two groups (P<0.05). Conclusion: Recurrent laryngeal nerve exposure can improve the effect of peroral total endoscopic thyroidectomy. It can not only protect recurrent laryngeal nerve and reduce the incidence of hoarseness, but also shorten hospital stay and promote recovery, and can be widely used in thyroid surgery.

2023 Vol. 20　(16):　57-60 [Abstract]（ 116 ） HTML (1 KB)  PDF  (1065 KB)  ( 13 )

Objective: To explore the clinical effect of accommodation training combined with convergence training in the training of children with true convergence insufficiency. Method: Using the random number table method, 60 children diagnosed with true convergence insufficiency in the First Affiliated Hospital of Jiangxi Medical College from January 2021 to February 2022 were divided into two groups, including 30 cases in the observation group and 30 cases in the control group. The control group received convergence training while the observation group was combined with accommodation training on the basis of the control group. The related parameters such as amplitude of accommodation (AMP), accommodation flexibility (AF), near point of convergence (NPC), accommodative convergence/accommodation (AC/A) and positive fusional convergence (PFC) and insufficient convergence were compared between the two groups before and after training, both groups were treated for 6 courses (15 d was one course). Result: After training, the NPC of ocular parameters in both groups decreased, and the observation group was lower than that of the control group (P<0.05); the AMP, AF, AC/A and PFC in the two groups of children were increased, and those in the observation group were higher than those in the control group (P<0.05); the scores of convergence insufficiency symptom survey (CISS) were declined in the two groups, and the score in the observation group was lower than that in the control group (P<0.05). Conclusion: Accommodation training combined with convergence training is aimed at training children with true convergence insufficiency, which can adjust the ocular parameters and improve the convergence insufficiency of children.

2023 Vol. 20　(16):　65-68 [Abstract]（ 106 ） HTML (1 KB)  PDF  (1095 KB)  ( 92 )

Objective: To analysis the results of colonoscopy screening for colorectal cancer in Lixia district of Jinan from 2020 to 2022. Method: The electronic colonoscopy was performed on residents aged 40 to 70 years in Lixia District of Jinan and detected intestinal lesions were taken pathology. Result: From 2020 to 2022, a total of 8 046 respondents participated in colonoscopy screening for colorectal cancer. 3 906 cases of intestinal lesions (polyps, adenomas, carcinomas) were detected, the detection rate was 48.55%, including 1 508 cases (38.61%) of non-adenomatous polyps, 1 891 cases (48.41%) of unprogressive adenoma, 485 cases (12.42%) of progressive adenoma and 22 cases (0.56%) of colorectal cancer. The detection rate of colorectal cancer in men was 4.41 times higher than that of women (P<0.001). As the age increased, the detection rate of intestinal lesions increased (P<0.001), and the detection rate of the 60-70 years group was 1.49 times higher than that of the 40-49 years group. Conclusion: Colorectal cancer screening can effectively detect cancer and precancerous lesions at an early stage, and is of great significance for the early diagnosis and treatment of colorectal cancer.

2023 Vol. 20　(16):　74-77 [Abstract]（ 130 ） HTML (1 KB)  PDF  (1079 KB)  ( 30 )

Objective: To investigate the effect of Suanzaoren Decoction combined with continuous iliac fascia space block on postoperative indexes in patients with hip operation. Method: A total of 100 patients with hip operation admitted to Jiujiang Hospital of Traditional Chinese Medicine from June 2020 to June 2021 were selected and divided into two groups with 50 patients in each group according to random number table method. The control group received routine perioperative analgesia, and the observation group received Suanzaoren Decoction combined with continuous iliac fascia space block. The levels of observation indexes (analgesic effect, hemodynamics, postoperative delirium, adverse reactions) before and after operation were compared between the two groups. Result: There were no significant differences in static and dynamic pain scores between the two groups before operation (P>0.05). Static pain scores at 4, 12, 24 and 48 h after surgery in the observation group and dynamic pain scores at 24 and 48 h after surgery were lower than those in the control group, there were statistically significant differences between the two groups (P<0.05). There was no significant difference in hemodynamic level between the two groups before operation (P>0.05). Diastolic blood pressure, systolic blood pressure and heart rate in the observation group were higher than those in the control group at 4, 12, 24 and 48 h after operation (P<0.05). The total incidence of delirium at 4, 12, 24 and 48 h after operation in the observation group was 4.00%, which was lower than 20.00% in the control group, the difference between groups was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 6.00%, lower than 22.00% in the control group, the difference between groups was statistically significant (P<0.05). Conclusion: After the application of Suanzaoren Decoction combined with continuous iliac fascia space block, the analgesic effect of patients undergoing hip surgery is significantly improved, the level of self-hemodynamics tends to be normal, and postoperative delirium and adverse reactions are significantly reduced, which lays the foundation for a good prognosis of patients.

2023 Vol. 20　(16):　83-87 [Abstract]（ 157 ） HTML (1 KB)  PDF  (1243 KB)  ( 31 )

Objective: To observe the curative effect of TCM combined with Remifemin Tablets in the treatment of vaginal dryness in middle-aged and elderly women, so as to provide an optimized scheme for the treatment of vaginal dryness with traditional Chinese medicine. Method: From June 2021 to May 2022, 96 patients with vaginal dryness (liver and kidney Yin deficiency syndrome) who met the inclusion criteria in Suizhou Maternal and Child Health Hospital were selected, the patients were randomly divided into experimental group and control group, 48 cases in each group. The experimental group was given Ziyin Runqiao Granules combined with Remifemin Tablets. The control group was treated with oral Estradiol Valerate Tablets combined with Dydrogesterone Tablets. After 3 courses of treatment, the related indexes of efficacy observation were compared between the two groups to evaluate their efficacy. Result: The total effective rate of combined efficacy in the experimental group was 93.75%, the control group was 77.08%, the difference was statistically significant (P<0.05). The total effective rate of TCM syndrome in the experimental group was 89.58%, and 70.83% in the control group, the difference was statistically significant (P<0.05). There were no significant differences in vaginal health index and TCM symptom scores between the two groups before treatment (P>0.05). After treatment, the vaginal health index and TCM symptom score of the two groups were improved, and the improvement of the experimental group were more obvious, with statistical significance (P<0.05), while there was no statistical significance in the score of the vaginal atrophy index between the two groups before and after treatment (P>0.05). Conclusion: Ziyin Runqiao Granules combined with Remifemin Tablets can play an effective role in the treatment of vaginal dryness in middle-aged and elderly women with liver and kidney Yin deficiency syndrome, and effectively improve the degree of vaginal dryness and TCM syndrome score.

2023 Vol. 20　(16):　91-94 [Abstract]（ 193 ） HTML (1 KB)  PDF  (1165 KB)  ( 50 )

Objective: To explore the application effect of Shu Mu point tapping in patients with epilepsy (deficiency epilepsy syndrome) and insomnia (liver kidney insufficiency type). Method: Using the convenience sampling method, 120 patients who visited the First Affiliated Hospital of Nanchang University from February to June 2022 were divided into the control group and the experimental group according to the random number table methods, with 60 cases in each group. The control group received routine drug treatment and nursing, while the experimental group received Shu Mu point tapping on the basis of the control group at the same time, traditional Chinese medicine syndrome scale score, Pittsburgh sleep quality index (PSQI) scale score, clinical efficacy of traditional Chinese medicine and clinical efficacy of western medicine in the two groups were statistically analyzed. Result: After one month and three months of intervention, the scores of traditional Chinese medicine syndrome scale and PSQI scale were lower than those before intervention (P<0.05), those in the experimental group were lower than those in the control group(P<0.05). The total effective rate of traditional Chinese medicine and the total effective rate of western medicine in the experimental group were higher than those in the control group (P<0.05). Conclusion: The clinical effect of Shu Mu point tapping in the treatment of epilepsy (deficiency epilepsy syndrome) and insomnia (liver kidney insufficiency type) is good.

2023 Vol. 20　(16):　99-102 [Abstract]（ 142 ） HTML (1 KB)  PDF  (1114 KB)  ( 16 )

Objective: To explore the correlation between complications and clinical indicators in patients with end-stage renal disease with different traditional Chinese medicine constitutions. Method: A total of 90 patients with end-stage renal disease who met the requirements in the Hemodialysis Room and the First Department of Meizhou Second Hospital of Traditional Chinese Medicine from December 2020 to December 2022 were retrospectively selected as the study objects. The distribution of three TCM constitutions of patients with end-stage renal disease, including Yang-deficiency, blood-stasis and phlegm-dampness were analyzed, and the incidence of complications in patients with Yang-deficiency, blood-stasis and phlegm-dampness as well as the correlation of clinical indicators were studied. Result: After syndrome differentiation of 90 patients with end-stage renal disease, the proportions of Yang deficiency type, blood stasis type and phlegm dampness type were higher, with 23 cases (25.56%) of Yang-deficiency type, 22 cases (24.44%) of blood-stasis type and 15 cases (16.67%) of phlegm-dampness type. There were significant differences in the levels of urea nitrogen (BUN), creatinine (Scr), hemog lobin (Hb), albumin (ALB), blood phosphorus (P), blood calcium (Ca), blood potassium (K) and the incidence of complications in patients with Yang-deficiency, blood stasis and phlegm-dampness (P<0.05). The BUN, Scr, Hb and ALB of phlegm-dampness type were significantly higher than those of Yang-deficiency type, and BUN, Hb and ALB were significantly higher than those of blood-stasis type (P<0.05). BUN, Scr, Hb and ALB in blood-stasis type were significantly higher than those in Yang-deficiency type (P<0.05). P, Ca and K of blood-stasis type were higher than those of phlegm-dampness type and Yang-deficiency type (P<0.05). The incidences of skin pruritus and infection in patients with phlegm-dampness type were higher than those in patients with Yang-deficiency type and blood-stasis type (P<0.05), and the incidence of heart dysfunction, metabolic disorder and anemia in patients with blood-stasis type were higher than those in patients with phlegm-dampness type (P<0.05). Patients with Yang-deficiency, blood-stasis and phlegm-dampness type were positively correlated with BUN clinical indicators, and the difference was statistically significant (P<0.05). Conclusion: The proportions of ESRD patients with constitution of Yang-deficiency type, blood-stasis type, phlegm-dampness type are high, the weight is important. There are significant differences in clinical indicators between different constitutions, and the level of toxin in patients with phlegm-dampness constitution is high which are prone to complications such as skin pruritus and infection. It is suggested to strengthen dialysis and reduce toxin levels as far as possible. The nutritional status of patients with Yang-deficiency and blood-stasis type is not as good as that of phlegm-dampness type. Attention should be paid to strengthening nutritional support treatment in the treatment to improve the quality of life.

2023 Vol. 20　(16):　107-111 [Abstract]（ 145 ） HTML (1 KB)  PDF  (1311 KB)  ( 33 )

Objective: To explore the clinical effect of Tiaojing Cuyun Pills combined with Letrozole in the treatment of ovulatory dysfunction infertility. Method: A total of 80 patients with ovulatory dysfunction infertility who were admitted to First Affiliated Hospital of Gannan Medical University from June 2021 to January 2022 were selected and randomly divided into two groups, 40 cases in each group. The control group was treated with Letrozole, and the observation group was treated with Tiaojing Cuyun Pills combined with Letrozole. The follicular development, endometrial thickness on the day of injection of Chorionic Gonadotrophin for Injection (hCG), the total dose of Menotropins (HMG) was used, serum estradiol (E2) and progesterone (P) levels one week after ovulation, cervical mucus scores, ovulation rate and pregnancy rate were compared between the two groups. Result: After treatment, the diameter of the main follicle in the two groups were higher than those before treatment, and that in the observation group was higher than that in the control group (P<0.05). The endometrial thickness in the observation group was higher than that in the control group on the day of hCG injection, and the total dose of HMG was used in the observation group was lower than that in the control group (P<0.05). One week after ovulation, the levels of E2 and P in the observation group were higher than those in the control group (P<0.05). After treatment, the cervical mucus scores of the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). The ovulation rate and pregnancy rate in the observation group were higher than those in the control group (P<0.05). Conclusion: Ovulatory dysfunction infertility treated with Tiaojing Cuyun Pills combined with Letrozole can improve the follicular development and endometrial, cervical mucus, and increase the hormone levels, ovulation rate and pregnancy rate of the patients.

2023 Vol. 20　(16):　115-118 [Abstract]（ 154 ） HTML (1 KB)  PDF  (1149 KB)  ( 25 )

Objective: To observe the effect of segmented personalized jumping exercise in accelerating the excretion of ureteral stones. Method: A total of 86 patients with ureteral calculi were admitted to Heze Municipal Hospital from January to December 2022 were selected, 43 patients were divided into the control group (providing various nursing measures according to the routine), and the remaining 43 patients were divided into the observation group (carrying out segmented personalized jumping exercise on the basis of the former group) by the random number table method. The stone removal time, total stone removal rate, pain score [visual analogue scale (VAS)] before and after intervention, comfort score [general conmfort qusetionnarie (GCQ)] and satisfaction were compared between the two groups. Result: There was no difference in stone removal time between the two groups (P>0.05), the total stone removal rate of the observation group was higher than that of the control group (P<0.05). Before intervention, there was no difference in VAS scores between the two groups (P>0.05); after intervention, the VAS scores of the observation group was lower than that of the control group (P<0.05). Before the intervention, there were no differences between the two groups in scores of body, movement, psychology and environment of GCQ (P>0.05); after intervention, scores of body, movement, psychology and environment of GCQ in the observation group were higher than those in the control group (P<0.05). The satisfaction of the observation group was higher than that of the control group (P<0.05). Conclusion: The segmented personalized jumping exercise has an ideal effect in accelerating the discharge of ureteral calculus, can reduce the pain of patients during the discharge of stones, and improve their comfort and satisfaction.

2023 Vol. 20　(16):　123-127 [Abstract]（ 183 ） HTML (1 KB)  PDF  (1368 KB)  ( 24 )

Objective: To investigate the application value of acupoint moxibustion combined with rapid rehabilitation intervention in laparoscopic radical resection of prostate cancer. Method: The clinical data of 80 patients with prostate cancer who underwent radical prostatectomy in Fujian Medical University 2nd Affiliated Hospital from January 2020 to January 2022 were retrospectively analyzed and divided into the control group and the observation group according to different nursing methods, with 40 cases in each group. Patients in control group were given fast recovery nursing intervention during perioperative period, the observation group was given acupuncture point moxibustion intervention on the basis of the control group. The postoperative rehabilitation of the two groups was compared, including the postoperative bowel sound recovery time, the first exhaust time, the first defecation time, the postoperative drainage tube removal time, the first ambulation time and the length of hospital stay. The occurrence of perioperative complications was recorded. The urodynamic parameters [maximum flow rate (Qmax), maximum bladder capacity (MCC)] were measured by Labory urodynamic instrument before and on the 7 th day after surgery. Immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) were measured by automatic biochemical analyzer. Inflammatory factors [procalcitonin (PCT), C reactive protein] were measured by enzyme-linked immunosorbent assay. Result: The postoperative bowel sound recovery time, first exhaust time, first defecation time, postoperative drainage tube removal time and the length of hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). The incidences of urinary incontinence and abdominal distension in the observation group were significantly lower than those in the control group (P<0.05), there were no significant differences in the incidences of nausea and vomiting and urinary system infection between the two groups (P>0.05). On the 7th day after surgery, the Qmax and MCC in the observation group were significantly higher than those before surgery and the control group (P<0.05). On the seventh day after surgery, the IgA, IgG and IgM of the observation group were significantly lower than those before surgery, but significantly higher than those of the control group (P<0.05). On the seventh day after surgery, PCT and C reactive protein in the observation group were significantly higher than those before surgery, but significantly lower than those in the control group (P<0.05). Conclusion: The application of acupoint moxibustion combined with rapid rehabilitation intervention in laparoscopic radical prostatectomy of prostate cancer can effectively improve the immune function, relieve postoperative inflammation, reduce the incidence of complications, and help to improve the postoperative urination function of patients, and promote postoperative rehabilitation of patients.

2023 Vol. 20　(16):　132-136 [Abstract]（ 241 ） HTML (1 KB)  PDF  (1302 KB)  ( 117 )

Objective: To analyze the application effect of evidence-based oriented predictive nursing intervention in emergency treatment of liver cancer rupture and bleeding and its influence on patients' psychological status. Method: A total of 60 patients with hepatocellular carcinoma (HCC) rupture and bleeding from January to March 2022 in the Emergency Department of Third People' s Hospital of Jiujiang City were selected and divided into an observation group and a control group according to the admisson time, 30 cases in each group. The control group received routine emergency nursing intervention, and the observation group received evidence-based oriented predictive nursing intervention. The hemoglobin, blood partial pressure of oxygen, and oxygen saturation before and after nursing, mental status scale in non-psychiatric settings (MSSNS) scores in waking state, shock correction time and hospitalization time, mortality and incidence of complications during hospitalization were compared between the two groups. Result: Before nursing, there were no significant differences in hemoglobin, blood partial pressure of oxygen, and oxygen saturation between the two groups (P>0.05). After nursing, the hemoglobin, blood partial pressure of oxygen, and oxygen saturation in the observation group were higher than those in the control group (P<0.05). The scores of anxiety, depression, anger, loneliness degree and overall psychological status in the observation group were lower than those in the control group (P<0.05). After nursing, the time of shock correction and hospitalization in the observation group were shorter than those in the control group (P<0.05). There was no significant difference in the mortality between the two groups during hospitalization (P>0.05), and the total incidence of complications in the observation group was lower than that in the control group (P<0.05). Conclusion: Evidence-based oriented predictive nursing intervention applied to HCC rupture and bleeding can improve patients' hemoglobin, blood partial pressure of oxygen, and oxygen saturation, relieve anxiety, depression, anger and other negative psychological emotions, shorten shock correction time and hospitalization time, and reduce the incidence of complications during hospitalization.

2023 Vol. 20　(16):　141-145 [Abstract]（ 128 ） HTML (1 KB)  PDF  (1467 KB)  ( 56 )

Objective: To investigate the application effect of Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops (trade name: Beifushu) combined with Olopatadine Eye Drops in allergic conjunctivitis. Method: A total of one hundred and fifteen patients with allergic conjunctivitis admitted to Suzhou Ninth People's Hospital between July 2019 and June 2022 were selected for this study and divided into control group (n=58) and study group (n=57) by random number table method. The control group was treated with Olopatadine Eye Drops, the study group was treated with Beifushu in combination with Olofadine Eye Drops. The efficacy, inflammatory level, immune level, tear film stability and occurrence of adverse drug reactions were compared between the two groups. Result: The efficacy of the study group was significantly better than that of the control group (P<0.05). Before treatment, there were no significant differences in the levels of eosinophil cationic protein (ECP), hypersensitivity c reactive protein (hs-CRP), and interleukin-10 (IL-10) between the two groups (P>0.05); after treatment, the levels of ECP and hs-CRP in the two groups were significantly decreased compared with those before treatment (P<0.05), the study group were significantly lower than those of the control group (P<0.05); the levels of IL-10 in the two groups increased significantly compared with those before treatment (P<0.05), the study group was significantly higher than that of the control group (P<0.05). Before treatment, there were no statistically significant differences in the levels of immunoglobulin A (IgA) and immunoglobulin E (IgE) between the two groups (P>0.05); after treatment, the levels of IgA and IgE in both groups decreased significantly compared with those before treatment (P<0.05), the study group were significantly higher than those in the control group (P<0.05). Before treatment, there were no statistically significant differences in tear film break up time (BUT), corneal fluorescein staining scores and tear secretion test between the two groups (P>0.05); after treatment, the corneal fluorescein staining scores decreased significantly compared with those before treatment (P<0.05), and tear secretion test significant increase compared with those before treatment (P<0.05), the study group were significantly higher than those in the control group (P<0.05); the levels of BUT in the two groups increased significantly compared with that before treatment (P<0.05), the study group was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combined treatment of Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops and Olofatadine Eye Drops in patients with allergic conjunctivitis has significant effects, significantly improving the levels of inflammation and immunity, and improving the stability of tear film without increasing adverse drug reactions, which is safe and controllable.

2023 Vol. 20　(16):　150-154 [Abstract]（ 241 ） HTML (1 KB)  PDF  (1360 KB)  ( 22 )

Objective: To evaluate the effect of controlled hypotension under general anesthesia on intraoperative blood loss and surgical field in patients undergoing spinal canal decompression and fusion with internal fixation. Method: A total of 60 patients with lumbar degenerative diseases who needed spinal canal decompression and fusion with internal fixation admitted to Wanzai County Hospital of Traditional Chinese Medicine from November 2019 to May 2021 were selected, they were divided into control group and observation group with 30 cases in each group by random number table method. Both groups received surgical treatment under static aspiration combined with general anesthesia, and the observation group received Nitroglycerin and Urapidil controlled hypotension during the operation. The related indexes of operative effect, operative field quality score and postoperative efficacy were compared between the two groups. Result: The amount of intraoperative blood loss, blood transfusion, urine volume, amount of crystal fluid and amount of colloidal fluid in the observation group were less than those in the control group, and the operation time was shorter than that in the control group (P<0.05). At 1, 2 h of surgery and at the end of surgery, the field quality scores in observation group were lower than those in control group (P<0.05). Conclusion: For patients with lumbar degenerative diseases, the implementation of spinal canal decompression and fusion with internal fixation, and the application of controlled hypotension under general anesthesia during the operation can reduce the amount of intraoperative bleeding, improve the quality of intraoperative vision, and improve the rehabilitation effect.

2023 Vol. 20　(16):　159-163 [Abstract]（ 147 ） HTML (1 KB)  PDF  (1448 KB)  ( 23 )

Objective: To analyze the diagnostic value of ultrasonography in cervical lymph node metastasis in patients with differentiated thyroid carcinoma (DTC). Method: A total of 135 patients with DTC who received subtotal or total thyroidectomy in People's Hospital of Ruijin City from January 2017 to July 2022 were selected. All patients underwent ultrasonography before operation, and the results of postoperative pathological examination as the gold standard, the diagnostic efficacy of ultrasonography in cervical lymph node metastasis of patients with DTC was statistically analyzed. In addition, the ultrasonic image characteristics of patients with cervical lymph node metastasis and patients without metastasis were analyzed. Result: Among 135 DTC patients, 36 cases were found to have lymph node metastasis by pathological examination and 31 cases were found to have lymph node metastasis by ultrasonography. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of ultrasonography respectively was 80.56%, 97.98%, 93.33%, 93.55% and 93.27%. Kappa test showed that ultrasonography of lymph node metastasis in DTC patients has excellent consistency with the results of gold standard examination (Kappa=0.822, P=0.000). The proportions of slight calcification, long/short diameter of lymph nodes <2, cystic or liquefied areas, abundant blood flow of lymph nodes, disappearance of lymphatic hilum or unclear lymph node structure in metastatic group respectively was 83.33%, 80.56%, 69.44%, 86.11% and 72.22%, which were higher than 13.33%, 17.17%, 20.20%, 24.24%, 10.10% in non-metastatic group (P<0.05). Conclusion: Ultrasonography has a high diagnostic efficiency in the diagnosis of lymph node metastasis in patients with DTC, and there are great differences in the ultrasonic image characteristics between patients with lymph node metastasis and patients without lymph node metastasis.

2023 Vol. 20　(16):　167-170 [Abstract]（ 182 ） HTML (1 KB)  PDF  (1354 KB)  ( 28 )

Objective: To investigate the risk factors of mood disorders in patients undergoing thoracolumbar compression fracture surgery. Method: A total of 96 patients with thoracolumbar compression fracture admitted to Leping Hospital of Traditional Chinese Medicine from January 2020 to August 2022 were selected to evaluate the emotional disorders of all patients. According to the results, the patients were divided into the occurrence group and the non-occurrence group. The baseline data questionnaire was designed, and the baseline data of the two groups were statistically analyzed and compared. The risk factors of mood disorders in patients undergoing thoracolumbar compression fracture surgery were analyzed. Result: Among the 96 patients with thoracolumbar compression fracture, there were 16 patients with emotional disorder, accounting for 16.67% (16/96). The age of the occurrence group was older than that of the non-occurrence group, the proportion of low social support and self-efficacy in the occurrence group were higher than those in the non-occurrence group, and the proportion of junior high school education or below was higher than that in the non-occurrence group, and the differences were statistically significant (P<0.05). There were no statistically significant differences in other data between the two groups (P>0.05). By regression analysis, the results showed that older age, low social support, low education level and low self-efficacy were risk factors for postoperative mood disorders in patients with thoracolumbar compression fracture (OR>1, P<0.05). Conclusion: Patients undergoing thoracolumbar compression fracture surgery have a higher risk of mood disorders. Older age, low social support, low education level and low self-efficacy are all risk factors for mood disorders in patients undergoing thoracolumbar compression fracture surgery.

2023 Vol. 20　(16):　175-178 [Abstract]（ 140 ） HTML (1 KB)  PDF  (1275 KB)  ( 17 )

In recent years, with the deepening of lipid-lowering therapy research, the level of lipoprotein A [Lp(a)] has become increasingly important in the cardiovascular field. The increased level of Lp (a) is an independent risk factor for cardiovascular and cerebrovascular diseases. This article mainly reviews the research progress of Lp(a) in acute myocardial infarction from its structure and anabolism, main pathogenic mechanisms, and current treatment progress.

2023 Vol. 20　(16):　184-188 [Abstract]（ 148 ） HTML (1 KB)  PDF  (1384 KB)  ( 31 )