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| The Effect of Glargine Combined with Pioglitazone in the Treatment of Secondary Failure of Sulfonylurea in Type 2 Diabetes |
| The Fifth People’s Hospital of Dalian City， Dalian 116021， China |
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Abstract To explore the effect of insulin glarage combined with pioglitazone in the treatment of type 2 diabetes. Method： 60 cases were randomly divided into group A and group B， 30 cases in each group. Group A was treated with insulin glargine combined with pioglitazone， while group B was given subcutaneous injection of insulin aspart 30R. Both groups were treated for 12 weeks. To compare the fasting plasma glucose（ FBG）， 2-hour postprandial plasma glucose（ 2 h PG）， glycosylated hemeglobi（ HbA1c）， fasting C-peptide（ FCP）， 2-hour postprandial C-peptide（ 2 h CP）and incidence of low blood glucose before and after treatment. Result：After treatment for 12 weeks， the FBG， 2hPG and HbA1c of the two groups remarkably decreased， but the FCP and 2 h CP of the two groups significantly increased， and the differences were statistically significant（ P<O.05）. But there were no statistical significant between the two groups（P>0.05）. The low blood glucose reaction was noticed in 1 case（ 3.3%） in group A， but 7 cases（ 23.3%）in group B，and the differences were statistically significant（ P<O.05）. Conclusion： Treating secondary failure of sulfonylurea in type 2 diabetes with insulin glargine combined with pioglitazone has good effect， and the method is simple， convenient and easy to master， which is worth clinical popularizing and application.
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