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Abstract Objective： To observe the clinical effect alpha1-antitrypsin（ α1-AT） and serum C reactive protein
（CRP） levels in patients with acute exacerbation chronic obstructive pulmonary disease（ COPD）. Method： 64 patients with AECOPD in our hospital were chosen and divided randomly to observation group and control group， which all treated by basis treatment and pulverization inhalation treatment with salbutamol and ipratropium bromide. Patients in observation group were also given pulverization inhalation treatment of budesonide. The levels of serum CRP and α1-AT were compared after seven days treatment， and the clinical effects were evaluated and compared. Result： The CRP level of the
AECOPD group was significantly higher than that of the stable COPD group（ P<0.05）， but the α1-AT level had no obviously differences between the two group（ P>0.05）. The levels of serum CRP and α1-AT significantly decreased after treatment， and the CRP level was significantly lower in observation group than that in the control group（ P<0.05）， while the α1-AT level between the two groups had no statistically significant differences（ P>0.05）. Conclusion： CRP is a sensitive indicator for the patients with COPD， combing with α1-AT associated detection， have clinical practical value
for diagnose and therapeutic effect judging in COPD.
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