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| Analysis of the Therapeutic Effect and Safety of the BDT Solution with Lower Quantity of Bortezomib
（Btz） for Treating Multiple Myeloma（ MM） of the Aged |
| The Fourth People’s Hospital of Shenyang， Shenyang 110031， China |
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Abstract Objective： To discuss the therapeutic effect and safety of the BDT solution quantity of Bortezomib（ Btz）for treating multiple myeloma（ MM） of the aged. Method： To retrospectively analyze the clinical data of 43 MM patients of the old aged of initial treatment， who accepted from October 2007 to October 2013 and cured with the BDT solution，and evaluate the therapeutic effects and adverse reactions of Btz treatment groups with different dosages. Result： After two courses of treatment， the total effective rate of the patient group with lower quantity was 72.0% and its CR rate was 28.0%，as well as 77.8% of the total effective rate and 33.3% of CR rate of the standard dosage group， there was no statistical significance（ P） between the two groups in difference. Adverse reaction higher than Ⅲ level： the generation rates of peripheral neuropathy， neutropenia and infection of the group with lower quantity were obviously decreased compared with those of the standard dosage group， and there was statistical significance in difference（ P）. Conclusion： The therapeutic
effect of the BDT solution with lower quantity of Btz on the MM patient of the aged of initial treatment is similar as that of the standard dosage group， but the adverse reactions of the BDT solution with lower quantity of Btz are obviously reduced，and better tolerance is available.
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