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| Nedaplatin Combined Gemcitabine Treatment of Advanced Non-small Cell Lung Cancer and Adverse Reactions |
| The Second People’s Hospital of Zhenjiang， Zhenjiang 212000， China |
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Abstract Objective：To analyze the treatment of advanced non-small cell lung cancer and the adverse reactions by combining nedaplatin with gemcitabine.Method：28 patients from 2013.6 to 2014.7 were chosen as research object，which had been diagnosed as non-small cell lung cancer through the cell and pathology morphology， and they all used intravenous nedaplatin 80 mg/m2 on the 1 st day， gemcitabine（ Gem） 800 mg/m2 IV， on the day 1， 8， 21.Repeat the treatment， evaluated the effective after two cycles.At the same time Tropisetron 5 mg intravenous injection was given to prevent vomiting.Result：The clinical evaluation of patients were CR 2 cases， PR 10 cases， NC 8 cases， PD 8 cases， RR（ PR+CR）（ 12/28） 42.9%， the adverse reaction was nausea and vomiting， there was no Ⅲ-Ⅳ degree of nausea and vomiting， and 25 cases were Ⅰ-Ⅲ mild bone marrow suppression， 4 cases were Ⅲ myelosuppression， no Ⅳmyelosuppression.Conclusion：The treatment of advanced lung cancer by combining nedaplatin with gemcitabine has better exact effect， and toxicity can be controlled， so it is worthy of clinical development.
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