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Abstract Objective：To study the effect of bundle interventions on prevention of the ventilator-associated pneumonia （VAP） in primary hospital so as to provide reference.Method：A total of 91 patients who underwent mechanical ventilation for more than 48 hours from 2012 to 2013 were enrolled in the study and divided into two groups.43 patients were subjected into the interventions group，and 48 patients were subjected into the control group，the bundle interventions were adopted，and the incidence of VAP was compared between the two groups.Result：The bundle interventions could effectively prevent the incidence of VAP.After the implementation of bundle interventions，there were 10 cases with VAP in the intervention group with the incidence of 17.48 ‰ and 23 cases in the control group with the incidence of 40.00 ‰ .The infect rate of the patients using breathing machine last 48 hours decreased from 47.92 ‰ to 23.26 ‰ .The bundle intervention compliance directly affected the consequence.Conclusion：Cluster intervention measures of fully implement can effectively reduce the occurrence of VAP in ICU，its compliance is directly affect the outcome.Measures implementation is the core of its intervention effect，take corresponding measures to improve the clinical medical staff compliance of intervention measures，is the feeling of department to reduce VAP have been the focus of the management by objectives.
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