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| Analysis on Clinical Significance of P16，ER and CEA Joint Detection of the Cervical Adenocarcinoma and the Endometrial Carcinoma |
| The Boai Hospital of Zhongshan，Zhongshan 528403，China |
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Abstract Objective：To observe and analysis the P16，ER and CEA protein expression in the cervical adenocarcinoma and endometrial adenocarcinoma and their clinical significance.Method：Immunohistoehemical method was used to detect P16，ER and CEA in paraffin-embedded tissues from 32 cases of endocervicaI adenocarcinomas and 32 cases of endometrial adenocarcinomas.The expression of P16，ER and CEA were retrospectively analyzed.Result：The positive rates of P16，ER，CEA in the cervical adenocarcinoma were 65.63%（21/32），28.13%（9/32），81.25%（26/32），respectively；those in
endocervicaI adenocarcinoma were various 9.36%（3/32），75.00%（24/32），43.75%（14/32）.P16 and CEA in the cervical adenocarcinoma positive expression rate were higher than those of endometrial adenocarcinoma（P<0.05）.Endometrial adenocarcinoma in the positive rate of ER was obviously higher than that of the cervical adenocarcinoma（P<0.05）.Conclusion：Joint detection expression of P16，ER and CEA protein has great clinical application value in the differential diagnosis of endocervical and endometrial adenocarcinomas.
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