Abstract Objective：To investigate the activation of astrocytes in spinal cord of spinal nerve selective ligation（SNL） rats’ mirror-image pain model. Method：The experimental group（ n=20） was SNL mirror-image pain model group， the control group（ n=20） was SNL model group. Every group was took the L4-L5 spinal cord to make paraffin slices. Labeled the expression of glial fibrillary acidic protein（ GFAP） by immunofluorescence method.Result：The positive
cells GFAP marked were increased in the number and the mean fluorescence intensity in the experimental groups’spinal dorsal horn of non-surgical side which had no statistical significance（ P>0.05） compared with the surgical side， but had statistical significance（ P<0.05） compared with the non-surgical side of the control group. Conclusion：In the neuropathic mirror-image pain， astrocytes were activated and involved the formation and maintenance of mirror pain in the mirror side of the spinal cord.
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