Abstract Objective： To analyze the feasibility and effectiveness of the first trimester of pregnancy ultrasoundscreening for fetal cardiac malformations. Method： 2400 pregnant women from February 2010 to February 2014 in ourhospital were selected for the study，in the first trimester of pregnancy and second trimester of pregnancy screening wasrespectively accepted transabdominal ultrasound systems， ultrasound abnormalities review，and neonatal conditions were
assessed by echocardiography and routine physical examination.Result： In the 2400 cases，18 cases were fetal cardiacmalformations，in which 9 cases were thickened nuchal translucency and accompanied by chromosomal abnormalities（including 3 cases of Turner syndrome，2 cases of Trisomy 18，4 cases of Trisomy 21），4 cases were lethal skeletalmalformations，2 cases were short ribs multi-finger（ toe） syndrome，1 case was single umbilical artery，1 case wasabdominal wall crack and 1 caes spina bifida. Ultrasound screening for fetal cardiac malformation rate sensitive was 90.0%（18/20），negative predictive value was 99.3%（2382/2400）. Another review in the pregnancy confirmed 2 cases offetal left kidney agenesis.Conclusion： Systematic ultrasound for screening pregnant women with high feasibility and
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