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| A Case-control Study on the CNTNAP2 Gene in Association with Autism in Chinese Han Children |
| The First Affiliated Hospital of University of South China，Hengyang 421001，China |
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Abstract Objective：To investigate the relationship between the rs10244837， rs7794745， rs10500171 SNPs of the CNTNAP2 gene and autism in Han Chinese.Method：The rs10244837， rs7794745， rs10500171 SNPs of CNTNAP2 was genotyped by PCR-RFLP in individuals with autism and normal subjects. An association study was performed used the data of genotyping.Result：The frequencies of the genotypes rs10244837， rs7794745， rs10500171 SNPs were in Hardy-Weinberg equilibrium（ HWE）（ P>0.05）.There were no significant differences in allele frequency and
haplotypes frequencies distribution of the CNTNAP2 gene between the autisms group and normal control group（ P>0.05）. Conclusion：The SNPs rs10244837， rs7794745， rs10500171 of CNTNAP2 gene were not association with autism in Han Chinese.
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