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Abstract Objective： To observe the effect of Otilonium bromide combined with Oxalic acid Ai Sciplan in the
treatment of irritable bowel syndrome（IBS）. Method： 60 cases with irritable bowel syndrome were selected according to the Rome Ⅲ diagnosis criteria， they were grouped by the visit order of odd and even， odd as the research group， even for the control group， 30 cases in each group. Before entering the group ，they were score by irritable bowel syndrome severity scale（IBS-SSS）， when enrolled the two groups were given otilonium bromide 40 mg，tid， the research group in conjunction with oxalic acid Ai Sciplan 10 mg/d within 12 weeks. After 12 weeks， the research group continues taking
escitalopram oxalate to 24 weeks， the two groups used otilonium bromide according to abdominal pain duringon-demand during 12 to 24 weeks（not as a conventional take）. Result： The treatment effect was evaluated respectively at the end of 2， 4， 8， 12， 24 weeks， and the IBS-SSS scores of the research group were（185.00±38.24），（149.07±38.30），（127.83±37.51），（112.97±37.55），（102.97±43.82）， the control group scores were（226.80±42.98），（183.33±41.90），（165.33±37.19），（152.30±39.41），（147.57±41.46）， followed by the two groups， the control group scores were significantly different（P<0.01）. Conclusion： Joint use of escitalopram oxalate and otilonium bromide can ease patients abdominal pain， abdominal discomfort and abnormal bowel movements， improve the quality of life of patients at the same time. This method has lasting efficacy，safety，well tolerated，and small relapse risk when sustained drug use.
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