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Abstract Objective：To evaluate the efficacy and safety of Donepezil combined with Paroxetine at acute cerebral infarction in the treatment of post-stroke depression.Method：79 patients with post-stroke depression were randomly divided into two groups from October 2012 to July 2014， among which 41 cases as experimental group， and 38 cases as control group.Experimental group was treated with Donepezil.It was 5 mg/d within the first 14 days.Additionally，20 mg Paroxetine was given once a day for 90 days.Control group was only treated with 20 mg Paroxetine was given once a day for 90 days.The degree of neurological deficit was compared using the Hamilton Depression Scale（HAMD）and modifies Rankin Scale（mRS）scoring between the two groups after treatment respectively.Result：Hamilton Depression Scale was significantly improved，and the modifies Rankin Scale were significant enhanced in the experimental group when compared with the control（P<0.05）.No serious adverse reaction occurred during treatment.Conclusion：Donepezil combined with Paroxetine at acute cerebral infarction which has a higher security probably improves the prognosis and reduces the disability of patients with post-stroke depression.
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