Abstract Objective： To study the relationship between collagen degradation in vascular remodeling and instability of coronary atherosclerosis plaque.Method： 131 inpatients who hade been through the coronary angiography exmination were selected. There were 171 patients with coronary angiography exmination ≥ 50%，
they were myocardial infarction（n=39，AMI group）， unstable angina pectoris（n=54，UAP group）， stable angina pectoris（n=24，SAP group），respectively. 14 patients with coronary atherosclerosis<50%. make up the control group. The concentrates of matrix metalloproteinases in serum-9 （MM-9）， tissue inhibitor of matrix metalloproteinase-1（ IMP-1）， MMP-9/TIMP-1 and I-Collagen carboxy terminal telopeptide（ ICTP） were analyzed by enzyme immunoassay. Result： The concentrates of MMP-9 were （270.42±37.64） μg/L，（201.24±28.20） μg/L，（ 142.65±18.62） μg/L and（ 139.28±16.85） μg/L for groups AMI， UAP， SAP and C， respectively. The concentrates of TIMP-1 were（ 264.56±26.18） μg/L，（ 245.07±21.50） μg/L,（ 208.89±31.94） μg/L and（ 197.69±28.52） μg/L， for groups AMI， UAP SAP and C， respectively. The concentrates of ICTP were（ 10.89±0.78） μg/L，（ 9.35±0.61） μg/L，（ 3.97±0.31） μg/L and（ 3.96±0.32） μg/L for groups AMI，UAP， SAP and C， respectively. The concentrates ratios of MMP-9/TIMP-1 were（ 1.020±0.077），（ 0.820±0.057），（0.700±0.060） and（ 0.700±0.090） for groups AMI， UAP， SAP and C， respectively. The above data suggests that the collagen metabolism increase with the aggravation of disease。The concentrate divergences of MMP-9， TIMP-1，MMP-9/TIMP-1 and ICTP between group C and SAP had no statistically meaning（ P>0.05）. The concentrates divergences of MMP-9， TIMP-1， MMP-9/TIMP-1 and ICTP between groups SAP and UAP， groups UAP and AMI had statistically meaning （P<0.05）.Conclusion： The progress of oronary arterial remodeling and vulnerability plate rupture with collagen degradation. The concentrates ratios of MMP-9/TIMP-1 and the concentrates of ICTP in serum may be the indexes for evaluating the instability about unstable plaque of coronary heart disease.
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