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| The Concentration and Clinical Meaning of Plasma Homocysteine on Chronic Heart Failure Patients |
| Xinhui Hospital Afiliated to Southern Medical University，Jiangmen 529100，China |
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Abstract Objective：To observe the concentration and clinical meaning of plasma homocysteine on chronic heart failure patients（CHF）.Method：There were 200 patients， 100 of them do not have CHF（ control group），100 of them have CHF（CHF group）.The CHF patients were separated as group Ⅱ，group Ⅲ，group Ⅳ according to the America New York Heart Association（ NYHA）.The plasma homocysteine，N-terminal B-type natriuretic peptide（ NTproBNP）
and left ventrical eject function（LVEF） were compared on all of the patients.Result：The plasma homocysteine was higher on the group CHF than on the control group（P<0.05）.The plasma homocysteine was different from group Ⅱ to group Ⅲ and group Ⅳ（P<0.05）.The NT-proBNP was higher on the group CHF than on the control group（P<0.05）.The plasma NT-proBNP was different from group Ⅱ to group Ⅲ and group Ⅳ（P<0.05）.The LVEF was lower on the
group CHF than on the control group（P<0.05）.The LVEF was different from group Ⅱ to group Ⅲ and group Ⅳ（P<0.05）.The plasma homocysteine was positively correlated with NT-proBNP， and negatively correlated with LVEF on the CHF patients.Conclusion：The plasma homocysteine is higher on the CHF， it may be considered as one of the important CHF markers.
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