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Abstract Objective：To investigate the efficiency of midazolam in treatment of status epilepticus. Method：52 patients with status epilepticus（from January 2012 to January 2014）were randomly divided into control group and midazolam group，the former were given conventional treatment and diazepam，while midazolam group were given conventional treatment and midazolam. Result：The total effective rate of midazolam group was 92.3%；the total effective rate of the control group was 80.7%，the difference was statistically significant（P<0.05）.Midazolam group‘s control time was （36.5±4.73）min，control group’s control time was（47.9±5.8）min，the difference was statistically significant（P<0.05）.There were one case of pulmonary infection，one case of hypotension in midazolam group， while two cases of pulmonary infection，one case of hypotension in control group，all these cases were relieved after symptomatic treatment.The difference was not statistically significant in adverse reactions between two groups（P>0.05）. Conclusion：Midazolam is safe， effective and rapid onset in treatment of status epilepticus.
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