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Abstract Objective： To investigate the individual differences of Han and Uygur patients receiving Sodium Valproate Tablet in the treatment of epileptic seizures. Method： There were a total of 100 epileptic patients with generalized tonic-clonic seizure， admitted to the Fourth People’s Hospital in Urumqi， Xinjiang from March 2010 to March 2014. Among them， 52 were Han Chinese and 48 were Uighurs. The average daily dose of sodium valproate was 15 mg/kg of body weight or 600-1200 mg in total at 2 to 3 times a day. The treatment was initiated with an dose of 5-10 mg/kg of body weight. Seven days later the dose began to increase gradually until it reached the maximum safe dose. The therapeutic effects were evaluated as follows： completely pletely seizure free（ 100% seizure reduction）， markedly effective（ ≥ 75% seizure reduction）， effective（ 50％ -75％ seizure reduction） and invalid（ <50％ seizure reduction）. Result： The treatment was observed effective on 88.46% of the Han group and 70.83% on the Uighur group within 8 weeks. Conclusion： Under the same dose sodium valproate tablet is more curative on Han epileptic patients with generalized tonic-clonic seizure than on the Uighur ones.
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