Objective：To investigate the clinical efficacy of different treatment methods on early onset preeclampsia.Method：96 cases of early pregnant women in the sampled in our hospital， were randomly divided into three groups， the group of magnesium sulfate， magnesium sulfate and low molecular heparin group（magnesium sulfate+LMWH group）， magnesium sulfate+low molecular weight heparin+Salvia miltiorrhiza hiza group（ magnesium sulfate+LMWH+SM group），32 cases in each group.Through the observation of pregnancy outcome， the changes of blood pressure， APTT
value， newborn and to determine the clinical effects of the three groups.Result：Three groups of patients with blood pressure and APTT value were compared before and after treatment，the differences were statistically significant（P<0.05）; magnesium sulfate group of neonatal asphyxia incidence was highest of 62.5% and the neonatal survival rate was the lowest of 87.5%，compared with other two groups had significant difference（ P<0.05）。Three groups of patients with treatment time and neonatal weight were compared，there were no significant differences.Conclusion：Magnesium sulfate+low molecular weight heparin+salvia miltiorrhiza combined treatment of early onset preeclampsia have best effect，worthy of
clinical application.