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Abstract Objective：To compare the effect of nasal mask and mask connected noninvasive ventilation with bilevel positive airway pressure（BiPAP） in the rescue of type Ⅱ respiratory failure and to explore the better noninvasive ventilation connection mode.Method：80 patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） combined with type II respiratory failure in our hospital from September 2013 to November 2014 were selected and randomly divided into two groups.All patients were given the basic treatment of anti infection，eliminating phlegm，relieving cough，spasmolysis，relieving asthma and respiratory stimulant.The two groups were given noninvasive ventilation with BiPAP on the basis of the basic treatment.The observation group was given nasal mask connection noninvasive ventilation and the control group was given mask connection noninvasive ventilation.The vital signs，indexes of blood gas，compliance rate，success rate， intubation rate，days of hospitalization and mortality rate of the two groups were observed and compared.Result：After ventilation，the vital signs and indexes of blood gas of the two groups were better than before ventilation.3 hours after the ventilation，the respiratory rate（R），oxygen saturation（SpO2） and indexes of blood gas in the control group were better than those in the observation group.The compliance rate and success rate of the observation group were higher than those of the control group.The differences above were all statistically significant（P<0.05）.The differences in the intubation rate，days of hospitalization and mortality rate of the two groups were not statistically significant（P>0.05）.Conclusion：The effect of nasal mask and mask connection noninvasive ventilation with BiPAP in the treatment of AECOPD complicated with type Ⅱ respiratory failure is significant. The improvement of R，SpO2 and indexes of blood gas in patients with mask connection is faster than that in patients with nasal mask connection.But there is no significant difference in terms of the effect between the two connection methods after 12 hours of ventilation.Nasal mask connection is better in comfortability，compliance and the success rate，it is easier for clinical application.
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