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| The Relationship between Galetin-3 and NYHA after Acute Myocardial Infarction and the Intervention Function of Atorvastatin on the NYHA Patients with after Acute Myocardial Infarction |
| Heze Clinical College of Taishan Medical College， Heze Municipal Hospital， Heze 274000， China |
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Abstract Objective： To study the relationship between Galetin-3 and NYHA after acute myocardial infarction and the intervention function of atorvastatin on the NYHA patients with after acute myocardial infarction.Method： 100 patients with acute myocardial infarction in our hospital from May 2012 to May 2014 were randomly divided into observation group and control group， 50 cases in each group， and 50 health cases as health group. The observation group was treated with atorvastatin， and the control group was treated with common anti heart failure drugs.The intervention of the two groups was observed after acute myocardial infarction， and the Galetin-3 levels of all patients were detected. Result： The Galetin-3 levels significantly decreased after treatment in the two groups， but the patients in the observation group were significantly lower than those in the control ntrol group（ P<0.05）. There were no significant differences in cardiac function index between the two groups before treatment（ P>0.05）， after treatment， the heart function level of the two groups was significantly relieved than before treatment， the difference was statistically significant（ P<0.05））. After treatment， inflammatory factors TNF-α， IL-6 and Hs-CRP levels of the two groups patients significantly decreased， the difference was statistically significant（ P<0.05）， and the observation group was significantly higher than that of the control group， the difference was statistically significant（ P<0.05）. The different NYHA levels of NT-proBNP when was grade Ⅰ，there was no difference before and after treatment（ P>0.05）， but significantly decreased in the other grade after treatment（P<0.05）. Conclusion： Galetin-3 has a very important significance in predicting the occurrence of heart failure after acute myocardial infarction， and the effect of atorvastatin is more significant， which is worthy of clinical application.
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