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| Clinical Observation of Insulin Glargine Combined with Repaglinide in the Treatment of Elderly Patients with Diabetic Nephropathy |
| The People’s Hospital of Fengshun County，Fengshun 514300，China |
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Abstract Objective：To evaluate the clinical efficacy of Insulin glargine combined with Repaglinide in the treatment of elderly type 2 diabetic nephropathy.Method：60 elderly patients with type 2 diabetes mellitus and early nephropathy admitted to our hospital from January 2012 to November 2014 were selected，and they were divided into the experimental group and the control group according to the random number table method，30 cases in each group.The experimental group was given Insulin glargine combined with Repaglinide for treatment，the control group was given Novolin 30R for treatment.The clinical curative effect，the changes of blood glucose and kidney function before and after treatment，incidence of hypoglycemic events between the two groups were observed and compared.Result：After 12 weeks of treatment，the total effective rate of the experimental group was 93.3%，which was significantly higher than 73.3% of the control group，the difference was statistically significant（ X2=4.3200，P=0.0377）.The fasting blood-glucose，postprandial 2 h blood glucose glycosylated hemoglobin level of the experimental group after treatment were significantly better than those of the control group，the usea nitrogen，serum creatinine，
glomerular filtration rate and urinary albumin excretion rate were significantly lower than those of the control group，the incidence of hypoglycemic events was significantly lower than the control group，the differences were statistically significant（P<0.05）.Conclusion：The clinical effect of Insulin glargine combined with Repaglinide in the treatment of elderly type 2 diabetic nephropathy is good，can effectively reduce the occurrence of complications，reduce the incidence of hypoglycemia，is worthy of clinical popularization and application.
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